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Author : Jean L. Chang
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (82 download)
Download or read book Regulation of Lytic Gene Expression in the Kaposi's Sarcoma-associated Herpesvirus written by Jean L. Chang and published by . This book was released on 1999 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jessica R. Kirshner
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.:/5 (82 download)
Download or read book Lytic Gene Regulation in Kaposi's Sarcoma-associated Herpesvirus written by Jessica R. Kirshner and published by . This book was released on 2001 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zhilong Yang
Publisher :
ISBN 13 : 9780549295013
Total Pages : pages
Book Rating : 4.2/5 (95 download)
Download or read book Regulation of Kaposi's Sarcoma-associated Herpesvirus (KSHV) Lytic Gene Expression by Viral Transactivator RTA and Cellular Repressor K-RBP written by Zhilong Yang and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Keiji Ueda
Publisher : Frontiers E-books
ISBN 13 : 2889190498
Total Pages : 185 pages
Book Rating : 4.8/5 (891 download)
Download or read book Research on Kaposi's sarcoma-associated herpesvirus: past, present, and future written by Keiji Ueda and published by Frontiers E-books. This book was released on with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been 16 years since Kaposi's sarcoma-associated herpesvirus (KSHV) was found from Kaposi's sarcoma. Very extensive studies on KSHV have been performed and we now know well that KSHV is actually the very etiologic agent to cause Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease and this virus is an oncogenic DNA virus in such sense. Though a lot of reports have been published, there are lots of enigmas on its epidemiology, entry, lytic replication/induction, viral particle assembly/egress, latency, oncogenesis and so on. At this time point, it is better for us to review what we learned from the studies of this virus and consider what we have to clarify about this virus nature for future by comparing the virus with the other virus research.
Download or read book A Negative Element Involved in Kaposi's Sarcoma-associated Herpesvirus-encoded ORF11 Gene Expression written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The ORF11 of the Kaposi's sarcoma-associated herpesvirus (KSHV) is a lytic viral gene with delayed-early expression kinetics. How the ORF11 gene expression is regulated in the KSHV lytic cascade is largely unknown. Here we report that the deletion of the KSHV viral IL-6 gene from the viral genome leads to deregulated ORF11 gene expression. The KSHV-encoded viral IL-6 protein was found not to be essentially involved in the regulation of ORF11, suggesting a potential transcriptional cis-regulation. A negative element was identified downstream of the ORF11 gene, which suppresses the ORF11 basal promoter activity in a position-independent manner.
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Moon Jung Song
Publisher :
ISBN 13 :
Total Pages : 462 pages
Book Rating : 4.:/5 ( download)
Download or read book Transcriptional Regulation of Polyadenylated Nuclear RNA by RTA in Kaposi's Sarcoma-associated Herpesvirus/human Herpesvirus 8 written by Moon Jung Song and published by . This book was released on 2002 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chris Boshoff
Publisher : Springer Science & Business Media
ISBN 13 : 354034344X
Total Pages : 332 pages
Book Rating : 4.5/5 (43 download)
Download or read book Kaposi Sarcoma Herpesvirus: New Perspectives written by Chris Boshoff and published by Springer Science & Business Media. This book was released on 2006-10-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: will follow
Author : Craig Meyers
Publisher : Springer
ISBN 13 : 3030035026
Total Pages : 250 pages
Book Rating : 4.0/5 (3 download)
Download or read book HIV/AIDS-Associated Viral Oncogenesis written by Craig Meyers and published by Springer. This book was released on 2018-12-06 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important aspects of AIDS is the loss of protective immune function in the infected host which leads to increased prevalence of opportunistic infections and cancers. This book specifically addresses viral-induced human cancers associated with AIDS and observed in the AIDS population. It addresses the specific treatment required in this special population and the molecular biology of the causative viral agents.
Author : Thomas James Ellison
Publisher :
ISBN 13 :
Total Pages : 358 pages
Book Rating : 4.:/5 (79 download)
Download or read book K-bZIP of Kaposi's Sarcoma-associated Herpesvirus written by Thomas James Ellison and published by . This book was released on 2008 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527810706
Total Pages : 530 pages
Book Rating : 4.5/5 (278 download)
Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.
