Author : Gudrun Antoons
Publisher : Leuven University Press
ISBN 13 : 9789058673121
Total Pages : 164 pages
Book Rating : 4.6/5 (731 download)
Book Synopsis Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart by : Gudrun Antoons
Download or read book Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart written by Gudrun Antoons and published by Leuven University Press. This book was released on 2003 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Cardiac excitation-contraction (EC) coupling is the process from electrical excitation to contraction of the heart. Electrical stimulation of cardiac cells gives rise to an action potential, which triggers a systolic rise of the intracellular Ca2+ concentration, initiating a contraction. Contents include: Introduction, Excitation-contraction coupling in cardiac muscle, Excitation-contraction coupling in the failing heart, Aims, Methods, Animal models, Cell isolation, Experimental setup, Experimental protocols, Protein expression levels, Echocardiographic measurements, Data analysis, Results, Mechanisms underlying the frequency dependence of contraction and Ca2+i transients in mouse ventricular myocytes, Ca2+ handling and contractile dysfunction in ventricular myocytes of MLP, Ca2+ handling in the SERCA 2b/b mouse, General discussion, and Summary."