Ribosome Biogenesis

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Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Author : Vijay Kumar
Publisher : Elsevier
ISBN 13 : 012816364X
Total Pages : 296 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Emerging Concepts in Ribosome Structure, Biogenesis, and Function by : Vijay Kumar

Download or read book Emerging Concepts in Ribosome Structure, Biogenesis, and Function written by Vijay Kumar and published by Elsevier. This book was released on 2021-09-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview on all parts in this process. The book begins with an introduction to the ribosome factory, its origin and its evolution of translation. Sections discuss subunits, RNA, protein components, and its emergence as a frontier research area for translational potential in cancer and other diseases. In addition, the book explores current developments in ribosome research, including the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes. This book provides the emerging research on ribosomes, their biogenesis, and other important topics on structure and function. Therefore, it will serve as a resourceful introduction for both new researchers and those engaged in interdisciplinary ribosomal research.

Emerging Concepts in Ribosome Structure, Biogenesis, and Function

Author : Vijay Kumar
Publisher : Academic Press
ISBN 13 : 0128167343
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Emerging Concepts in Ribosome Structure, Biogenesis, and Function by : Vijay Kumar

Download or read book Emerging Concepts in Ribosome Structure, Biogenesis, and Function written by Vijay Kumar and published by Academic Press. This book was released on 2021-09-25 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations

Ribosome Biogenesis

Author : Karl-Dieter Entian
Publisher : Springer Nature
ISBN 13 : 1071625012
Total Pages : 287 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Ribosome Biogenesis by : Karl-Dieter Entian

Download or read book Ribosome Biogenesis written by Karl-Dieter Entian and published by Springer Nature. This book was released on 2022-07-07 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access volume provides comprehensive reviews and describes the latest techniques to study eukaryotic ribosome biogenesis. For more than 50 years ribosomes are a major research topic. Our knowledge about ribosome biogenesis and function such as transcription, mRNA modification, and translation was the sine qua non for developing the powerful RNA-based vaccines against RNA-viruses causing the world-threatening Covid-19 pandemia. The chapters in this book are organized into six parts. Part One discusses a comparative survey about the unity and diversity of ribosome biogenesis in pro- and eukaryotic cells. Part Two deals with the genomic organization of eukaryotic rDNA and the role of RNA polymerase I in ribosomal RNA transcription. Part Three explores in vitro methods to study RNA polymerase I structure and its function, and Part Four analyzes the nucleo-cytoplasmic transport of assembled ribosomes and RNP complexes. Part Five covers modifications that increase the complexity of rRNAs, and Part Six provides readers with a review of eukaryotic translation and - for the first time - describes a new method to analyze translation in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Ribosome Biogenesis: Methods and Protocols is a valuable resource for scientists and researchers interested in learning more about the increasing importance of in vitro RNA-technologies.

The Nucleolus and Ribosome Biogenesis

Author : A.A. Hadjiolov
Publisher : Springer Science & Business Media
ISBN 13 : 3709187427
Total Pages : 281 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis The Nucleolus and Ribosome Biogenesis by : A.A. Hadjiolov

Download or read book The Nucleolus and Ribosome Biogenesis written by A.A. Hadjiolov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nucleolus had consistently attracted the attention of investigators in the fields of cell biology and pathology. Because of its ubiquitous presence in the nucleus of eukaryotic cells, its rapid changes during their life cycle, and its rapid response to noxious agents, this organelle has been the subject of a large number of studies. Yet, the exact function and the very reason for the existence of the nucleolus (the only large cellular structure not delimited by a membrane) remain largely unknown. The ribosomes were discovered relatively late in the study of cells, but due to their crucial involvement in the protein synthesis machinery of all living organisms, the elucidation of their structure and function quickly became one of the major goals of molecular biology. The relatively simple structure of the ribosome strengthens the hope that a full understanding of the structure and function of this organelle in molecular terms is within the reach of contemporary research~ Since each of the rRNA and protein molecules embodied in the ribosome is the product of a distinct gene, studies on the biogenesis of ribosomes expanded rapidly to become a core topic in molecular genetics.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

RNA-Based Regulation in Human Health and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128171944
Total Pages : 444 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis RNA-Based Regulation in Human Health and Disease by :

Download or read book RNA-Based Regulation in Human Health and Disease written by and published by Academic Press. This book was released on 2020-08-19 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Archaeal Ribosomes: Biogenesis, Structure and Function

Author : Paola Londei
Publisher : Frontiers Media SA
ISBN 13 : 2889741419
Total Pages : 164 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Archaeal Ribosomes: Biogenesis, Structure and Function by : Paola Londei

Download or read book Archaeal Ribosomes: Biogenesis, Structure and Function written by Paola Londei and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulation of Ribosome Biogenesis and Rna Polymerase I Transcription

Author : Robert Steinbauer
Publisher : Sudwestdeutscher Verlag Fur Hochschulschriften AG
ISBN 13 : 9783838126142
Total Pages : 148 pages
Book Rating : 4.1/5 (261 download)

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Book Synopsis Regulation of Ribosome Biogenesis and Rna Polymerase I Transcription by : Robert Steinbauer

Download or read book Regulation of Ribosome Biogenesis and Rna Polymerase I Transcription written by Robert Steinbauer and published by Sudwestdeutscher Verlag Fur Hochschulschriften AG. This book was released on 2011-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ribosome synthesis depends on nutrient availability sensed by the target of rapamycin (TOR) signaling pathway in eukaryotic cells. TOR inactivation affects ribosome biogenesis at the level of RNA polymerase I (Pol I)-dependent transcription of ribosomal RNA (rRNA) genes, expression of ribosomal proteins (r-proteins) and ribosome biogenesis factors, pre-ribosome processing, and transport. Detailed analysis shows that upon TOR inactivation the levels of newly synthesized ribosomal subunits drop drastically before the integrity of the Pol I apparatus is severely impaired but in good correlation with a sharp decrease in r-protein production. Inhibition of translation by cycloheximide mimics the rRNA maturation defect observed immediately after TOR inactivation. Both cycloheximide addition and the depletion of individual r-proteins also reproduce TOR-dependent nucleolar entrapment of specific ribosomal precursor complexes. The conclusion could be drawn that shortage of newly synthesized r-proteins after short-term TOR inactivation is sufficient to explain most of the observed effects on ribosome production.

The Nucleolus

Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
ISBN 13 : 1461405149
Total Pages : 434 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis The Nucleolus by : Mark O. J. Olson

Download or read book The Nucleolus written by Mark O. J. Olson and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

The Eukaryotic Ribosome

Author : Heinz Bielka
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3112729757
Total Pages : 340 pages
Book Rating : 4.1/5 (127 download)

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Book Synopsis The Eukaryotic Ribosome by : Heinz Bielka

Download or read book The Eukaryotic Ribosome written by Heinz Bielka and published by Walter de Gruyter GmbH & Co KG. This book was released on 1982-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "The Eukaryotic Ribosome".

Xenopus

Author : Kris Vleminckx
Publisher : Humana
ISBN 13 : 9781493987832
Total Pages : 0 pages
Book Rating : 4.9/5 (878 download)

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Book Synopsis Xenopus by : Kris Vleminckx

Download or read book Xenopus written by Kris Vleminckx and published by Humana. This book was released on 2018-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores techniques used to study and experiment with Xenopus in order to model or understand human disease. The chapters in this book cover topics such as implementation of CRISPR/Cas9 and TALEN in Xenopus from the design stage up to the genotyping stage; methods to explore generation of knock-in animals; cancer modelling and in vivo screening of congenital heart disease; electroporation; and phenotyping at the organismal level, cellular level, and proteome level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Xenopus: Methods and Protocols is a valuable resource for researchers who are interested in expanding their knowledge of this wide and developing field. This book will aid in keeping Xenopus at the forefront for biochemical, cell biological, and developmental studies and forward it as a preclinical disease model.

Multiple Mechanisms Regulating Ribosome Biogenesis in Saccharomyces Cerevisiae

Author : Chrissie Young Lee
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Multiple Mechanisms Regulating Ribosome Biogenesis in Saccharomyces Cerevisiae by : Chrissie Young Lee

Download or read book Multiple Mechanisms Regulating Ribosome Biogenesis in Saccharomyces Cerevisiae written by Chrissie Young Lee and published by . This book was released on 2008 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulation of Alternative Splicing

Author : Philippe Jeanteur
Publisher : Springer Science & Business Media
ISBN 13 : 3662097281
Total Pages : 254 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Regulation of Alternative Splicing by : Philippe Jeanteur

Download or read book Regulation of Alternative Splicing written by Philippe Jeanteur and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery in 1977 that genes are split into exons and introns has done away with the one gene - one protein dogma. Indeed, the removal of introns from the primary RNA transcript is not necessarily straightforward since there may be optional pathways leading to different messenger RNAs and consequently to different proteins. Examples of such an alternative splicing mechanism cover all fields of biology. Moreover, there are plenty of occurrences where deviant splicing can have pathological effects. Despite the high number of specific cases of alternative splicing, it was not until recently that the generality and extent of this phenomenon was fully appreciated. A superficial reading of the preliminary sequence of the human genome published in 2001 led to the surprising, and even deceiving to many scientists, low number of genes (around 32,000) which contrasted with the much higher figure around 150,000 which was previously envisioned. Attempts to make a global assessment of the use of alternative splicing are recent and rely essentially on the comparison of genomic mRNA and EST sequences as reviewed by Thanaraj and Stamm in the first chapter of this volume. Most recent estimates suggest that 40-60% of human genes might be alternatively spliced, as opposed to about 22% for C. elegans.

Maternal Effect Genes in Development

Author :
Publisher : Academic Press
ISBN 13 : 0128152214
Total Pages : 450 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Maternal Effect Genes in Development by :

Download or read book Maternal Effect Genes in Development written by and published by Academic Press. This book was released on 2020-06-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by one or more members of an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology series Includes the latest information on maternal effect genes in development

Pathobiology of Human Disease

Author :
Publisher : Elsevier
ISBN 13 : 0123864577
Total Pages : 5000 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Pathobiology of Human Disease by :

Download or read book Pathobiology of Human Disease written by and published by Elsevier. This book was released on 2014-08-01 with total page 5000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Plant Epigenetics

Author : Nikolaus Rajewsky
Publisher : Springer
ISBN 13 : 3319555200
Total Pages : 536 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Plant Epigenetics by : Nikolaus Rajewsky

Download or read book Plant Epigenetics written by Nikolaus Rajewsky and published by Springer. This book was released on 2017-04-27 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.

Protein Synthesis and Ribosome Structure

Author : Knud H. Nierhaus
Publisher : John Wiley & Sons
ISBN 13 : 3527616381
Total Pages : 597 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Protein Synthesis and Ribosome Structure by : Knud H. Nierhaus

Download or read book Protein Synthesis and Ribosome Structure written by Knud H. Nierhaus and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.