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Author : Jean-Hilaire Saurat
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.3/5 (91 download)
Download or read book Retinoids, New Trends in Research and Therapy written by Jean-Hilaire Saurat and published by S. Karger AG (Switzerland). This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jean-Hilaire Saurat
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 536 pages
Book Rating : 4.:/5 (45 download)
Download or read book Retinoids, New Trends in Research and Therapy written by Jean-Hilaire Saurat and published by S. Karger AG (Switzerland). This book was released on 1985 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Maria A Livrea
Publisher : CRC Press
ISBN 13 : 9780824787585
Total Pages : 682 pages
Book Rating : 4.7/5 (875 download)
Download or read book Retinoids written by Maria A Livrea and published by CRC Press. This book was released on 1993-01-18 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications, held in 1991 in Palermo, Italy, describing the latest research findings on biochemistry, nutrition, molecular and cell biology and developmental biology, as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by leading authorities in the field from the USA, Europe and Japan, Retinoids, amongst other things: addresses retinol-supported retinoic acid (RA) synthesis and catabolism; identifies synthetic ligands with a high selective affinity for RAR-alpha, -beta and -gamma nuclear receptors, determining if they would show pharmacological properties similar to the natural parent substance all-trans RA; considers the embryonic/foetal cellular retinoid-binding proteins and evidence for their participation in normal and abnormal morphogenesis; discusses a novel arotinoid, Ro 40-8757, that exhibited improved anti-tumour efficacy and safety in pre-clinical tests; and reports the audioradiographic distribution of retinol and RA in organs of pregnant hamsters and foetuses.
Author : C.E. Orfanos
Publisher : Springer Science & Business Media
ISBN 13 : 3642680232
Total Pages : 500 pages
Book Rating : 4.6/5 (426 download)
Download or read book Retinoids written by C.E. Orfanos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the aromatic retinoic acid analog Tigason oral and intravenous pharmacokinetic studies have been performed in 5 normal volunteers. Simultaneous fitting of single i. v. and oral data to a three-compartment model assuming first-order absorption was possible. Using Nonlin parameter estimates of the single-dose data, one is able to predict the decline in plasma levels of parent drug following cessation of a 10 days multiple dosing regimen up to 24 hours. The model is however unable to predict a phase of prolonged elimination observed beyond 24 hours. Moreover in 5 patients, who underwent chronic therapy (8-15 months), substantial plasma levels of both unchanged drug and main metabolite (corre sponding carboxylic acid) were observed up to 140 days after cessation of the therapy. An apparent half-life of elimination of 80-100 days can be calculated. The drug appears to be stored at some yet unknown storage site. Investigation of metabolism of Tigason in rats and humans revealed 19 different bio transformation products thus far, most of them appearing in the urine in low amounts (20010 of dose). A few of them (mainly the acid Ro 10-1670) after conjugation to glucuronic acid are excreted in the bile in high amounts (60-80% of dose). No drug appeared unchanged in the excreta after i. v. administration to rats. References 1. Bollag W (1971) Effects of vitamin A acid (NSC-122758) on transplantable and chemically-induced tumors. Cancer Chemother Rep 55:53-58 2.
Author : Laurent Degos
Publisher : Springer Science & Business Media
ISBN 13 : 3642797067
Total Pages : 280 pages
Book Rating : 4.6/5 (427 download)
Download or read book Retinoids in Oncology written by Laurent Degos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments with respect to the biology and clinical use of retinoids in cancer therapy and prevention are comprehensively covered by experts in this new field. Newer aspects of molecular mechanisms of retinoid effects, the cellular biology and the developmental effects of these compounds are presented together with a comprehensive description of the latest findings of retinoid pharmacology, toxicology and clinical effects in a wide range of hematological and solid malignancies.
Author : Marcia I. Dawson
Publisher : CRC Press
ISBN 13 : 1351079085
Total Pages : 627 pages
Book Rating : 4.3/5 (51 download)
Download or read book Chemistry and Biology of Synthetic Retinoids written by Marcia I. Dawson and published by CRC Press. This book was released on 2018-01-18 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to present an overview of advances in both retinal and retinoic acid synthetic chemistry and biology. Chapters are written by research workers who are active in these fields. Emphasis is placed on structure-activity relationships. It includes topics of cell differentiation, maintenance of cell morphology, and vision. This reference contains a special section on assays which were developed to measure retinoid activity. This book is ideal for those interested in the fields of photobiology, organic chemistry, biological chemistry, and nutrition.
Author : G.V. Sherbet
Publisher : Elsevier
ISBN 13 : 0080877176
Total Pages : 313 pages
Book Rating : 4.0/5 (88 download)
Download or read book Retinoids: Their Physiological Function and Therapeutic Potential written by G.V. Sherbet and published by Elsevier. This book was released on 1997-10-30 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoids have received considerable attention in recent years and due cognizance has been given to their versatility as biological response modifiers, as evidenced by the virtually explosive growth of literature in this field in the past few years. This volume has been designed to give a current state-of-the-art picture of retinoids. The perceived potential of retinoids in the treatment of certain disease stated has initiated attempts at identifying and synthesizing new retinoid derivatives with definable and selective effects on aberrant biological phenomena. Appropriately, therefore, we begin with the chemistry of retinoids and their derivatives together with discussions of their biological activity. Major advances have been made in understanding the mechanisms by which retinoids modulate physiological and phenotypic traits of cells. The transduction of retinoid signaling by the mediation of nuclear receptors of the steroid/thyroid receptor superfamily has now been studied extensively and the cloning and defining the characteristics of these receptors has been a focus of discussion in this volume. Retinoids also markedly modulate the transduction of extracellular signals such as those imparted by growth factors and hormones, and thus actively influence and control cellular proliferative patterns. Retinoids can alter epidermal growth factor receptor expression (Kawaguchi et al., 1994), responsiveness to thyroid hormone (Esfandiari et al., 1994; Pallet et al., 1994), inhibit the proliferative responses of hematopoietic progenitor cells to granulocyte colony stimulating factor (Smeland et al., 1994), and modulate secretion on interleukins by leukaemic cells (Balitrand et al., 1994), among other things. This has obvious implications for pharmacological manipulation of deregulated growth (Dickens and Colletta, 1993; Mulshine et al., 1993). Apoptosis is another component in the regulation of growth control. Apoptotic cell death is influenced by several agents and retinoids may function by interfering with apoptotic pathways of regulation of growth control and quite legitimately, therefore, the importance of this aspect of retinoid function has been duly recognized here.
