Recombinant Poxviruses

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Author :
Publisher : CRC Press
ISBN 13 : 9780849361791
Total Pages : 360 pages
Book Rating : 4.3/5 (617 download)

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Book Synopsis Recombinant Poxviruses by : Matthew M. Binns

Download or read book Recombinant Poxviruses written by Matthew M. Binns and published by CRC Press. This book was released on 1992-05-27 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.

Vaccinia Virus and Poxvirology

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592597890
Total Pages : 402 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Vaccinia Virus and Poxvirology by : Stuart N. Isaacs

Download or read book Vaccinia Virus and Poxvirology written by Stuart N. Isaacs and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.

Poxviruses

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642756050
Total Pages : 220 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Poxviruses by : Richard W. Moyer

Download or read book Poxviruses written by Richard W. Moyer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this volume is to highlight some current areas of poxvirus research which are likely to be particularly fruitful in the upcoming few years. The first chapter, by Drs. Condit and Niles, discusses poxvirus genetics. Work in this area has provided mutants, produced practical procedures to simplify the manipulation of viral genes, and generated information about the molecular architecture and organization of genes characteristic of pox viruses. One of the most intensively studied regions of the viral genome is the HindIII D region of vaccinia, in which a combination of classical and molecular genetic analysis of the region has been particularly revealing. Within this region are open reading frames, some of which are expressed early and others late, organized in a fashion which is now known to be typical of these viruses. Other studies, related to temperature sensitive, drug resistant, and drug dependent mutants, are also discussed. Each of the other reviews included in this volume summarizes areas of research which have depended heavily on the genetics of the system. The intracellular site of a poxvirus infection is mostly, if not exclusively, limited to the cytoplasm which dictates several interesting biological ramifications. For example, poxvirus transcription must occur in the cytoplasm, rather than in the nucleus. The virus copes with this situation by incorporating into the virion the enzymatic machinery necessary to initiate transcription from input virus.

Biology of Poxviruses

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3709186250
Total Pages : 202 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Biology of Poxviruses by : Samuel Dales

Download or read book Biology of Poxviruses written by Samuel Dales and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, Biology of Poxviruses, marks our debut as editors of this well known series. We plan to continue the tradition of providing a forum for exten sive, critical reviews of individual virus groups, as exemplified by the present volume. But the pace of discovery is accelerating so rapidly that we feel the need to offer an additional format: volumes that contain collections of shorter, topical reviews on a group of related subjects. Such collections might cut across con ventional boundaries between virus groups, dealing, as an example, with a partic ular aspect of virus-cell interaction. Admittedly, this new format stretches the term "monograph" beyond the accepted definition, but we believe that we should pay that price to maintain the usefulness of the series as a medium of scientific communication. Whenever possible, we will enlist the aid of deputy editors to bring such col lections to fruition. As in the past, the editors and the publisher will welcome suggestions for topics and contributions.

Poxviruses

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3764375574
Total Pages : 447 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis Poxviruses by : Andrew Mercer

Download or read book Poxviruses written by Andrew Mercer and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph provides a comprehensive review of the poxvirus family with a particular emphasis on current developments. It includes the latest insights into poxviral molecular biology, diagnosis, therapy, vaccine development and the beneficial exploitation of these viruses in biomedical research. Each chapter is written by a leader in the field, and the book includes historical perspectives and summaries of recent advances in the field.

Recombinant Raccoon Poxvirus-vectored Feline Vaccines

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Author :
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Recombinant Raccoon Poxvirus-vectored Feline Vaccines by : Christopher Kulova Ngichabe

Download or read book Recombinant Raccoon Poxvirus-vectored Feline Vaccines written by Christopher Kulova Ngichabe and published by . This book was released on 1992 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Assessment of Future Scientific Needs for Live Variola Virus

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Author :
Publisher : National Academies Press
ISBN 13 : 030959698X
Total Pages : 126 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Assessment of Future Scientific Needs for Live Variola Virus by : Committee on the Assessment of Future Scientific Needs for Variola Virus

Download or read book Assessment of Future Scientific Needs for Live Variola Virus written by Committee on the Assessment of Future Scientific Needs for Variola Virus and published by National Academies Press. This book was released on 1999-05-14 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1980, the World Health Organization (WHO) officially declared that smallpox had been eradicated. In 1986, WHO's international Ad Hoc Committee on Orthopox Virus Infections unanimously recommended destruction of the two remaining official stocks of variola virus, one at the Centers for Disease Control and Prevention and the other at the VECTOR laboratory in Siberia. In June 1999, WHO decided to delay the destruction of these stocks. Informing that decision was Assessment of Future Scientific Needs for Variola Virus, which examines: -- Whether the sequenced variola genome, vaccinia, and monkey pox virus are adequate for future research or whether the live variola virus itself is needed to assist in the development of antiviral therapies. -- What further benefits, if any, would likely be gained through the use of variola in research and development efforts related to agent detection, diagnosis, prevention, and treatment. -- What unique potential benefits, if any, the study of variola would have in increasing our fundamental understanding of the biology, host-agent interactions, pathogenesis, and immune mechanisms of viral diseases.

