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Author : Su Wang
Publisher :
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.:/5 (911 download)
Download or read book Regulatory Mechanisms of Epithelial Sodium Channel written by Su Wang and published by . This book was released on 2009 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Mechanisms of Epithelial Sodium Channel written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the regulation mechanism of ENaC, many questions still remain unclear. Therefore, we employed various techniques including electrophysiology and molecular biology approaches to investigate the mechanisms underlying the regulation of ENaCs by lipid metabolites, oxygen and mechanical stress. We have identified profound regulation mechanisms of ENaC in distal renal epithelial cells and vascular endothelial cells by lipid metabolites, heme and mechanical forces. Our results revealed a novel O\(_2\) sensitive regulation pathway of ENaC channels, in which hemeoxygenase acts as the O\(_2\) sensor and the substrate and product of which either inhibits or stimulates ENaC activity. This finding may eventually lead to novel clinic strategies in dealing with diseases e.g. renal failure, kidney reperfusion injury, hypertension, pulmonary edema and pre-clampsia. In addition, we, at the first time, have revealed that ENaC is functionally expressed in a variety of endothelial cells and is able to serve as mechano-transducing sensors in the vascular endothelial cells which play important roles in vascular physiology and pathology progresses.
Author :
Publisher :
ISBN 13 :
Total Pages : 213 pages
Book Rating : 4.:/5 (472 download)
Download or read book The Regulation of Epithelial Sodium Channels in Mammalian Taste Receptors Cells written by and published by . This book was released on 2009 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrient recognition is one of the main physiological roles of the gustatory system. In mammals, it is well established that the taste of sodium salts is primarily mediated by sodium influx through the epithelial sodium channel. The epithelial sodium channel is a sodium-specific ion channel that is expressed across a wide range of transporting epithelia such as colon, kidney, and taste. In addition to its role as a salt taste receptor, sodium influx through the epithelial sodium channel is important systemically for maintaining sodium balance and blood pressure. Following our earlier work on the endocrine regulation of salt taste at the level of the epithelial sodium channel, we hypothesize that the epithelial sodium channel expressed in mouse taste receptor cells plays a central role in the restoration of salt and water balance. Using a multidisciplinary approach that includes patch clamp recording, functional sodium imaging, molecular biology, Western blotting, and behavioral assays, we have begun to investigate different mechanisms of the epithelial sodium channel regulation in the taste system. In the present study, we have demonstrated a number of mechanisms that regulate the epithelial sodium channel by both ions and/or hormones in mouse taste cells. In general, three new mechanisms of the epithelial sodium channel regulation were identified: (1) regulation of the epithelial sodium channel by chloride ions, (2) regulation of the epithelial sodium channel by insulin, and (3) alterations of the epithelial sodium channel function in diabetic taste cells. To test the relevance of one or more of these regulatory mechanisms in the animals' behavior, we used a variety of short-term behavioral assays. Interestingly, the results suggested that insulin regulates salt intake in rodents, which dovetails nicely with our functional and molecular findings. Consistent with insulin's physiological role in salt taste transduction, we investigated the modification of the epithelial sodium channel function during the onset of diabetes. Diabetic rodents displayed alterations in salt taste transduction via epithelial sodium channel from the gene level to the animals' behavior. These results are an example of how regulatory cues, like hormones, act on specific transduction elements to modulate the peripheral gustatory system.
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Author : Diana Luise Wesch
Publisher :
ISBN 13 : 9788415287988
Total Pages : 100 pages
Book Rating : 4.2/5 (879 download)
Download or read book Molecular Mechanisms Underlying the Regulation of [delta]-epithelial Sodium Channel ([delta]-ENaC) Function written by Diana Luise Wesch and published by . This book was released on 2013 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Venkataramana K Sidhaye
Publisher : Academic Press
ISBN 13 : 0128038810
Total Pages : 277 pages
Book Rating : 4.1/5 (28 download)
Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Author : Richard A. Kahn
Publisher : Springer Science & Business Media
ISBN 13 : 1402017197
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)
Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2004-02-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)
Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Author : Kuang-Yi Chou
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (122 download)
Download or read book Sodium Channel Regulatory Mechanisms written by Kuang-Yi Chou and published by . This book was released on 1994* with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shin-Ho Chung
Publisher : Springer Science & Business Media
ISBN 13 : 0387689192
Total Pages : 657 pages
Book Rating : 4.3/5 (876 download)
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
Author : Michael Bruce Butterworth
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.:/5 (55 download)
Download or read book Regulation of Sodium Channel Densities in A6 Renal Epithelial Cells by Hormonally-dependent Mechanisms written by Michael Bruce Butterworth and published by . This book was released on 2001 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0128096217
Total Pages : 350 pages
Book Rating : 4.1/5 (28 download)
Download or read book Piezo Channels written by and published by Academic Press. This book was released on 2017-07-17 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piezo Channels, Volume 79, the latest volume in the Current Topics in Membranes series provides the necessary membrane research to assist readers in discovering the current state of a particular field and future directions. New chapters in the updated volume include A Tour de Force: The Discovery, Properties, and Function of Piezo Channels, Piezo1 Channels in Vascular Development and the Sensing of Shear Stress, the Origin of the Force: The Force-From-Lipids Principle Applied to Piezo Channels, Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction, and The Structural Basis for Sensing by the Piezo1 Protein. Users of this series will find an up-to-date presentation of the current knowledge in the field of Piezo Channels. Written by leading experts in the field Contains original material, both textual and illustrative, that make it a very relevant reference Presented in a very comprehensive manner Ideal reference for both researchers in the field and general readers who will find this book to be relevant and up-to-date
Author : Craig Raymond Campbell
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (741 download)
Download or read book Regulation of the Epithelial Sodium Channel written by Craig Raymond Campbell and published by . This book was released on 2010 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andre Kamkin
Publisher : Springer Science & Business Media
ISBN 13 : 1402064268
Total Pages : 390 pages
Book Rating : 4.4/5 (2 download)
Download or read book Mechanosensitive Ion Channels written by Andre Kamkin and published by Springer Science & Business Media. This book was released on 2007-10-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.
Author : Daniel Mohr Collier
Publisher :
ISBN 13 :
Total Pages : 165 pages
Book Rating : 4.:/5 (87 download)
Download or read book Regulation of Epithelial Sodium Channel (ENaC) Activity by Extracellular Stimuli written by Daniel Mohr Collier and published by . This book was released on 2011 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gerald Litwack
Publisher : Academic Press
ISBN 13 : 032391053X
Total Pages : 883 pages
Book Rating : 4.3/5 (239 download)
Download or read book Human Biochemistry written by Gerald Litwack and published by Academic Press. This book was released on 2021-11-28 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers
Author : Arun Anantharam
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (416 download)
Download or read book Structure and Regulation of the Epithelial Sodium Channel written by Arun Anantharam and published by . This book was released on 2007 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ying Kevin Ke
Publisher :
ISBN 13 :
Total Pages : 450 pages
Book Rating : 4.:/5 (277 download)
Download or read book Mechanisms by which COMMD1 Down-regulates Epithelial Sodium Channel (ENaC) Activity written by Ying Kevin Ke and published by . This book was released on 2008 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:
