Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart

Download Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart PDF Online Free

Author :
Publisher : Leuven University Press
ISBN 13 : 9789058673121
Total Pages : 164 pages
Book Rating : 4.6/5 (731 download)

DOWNLOAD NOW!


Book Synopsis Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart by : Gudrun Antoons

Download or read book Regulation of Ca2+ Release from the Sarcoplasmic Reticulum in the Normal and Failing Heart written by Gudrun Antoons and published by Leuven University Press. This book was released on 2003 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Cardiac excitation-contraction (EC) coupling is the process from electrical excitation to contraction of the heart. Electrical stimulation of cardiac cells gives rise to an action potential, which triggers a systolic rise of the intracellular Ca2+ concentration, initiating a contraction. Contents include: Introduction, Excitation-contraction coupling in cardiac muscle, Excitation-contraction coupling in the failing heart, Aims, Methods, Animal models, Cell isolation, Experimental setup, Experimental protocols, Protein expression levels, Echocardiographic measurements, Data analysis, Results, Mechanisms underlying the frequency dependence of contraction and Ca2+i transients in mouse ventricular myocytes, Ca2+ handling and contractile dysfunction in ventricular myocytes of MLP, Ca2+ handling in the SERCA 2b/b mouse, General discussion, and Summary."

The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias

Download The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias PDF Online Free

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889458253
Total Pages : 191 pages
Book Rating : 4.8/5 (894 download)

DOWNLOAD NOW!


Book Synopsis The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias by : Elisabetta Cerbai

Download or read book The Role of Calcium Handling in Heart Failure and Heart Failure Associated Arrhythmias written by Elisabetta Cerbai and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Under normal, healthy conditions, the contraction of cardiac myocytes, leading to the pump function of this organ, is driven by calcium-dependent mechanisms. Entry of calcium into the myocyte during the cardiac action potential causes activation of the ryanodine receptors and release of calcium from the sarcoplasmic reticulum. This process termed calcium-induced calcium release is essential for excitation-contraction coupling and enables each action potential to be transduced into a mechanical event. Indeed, in healthy myocytes, the calcium concentration in the cytosol of is elevated approximately 10-fold from a resting level of ∼100 nM to ∼1 μM. This process is finely orchestrated by a number of key proteins, which can be specifically regulated by various pathways depending on the oxygen demand. Furthermore, the specific structure of the myocyte allows certain calcium-dependent processes to be compartmentalised, increasing the efficiency and safety of this regulation. Heart failure is a common, costly, and life-threatening condition. In 2015, for example, it affected around 40 million people globally. In patients with heart failure, the risk of sudden cardiac death and arrhythmias increases substantially. Cellular remodelling and alterations in calcium handling, which appear to contribute to the arrhythmogenic burden in heart failure, have been extensively reported. However, a number of unanswered questions remain, and each new study - while continuing to shed light on this subject - raises additional novel questions. This current compendium of articles covers a number of aspects and comprehensively reviews current knowledge and perspectives regarding the link between calcium handling, arrhythmias and heart failure providing at the same time insights that may lead to novel therapeutic options for the future.

Excitation-Contraction Coupling and Cardiac Contractile Force

Download Excitation-Contraction Coupling and Cardiac Contractile Force PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 940100658X
Total Pages : 468 pages
Book Rating : 4.4/5 (1 download)

DOWNLOAD NOW!


Book Synopsis Excitation-Contraction Coupling and Cardiac Contractile Force by : Donald Bers

Download or read book Excitation-Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility

Download Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.F/5 ( download)

DOWNLOAD NOW!


Book Synopsis Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility by : Robert Gahagen Johnson

Download or read book Cardiac Sarcoplasmic Reticulum Function and Regulation of Contractility written by Robert Gahagen Johnson and published by . This book was released on 1998 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work brings together an interdisciplinary group of internationally recognized investigators in the field of cardiac SR proteins, ranging from molecular and structural biologists to clinical cardiologists and pharmacologists. It reviews the progress in the field, charts the unresolved questions, and discusses new insights related to the pathophysiology of and potential therapy for heart failure.

Biochemistry of Smooth Muscle Contraction

Download Biochemistry of Smooth Muscle Contraction PDF Online Free

Author :
Publisher : Elsevier
ISBN 13 : 0080527892
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!


Book Synopsis Biochemistry of Smooth Muscle Contraction by : Michael Barany

Download or read book Biochemistry of Smooth Muscle Contraction written by Michael Barany and published by Elsevier. This book was released on 1996-01-04 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.

Interactive Phenomena in the Cardiac System

Download Interactive Phenomena in the Cardiac System PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461529468
Total Pages : 417 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!


Book Synopsis Interactive Phenomena in the Cardiac System by : S. Sideman

Download or read book Interactive Phenomena in the Cardiac System written by S. Sideman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cardiac system represents one of the most exciting challenges to human ingenuity. Critical to our survival, it consists of a tantalizing array of interacting phenomena, from ionic transport, membrane channels and receptors through cellular metabolism, energy production to fiber mechanics, microcirculation, electrical activation to the global, clinically observed, function, which is measured by pressure, volume, coronary flow, heart rate, shape changes and responds to imposed loads and pharmaceutical challenges. It is a complex interdisciplinary system requiring the joint efforts of the life sciences, the exact sciences, engineering and technology to understand and control the pathologies involved. The Henry Goldberg Workshops were set up to address these multivariable, multidisciplinary challenges. Briefly, our goals are: To encourage international cooperation and foster interdisciplinary interaction between scientists from the different areas of cardiology; to relate microscale cellular phenomena to the global, clinically manifested cardiac function; to relate conceptual modeling and quantitative analysis to experimental and clinical data; to gain an integrated view of the various interacting parameters, identify missing links, catalyze new questions, and lead to better understanding of the cardiac system. The outstanding success of past workshops has encouraged their continuation. The first Henry Goldberg Workshop, held in Haifa in 1984, introduced the concept of interaction between mechanics, electrical activation, perfusion and metabolism, emphasizing imaging in the clinical environment. The second Workshop, in 1985, discussed the same parameters with a slant towards the control aspects.

