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Research Efforts With Respect To Combatting Parkinsons Disease And Other Neurological Disorders
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Author :United States. Congress. House. Committee on Commerce. Subcommittee on Health and the Environment Publisher : ISBN 13 : Total Pages :88 pages Book Rating :4.3/5 (121 download)
Book Synopsis Research Efforts with Respect to Combatting Parkinson's Disease and Other Neurological Disorders by : United States. Congress. House. Committee on Commerce. Subcommittee on Health and the Environment
Download or read book Research Efforts with Respect to Combatting Parkinson's Disease and Other Neurological Disorders written by United States. Congress. House. Committee on Commerce. Subcommittee on Health and the Environment and published by . This book was released on 1996 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author :National Institute of Neurological and Communicative Disorders and Stroke Publisher : ISBN 13 : Total Pages :20 pages Book Rating :4.F/5 ( download)
Book Synopsis Parkinson's Disease by : National Institute of Neurological and Communicative Disorders and Stroke
Download or read book Parkinson's Disease written by National Institute of Neurological and Communicative Disorders and Stroke and published by . This book was released on 1976 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Autonomic Dysfunction in Parkinson's Disease by : Cristian Falup-Pecurariu
Download or read book Autonomic Dysfunction in Parkinson's Disease written by Cristian Falup-Pecurariu and published by Academic Press. This book was released on 2021-09-28 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson's disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction. - Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson's disease - Each chapter covers a specific autonomic symptom: classification, assessment, treatment - Presents the newest information on each autonomic symptom in Parkinson's disease
Book Synopsis An Essay on the Shaking Palsy by : James Parkinson
Download or read book An Essay on the Shaking Palsy written by James Parkinson and published by . This book was released on 1817 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Disease Control Priorities, Third Edition (Volume 4) by : Vikram Patel
Download or read book Disease Control Priorities, Third Edition (Volume 4) written by Vikram Patel and published by World Bank Publications. This book was released on 2016-03-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mental, neurological, and substance use disorders are common, highly disabling, and associated with significant premature mortality. The impact of these disorders on the social and economic well-being of individuals, families, and societies is large, growing, and underestimated. Despite this burden, these disorders have been systematically neglected, particularly in low- and middle-income countries, with pitifully small contributions to scaling up cost-effective prevention and treatment strategies. Systematically compiling the substantial existing knowledge to address this inequity is the central goal of this volume. This evidence-base can help policy makers in resource-constrained settings as they prioritize programs and interventions to address these disorders.
Book Synopsis Occupational Therapy for People with Parkinson's Disease by : Ana Aragon
Download or read book Occupational Therapy for People with Parkinson's Disease written by Ana Aragon and published by . This book was released on 2010 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: These practice guidelines draw upon the widest relevant knowledge and evidence available to describe and inform contemporary best practice occupational therapy for people with Parkinson's disease. They include practical examples of interventions to allow occupational therapists to apply new treatments to their practice.
Book Synopsis Ending Parkinson's Disease by : Ray Dorsey
Download or read book Ending Parkinson's Disease written by Ray Dorsey and published by PublicAffairs. This book was released on 2020-03-17 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.
Book Synopsis Neurological Disorders by : World Health Organization
Download or read book Neurological Disorders written by World Health Organization and published by World Health Organization. This book was released on 2006 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.
Book Synopsis Parkinson’s Disease and Movement Disorders by : Charles H. Adler
Download or read book Parkinson’s Disease and Movement Disorders written by Charles H. Adler and published by Springer Science & Business Media. This book was released on 2000-04-07 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of movement disorders is relatively broad, encompassing disorders of increased movement, such as tremors, dystonia, and tics, to disorders characterized by a paucity of movement, such as Parkinson's disease. Our understanding of the pathogenic mechanisms and our treatment options are expanding at a rapid pace. This expansion ranges from the medical and surgical advances in treating Parkinson's disease to the flood of genetic abnormalities that have now been found to cause various movement disorders. Although many patients are seen by the movement disorders specialist in neurology clinics around the country, most of these patients receive their followup care from a primary care physician or "general" neurologist who must be versed in the character istics and treatment plans of this diverse group of disorders. The major goal of Parkinson's Disease and Movement Disorders: Diagnosis and Treatment Guidelines for the Practicing Physician is to distill this immense amount of information and to educate the practitioner about the many facets of the movement disorders field. We believe that this book fills a large void, since most texts on movement disorders are more detailed and geared toward the specialist. We have asked the chapter authors to emphasize the clinical characteristics of each disorder, discuss the differential diagnosis and the diagnostic testing, and then outline the various treatment options, as if they were teaching during a preceptorship in their clinic.
