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Relationship Between Experimental Angiotensin Ii Induced Hypertension And Activation Of The Endothelin System In Male Rats
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Book Synopsis Relationship Between Experimental Angiotensin II Induced Hypertension and Activation of the Endothelin System in Male Rats by : Jennifer Rebecca Ballew
Download or read book Relationship Between Experimental Angiotensin II Induced Hypertension and Activation of the Endothelin System in Male Rats written by Jennifer Rebecca Ballew and published by . This book was released on 2000 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Angiotensin II Receptor Blockade Physiological and Clinical Implications by : Naranjan S. Dhalla
Download or read book Angiotensin II Receptor Blockade Physiological and Clinical Implications written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relationship between angiotensin II and hypertension was established in 1898 when angiotensin II was shown to modulate systemic blood pressure. Over the intervening decades, a complete characterization of the renin-angiotensin system (RAS) has been achieved, and our understanding of its biochemistry and physiology has led to the directed development of agents such ·as ACE inhibitors and receptor antagonists capable of controlling hypertension. More recently, it was shown that angiotensin II is secreted within certain tissues and that these tissue-specific systems operate independently of the systemic RAS. The novel concept that angiotensin II regulates a number of cardiovascular processes that are unrelated to blood pressure has renewed the interest of both basic and clinical scientists in angiotensin II. The association between angiotensin II and cardiac growth, in particular, has indicated that therapies currently in use for hypertension may have direct application to the treatment of heart failure. The Manitoba Cardiovascular Forum on Angiotensin Receptor Blockade in Winnipeg was convened October 18-20, 1996 to examine the clinical and basic aspects of angiotensin receptor biology as they apply to hypertension and heart failure. In addition, the potential treatment of these conditions using specific angio tensin receptor antagonists was addressed within the context of their immediate therapeutic application and future potential.
Book Synopsis Role of Angiotensin II Type 2 Receptor in Blood Pressure Regulation in Obese Rats by : Quaisar Ali
Download or read book Role of Angiotensin II Type 2 Receptor in Blood Pressure Regulation in Obese Rats written by Quaisar Ali and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Renin angiotensin system (RAS) consists of enzymes, hormones, proteins and peptides. Angiotensin II (Ang II) is an important peptide of RAS. Ang II acts via AT1 receptor (AT1R) and AT2 receptor (AT2R). While AT1R is known to cause antinatriuresis and increase in blood pressure, the role of AT2R in renal function and long-term BP regulation is not well defined. Recently our laboratory showed that AT2R are upregulated in the kidney of obese rats and selective activation of these receptors stimulates nitric oxide/cGMP pathway, inhibits proximal tubules Na+/K+-ATPase (NKA) activity and increases urinary sodium excretion. In light of those findings, we undertook this project to investigate the role of AT2R in renal function, long-term blood pressure control and interaction with renal AT1R function in obese Zucker rats, an animal model exhibiting hyperinsulinemia, hyperglycemia and hypertension. Also, we studied the mechanism associated with hyperglycemia induced AT2R upregulation in proximal tubule cells. First, we designed experiment to determine whether AT2R has a protective role in blood pressure increase in obese rats. We treated obese Zucker rats with AT2R antagonist PD123319 (PD) for two weeks and BP was measured. Treatment with PD significantly increased the blood pressure, which was associated with increased renal renin expression in obese rats. This suggested that AT2R protect against increase in blood pressure by keeping renal renin expression low. Then, we designed experiments to determine whether chronic AT2R activation affects Na-balance and lowers BP in obese rats. We treated lean and obese Zucker rats with AT2R agonist CGP42112A (CGP) for two weeks. Two weeks treatment caused a decrease in BP by 19 mmHg and in Na-balance in obese but not in lean rats. The plasma renin activity was significantly decreased in both lean and obese CGP-treated rats. The expression of AT2R, AT1R, angiotensin converting enzyme (ACE) and renin in the kidney cortex was not affected by the CGP-treatment of obese or lean rats. However, ACE2 expression and activity was significantly increased in CGP-treated obese rats and not in lean rats. These studies suggest that long-term activation of AT2R decreases BP in obese rats. The reduction in BP by AT2R agonist treatment may have been contributed by a decrease in Na-balance and an enhanced expression and activity of ACE2 in renal cortex. In order to determine whether the reduction in BP and decrease in Na-balance might have been contributed by the ability of AT2R to antagonize renal AT1R function in CGP-treated obese rats, we again treated the obese Zucker rats with CGP for two weeks. We