Regulation of Coronary Blood Flow

Download Regulation of Coronary Blood Flow PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 4431683674
Total Pages : 330 pages
Book Rating : 4.4/5 (316 download)

DOWNLOAD NOW!


Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Activation, Metabolism and Perfusion of the Heart

Download Activation, Metabolism and Perfusion of the Heart PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9400933134
Total Pages : 735 pages
Book Rating : 4.4/5 (9 download)

DOWNLOAD NOW!


Book Synopsis Activation, Metabolism and Perfusion of the Heart by : S. Sideman

Download or read book Activation, Metabolism and Perfusion of the Heart written by S. Sideman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic mechanism underlying directional differences in excitability, con duction velocity, andsafetyfactor thatleadtocircusmovementreentry incardiac muscle is generally attributed to a spatial difference in the refractory period as originally described by Mines [1] or to a depressed segment as described by Schmitt and Erlanger [2]. A departure from this depolarization in cardiac muscle involve quantities, such as Vmax' that are not directly descriptive of the underlying mechanisms of propagation.

Transport ATPases

Download Transport ATPases PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 626 pages
Book Rating : 4.F/5 ( download)

DOWNLOAD NOW!


Book Synopsis Transport ATPases by : Ernesto Carafoli

Download or read book Transport ATPases written by Ernesto Carafoli and published by . This book was released on 1982 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Calcium Signaling

Download Calcium Signaling PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 3030124576
Total Pages : 1110 pages
Book Rating : 4.0/5 (31 download)

DOWNLOAD NOW!


Book Synopsis Calcium Signaling by : Md. Shahidul Islam

Download or read book Calcium Signaling written by Md. Shahidul Islam and published by Springer Nature. This book was released on 2019-10-23 with total page 1110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Store-Operated Calcium Channels

Download Store-Operated Calcium Channels PDF Online Free

Author :
Publisher : Academic Press
ISBN 13 : 0124079385
Total Pages : 307 pages
Book Rating : 4.1/5 (24 download)

DOWNLOAD NOW!


Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Anesthetic Pharmacology

Download Anesthetic Pharmacology PDF Online Free

Author :
Publisher : Cambridge University Press
ISBN 13 : 1139497022
Total Pages : 2902 pages
Book Rating : 4.1/5 (394 download)

DOWNLOAD NOW!


Book Synopsis Anesthetic Pharmacology by : Alex S. Evers

Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Dilated Cardiomyopathy

Download Dilated Cardiomyopathy PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 303013864X
Total Pages : 241 pages
Book Rating : 4.0/5 (31 download)

DOWNLOAD NOW!


Book Synopsis Dilated Cardiomyopathy by : Gianfranco Sinagra

Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues

Download Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues PDF Online Free

Author :
Publisher : IntechOpen
ISBN 13 : 9789535106791
Total Pages : 0 pages
Book Rating : 4.1/5 (67 download)

DOWNLOAD NOW!


Book Synopsis Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues by : Haruo Sugi

Download or read book Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues written by Haruo Sugi and published by IntechOpen. This book was released on 2012-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 17 short review articles classified into 3 parts. Part I consists of 7 articles dealing with basic aspects of contractile mechanism in skeletal and smooth muscle cells and also function of melanocytes having many properties common to those of smooth muscles. Part II and Part III contain articles dealing with pathological aspects of cardiac and smooth muscle cell functions, and dealing with factors influencing structure and function of cardiac and smooth muscle cells and tissues. The Editor believes that these articles are stimulating and informative for readers interested in basic, pathological and clinical aspects of muscle cells and tissues.

Stress-Activated Protein Kinases

Download Stress-Activated Protein Kinases PDF Online Free

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3540755691
Total Pages : 322 pages
Book Rating : 4.5/5 (47 download)

DOWNLOAD NOW!


Book Synopsis Stress-Activated Protein Kinases by : Francesc Posas

Download or read book Stress-Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.

Neuromuscular Function and Disorders

Download Neuromuscular Function and Disorders PDF Online Free

Author :
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Neuromuscular Function and Disorders by : Alan J. McComas

Download or read book Neuromuscular Function and Disorders written by Alan J. McComas and published by Butterworth-Heinemann. This book was released on 1977 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromuscular Function and Disorders focuses on the various processes underlying disordered neuromuscular function. Topics covered include the nature of membrane defects in myotonia and familial periodic paralysis; the disorder of neuromuscular transmission responsible for myasthenia gravis and the various pseudo-myasthenic syndromes; and the disorders of Schwann cell function which cause demyelination. This book is comprised of 28 chapters divided into two sections and begins with a discussion on the normal anatomy and physiology of peripheral nerve and muscle. Included in the first section a ...

Organellar Ion Channels and Transporters

Download Organellar Ion Channels and Transporters PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 275 pages
Book Rating : 4.:/5 (64 download)

DOWNLOAD NOW!


Book Synopsis Organellar Ion Channels and Transporters by : Barbara E. Ehrlich

Download or read book Organellar Ion Channels and Transporters written by Barbara E. Ehrlich and published by . This book was released on 1996 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: