Recombinant Antibodies For Cancer Therapy

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Recombinant Antibodies for Cancer Therapy

Author : Martin Welschof
Publisher : Springer Science & Business Media
ISBN 13 : 1592593348
Total Pages : 476 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Recombinant Antibodies for Cancer Therapy by : Martin Welschof

Download or read book Recombinant Antibodies for Cancer Therapy written by Martin Welschof and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the advent of hybridoma technology more than two decades ago, numerous antibodies have entered the clinical setting as potent therapeutic agents. Their repeated application in humans, however, is limited by the development of human antimouse antibodies (HAMA) in the recipient, leading to allergic re- tions against the foreign murine protein and rapid neutralization. To circumvent these limitations many new antibodies have recently been tailored through recombinant antibody technology. The initial clinical data show encouraging results, thus demonstrating the potential of these new therapeutic agents. The purpose of Recombinant Antibodies for Cancer Therapy is to present a collection of detailed protocols in recombinant antibody technology. It is pri- rily addressed to scientists working on recombinant antibodies as well as cli- cians involved with antibody-based therapies. As with other volumes of this series, we placed the main focus on providing detailed protocols describing procedures step-by-step. Moreover, each protocol supplies a troubleshooting guide containing detailed information on possible problems and hints for pot- tial solutions. Antibody technology is a subject of constant and rapid change. This volume, therefore, does not attempt to cover all possible current experimental approaches in the field. Rather, we present carefully selected protocols, written by competent authors who have successfully verified the particular method described. Given our own professional backgrounds and interest in oncology, we chose to conc- trate chiefly on therapeutic agents for cancer patients.

Methods in Molecular Biology: Recombinant antibodies for cancer therapy: methods and protocols

Author : John M. Walker
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (84 download)

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Book Synopsis Methods in Molecular Biology: Recombinant antibodies for cancer therapy: methods and protocols by : John M. Walker

Download or read book Methods in Molecular Biology: Recombinant antibodies for cancer therapy: methods and protocols written by John M. Walker and published by . This book was released on 1984 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Humanised Recombinant Antibodies for Human Cancer Therapy

Author : Lisa Davidson
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Humanised Recombinant Antibodies for Human Cancer Therapy by : Lisa Davidson

Download or read book Humanised Recombinant Antibodies for Human Cancer Therapy written by Lisa Davidson and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recombinant Antibodies for Immunotherapy

Author : Melvyn Little
Publisher : Cambridge University Press
ISBN 13 : 1139481096
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Recombinant Antibodies for Immunotherapy by : Melvyn Little

Download or read book Recombinant Antibodies for Immunotherapy written by Melvyn Little and published by Cambridge University Press. This book was released on 2009-07-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.

Antibodies for Treating Cancer

Author : Melvyn Little
Publisher : Springer Nature
ISBN 13 : 3030725995
Total Pages : 153 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Antibodies for Treating Cancer by : Melvyn Little

Download or read book Antibodies for Treating Cancer written by Melvyn Little and published by Springer Nature. This book was released on 2021-05-10 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compact overview of the history, evolution and fascinating novel applications of antibodies for the treatment of cancer, leading the reader step by step to the latest advances. Interesting anecdotes, together with self-explanatory and clearly structured figures with a humorous touch, facilitate the reader’s understanding of this complex topic. Clinical cases round out the book, making it a valuable aid for professionals in their everyday practice. The growing importance of the topics covered here was highlighted by the joint award of the 2018 Nobel Prize in Chemistry to Frances H. Arnold (directed evolution of enzymes), George P. Smith (phage display of peptides) and Sir Gregory P. Winter (phage display of antibodies). Furthermore, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. Many of the antibodies that are now being brought to market target precisely these immune checkpoint modulators. The book addresses a broad readership, ranging from professionals and experts in the field to residents and medical students.

Safety of Biologics Therapy

Author : Brian A. Baldo
Publisher : Springer
ISBN 13 : 3319304720
Total Pages : 610 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Safety of Biologics Therapy by : Brian A. Baldo

Download or read book Safety of Biologics Therapy written by Brian A. Baldo and published by Springer. This book was released on 2016-08-12 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long overdue title provides a comprehensive, up-to-date, state-of-the art review of approved biologic therapies, with coverage of mechanisms of action, Indications for therapy, immunogenicity and a detailed examination of adverse effects and safety of the many and diverse therapeutic agents presented in a total of 13 chapters. It is predicted that by 2016, biologics will make up half of the world's 20 top-selling drugs and by 2018, biologic medicine sales will account for almost half of the world's 100 biggest selling drugs. Recombinant proteins dominate the growing list of the more than 200 approved biotherapeutic agents with targeted antibodies, fusion proteins and receptors; cytokines; hormones; enzymes; proteins involved in blood-clotting, homeostasis and thrombosis; vaccines; botulinum neurotoxins; and, more recently, biosimilar preparations, comprising the majority of approved biologics. Written with clinicians, other health care professionals, and researchers in mind, Safety of Biologics Therapy examines, in a single volume, the full range of issues surrounding the safety of approved biologic therapies. A good understanding of the risks and safety issues of modern biologics therapy is increasingly being demanded of all those connected with their development, handling, prescribing, administration and subsequent patient management. In addition to being of great value to clinicians in all branches of medicine, and to nurses, pharmacists and researchers, this book will prove invaluable for students taking undergraduate and graduate courses in the above disciplines and in the biomedical sciences.

Monoclonal Antibodies in Cancer

Author : Stewart Sell
Publisher : Springer Science & Business Media
ISBN 13 : 1461251761
Total Pages : 440 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Monoclonal Antibodies in Cancer by : Stewart Sell

Download or read book Monoclonal Antibodies in Cancer written by Stewart Sell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This represents the third volume in a series on cancer markers pub lished by the Humana Press. The first volume, published in 1980, stressed the relationship of development and cancer as reflected in the production of markers by cancer that are also produced by normal cells during fetal development. The concept that cancer represents a problem of differentiation was introduced by Barry Pierce in describing differenti ation of teratocarcinomas. Highlighted were lymphocyte markers, alphafetoprotein, carcinoembryonic antigen, ectopic hormones, enzymes and isozymes, pregnancy proteins, and fibronectin. The second volume, published in 1982 and coedited with Britta Wahren, focused on the diagnostic use of oncological markers in human cancers, which were systematically treated on an organ by organ basis. At that time, the application of monoclonal antibodies to the identification of cancer markers was still in a very preliminary stage. A general introduc tion to monoclonal antibodies to human tumor antigens was given there by William Raschke, and other authors included coverage of those mark ers then detectable by monoclonal antibodies in their chapters.

Bispecific Antibodies

Author : Roland E. Kontermann
Publisher : Springer Science & Business Media
ISBN 13 : 9783642209109
Total Pages : 373 pages
Book Rating : 4.2/5 (91 download)

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Book Synopsis Bispecific Antibodies by : Roland E. Kontermann

Download or read book Bispecific Antibodies written by Roland E. Kontermann and published by Springer Science & Business Media. This book was released on 2011-07-21 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Recombinant Antibodies

Author : Frank Breitling
Publisher : Wiley-Spektrum
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Recombinant Antibodies by : Frank Breitling