Development of Raccoon Poxvirus Vectored Feline Recombinant Vaccines

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Author :
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Development of Raccoon Poxvirus Vectored Feline Recombinant Vaccines by : Liangbiao Hu

Download or read book Development of Raccoon Poxvirus Vectored Feline Recombinant Vaccines written by Liangbiao Hu and published by . This book was released on 1995 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fenner and White's Medical Virology

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Publisher : Academic Press
ISBN 13 : 0123751578
Total Pages : 604 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Fenner and White's Medical Virology by : Christopher J. Burrell

Download or read book Fenner and White's Medical Virology written by Christopher J. Burrell and published by Academic Press. This book was released on 2016-11-09 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Gene Therapy for Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 159745222X
Total Pages : 469 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Gene Therapy for Cancer by : Kelly K. Hunt

Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Viruses in Human Gene Therapy

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Publisher : Springer Science & Business Media
ISBN 13 : 9401105553
Total Pages : 228 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Viruses in Human Gene Therapy by : J. Vos

Download or read book Viruses in Human Gene Therapy written by J. Vos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: W. French Anderson, M.D. The publication of this book comes at an opportune time for the young field of human gene therapy. After a decade of long struggle at the laboratory bench and many long hours under the harsh lights of the federal review process, gene therapy has emerged as a legitimate scientific discipline. It is now time to move away from the period of questioning whether gene therapy will be a useful part of the physician armamentarium to begin to actively teach the concepts and practices that make gene therapy a reality. This book is a comprehensive collection of chapters that describe the basic biology and potential application of viruses as gene transfer reagents. It is not a coincidence that a modified virus was the reagent used in the first human gene therapy trials. Viruses have evolved with the human species (and most likely with all forms of life) to be the masters of gene transfer.

Vaccinia Virus

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Publisher : Humana
ISBN 13 : 9781493995950
Total Pages : 315 pages
Book Rating : 4.9/5 (959 download)

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Book Synopsis Vaccinia Virus by : Jason Mercer

Download or read book Vaccinia Virus written by Jason Mercer and published by Humana. This book was released on 2020-08-14 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book provides practical information for the laboratory that can be applied to the study of vaccinia and other poxviruses while emphasizing long-standing field standards and focusing on emerging new technologies applied in the field of poxvirology. The methods and protocols have been designed with the bench scientist in mind, being presented in a fashion that makes them useful for both starting and veteran poxvirus researchers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Vaccinia Virus: Methods and Protocols serves as a valuable resource for scientists looking to bring new methods and procedures into their lab in order to make exciting discoveries that will continue to deepen our understanding of this fascinating virus family.

The Orthopoxviruses

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Publisher : Elsevier
ISBN 13 : 0323150225
Total Pages : 442 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis The Orthopoxviruses by : Frank Fenner

Download or read book The Orthopoxviruses written by Frank Fenner and published by Elsevier. This book was released on 2012-12-02 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Orthopoxviruses presents knowledge and comprehensive and integrated picture of orthopoxviruses. The book looks into the molecular biology of this genusof viruses, particularly, the structure and chemical composition of the virion, replication, morphogenesis, pathogenesis, pathology, and immunology of this virus’ infections. It also elucidates the global spread, control, and eradication of smallpox. Additionally, the book describes a potentially important use of vaccinia virus, namely, its use as a vector for genes from other viruses, bacteria, or protozoa that specify antigens important in stimulating the production of a protective immune response. Such comprehensive account of all aspects of the biology of all known species of orthopoxviruses will be valuable to molecular biologists, virologists, immunologists, pathologists, and researchers in the veterinary sciences.

Pharmaceutical Biotechnology

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Publisher : John Wiley & Sons
ISBN 13 : 3527329943
Total Pages : 677 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Pharmaceutical Biotechnology by : Oliver Kayser

Download or read book Pharmaceutical Biotechnology written by Oliver Kayser and published by John Wiley & Sons. This book was released on 2012-05-21 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a very successful book is thoroughly updated with existing chapters completely rewritten while the content has more than doubled from 16 to 36 chapters. As with the first edition, the focus is on industrial pharmaceutical research, written by a team of industry experts from around the world, while quality and safety management, drug approval and regulation, patenting issues, and biotechnology fundamentals are also covered. In addition, this new edition now not only includes biotech drug development but also the use of biopharmaceuticals in diagnostics and vaccinations. With a foreword by Robert Langer, Kenneth J Germeshausen Professor of Chemical and Biomedical Engineering at MIT and member of the National Academy of Engineering and the National Academy of Sciences.

Library of Congress Subject Headings

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Publisher :
ISBN 13 :
Total Pages : 1274 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress

Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 2002 with total page 1274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Library of Congress Subject Headings

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Publisher :
ISBN 13 :
Total Pages : 1596 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Library of Congress Subject Headings by : Library of Congress. Cataloging Policy and Support Office

Download or read book Library of Congress Subject Headings written by Library of Congress. Cataloging Policy and Support Office and published by . This book was released on 2009 with total page 1596 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Monkeypox

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Author :
Publisher :
ISBN 13 : 9783805548182
Total Pages : 140 pages
Book Rating : 4.5/5 (481 download)

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Book Synopsis Human Monkeypox by :

Download or read book Human Monkeypox written by and published by . This book was released on 1988 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: