Reversing Polycystic Kidney Disease Pkd

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Cystogenesis

Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Cystogenesis by : Jong Hoon Park

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Chronic Kidney Disease

Author : Thomas Rath
Publisher : BoD – Books on Demand
ISBN 13 : 953513843X
Total Pages : 307 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Chronic Kidney Disease by : Thomas Rath

Download or read book Chronic Kidney Disease written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2018-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

The Cystic Kidney

Author : K.D. Gardner
Publisher : Springer Science & Business Media
ISBN 13 : 9400904576
Total Pages : 441 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Cystic Kidney by : K.D. Gardner

Download or read book The Cystic Kidney written by K.D. Gardner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about renal cysts and cystic kidneys. Its contributors have created a resource of current information in a field that once aroused only curiosity, but that now stands at the leading edge of molecular nephrology. Its authorship includes 'oldtimers', who bring the wisdom of experience, and 'newcomers', whose presence attests to the contributions made by the investigative and technological advances of the past decade. Its text is organized to carry the reader from renal cyst to cystic renal disease. Each of its chapters defines or explores a challenge or an advance. Cells that line renal cysts are diverse in structure, type, and perhaps function. The cysts themselves lie within an interstitium that is not normal and may influence cyst development and growth. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.

Ferri's Clinical Advisor 2020 E-Book

Author : Fred F. Ferri
Publisher : Elsevier Health Sciences
ISBN 13 : 0323679773
Total Pages : 7615 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Ferri's Clinical Advisor 2020 E-Book by : Fred F. Ferri

Download or read book Ferri's Clinical Advisor 2020 E-Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2019-06-01 with total page 7615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri's Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today's medical practice. - Contains significant updates throughout, covering all aspects of current diagnosis and treatment. - Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. - Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. - Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. - Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.

Why I Think about Urine

Author : Jared James Grantham
Publisher : Rockhill Books
ISBN 13 : 9781611691283
Total Pages : 282 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Why I Think about Urine by : Jared James Grantham

Download or read book Why I Think about Urine written by Jared James Grantham and published by Rockhill Books. This book was released on 2014-04-11 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this page-turner, Dr. Jared Grantham, a noted researcher with the University of Kansas Medical Center, takes the reader through his life of scientific discovery, but a life also of hardship beset by tragedy. It follows a career path that begins in Kansas, finishes in Kansas and ultimately leads to the development of a treatment for a devastating kidney disease suffered by his boyhood friend.

Kidney Development and Disease

Author : Rachel K. Miller
Publisher : Springer
ISBN 13 : 3319514369
Total Pages : 373 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Kidney Development and Disease by : Rachel K. Miller

Download or read book Kidney Development and Disease written by Rachel K. Miller and published by Springer. This book was released on 2017-04-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Polycystic Kidney Disease

Author : Benjamin D. Cowley, Jr.
Publisher : Springer
ISBN 13 : 1493977849
Total Pages : 274 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Polycystic Kidney Disease by : Benjamin D. Cowley, Jr.

Download or read book Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and published by Springer. This book was released on 2018-05-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Genetic Diseases of the Kidney

Author : Richard P. Lifton
Publisher : Academic Press
ISBN 13 : 0080924271
Total Pages : 895 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Genetic Diseases of the Kidney by : Richard P. Lifton

Download or read book Genetic Diseases of the Kidney written by Richard P. Lifton and published by Academic Press. This book was released on 2009-02-25 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic "disturbance to the systemic appearance of disease. - Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics - Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes - World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

Reversing Polycystic Kidney Disease (PKD)

Author : Health Central
Publisher : Raw Power
ISBN 13 : 9781395764128
Total Pages : 74 pages
Book Rating : 4.7/5 (641 download)

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Book Synopsis Reversing Polycystic Kidney Disease (PKD) by : Health Central

Download or read book Reversing Polycystic Kidney Disease (PKD) written by Health Central and published by Raw Power. This book was released on 2019-10-07 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: A truly resourceful and supporting workbook which will help you reach your health goals in a short space of time. A Must Have!

Pediatric Nephrology

Author : Ellis D. Avner
Publisher : Springer Science & Business Media
ISBN 13 : 3540763279
Total Pages : 2059 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Pediatric Nephrology by : Ellis D. Avner

Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.

Handbook of Life Course Health Development

Author : Neal Halfon
Publisher : Springer
ISBN 13 : 3319471430
Total Pages : 667 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Handbook of Life Course Health Development by : Neal Halfon

Download or read book Handbook of Life Course Health Development written by Neal Halfon and published by Springer. This book was released on 2017-11-20 with total page 667 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.

Biomarkers in Kidney Disease

Author : Vinood B. Patel
Publisher : Springer
ISBN 13 : 9789400776982
Total Pages : 0 pages
Book Rating : 4.7/5 (769 download)

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Book Synopsis Biomarkers in Kidney Disease by : Vinood B. Patel

Download or read book Biomarkers in Kidney Disease written by Vinood B. Patel and published by Springer. This book was released on 2016-03-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.

Renal Physiology E-Book

Author : Bruce M. Koeppen
Publisher : Elsevier Health Sciences
ISBN 13 : 0323088252
Total Pages : 257 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Renal Physiology E-Book by : Bruce M. Koeppen

Download or read book Renal Physiology E-Book written by Bruce M. Koeppen and published by Elsevier Health Sciences. This book was released on 2012-10-12 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical reference book in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers. Stay current with clear, accurate coverage of the physiology of normal renal function focusing on the needs of the student. Bridge the gap between normal function and disease with pathophysiology content throughout the book. Understand complex concepts by examining more than more than 250 clear, 2-color diagrams. Perform quick searches ... add your own notes and bookmarks ... and more! Put theory into practice with "In the Clinic" or "At the Molecular Level " boxes in each chapter that explain the practical applications of fundamental knowledge. Deepen your understanding of fundamental and advanced information with an expanded collection of review questions reviewed and reorganized by chapter. Master the material more easily with learning objectives, overview boxes, key words and concepts, and chapter summaries. Apply what you've learned to real-life clinical situations with clinical cases in question-answer format at the end of each chapter. Gain a quick and easy understanding of the physiology of kidney and renal function

Renal Diet Cookbook

Author : Susan Zogheib
Publisher : Rockridge Press
ISBN 13 : 9781623156619
Total Pages : 0 pages
Book Rating : 4.1/5 (566 download)

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Book Synopsis Renal Diet Cookbook by : Susan Zogheib

Download or read book Renal Diet Cookbook written by Susan Zogheib and published by Rockridge Press. This book was released on 2015-11-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Better eating for healthier kidneys — the renal diet cookbook and meal plan. While a kidney disease diagnosis can be overwhelming, you're not alone. Nearly 26 million adults are affected by chronic kidney disease, but there is hope: your diet. In the Renal Diet Cookbook, renal dietician Susan Zogheib, MHS, RD, LDN provides a 28-day plan to establish long-term dietary changes to slow the progression of kidney disease. She knows it can be confusing to figure out which foods to eat and which to avoid. In her comprehensive renal diet cookbook, she details weekly meal plans featuring recipes that keep your potassium, sodium, and phosphorous levels in check. The Renal Diet Cookbook removes the mystery and stress of figuring out what foods to eat, with: Targeted weekly meal plans to preserve your kidney health Recipe modifications for dialysis patients Helpful FAQs about managing chronic kidney disease Recipes in the Renal Diet Cookbook include: Strawberry Cream Cheese Stuffed French Toast, Baba Ganoush, Roasted Beef Stew, Baked Mac and Cheese, Herb Pesto Tuna, Persian Chicken, Honey Bread Pudding, and much more! More than a recipe book, The Renal Diet Cookbook is your 28-day action plan to kick-start a kidney-healthy diet.

Liver Disease in Children

Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1139464035
Total Pages : 995 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Liver Disease in Children by : Frederick J. Suchy

Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2007-05-07 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Cilia and Flagella

Author :
Publisher : Academic Press
ISBN 13 : 0080859453
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Cilia and Flagella by :

Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella.Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures