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Author : Ann C. Morris
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (142 download)
Download or read book Regulation of MHC Class II Gene Expression at the Fetal-maternal Interface written by Ann C. Morris and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. Eric Blair
Publisher : Cambridge University Press
ISBN 13 : 9780521495783
Total Pages : 462 pages
Book Rating : 4.4/5 (957 download)
Download or read book Modulation of MHC Antigen Expression and Disease written by G. Eric Blair and published by Cambridge University Press. This book was released on 1995-11-09 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.
Author : Erica Lynn Scott
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (381 download)
Download or read book Transcriptional Regulation of MHC Class II Genes in Trophoblast Cells written by Erica Lynn Scott and published by . This book was released on 1997 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gil Mor
Publisher : Springer Science & Business Media
ISBN 13 : 0387349448
Total Pages : 338 pages
Book Rating : 4.3/5 (873 download)
Download or read book Immunology of Pregnancy written by Gil Mor and published by Springer Science & Business Media. This book was released on 2007-12-27 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers in detail contemporary hypotheses and studies related to the immunology of implantation and provides a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR. Provides complete and up to date review of current knowledge of the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system.
Author : Hongquan Zhang
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (478 download)
Download or read book Regulation of MHC Class II and IL-8 Gene Expression by RB written by Hongquan Zhang and published by . This book was released on 2000 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (155 download)
Download or read book Chromatin Regulation of MHC Class II Expression written by and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The eukaryotic cell, DNA is assembled into higher order structure to allow the packaging of genetic material into the confined space within the cell nucleus. Chromatin remodeling must occur too allow transcription factors binding and the activation of gene expression. Class II transactivator (CIITA) is the master regulator of MHC class II expression and it has been shown to participate in chromatin remodeling at the MHC class II promoter. We found that in several tumor cell lines (Colon 26 and RJ2.2.5), MHC class II expression is silenced and can be induced by treatment with the histone deacetylase inhibitor Trichostatin A (TSA) in the absence of CIITA. Although Colon 26 contains an intrinsic, active IFN-[gamma] pathway, TSA pretreatment inhibited the IFN-[gamma] induced STAT-1 phosphorylation suggesting a different TSA activation pathway from that induced by IFN-[gamma]. Chromatin immunoprecipitation (ChIP) assays demonstrated similar patterns of histone modification changes upon IFN-[gamma] (CIITA-dependent) and TSA (CIITA-independent) stimulation. Both IFN-[gamma] and TSA treated cells demonstrated an enhancement of markers associated with active gene expression (Acetylated histone H3 and H4 and trimethylated H3 lysine 4) at the MHC class II promoter while the level of the repressive state marker, trimethylated H3 lysine 9, was decreased. Unlike other histone modifications, enhanced trimethylated H3 lysine 36 was detected at the 3'region but not the promoter of the MHC class II gene in both IFN-[gamma] inducible (HeLa) and TSA inducible (RJ2.2.5) cell lines. Such differential localization of the histone modifications suggests that each mark may be involved in the different phases of the transcription process. H3K79me2 remained unchanged and at low level after IFN-[gamma] (HeLa) or TSA (RJ2.2.5) treatment when compared to the MHC class II expressing cell line Raji. However, H3K79 methylation can be rescued by the reconstitution of CIITA expression in the CIITA deficient cell line RJ2.2.5 by stable transfection. Together, our data suggests that TSA treatment can replace the function of CIITA in activating MHC class II expression. Although IFN-[gamma] and TSA induced MHC class II expression through different regulatory pathways, both resulted in similar patterns of histone modifications and chromatin remodeling. Lastly, CIITA may be crucial for the recruitment of histone methyltransferase to the MHC class II gene.
Author : Walter Reith
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (437 download)
Download or read book Regulation of Major Histocompatibility Complex Class II Gene Expression written by Walter Reith and published by . This book was released on 1999 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Compleat Instructions for the Common Flute written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Silvia Gregori
Publisher : Frontiers Media SA
ISBN 13 : 2889451194
Total Pages : 94 pages
Book Rating : 4.8/5 (894 download)
Download or read book HLA-G-mediated Immune Tolerance: Past and New Outlooks written by Silvia Gregori and published by Frontiers Media SA. This book was released on 2017-02-14 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
Author : Barry D. Bavister
Publisher : Springer Science & Business Media
ISBN 13 : 1461393175
Total Pages : 359 pages
Book Rating : 4.4/5 (613 download)
Download or read book Preimplantation Embryo Development written by Barry D. Bavister and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the Serono Symposium on Pre implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic. This was indeed a timely subject in view of the recent resurgence of interest in this funda mental phase of embryogenesis and its relevance to basic research and applied fertility studies in humans, food-producing animals, and endangered species. The symposium brought together speakers from a broad range of disciplines in order to focus on key regulatory mechanisms in embryo development, using a wide variety of animal models, and on representative topics in human preimplantation embryogenesis. The culmination of preimplantation development is a blastocyst con taining the first differentiated embryonic tissues and capable of initiating and sustaining pregnancy. The central objective of the symposium was to throw light on the regulation of cellular and molecular events underlying blastocyst formation. It was particularly appropriate that the date of the symposium marked the 20th anniversary of the publication of the classic volume Biology of the Blastocyst, the proceedings of an international workshop held in 1970. This book, which summarized most of the information then available on this topic in mammals, was edited by the pioneer in blastocyst research, Dr. Richard B1andau, who was the guest speaker at the symposium.
Author : Ernst Knobil
Publisher : Academic Press
ISBN 13 :
Total Pages : 1160 pages
Book Rating : 4.3/5 (91 download)
Download or read book Encyclopedia of Reproduction written by Ernst Knobil and published by Academic Press. This book was released on 1998-10-23 with total page 1160 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The present work should serve as a convenient and comprensive source of information encompassing all aspects of the subject of reproduction as it relates to the entire animal kingdom." -- Preface, p. xxxiii.
Author : Anthony Carter
Publisher : Boydell & Brewer
ISBN 13 : 9781580460439
Total Pages : 456 pages
Book Rating : 4.4/5 (64 download)
Download or read book The Maternal Fetal Interface written by Anthony Carter and published by Boydell & Brewer. This book was released on 1998 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 29 papers contained in this volume look closely at various aspects of what is termed, "The Maternal-Fetal Interface," as it relates to the latest research in placental science. A substantial section of the book is devoted to the troublesome question of vertical transmission of infectious agents: namely, the HIV-1 virus. However, other sections of the volume examine related issues such as drug and toxin transfer across the term placenta and the diversity of placental types and how this can affect a placenta's effectiveness as a barrier. Anthony Carter is at the University of Odense, Denmark Vibeke Dantzer is at the University of Copenhagen, DenmarkThomas Jansson is at the University of Gothenburg, Sweden
Author : Udo R. Markert
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805579705
Total Pages : 201 pages
Book Rating : 4.8/5 (55 download)
Download or read book Immunology of Pregnancy written by Udo R. Markert and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the discipline of immunology which studies a unique physiological phenomenon contradicting many of the generally established rules in the field: immunology of pregnancy. It provides a wide overview of the current research of this topic. Prominent and leading international groups contributed by reviewing the most significant findings in the field.
Author : Alison Fiander
Publisher : Cambridge University Press
ISBN 13 : 1107667135
Total Pages : 557 pages
Book Rating : 4.1/5 (76 download)
Download or read book MRCOG Part One written by Alison Fiander and published by Cambridge University Press. This book was released on 2016-10-13 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Mary Ellen Avery
Publisher : Elsevier Health Sciences
ISBN 13 : 0721693474
Total Pages : 1675 pages
Book Rating : 4.7/5 (216 download)
Download or read book Avery's Diseases of the Newborn written by Mary Ellen Avery and published by Elsevier Health Sciences. This book was released on 2005-01-01 with total page 1675 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods. It maintains a clinical focus while providing state-of-the-art diagnosis and treatment techniques. Written by more than 55 specialists who are actively involved in the care of sick newborns, it serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal board exams, and a useful resource for the entire neonatal care team. Focuses on diagnosis and management, describing pertinent developmental physiology and the pathogenesis of neonatal problems.Includes over 500 crisp illustrations that clarify important concepts and techniques. Features the contributions of new editor Christine Gleason, a well-known neonatologist specializing in fetal physiology and drug/alcohol effects on the brain.Discusses hot topics such as ethical decisions in the neonatal-perinatal period * maternal medical disorders of fetal significance, seizure disorders, isoimmunization, cancer and mental disorders * maternal and fetal anesthesia and analgesia * prenatal genetic diagnosis * overview of clinical evaluation of metabolic disease * neonatal pain in the 21st Century * immunology of the fetus and newborn * wonders of surfactant * long-term neurological outcomes in children with congenital heart disease * developmental biology of the hematologic system * and illustrative forms and normal values: blood, CSF, urine.Features extensive cross-referencing, making it quick and easy to navigate through the organ-related sections.Includes coverage of perinatology-providing a well-rounded, comprehensive approach to patient care.Presents case studies designed to help readers recognize and manage cases in the office setting and asses their understanding of the topic.
Author : Paul A. Krieg
Publisher : John Wiley & Sons
ISBN 13 : 9780471125365
Total Pages : 470 pages
Book Rating : 4.1/5 (253 download)
Download or read book A Laboratory Guide to RNA written by Paul A. Krieg and published by John Wiley & Sons. This book was released on 1996-08-15 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is the most complete guide available to the isolation, analysis, and synthesis of RNA. It covers everything researchers and laboratory workers need to know about the study of gene expression via RNA analysis-from the theory behind the methods, to actual problem-solving techniques. Step-by-step protocols are presented for each method. A careful presentation of the experimental formalities of these protocols enables specialists and nonspecialists alike to implement the methods easily in the laboratory. Each protocol is accompanied by the theoretical background underlying the experimental procedure and most chapters contain illustrations of typical results and troubleshooting tips. A Laboratory Guide to RNA offers a straightforward detailed account of experimental procedures, ranging from the isolation of RNA from a variety of cell and tissue types, detection analysis, and quantitation using a range of strategies, to large- and small-scale synthesis of RNA. This unique guide not only covers established procedures such as RNA blotting and nuclease protection, but also the latest protocols for quantitative PCR and differential display. Protocols addressing in situ hybridization are highlighted in an eight-page, full-color section that illustrates the power of the technique for detection of gene expression in tissues and whole organisms. Featuring contributions from leading research laboratories and the biotechnology field, A Laboratory Guide to RNA: Isolation, Analysis, and Synthesis provides all the methods required for RNA analysis. It is the ideal laboratory guide for research scientists, graduate students, and lab personnel who need a solid reference on the analysis of gene expression at the RNA level.
