Rho Gtpases Molecular Biology In Health And Disease

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Rho Gtpases: Molecular Biology In Health And Disease

Author : Fort Philippe
Publisher : World Scientific
ISBN 13 : 9813228806
Total Pages : 212 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Rho Gtpases: Molecular Biology In Health And Disease by : Fort Philippe

Download or read book Rho Gtpases: Molecular Biology In Health And Disease written by Fort Philippe and published by World Scientific. This book was released on 2017-12-12 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rho GTPases control many aspects of cell physiology. This includes polarity, endo/exocytosis, adhesion, motility, transcriptional activation, cell cycle progression or apoptosis. In view of such pleiotropic activities, Rho-controlled signaling has proven to be of medical relevance, especially in tumorigenesis, disease-associated bone remodeling and infectiology. This book is divided into three parts. Part 1 gives an evolutionary perspective of the Rho family, its atypical members, and an overview of how Rho activity is regulated. Part 2 addresses two important aspects of multicellularity controlled by Rho-dependent pathways, namely, cell-cell interactions and mechanotransduction. It also describes how post-translational modifications control Rho activity and how this is exploited by pathogenic bacteria. Part 3 explores several examples of the variety of pathophysiological processes controlled by Rho signaling, and gives a successful example of translational research, from the inhibition of Rho activation to the development of new molecules against osteoporosis. This updated review on the biology of Rho GTPases is an essential read for molecular and cell biologists. It is also an invaluable guide to post-graduate and medical students who wish to deepen their knowledge in cell biology. Contents: An Historical and Evolutionary PerspectiveAtypical Rho GTPases in Health and DiseaseRegulators of Rho SignalingRho GTPases in Cadherin-Based Cell-Cell InteractionsRho Signaling in MechanotransductionPost-Translational modifications of Rho GTPasesRhoA Mutations in Cancer: Oncogenes or Tumor-SuppressorsModulation of Osteoclast Differentiation and Function by Rho GTPasesRhoGEFs as Therapeutic TargetsEndothelial-Specific Rho GTPase Signaling During Leukocyte Extravasation Readership: Molecular and cell biologists, post-graduate and medical students interested in cell biology. Keywords: Rho GTPases;Signaling Oathways;F-actin;Cytoskeleton;Adhesion;Migration;CancerReview: Key Features: Different integration levels for a better understanding of biological and pathological implications of Rho signalingChapters cover updated and original Rho-controlled aspects of cell biologyContributors are leaders in their fields of research

Rho Family GTPases

Author : Edward J. Manser
Publisher : Springer Science & Business Media
ISBN 13 : 1402034628
Total Pages : 307 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Rho Family GTPases by : Edward J. Manser

Download or read book Rho Family GTPases written by Edward J. Manser and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

Rho GTPases

Author : Marc H. Symons
Publisher : Springer Science & Business Media
ISBN 13 : 9780306479922
Total Pages : 256 pages
Book Rating : 4.4/5 (799 download)

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Book Synopsis Rho GTPases by : Marc H. Symons

Download or read book Rho GTPases written by Marc H. Symons and published by Springer Science & Business Media. This book was released on 2004-05-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases. Additional chapters discuss the wide range of biological functions that are controlled by Rho GTPases, including the organization of the actin cytoskeleton, cell proliferation and cell motility. Rho GTPases is essential reading for cell and molecular biologists, biochemists and geneticists. The critical roles of Rho family members in cancer and inflammatory diseases makes Rho GTPases also an invaluable guide for clinical investigators and pharmacologists.

The Rho GTPases in Cancer

Author : Kenneth van Golen
Publisher : Springer Science & Business Media
ISBN 13 : 1441911111
Total Pages : 219 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Rho GTPases in Cancer by : Kenneth van Golen

Download or read book The Rho GTPases in Cancer written by Kenneth van Golen and published by Springer Science & Business Media. This book was released on 2009-12-04 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Channing Der and colleagues provide an encyclopedic overview of the Rho GTPases, providing enough detail to make any reader well-versed in the Rho field. Finally, Sofia Merajver’s laboratory provides an overview, which details the roles of the Rho proteins in cancer progression. She provides us with the history of the study of the Rho GTPases, their regulatory and effector proteins in cancer and gives us a benchmark of where the field is today. The second section of the book details the current knowledge of the Rho regu- tory proteins in cancer progression: aberrant expression and activation of these proteins leads to dysfunctional Rho signaling and a cancer phenotype. Gary Bokoch’s laboratory has provided a detailed overview of the role of Rho guanine dissociation inhibitors (GDIs) in cancer. These molecules are involved in preventing the Rho protein from associating with the inner plasma membrane and exchanging GDP for GTP, and thus becoming active. Next, Tozu Kazasa’s labo- tory has worked on the link between heterotrimeric G proteins and Rho activation via the RGS–RhoGEFs. This aspect of Rho activation is particularly interesting in that heterotrimeric G proteins and their associated G-protein-coupled receptors are attractive and attainable therapeutic targets. Dan Billadeau’s laboratory has worked extensively on the Vav RhoGEFs, which are potent oncogenes in their own right.