performed the renal function study after two weeks under anesthesia. We found that CGP-treatment of obese rats caused reduction in Ang II pressor response and blunted the candesartan-induced natriuresis/diuresis in these rats suggesting that chronic activation of AT2R antagonizes the function of AT1R. Earlier studies from our laboratory suggest that AT2R promote Na-excretion but the contribution of different nephron segments in AT2R-induced natriuresis is not known. We investigated the involvement of proximal tubule AT2R in natriuresis by blocking the two important distal tubule Na-transporters (NaCl cotransporter and ENaC). We found that selective activation of AT2R with a novel AT2R agonist C21 promoted natriuresis predominantly via proximal tubules. We also performed in vitro experiments (HK2 cells) to elucidate the potential signaling mechanism involved in the proximal tubule AT2R upregulation in diabetes/hyperglycemia. In this experiment, we exposed HK2 cells with high glucose with and without IRF-1 siRNA. High glucose increased AT2R expression in HK2 cells and is mediated via transcriptional mechanism involving the transcription factor IRF-1. Collectively, the data suggest that long-term treatment with AT2R agonist attenuates positive Na-balance, lowers renal renin expression, antagonizes the function of AT1R and decreases blood pressure in obese Zucker rats. Moreover AT2R upregulation in response to hyperglycemia may be compensatory mechanism to exert a beneficial role in kidney function. These findings highlight the therapeutic potential of AT2R for treating obesity/diabetes related hypertension.
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Book Synopsis The Role of Angiotensin II and Endothelin-1 in the Hypertension of Experimental Chronic Renal Failure by : Gregg Steven Potter
Download or read book The Role of Angiotensin II and Endothelin-1 in the Hypertension of Experimental Chronic Renal Failure written by Gregg Steven Potter and published by . This book was released on 1997 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Angiotensin II Receptor Antagonists by : Murray Epstein
Download or read book Angiotensin II Receptor Antagonists written by Murray Epstein and published by . This book was released on 2001 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of several new, non-peptide, orally active angiotensin II receptor antagonists is revolutionizing the treatment of patients with hypertension and various cardiovascular disorders. In this book experts review the current state of angiotensin II antagonists and survey the progress of these diverse applications. Issues relating to angiotensin II and their receptors are examined in relation to their effects on the kidney, non-diabetic renal disease, heart disease, diabetes mellitus, and various other disorders. The combination of AT1 receptor antagonists with other antihypertensive agents is reviewed in depth. The clinical attributes of these drugs are complemented by in-depth reviews of the physiology and pharmacology of angiotensin II peptides. The authors present the most recent findings in ligand recognition, activation, signal coupling, desensitization and functional alterations of vessels, especially small arteries, in patients with hypertension. This book constitutes the only available compendium on the clinical and experimental features of angiotensin II receptor antagonists. The unique features of the rapidly emerging class of drugs are surveyed throughout. Contributions have been made from international experts who have personally contributed to the discovery and development of these novel drugs. Recent cutting-edge physiology and pharmacology studies by renowned international experts provide a platform for considering the clinical applications of these agents.
Book Synopsis Comprehensive Hypertension E-Book by : Gregory Y. H. Lip
Download or read book Comprehensive Hypertension E-Book written by Gregory Y. H. Lip and published by Elsevier Health Sciences. This book was released on 2007-06-28 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is today's most in-depth reference for any cardiologist, internist, or nephrologist interested in hypertension. Drawing from international experience in cardiology, physiology, and nephrology, Drs. Lip and Hall have assembled a group of section editors and contributors second to none. You'll find the long-term effects of primary and secondary hypertension and a lengthy section on hypertensions for special populations featured prominently. Prevention and treatment of hypertension are covered in detail, from lifestyle and diet issues to drug choice and delivery, and the section on comparison of guidelines is unique to this book. Find comprehensive coverage of hypertension including pathogenesis, prevention, and treatment all in one practical volume. See the complete systemic problems of hypertension at a glance with detailed, full-color illustrations of cellular and clinical manifestations. Simplify navigating the complexities of hypertension using algorithms for clinical exam and diagnosis. Get specific insight into prevention and treatment of hypertension in special populations. Go global with a comprehensive section on worldwide guidelines and the application of clinical material to local standards of practice.