Author : Thomas E. Shenk
Publisher : Springer Science & Business Media
ISBN 13 : 3540773495
Total Pages : 477 pages
Book Rating : 4.5/5 (47 download)
Download or read book Human Cytomegalovirus written by Thomas E. Shenk and published by Springer Science & Business Media. This book was released on 2008-05-09 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
![Download Inhibition of the PLC[gamma]1 Recruitment to the Kaposi's Sarcoma-associated Herpesvirus K15 Protein as a Novel Approach to Interfere with Early Viral Lytic Gene Expression and Pathogenesis PDF Online Free](https://books.google.com/books/content/images/frontcover/k3U0uwEACAAJ?fife=w200-h370)
Author : Naira Samarina
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (14 download)
Download or read book Inhibition of the PLC[gamma]1 Recruitment to the Kaposi's Sarcoma-associated Herpesvirus K15 Protein as a Novel Approach to Interfere with Early Viral Lytic Gene Expression and Pathogenesis written by Naira Samarina and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889716147
Total Pages : 179 pages
Book Rating : 4.8/5 (897 download)
Download or read book Molecular and Cellular Interactions Between the Host and Herpesviruses written by and published by Frontiers Media SA. This book was released on 2021-11-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Benjamin P. Johnston
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS MODULATES THE UNFOLDED PROTEIN RESPONSE DURING LYTIC REPLICATION. written by Benjamin P. Johnston and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi's sarcoma-associated herpesvirus (KSHV) is the infectious cause of the complex endothelial neoplasm Kaposi's sarcoma, and two B cell malignancies, primary effusion lymphoma and multicentric Castleman's disease. KSHV activates multiple cellular stress responses during infection but the impact of stress on viral replication and tumorigenesis remain obscure. One such stress management pathway is the unfolded protein response (UPR), which is activated by endoplasmic reticulum (ER) stress. Activation of the three host cell sensors of ER stress, IRE1, PERK, and ATF6, stimulates synthesis of transcription factors XBP1s, ATF4, and ATF6-N, respectively, which coordinate a transcriptional program to mitigate stress and restore protein homeostasis. Failure to restore homeostasis results causes the UPR to shift from an adaptive response to a pro-apoptotic response. In cells latently infected with KSHV, ER stress initiates lytic reactivation through XBP1s-mediated transcription of the KSHV lytic switch gene, RTA. Thus, it appears that KSHV has evolved a mechanism to respond to ER stress. I investigated the role of the UPR during lytic replication in this thesis. Here, I demonstrate that lytic replication activates all three sensors of the UPR, but the downstream transcription factors are inhibited. RNA silencing or chemical inhibition of any of the UPR sensors inhibits virion production, indicating that their activation is important for some aspect of productive viral replication. Surprisingly, ectopic expression of XBP1s can also inhibit viral production. Therefore, while XBP1s plays an important role in reactivation from latency, it inhibits later steps in lytic replication. This suggests that XBP1s downregulation by viral gene products may effectively remove an anti-viral host factor. To identify potential KSHV proteins that can modulate the UPR, I screened a KSHV lentiviral ORF library with a UPR fluorescent reporter cell line. I found multiple viral proteins that showed UPR-modulating ability. Of these hits, I found that ectopic expression of Kaposin C inhibits IRE1, and that ORF45 upregulates multiple UPR markers, but likely not through ER stress induction. Overall these findings suggest that KSHV modulates UPR signaling during lytic replication to promote virus production instead of resolving ER stress.
Author : Daniel Pfalmer
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (957 download)
Download or read book Kaposi’s Sarcoma-associated Herpesvirus Replication and Transcription Activator Regulates Extracellular Matrix Signal Pathway written by Daniel Pfalmer and published by . This book was released on 2016 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kaposi’s Sarcoma (KS) is a malignancy caused by infection with Kaposi’s Sarcoma-associated Herpesvirus [KSHV; also known as Human Herpesvirus 8 (HHV8)] in which tumor cells show a characteristic ‘spindle-like’ morphology. The transcription factor RTA (Replication and Transcription Activator) is the viral protein responsible for reactivating KSHV from its latent state. Production of RTA in latently infected cells causes a number of viral proteins to be produced and leads to a cascade of gene expression changes in both viral and host genes. Previous work in our lab showed that RTA was capable of reprogramming cells in vitro to display a spindle-like morphology. In this study we aimed to identify the host gene expression changes caused directly by RTA which could be responsible for that reprogramming. To that end, Madin-Darby Canine Kidney cells (MDCK cells) were chosen as a model for KSHV-naïve mammalian cells. Differences in host gene expression levels in a culture of MDCK cells transfected with a plasmid coding for expression of RTA compared to MDCK cells transfected with a similar plasmid lacking the RTA gene were measured by whole transcriptome sequencing (RNA-Seq). Cells containing the RTA-coding plasmid adopted a spindle-like morphology and showed at least a two-fold change in expression level in approximately 180 genes. Those 180 genes were then screened for known associations to signaling pathways in order to determine which might be involved with the morphological changes observed and/or biological significance. The expression levels of the 10 genes identified by that screening were then verified by quantitative real time PCR (qPCR). Of those 10 genes, eight were identified as potentially associated with the morphological changes, including three genes associated with extra cellular matrix (ECM) destruction (MMP9, CTSD, and CTSS) that were down-regulated; two genes associated with blocking ECM destruction (TIMP1 and TIMP2) that were pregulated; two ECM component genes (LAMC2 and COL1A2) that were upregulated; and one gene associated with blocking cell-cell and cell-ECM adhesion (MUC1) that was downregulated. The remaining two genes (MAP2K1 and podoplanin) were identified as potentially biologically significant, but not directly involved in regulating morphology. MAP2K1 is associated with epithelial dedifferentiation and was down-regulated; and the lymphatic endothelial specific marker podoplanin (PDPN) was up-regulated. Taken together, the differences in morphology and gene expression between RTA-producing cells and controls suggest a possible role for RTA in the formation of the spindle cells that characterize Kaposi’s sarcoma.
Author : Wenjing Duan
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 (423 download)
Download or read book Regulation of Expression of the Kaposi's Sarcoma Associated Herpesvirus/human Herpesvirus-8 Early Gene ORF57 written by Wenjing Duan and published by . This book was released on 1999 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