Rho GTPases

Author : Francisco Rivero
Publisher : Humana Press
ISBN 13 : 9781617794414
Total Pages : 0 pages
Book Rating : 4.7/5 (944 download)

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Book Synopsis Rho GTPases by : Francisco Rivero

Download or read book Rho GTPases written by Francisco Rivero and published by Humana Press. This book was released on 2011-12-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although initially described as major regulators of cytoskeletal remodeling, Rho GTPases have been implicated in the establishment of polarity, endocytosis, vesicle trafficking, morphogenesis, cytokinesis, transcriptional activation, cell cycle progression, and apoptosis, to mention a few. In addition, Rho GTPases have acquired medical relevance because of their participation in tumorigenesis and metastasis, in cardiovascular conditions, and as targets of infectious agents. The field has broadened even more with the contribution of studies in model organisms (plants, amoebas, fungi, invertebrates), each adding a particular view to the complexity of the family and vastly enriching our perception of these important signaling components. Divided into five convenient sections, Rho GTPase: Methods and Protocols provides an historical overview of the field and an account of the phylogenetics of the Rho family, general biochemical methods, and functional assays that allow monitoring the consequences of manipulating Rho GTPases in a variety of contexts. Additionally, the volume devotes a section to advanced imaging methods and to recently developed high throughput methods, closing with techniques specifically designed for studies in selected non-mammalian model organisms. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Rho GTPase: Methods and Protocols provides techniques that are standard for researchers in the field but also includes protocols for those who, being already familiar with some of the techniques, wish to explore additional aspects.

Small GTPases in Disease

Author :
Publisher : Academic Press
ISBN 13 : 9780080570075
Total Pages : 616 pages
Book Rating : 4.5/5 (7 download)

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Book Synopsis Small GTPases in Disease by :

Download or read book Small GTPases in Disease written by and published by Academic Press. This book was released on 2008-04-01 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volume 1 onward.

The Rho Gtpases in Cancer

Author : Kenneth Van Golen
Publisher :
ISBN 13 : 9781441911124
Total Pages : 230 pages
Book Rating : 4.9/5 (111 download)

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Book Synopsis The Rho Gtpases in Cancer by : Kenneth Van Golen

Download or read book The Rho Gtpases in Cancer written by Kenneth Van Golen and published by . This book was released on 2010-04-17 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regulators and Effectors of Small GTPases, Part D: Rho Family

Author :
Publisher : Elsevier
ISBN 13 : 0080496806
Total Pages : 583 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Regulators and Effectors of Small GTPases, Part D: Rho Family by :

Download or read book Regulators and Effectors of Small GTPases, Part D: Rho Family written by and published by Elsevier. This book was released on 2000-10-11 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume and its companions (Volumes 255, 256, 257, and the forthcoming 329) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Ras Superfamily Small G Proteins: Biology and Mechanisms 1

Author : Alfred Wittinghofer
Publisher : Springer
ISBN 13 : 3709118069
Total Pages : 447 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Ras Superfamily Small G Proteins: Biology and Mechanisms 1 by : Alfred Wittinghofer

Download or read book Ras Superfamily Small G Proteins: Biology and Mechanisms 1 written by Alfred Wittinghofer and published by Springer. This book was released on 2014-09-22 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins. Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.

Molecular and Cellular Mechanobiology

Author : Shu Chien
Publisher : Springer
ISBN 13 : 1493956175
Total Pages : 302 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Molecular and Cellular Mechanobiology by : Shu Chien

Download or read book Molecular and Cellular Mechanobiology written by Shu Chien and published by Springer. This book was released on 2016-08-10 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Handbook of Cell Signaling

Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3048 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

The Cytoskeleton in Health and Disease

Author : Heide Schatten
Publisher : Springer
ISBN 13 : 1493929046
Total Pages : 395 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis The Cytoskeleton in Health and Disease by : Heide Schatten

Download or read book The Cytoskeleton in Health and Disease written by Heide Schatten and published by Springer. This book was released on 2015-08-21 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease

Author : Selwin K. Wu
Publisher : Frontiers Media SA
ISBN 13 : 2889662179
Total Pages : 171 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease by : Selwin K. Wu

Download or read book Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease written by Selwin K. Wu and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trafficking Inside Cells

Author : Nava Segev
Publisher : Springer Science & Business Media
ISBN 13 : 038793877X
Total Pages : 459 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Trafficking Inside Cells by : Nava Segev

Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Bacterial Protein Toxins

Author : K. Aktories
Publisher : Springer Science & Business Media
ISBN 13 : 3662059711
Total Pages : 713 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Bacterial Protein Toxins by : K. Aktories

Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Molecular and Cellular Biology of Platelet Formation

Author : Harald Schulze
Publisher : Springer
ISBN 13 : 9783319819143
Total Pages : 0 pages
Book Rating : 4.8/5 (191 download)

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Book Synopsis Molecular and Cellular Biology of Platelet Formation by : Harald Schulze

Download or read book Molecular and Cellular Biology of Platelet Formation written by Harald Schulze and published by Springer. This book was released on 2018-07-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.