Regenerative Nephrology

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Regenerative Nephrology

Author : Michael S. Goligorsky
Publisher : Academic Press
ISBN 13 : 0123809290
Total Pages : 473 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Regenerative Nephrology by : Michael S. Goligorsky

Download or read book Regenerative Nephrology written by Michael S. Goligorsky and published by Academic Press. This book was released on 2010-11-26 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. - Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers - Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Regenerative Nephrology

Author : Michael S. Goligorsky
Publisher : Academic Press
ISBN 13 : 0128233192
Total Pages : 530 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Regenerative Nephrology by : Michael S. Goligorsky

Download or read book Regenerative Nephrology written by Michael S. Goligorsky and published by Academic Press. This book was released on 2021-06-12 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. - A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes - A new section on tissue engineering of the kidney of interest to nephrologists and urologists - An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies - A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Kidney Development, Disease, Repair and Regeneration

Author : Melissa Helen Little
Publisher : Academic Press
ISBN 13 : 012800438X
Total Pages : 615 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Kidney Development, Disease, Repair and Regeneration by : Melissa Helen Little

Download or read book Kidney Development, Disease, Repair and Regeneration written by Melissa Helen Little and published by Academic Press. This book was released on 2015-08-06 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. - Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities - Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally - Explains the underlying developmental mechanisms which influence the kidney's inherent repair capacity - Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Cellular Dedifferentiation and Regenerative Medicine

Author : Xiaobing Fu
Publisher : Springer
ISBN 13 : 3662561794
Total Pages : 296 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Cellular Dedifferentiation and Regenerative Medicine by : Xiaobing Fu

Download or read book Cellular Dedifferentiation and Regenerative Medicine written by Xiaobing Fu and published by Springer. This book was released on 2018-02-09 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the contribution of cell dedifferentiation to the regenerative process in all body systems, as well as its underlying molecular mechanisms and applications. The book is divided into four parts, the first of which addresses the history of cell dedifferentiation and regenerative medicine. In turn, Part II compares three routes by which cells change their phenotype: dedifferentiation, transdifferentiation, and reprogramming. Part III includes an extensive review of cell dedifferentiation events in all nine body systems for lower organisms and mammalians, respectively. The final part reviews the relationship between cell dedifferentiation and the development of cancer and several other diseases, while also outlining the prospects of and future research directions in cell dedifferentiation and regenerative medicine. The main purpose of the book is to underline the importance of cell dedifferentiation in stem cell and regenerative medicine by providing a systematical review of dedifferentiation in all body systems, together with the latest reliable evidence.

Oxford Textbook of Clinical Nephrology

Author : Neil N. Turner
Publisher : Oxford University Press
ISBN 13 : 0191017655
Total Pages : 3045 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Oxford Textbook of Clinical Nephrology by : Neil N. Turner

Download or read book Oxford Textbook of Clinical Nephrology written by Neil N. Turner and published by Oxford University Press. This book was released on 2015-10-29 with total page 3045 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence. This print edition of The Oxford Textbook of Clinical Nephrology comes with a year's access to the online version on Oxford Medicine Online. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. Oxford Medicine Online is mobile optimized for access when and where you need it.

Oxford Textbook of Clinical Nephrology

Author : Neil Turner
Publisher : Oxford University Press
ISBN 13 : 0199592543
Total Pages : 3045 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Oxford Textbook of Clinical Nephrology by : Neil Turner

Download or read book Oxford Textbook of Clinical Nephrology written by Neil Turner and published by Oxford University Press. This book was released on 2015-12-22 with total page 3045 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrated in full colour throughout, this comprehensive edition provides the reader with complete information on clinical and practical problems in nephrology.

Renal Reflections: Exploring the Marvels of Nephrology

Author : Tanzir Islam Britto
Publisher : BookRix
ISBN 13 : 3755446014
Total Pages : 57 pages
Book Rating : 4.7/5 (554 download)

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Book Synopsis Renal Reflections: Exploring the Marvels of Nephrology by : Tanzir Islam Britto

Download or read book Renal Reflections: Exploring the Marvels of Nephrology written by Tanzir Islam Britto and published by BookRix. This book was released on 2023-07-03 with total page 57 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dive into the captivating world of nephrology with "Renal Chronicles: Exploring Kidney Health." From renal physiology to transplantation and beyond, this comprehensive book unravels the complexities of kidney diseases and their management. Discover the anatomy, diagnostic tools, and therapeutic strategies in chronic kidney disease and dialysis. Explore the intricacies of transplantation and delve into the complications encountered in nephrology practice. Written by experts, this invaluable resource empowers medical students, practitioners, and researchers to navigate the fascinating field of nephrology with confidence. Enhance your understanding and shape the future of kidney health.

The Urinary Sediment

Author : Giovanni B. Fogazzi
Publisher : Oxford University Press, USA
ISBN 13 : 9780192630742
Total Pages : 188 pages
Book Rating : 4.6/5 (37 download)

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Book Synopsis The Urinary Sediment by : Giovanni B. Fogazzi

Download or read book The Urinary Sediment written by Giovanni B. Fogazzi and published by Oxford University Press, USA. This book was released on 1999 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet' These few comments should not obscure the significant contribution of The Urinary Sediment to the diagnostic armamentarium of the nephrologist. Each renal unit should have a copy for daily clinical discussions...Finally this book should be included in the required reading list of courses in renal medicine.' Nephrology Dialysis TransplantationThis is the second edition of a full colour reference atlas published first to excellent reviews in 1994. Every renal unit needs to have a reference text of this kind and urine microscopy is an important diagnostic aid in nephrology. After the 'Historical Introduction' by J Stewart Cameron, chapter 1 descibes the methods used to prepare and analyse the urine samples. Chapter 2, which is the most important section of the book, describes with the help of 249 illustrations (over 200 in full colour) the elements of the urinary sediment. Chapter 3 deals with the urinary sediment of the normal subject, while chapter 4 deals with the urinary changes which are observed in the main diseases of the kidney and urinary tract. Chapter 5 describes the changes of the urinary sediment caused by drugs. Chapter 6 is about the interpretation of the urinary findings shown in the previous chapters. Chapter 7 covers the new systems to analyse the urinary sediments. An appendix shows how to adjust the microscope to analyse the urine specimens. The primary audience is practising nephrologists and nephrologists in training, and also those in internal medicine rotating through the renal unit who perform routinely the analysis of the urinary sediment. Clinical pathologists would also find this an attractive and useful book. The illustrations are outstanding and additional clinical information has been added in this new edition. From review from the Lancet of the first edition in comparison with a competing title: 'Every nephrologist knows and teaches that urine microscopy is an important diagnostic aid. What has been urgently needed is a colour guide to the subject.....I preferred the pictures in the European book. They were of high quality, not repetitive and with clear legends...if I wanted to teach myself.. then the European book was well ahead. The latter is also accompanied by an elegant introductory essay by JS Cameron on the history of urine analysis. Every renal unit needs at least one of these books.' The Lancet

Cell Communication and Signaling in Health and Disease

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 0850144809
Total Pages : 202 pages
Book Rating : 4.8/5 (51 download)

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Book Synopsis Cell Communication and Signaling in Health and Disease by :

Download or read book Cell Communication and Signaling in Health and Disease written by and published by BoD – Books on Demand. This book was released on 2024-11-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell communication and signaling are essential functions for life. The topic encompasses all basic and translational aspects of cellular communication and signaling pathways in normal and pathological conditions. Many diseases are the result of dysfunction in cell communication and signaling. This book presents contributions ranging from studies of sensory transduction, membrane receptors, ion channels, protein modification, cell transformation, receptor internalization, and trafficking to disease-oriented studies focusing on neurodegenerative diseases or cancer. As such, the book will provide a gateway for newly interested investigators and serve as a resource for seasoned researchers of cell biological phenomena in health and disease. Targeted at students and researchers in biological, medical, and chemical disciplines, this book will provide an overview of the work that is being done on this cell biology topic. The book highlights any gaps and areas that would benefit from further exploration pertaining to both intracellular and intercellular cell communication and signaling. In addition, the book will contribute to the training of current and future cell biologists.

Advances in Biomedical Engineering Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481669591
Total Pages : 546 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Advances in Biomedical Engineering Research and Application: 2013 Edition by :

Download or read book Advances in Biomedical Engineering Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Biomedical Engineering Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Biomedical Engineering Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Biomedical Engineering Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Stem Cells Heterogeneity - Novel Concepts

Author : Alexander Birbrair
Publisher : Springer
ISBN 13 : 3030110966
Total Pages : 233 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Stem Cells Heterogeneity - Novel Concepts by : Alexander Birbrair

Download or read book Stem Cells Heterogeneity - Novel Concepts written by Alexander Birbrair and published by Springer. This book was released on 2019-04-23 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.

Handbook of Stem Cell Applications

Author : Khawaja H. Haider
Publisher : Springer Nature
ISBN 13 : 9819971195
Total Pages : 1422 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Handbook of Stem Cell Applications by : Khawaja H. Haider

Download or read book Handbook of Stem Cell Applications written by Khawaja H. Haider and published by Springer Nature. This book was released on with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Silva's Diagnostic Renal Pathology

Author : Xin J. Zhou
Publisher : Cambridge University Press
ISBN 13 : 1316613984
Total Pages : 691 pages
Book Rating : 4.3/5 (166 download)

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Book Synopsis Silva's Diagnostic Renal Pathology by : Xin J. Zhou

Download or read book Silva's Diagnostic Renal Pathology written by Xin J. Zhou and published by Cambridge University Press. This book was released on 2017-03-02 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Acute Kidney Injury and Regenerative Medicine