Book Synopsis Role of the Slow Pressor Effect of Angiotensin II in Experimental Hypertension by : Matthew Gerard Melaragno
Download or read book Role of the Slow Pressor Effect of Angiotensin II in Experimental Hypertension written by Matthew Gerard Melaragno and published by . This book was released on 1995 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interaction Between Angiotensin II and BDNF in Modulating Sympathetic Nerve Activity by : Bryan K. Becker
Download or read book Interaction Between Angiotensin II and BDNF in Modulating Sympathetic Nerve Activity written by Bryan K. Becker and published by . This book was released on 2015 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over activation of the sympathetic nervous system is prevalent in many forms of cardiovascular disease such as chronic heart failure (CHF) and hypertension. Although increased neuronal renin-angiotensin system activity in presympathetic neurons has been well implicated in mediating this sympatho-excitation, many of the neuronal effects of angiotensin II (Ang II) signaling remain poorly understood. One particular mechanism of Ang II-mediated increases in presympathetic neuronal activity is through reductions in voltage-gated K+ currents. Another pathway that has profound effects on neuronal K+ currents and that has been previously implicated in Ang II-signaling is brain-derived neurotrophic factor (BDNF) activity through its receptor tyrosine kinase B (TrkB). Therefore, we hypothesized that BDNF/TrkB signaling is an important mediator of the neuronal effects of Ang II in modulating voltage-gated K+ currents and autonomic dysfunction in cardiovascular disease states such as CHF and hypertension. We employed cell culture and whole-animal models to explore this hypothesis and utilized electrophysiological, molecular, and in vivo physiological techniques. Patch-clamp studies demonstrated that BDNF is involved in Ang II-induced reductions to K+ currents. Further in-vivo experiments found that overexpression of Kv4.3 into the rostral ventrolateral medulla attenuates the increase in sympathetic nerve activity of rats post-myocardial infarction. Baroreflex dysfunction is common in CHF, and desensitization of central neuronal areas such as the nucleus tractus solitarius (NTS) can mediate this dysfunction. We therefore hypothesized that changes in BDNF/TrkB signaling in the NTS mediated baroreflex dysfunction in CHF. Blocking TrkB with ANA-12 in the NTS blunted baroreflex sensitivity in sham rats but had little effect on the already blunted baroreflex sensitivity of CHF rats. TrkB expression was reduced in CHF rats, implicating reduced BDNF/TrkB signaling in the NTS as a mechanism for reduced baroreflex sensitivity during CHF. In a final set of experiments we explored the connection between Ang II and BDNF in vivo. Central administration of Ang II increased mean arterial pressure and induced sympatho-excitation, both of which were attenuated by coinfusion of ANA-12. Overall, these data implicate BDNF as an important factor in mediating the neuronal effects of Ang II on K+ currents, hemodynamics, baroreflex sensitivity, and sympathetic nerve activity.
Book Synopsis Hypertension in Postmenopausal Women by : Michel E. Safar
Download or read book Hypertension in Postmenopausal Women written by Michel E. Safar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: On the occasion of the symposium on Hypertension in Postmenopausal Women (Monte Carlo, January 19-22, 1994), international scientists and clinicians discussed the various aspects of high blood pressure in older women. This volume presents an overview of this important aspect of both cardiology and gynecology. Special emphasis is given to the different approaches to antihypertension treatment.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The ESC Textbook of Vascular Biology by : Rob Krams
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Book Synopsis Pediatric Hypertension by : Joseph Flynn
Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Hypertrophy and Failure by : Bernard Swynghedauw
Download or read book Cardiac Hypertrophy and Failure written by Bernard Swynghedauw and published by . This book was released on 1990 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac insufficiency, a major cause of premature mortality, is a key focus of medical and pharmaceutical research. This book aims to bring clinicians and researchers up-to-date on recent biophysical, cellular physiological and molecular biological developments and their clinical applications.
Book Synopsis Endothelial Regulation of Vascular Tone by : Una S. Ryan
Download or read book Endothelial Regulation of Vascular Tone written by Una S. Ryan and published by CRC Press. This book was released on 1991-11-27 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This unique monograph provides an in-depth account of the interactions between endothelial cells and their products with vascular smooth muscle -- highlighting how endothelial-derived products influence vascular tone and regulation of blood flow, including platelet aggregation. "
Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel
Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.