Book Synopsis Levodopa pharmacokinetics -from stomach to brain by : Maria Nord
Download or read book Levodopa pharmacokinetics -from stomach to brain written by Maria Nord and published by Linköping University Electronic Press. This book was released on 2019-01-07 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.
Book Synopsis Integrative approach to Parkinson’s disease by : Hi-Joon Park
Download or read book Integrative approach to Parkinson’s disease written by Hi-Joon Park and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis Disease and Mortality in Sub-Saharan Africa by : Dean T. Jamison
Download or read book Disease and Mortality in Sub-Saharan Africa written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-01-01 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current data and trends in morbidity and mortality for the sub-Saharan Region as presented in this new edition reflect the heavy toll that HIV/AIDS has had on health indicators, leading to either a stalling or reversal of the gains made, not just for communicable disorders, but for cancers, as well as mental and neurological disorders.
Book Synopsis Marijuana As Medicine? by : Institute of Medicine
Download or read book Marijuana As Medicine? written by Institute of Medicine and published by National Academies Press. This book was released on 2000-12-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.
Book Synopsis The Complete Guide for People With Parkinson’s Disease and Their Loved Ones by : Lianna Marie
Download or read book The Complete Guide for People With Parkinson’s Disease and Their Loved Ones written by Lianna Marie and published by Purdue University Press. This book was released on 2020-10-15 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: A diagnosis of Parkinson’s disease is as disorienting as it is devastating. The Complete Guide for People With Parkinson’s Disease and Their Loved Ones helps make sense of what comes next and what can be done, not just for those suffering from the disease but for their family and friends as well. A trained nurse and primary caregiver for her mother, who was diagnosed with Parkinson’s disease in 1991, Lianna Marie draws upon over twenty years of education, research, and direct experience. Written in straightforward and easily accessible language, this essential guide aims to help patients better understand their role in their treatment so that they may continue to lead happy and hopeful lives. Topics covered include nutrition and exercise, alternative and complementary therapies, medication and treatment, and what caregivers can do to help. Written by an international expert on Parkinson’s who has confronted the disease firsthand, The Complete Guide serves as the go-to book for comprehensive, easy-to-understand information for all Parkinson’s patients and their loved ones.
Book Synopsis Marsden's Book of Movement Disorders by : Ivan Donaldson
Download or read book Marsden's Book of Movement Disorders written by Ivan Donaldson and published by Oxford University Press. This book was released on 2012-03-29 with total page 1512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the final work of the late Professor C. David Marsden, who was the most influential figure in the field of movement disorders, in terms of his contributions to both research and clinical practice, in the modern era. It was conceived and written by David Marsden and his colleague at the Institute of Neurology, Prof. Ivan Donaldson. It was their intention that this would be the most comprehensive book on movement disorders and also that it would serve as the 'clinical Bible' for the management of these conditions. It provides a masterly survey of the entire topic, which has been made possible only by vast laboratory and bedside experience. Marsden's Book of Movement Disorders covers the full breadth of movement disorders, from the underlying anatomy and understanding of basal ganglia function to the diagnosis and management of specific movement disorders, including the more common conditions such as Parkinson's Disease through to rare, and very rare conditions such as Niemann-Pick disease. Chapters follow a structured format with historical overviews, definitions, clinical features, differential diagnosis, investigations and treatment covered in a structured way. It is extensively illustrated with many original photographs and diagrams of historical significance. Among these illustrations are still images of some original film clips of some of Dr. Marsden's patients published here for the first time. Comprehensively referenced and updated by experts from the Institute of Neurology at Queen Square, this book is a valuable reference for, not just movement disorder specialists and researchers, but also for clinicians who care for patients with movement disorders.
Book Synopsis Sleep Disorders in Parkinson’s Disease by : Chun-Feng Liu
Download or read book Sleep Disorders in Parkinson’s Disease written by Chun-Feng Liu and published by Springer. This book was released on 2021-03-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the sleep-related disorders in Parkinson's disease (PD), demonstrating that they are among the most common non-motor manifestations of PD and have a significant negative impact on quality of life. Sleep changes may also serve as markers to identify patients in the preclinical stage of PD. This book presents recent major breakthroughs related to sleep disorders in PD, such as REM sleep behavior disorder (RBD), insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders. It also discusses the epidemiology, etiology, diagnosis, clinical implications, associated features, evaluation and management of these disorders and suggests some further research directions in these areas in order to develop neuroprotective therapies for PD. Focusing on Chinese PD patients, it addresses traditional Chinese Medicine, and compares the epidemiology and management of PD in China and Western countries to provide a frame of reference values for further studies. Further, it features numerous case reports to enable readers gain a better uderstanding of the subject matter. This comprehensive yet practical book is a valuable resource for scientists and clinicians.