Author : Yoshio Terada
Publisher : Springer Nature
ISBN 13 : 981151108X
Total Pages : 390 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Acute Kidney Injury and Regenerative Medicine by : Yoshio Terada

Download or read book Acute Kidney Injury and Regenerative Medicine written by Yoshio Terada and published by Springer Nature. This book was released on 2020-05-14 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Pediatric Nephrology

Author : Francesco Emma
Publisher : Springer Nature
ISBN 13 : 3030527190
Total Pages : 2112 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Pediatric Nephrology by : Francesco Emma

Download or read book Pediatric Nephrology written by Francesco Emma and published by Springer Nature. This book was released on 2022-09-01 with total page 2112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the course of the previous seven editions, Pediatric Nephrology has become the standard reference text for students, trainees, practicing physicians (pediatricians, nephrologists, internists, and urologists), subspecialists, and allied health professionals seeking information about children’s kidney diseases. It is global in perspective, reflecting the fact that the international group of editors are all acknowledged world experts. The latest edition of this text is no different, providing a comprehensive, state-of-the-art overview on pediatric nephrology. Much like the previous edition, the latest edition reviews the most critical aspects of the field. Topics covered include developmental physiology and diseases, renal physiology and diagnostic approaches, glomerular disease, kidney involvement in systemic diseases, renal tubular disorders, homeostasis, cystic kidney disease and related disorders, urinary tract disorders, hypertension, acute kidney injury, and chronic kidney failure. Unlike the previous edition, however, the chapters in this edition now combine physiology, clinical management, and pathology for ease of use. The latest edition also includes a new section on the evaluation of different disorders that can have multiple etiologies, setting the stage for the evaluation and management of specific diseases. This book serves as a superb resource and an invaluable asset for practitioners, health professionals, and trainees seeking out information about children's kidney diseases.

Innovations in Nephrology

Author : Geraldo Bezerra da Silva Junior
Publisher : Springer Nature
ISBN 13 : 3031115708
Total Pages : 538 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Innovations in Nephrology by : Geraldo Bezerra da Silva Junior

Download or read book Innovations in Nephrology written by Geraldo Bezerra da Silva Junior and published by Springer Nature. This book was released on 2022-10-28 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our world is facing unprecedented technological development, which affects all the sectors of society. The 4th industrial revolution has brought numerous advances that are currently integrated in our daily life, including artificial intelligence (A.I.), internet of things (IoT), genetic engineering, 3D-printing and robotics. The health care sector is one of the most impacted by these technologies of the so-called digital era. From the simple advent of medical records to robotic surgery, health care has significantly changed from the XX to XXI century and is constantly changing, incorporating novel technologies. Nephrology is itself an innovative branch of medicine, created as a discipline in the 1960s, with breakthrough inventions, such as the dialysis machine, which made it possible to prolong life of those who suffer from chronic kidney disease; kidney transplant, with point-of-care immunosuppression that favours maintenance of kidney allografts for long years; kidney biopsy, which made it possible to discover the mysteries of glomerulonephritis and nephropathology. Novel technologies, such as A.I., IoT, robotics, stem cells, 3D-printing, mHealth, eHealth and several others are starting to be applied in nephrology, with promising results. It is possible that a great part of these technologies will become routinely available in clinical practice, and the burden of kidney diseases will significantly decrease once prevention, prediction, detection, monitoring and treatment of kidney diseases are more precise, with patients taking part in the process and becoming more and more connected. This book gathers essential information on the technologies that have been applied in nephrology and that can be applied in the future, with real possibilities of improving the care of kidney diseases. At first glance, this work is directed to the entire nephrology community and all the healthcare professionals that deal with kidney diseases. Researchers from different fields, not directly linked to nephrology, may also be interested in the book since many of the topics presented are related to other areas and serve as examples of their uses in medicine, such as artificial intelligence, robotics, and big data. Finally, the content provides an important resource to medical students, discussing technologies that will certainly be integrated in their professional practice.

Heptinstall's Pathology of the Kidney

Author : J. Charles Jennette
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975161556
Total Pages : 5054 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Heptinstall's Pathology of the Kidney by : J. Charles Jennette

Download or read book Heptinstall's Pathology of the Kidney written by J. Charles Jennette and published by Lippincott Williams & Wilkins. This book was released on 2023-05-22 with total page 5054 pages. Available in PDF, EPUB and Kindle. Book excerpt: For nearly 60 years, Heptinstall’s Pathology of the Kidney has been the reference of choice for both pathologists and nephrologists for expert, authoritative coverage of kidney disease. The fully revised and reorganized Eighth Edition, edited by Drs. J. Charles Jennette, Vivette D. D’Agati, Agnes B. Fogo, Volker Nickeleit and Michael Barry Stokes offers thorough pathologic descriptions, important clinical correlations, and up-to-date discussions of causes and pathogenesis to improve understanding of kidney disease and to facilitate accurate diagnosis and optimum care of patients with kidney disease. Now in a single volume, this image-rich text conveys the unique challenges and intricacies of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research.