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Resolving The Cholesterol Controversy The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease
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Book Synopsis Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease by : Gilbert R Thompson
Download or read book Resolving The Cholesterol Controversy: The Scientists Who Proved The Lipid Hypothesis Of Causation Of Atherosclerosis And Coronary Heart Disease written by Gilbert R Thompson and published by World Scientific. This book was released on 2023-06-20 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy.
Book Synopsis The Lipid Hypothesis of Atherogenesis by : William E. Stehbens
Download or read book The Lipid Hypothesis of Atherogenesis written by William E. Stehbens and published by R. G. Landes. This book was released on 1993 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the rational and scientific basis for discussion and evaluation of the lipid hypothesis, the dominant but still contended theory of the etiology of atherosclerosis. The volume is divided into seven chapters: the genesis of the lipid hypothesis and terminology; the pathology of atherosclerosis and experimental atherosclerosis; basic scientific precepts in the epidemiology of coronary heart disease and atherosclerosis; diagnostic error and the validity of vital statistics; lipids and cholesterol in the lipid hypothesis; risk factors, prediction, clinical trials and regression of atherosclerosis; and epidemiology, atherogenesis and the future. From the verso of the title page: submitted June 1993--published August 1993. Annotation c. by Book News, Inc., Portland, Or.
Book Synopsis The Cholesterol Delusion by : Ernest N. Curtis
Download or read book The Cholesterol Delusion written by Ernest N. Curtis and published by Dog Ear Publishing. This book was released on 2010-11 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approximately one-half of the adult population of the United States are being told that they harbor within their bodies a silent killer. This "killer" is cholesterol. Millions are prescribed cholesterol lowering drugs making these pills the most prescribed (and most profitable) medications in the history of American medicine. They are told that these drugs will protect them from the ravages of heart disease. This is patently untrue and can be easily demonstrated by critical analysis of the data presented in the very medical studies that purport to show their benefit. The cholesterol mania that has gripped the country and dominated mainstream medical thought for the past 40 years is based on widespread acceptance of a set of closely related theories variously called the Cholesterol Theory, the Lipid Hypothesis, or the Diet-Heart Theory. The Cholesterol Delusion systematically refutes these prevailing theories that link diet and blood cholesterol levels to coronary heart disease and heart attacks. The Cholesterol Delusion traces the development of these theories from their origins and shows that each step in their evolution was based on faulty evidence and unscientific reasoning. The book then takes it one step further and attacks the very foundation of the "risk factor" paradigm that has dominated cardiovascular research in particular and much of medical research in general for the past 50 years. Written in plain language for the intelligent layman, the arguments are presented in a way that can be easily understood by readers with a limited medical or technical background. The Cholesterol Delusion is must reading for anyone that has been told they have elevated cholesterol levels and/or must take medication to lower them.
Book Synopsis The Cholesterol Myths by : Uffe Ravnskov
Download or read book The Cholesterol Myths written by Uffe Ravnskov and published by New Trends Publishing. This book was released on 2000 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly qualified doctor and scientist analyzes the studies used to justify the cholesterol hypothesis and demonstrates that the idea that animal fats and cholesterol cause heart disease is based on flimsy, even fraudulent evidence and wishful thinking. Includes a discussion on the dangers of vegetable oils and cholesterol-lowering drugs.
Book Synopsis Cholesterol and Saturated Fat Prevent Heart Disease - Evidence from 101 Scientific Papers by : David Evans
Download or read book Cholesterol and Saturated Fat Prevent Heart Disease - Evidence from 101 Scientific Papers written by David Evans and published by . This book was released on 2012 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: These 101 scientific papers reveal... ...cholesterol and saturated fat are in fact essential for a healthy heart. ...high cholesterol levels help you live longer. ...high carbohydrate diets promote the factors that cause heart disease. ...margarine is an industrially produced unhealthy product that should be avoided. ...the cholesterol/saturated fat causes heart disease hypothesis has never been proved. This book is based on the research of doctors, professors and scientists and includes 101 scientific papers which are explained in an easy to read user friendly format. This information will enable readers to make informed choices about the prevention of heart disease.
Book Synopsis The Cholesterol Wars by : Daniel Steinberg
Download or read book The Cholesterol Wars written by Daniel Steinberg and published by . This book was released on 2007 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future. * Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community. * Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs * Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Coronary Primary Prevention Trial by :
Download or read book Coronary Primary Prevention Trial written by and published by . This book was released on 1984 with total page 2 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundamentals of Vascular Biology by : Margarethe Geiger
Download or read book Fundamentals of Vascular Biology written by Margarethe Geiger and published by Springer. This book was released on 2019-05-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-structured textbook offers essential knowledge on the vascular system. The reader will learn the properties, basic cellular mechanisms and development of the different parts of the vascular system (including the heart), gain knowledge on vascular and related diseases, and will be made familiar with common and most current methods and techniques applied to analyze the vascular system in patients, in animal models, and ex vivo. This book is based on a PhD Course for students from various bioscientific backgrounds given at the Medical University of Vienna, and it will be a valuable resource for Master ́s Students in vascular biology and biomedicine in general and a helpful tool for young researchers world-wide wishing to gain or refresh their knowledge in this field.
Author :Charles M. Mansbach Publisher :Springer Science & Business Media ISBN 13 :9780306462412 Total Pages :464 pages Book Rating :4.4/5 (624 download)
Book Synopsis Intestinal Lipid Metabolism by : Charles M. Mansbach
Download or read book Intestinal Lipid Metabolism written by Charles M. Mansbach and published by Springer Science & Business Media. This book was released on 2000-11-30 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was stimulated by the enthusiasm shown by attendees at the meetings in Saxon River, VT, sponsored by the Federation ofAmerican Societies for Experimental Biology (FASEB), on the subject of the intestinal processing of lipids. When these meetings were first started in 1990, the original organizers, two of whom are editors ofthis volume (CMM and PT), had two major goals. The first was to bring together a diverse group ofinvestiga tors who had the common goal of gaining a better understanding of how the intestine ab sorbs lipids. The second was to stimulate the interest of younger individuals whom we wished to recruit into what we believed was an exciting and fruitful area ofresearch. Since that time, the field has opened up considerably with new questions being asked and new an swers obtained, suggesting that our original goals for the meetings were being met. In the same spirit, it occurred to us that there has not been a recentbook that draws to gethermuch ofthe informationavailableconcerninghow the intestineprocesses lipids. This book is intended to reach investigators with an interest in this area and their pre- and post doctoral students. The chapters are written by individuals who have a long-term interest in the areas about which they write, and many have been speakers at the subsequent FASEB conferences that have followed on the first.
Book Synopsis The Coronary Drug Project by : National Heart Institute (U.S.)
Download or read book The Coronary Drug Project written by National Heart Institute (U.S.) and published by . This book was released on 1968 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Smoking, Personality, and Stress by : Hans J. Eysenck
Download or read book Smoking, Personality, and Stress written by Hans J. Eysenck and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is often suggested that the incidence of cancer and coronary heart disease could be much reduced or even eliminated if only people would stop smoking cigarettes and eat fewer high-cholesterol foods. The evidence, however, shows that such views are simplistic and unrealistic and that, instead, cancer and CHD are the product of many risk factors acting synergistically. Psychosocial factors (stress, personality) are six times as predictive as smoking, cholesterol level or blood pressure and much more responsive to prophylactic treatment. This book admits that, while smoking is a risk factor for cancer and CHD, its effects have been exaggerated. A more realistic appraisal of a very complex chain of events incorporating many diverse factors is given, and appropriate action to prevent cancer and coronary heart disease is discussed.
Book Synopsis Diet and Health by : National Research Council
Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.
Book Synopsis Cerebral Small Vessel Disease by : Leonardo Pantoni
Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Book Synopsis Prevention and Treatment of Atherosclerosis by : Arnold von Eckardstein
Download or read book Prevention and Treatment of Atherosclerosis written by Arnold von Eckardstein and published by Springer Nature. This book was released on 2022 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets.
Book Synopsis The Seven Countries Study by : Daan Kromhout
Download or read book The Seven Countries Study written by Daan Kromhout and published by . This book was released on 1994 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicological Profile for Polycyclic Aromatic Hydrocarbons by :
Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
