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Author : Marc Andrew Thomas
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (222 download)
Download or read book Regulation Studies of the Interleukin-5 Gene in T-lymphocytes written by Marc Andrew Thomas and published by . This book was released on 1999 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chiok Ling Tan
Publisher :
ISBN 13 :
Total Pages : 374 pages
Book Rating : 4.:/5 (222 download)
Download or read book Transcriptional Regulation of the Mouse Interleukin-5 Gene in T-Lymphocytes written by Chiok Ling Tan and published by . This book was released on 1998 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter Francis Bourke
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (223 download)
Download or read book Transcriptional Regulation of the Mouse Interleukin-5 Gene in T Lymphocytes written by Peter Francis Bourke and published by . This book was released on 1993 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jun Wang
Publisher :
ISBN 13 :
Total Pages : 302 pages
Book Rating : 4.:/5 (223 download)
Download or read book Transcriptional Regulation of the Mouse and Human Interleukin-5 Genes in T-lymphocytes written by Jun Wang and published by . This book was released on 2001 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anish D. Singh
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (155 download)
Download or read book Studies on the Transcriptional Regulation of Human Interleukin 5 written by Anish D. Singh and published by . This book was released on 2000 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dorothea Busse
Publisher : Logos Verlag Berlin GmbH
ISBN 13 : 3832526935
Total Pages : 114 pages
Book Rating : 4.8/5 (325 download)
Download or read book Dynamics of the Il-2 Cytokine Network and T-cell Proliferation written by Dorothea Busse and published by Logos Verlag Berlin GmbH. This book was released on 2010 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book adds to a intensively investigated question of immunological research. How do regulatory T cells mediate their function to ensure tolerance against self-antigen? The author analyzes the interaction via the cytokine interleukin 2 between T helper cells, which mediate immune responses, and regulatory T cells. Since both cell types depend on interleukin 2 to mediate their functions, competition for interleukin 2 is likely. A mathematical model is developed to describe the interaction. This model focuses on the interleukin 2 receptor dynamics on helper and regulatory T cells and the extracellular interleukin 2 diffusion. The interleukin 2 receptor dynamics is governed mainly by an autocrine positive feedback loop on both cell types. However, its differential regulation results in a switch-like up-regulation of the receptors on T helper cells and a gradual adaptation of the receptor levels to extracellular interleukin 2 supply on regulatory T cells. This difference enables regulatory T cells to efficiently compete for interleukin 2 and deprive T helper cells of their growth factor. Cell culture experiments verify these findings. It can be shown that the antigen stimulus and the intercellular distance are relevant control parameters for competition. Other mechanisms are described for suppression of T helper cell action by regulatory T cells; competition for interleukin 2 may act in concert with them.
Author : James J. Lee
Publisher : Academic Press
ISBN 13 : 012394385X
Total Pages : 679 pages
Book Rating : 4.1/5 (239 download)
Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.
Author : Sudhir Gupta
Publisher : Springer Science & Business Media
ISBN 13 : 1468453238
Total Pages : 333 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Lymphocyte Activation and Immune Regulation written by Sudhir Gupta and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
Author : Jeffrey Scott Riegel
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (33 download)
Download or read book Induction of T Cell Activation Gene Expression in Thymocyte Subsets written by Jeffrey Scott Riegel and published by . This book was released on 1990 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lyndee Louise Scurr
Publisher :
ISBN 13 :
Total Pages : 470 pages
Book Rating : 4.:/5 (223 download)
Download or read book Protein Regulation of Interleukin-5 Gene Expression in Mast Cells written by Lyndee Louise Scurr and published by . This book was released on 2001 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sang-Mo Kang
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.:/5 (799 download)
Download or read book Interleukin-2 Gene Regulation in Non-transformed T Lymphocytes written by Sang-Mo Kang and published by . This book was released on 1992 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dan Yang Huang
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (187 download)
Download or read book The Regulation of Interleukin 2-induced Proliferating Cell Nuclear Antigen Gene Expression in a Cloned T Lymphocyte written by Dan Yang Huang and published by . This book was released on 1995 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Interleukin-2 Gene Expression in T Lymphocytes by Tumour Necrosis Factor-Alpha written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sonia Barange
Publisher :
ISBN 13 :
Total Pages : 113 pages
Book Rating : 4.:/5 (715 download)
Download or read book Regulation of the Expression of Genes Induced in T Lymphocytes Upon Antigen and Interleukin-2 Stimulation written by Sonia Barange and published by . This book was released on 1994 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.:/5 (686 download)
Download or read book Interleukin-17 Gene Regulation in T Cells written by and published by . This book was released on 2005 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: IL-17 is the founding member of a novel family of cytokines and plays a central role in inflammation, rheumatoid arthritis and lung disease. However, little is known about how IL-17 expression is controlled. This study explores three aspects of the mechanism of IL-17 gene regulation: proximal cis -acting elements in the human IL-17 promoter that respond to T cell receptor (TCR) signaling, signals provided by antigen presenting cells that are necessary for optimal IL-17 production in mouse primary cells, and IL-17 gene regulation in a mouse cell model. To define cis -acting elements important for IL-17 gene regulation, we cloned 1 kb of a putative promoter, and found that it was active in Jurkat T cells. Studies using pharmacological inhibitors, over-expression systems and Jurkat sublines all indicated a role for the transcription factor nuclear factor of activated T cells (NFAT). We then showed that a region containing two NFAT sites was sufficient for TCR inducible promoter activity. Moreover, mutations of these sites dramatically reduced reporter gene activity. Chromatin immunoprecipitation assays showed occupancy of NFAT at this region in vivo . Together, these data show that NFAT is a crucial sensor of TCR signaling in the IL-17 promoter. IL-17 is primarily made by T cells, but relatively little is known about the requirements and mechanisms for IL-17 expression in mouse lymphocytes. Like many cytokines, we found that IL-17 was induced rapidly in primary lymphocytes after CD3 crosslinking. Although a panel of costimulatory signals failed to increase IL-I7 levels, we found that IL-23, produced by activated dendritic cells, increased IL-17 production both independently and in conjugation with TCR signals. To begin to characterize signaling pathways required for IL-17 production in mice, we identified an IL-17-producing EL4 T cell line. Next, we cloned a 3000 by putative promoter, and showed that it was transcriptionally active in EL4 cells. This cell line will be a useful tool for further work on the mouse IL-17 promoter study in vitro . Overall, these studies are the first report about the mechanism of IL-17 gene regulation, and they may offer new opportunities for therapeutic intervention for diseases involving this cytokine.
Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Author : Patricia L. Podolin
Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (244 download)
Download or read book The Regulation of Interleukin 2-induced Vimentin Gene Expression in a Cloned T Lymphocyte written by Patricia L. Podolin and published by . This book was released on 1991 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