Author : IARC Working Group on the Evaluation of Cancer-preventive Agents
Publisher : IARC
ISBN 13 : 9789283230045
Total Pages : 360 pages
Book Rating : 4.2/5 (3 download)
Download or read book Retinoids written by IARC Working Group on the Evaluation of Cancer-preventive Agents and published by IARC. This book was released on 1999 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1712 pages
Book Rating : 4.3/5 (91 download)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Author : W.J. Cunliffe
Publisher : Springer Science & Business Media
ISBN 13 : 9401163499
Total Pages : 312 pages
Book Rating : 4.4/5 (11 download)
Download or read book Retinoid Therapy written by W.J. Cunliffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited.
Author : W. J. CUNLIFFE
Publisher : Kluwer Academic Publishers
ISBN 13 : 9780852007402
Total Pages : 376 pages
Book Rating : 4.0/5 (74 download)
Download or read book Retinoid Therapy written by W. J. CUNLIFFE and published by Kluwer Academic Publishers. This book was released on 1983-01-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pascal Dollé
Publisher : John Wiley & Sons
ISBN 13 : 1118628276
Total Pages : 634 pages
Book Rating : 4.1/5 (186 download)
Download or read book The Retinoids written by Pascal Dollé and published by John Wiley & Sons. This book was released on 2015-04-13 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Author :
Publisher :
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.:/5 (319 download)
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1987 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William J. Cunliffe
Publisher : CRC Press
ISBN 13 : 9780948269394
Total Pages : 414 pages
Book Rating : 4.2/5 (693 download)
Download or read book Acne written by William J. Cunliffe and published by CRC Press. This book was released on 1999-04-12 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasis is place on the knowledge of the disease, its investigation and its treatment. Invaluable for the training dermatologists and physicians completing their specialist training.
Author : Heinz Nau
Publisher : Springer Science & Business Media
ISBN 13 : 3642584837
Total Pages : 631 pages
Book Rating : 4.6/5 (425 download)
Download or read book Retinoids written by Heinz Nau and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the future' the decade of the 1990s will likely be viewed as a Golden Age for retinoid research. There have been unprecedented research gains in the understanding of retinoid actions and physiology; since the retinoid nuclear receptors were first identified and the importance of retinoic acid in develop mental processes was first broadly recognized in the late 1980s. Between then and now, our knowledge of retinoid action has evolved from one of a near complete lack of understanding of how retinoids act within cells to one of sophisticated understanding of the molecular processes through which retinoids modulate transcription. In this volume, we have tried to provide a comprehensive update of the present understanding of retinoid actions, with an emphasis on re cent advances. The initial chapters of the volume, or Section A, focus on the physicochemical properties and metabolism of naturally occurring retinoids: - N OY provides an uncommonly encountered view of retinoid effects from the perspective of the physiochemical properties of retinoids. - V AKIANI and BUCK lend a perspective on the biological occurrence and actions of retro- and anhydro-retinoids. Section B considers both the retinoid nuclear receptors and their mechanisms of action as well as synthetic retinoids that have been used exper imentally to provide mechanistic insights into receptor actions and have potential therapeutic use for treating disease: - PIEDRAFITA and PFAHL provide a comprehensive review of retinoid nuclear receptor biochemistry and molecular biology.
Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642740545
Total Pages : 602 pages
Book Rating : 4.6/5 (427 download)
Download or read book Pharmacology of the Skin II written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Author : H.W. Lim
Publisher : Routledge
ISBN 13 : 1351460064
Total Pages : 460 pages
Book Rating : 4.3/5 (514 download)
Download or read book Clinical Photomedicine written by H.W. Lim and published by Routledge. This book was released on 2018-10-03 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering broad coverage of the basic, clinical and curative aspects of photomedicine, this reference reflects the recent expansion of knowledge on the effects of light on normal skin as well as photosensitivity disorders and the use of light in treating various diseases and conditions.;The book demonstrates how light acts as a therapeutic agent by means such as phototherapy, photochemotherapy, extracorporeal photopheresis, and the use of lasers in photomedicine and photodynamic therapy.;Providing a detailed introduction to the subject, Clinical Photomedicine: discusses the fundamental principles of photomedicine such as skin optics, light sources, and pharmacology; explicates the acute and chronic effects of light on normal skin, including sunburn reaction, photoaging, and skin cancer; considers photoimmunology; examines clinical photosensitivity diseases as well as topical and systemic photoprotection; and much more.;With over 1300 literature citations, Clinical Photomedicine is designed as a resource for dermatologists and photobiologists, as well as residents and fellows in these disciplines.