Download or read book Recombinant Antibodies written by Frank Breitling and published by Wiley-Spektrum. This book was released on 1999-09-30 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: As new recombinant DNA technology continues to join with cellular and molecular immunology, the field of antibody engineering has become a flourishing discipline. Antibody genes are now being cloned, genetically manipulated, and expressed to produce antigen binding proteins. Recombinant Antibodies addresses this burgeoning field with its comprehensive survey of the developing possibilities for producing specific antibodies by combinatorial methods. Following a comprehensive introduction to the field, the book is divided into four parts: a detailed introduction to the underlying concepts of recombinant antibodies, a description of the various methods for the generation of recombinant antibodies, their production and purification, and various designs and applications of genetically engineered proteins. The combination of these techniques substantially extends the functionality of natural antibodies. In addition, the book will focus on: Hybridoma immortalization. Generation and functional screening of highly complex antibody gene libraries. Human monoclonal antibodies to highly toxic and pathogenic antigens. Improving specificity or affinity of antibodies. New agents for cancer diagnosis and therapy. Genetic fusions for the production of bi- and multifunctional molecules. Production of large quantities of recombinant antibodies. New methods of purification. Emerging technologies. Recombinant Antibodies is the first general overview of the emerging field of antibody engineering and will serve as the definitive source for researchers and engineers in biology and medicine, biochemistry, immunology, and molecular biology, as well as anyone who is interested in biotechnology and antibody engineering.

Antibodies

Author : G. Subramanian
Publisher : Springer Science & Business Media
ISBN 13 : 1441988777
Total Pages : 287 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Antibodies by : G. Subramanian

Download or read book Antibodies written by G. Subramanian and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now over one hundred years since von Behring and Kitsato first concluded experiments that led to the use of passive immunisation, employing antibodies raised in animals against tetanus and diphtheria toxins. The advancement of technology both in manufacturing purity product in a cost effective way and the clinical research has proved that antibodies are one ofthe most successful products in biotechnology. Monoclonal antibodies account for between one-third and one-halfof all pharmaceutical products in development and human clinical trials. Both the nature of monoclonal antibody therapies and the relatively large size of the monoclonal antibody dictate the production requirements, for many ofthese therapeutics the monoclonal antibody product will be 100 kilogrammes or more per year. It is widely acknowledged that there is currently a worldwide shortage of biomanufacturing capacity, and the active pharmaceutical ingredient material requirements for these products are expected to increase. Thus the industry is looking for new sources and extensive studies are being carried out not only for alternative technology to meet the needs but also to reveal the new therapeutic applicationsofantibodies. This book brings to the forefront current advances in novel technologies for the manufacturing of monoclonal antibodies and also their extensive clinical importance. The first four chapters give an overview of the new technologies and the successful application in the manufacture of monoclonal antibodies with clinical purity. The next chapters address the application of antibodies in cancer therapy and functional genomic therapy.

Handbook of Therapeutic Antibodies

Author : Stefan Dübel
Publisher : John Wiley & Sons
ISBN 13 : 3527329374
Total Pages : 2538 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Handbook of Therapeutic Antibodies by : Stefan Dübel

Download or read book Handbook of Therapeutic Antibodies written by Stefan Dübel and published by John Wiley & Sons. This book was released on 2014-12-03 with total page 2538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Cancer Therapy

Author : Hans G. Beger
Publisher : Springer Science & Business Media
ISBN 13 : 3642737218
Total Pages : 308 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Cancer Therapy by : Hans G. Beger

Download or read book Cancer Therapy written by Hans G. Beger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of new cancer therapy modalities are discussed and evaluated in this book. It aims to demonstrate that the combination of classical chemo- and radiotherapy with new approaches in the field of immunotherapy can result in an improved treatment modality. Immunotherapy in this context consists of therapy with monoclonal antibodies, hematopoietic growth factors and other lymphokines. Results of early clinical trials with IL-2, GM-CSF and monoclonal antibodies against gastrointestinal tumors and melanoma are included. The progress in regional chemotherapy strategies, for example of the liver, is shown. In addition, the development of new chemotherapeutic agents with a different mode of action as well as better tolerability is presented. The use of hormones, such as LH-RH agonists, allows hormone-dependent tumors such as prostatic and breast cancer to be treated without strong adverse reactions. These recent findings give the reader insight into exciting therapeutic directions made possible by such combined, rather than single, modalities.

Methods in Protein Structure and Stability Analysis: NMR and EPR spectroscopies, mass-spectrometry, and protein imaging

Author : Vladimir N. Uversky
Publisher : Nova Science Publishers
ISBN 13 : 9781600217050
Total Pages : 0 pages
Book Rating : 4.2/5 (17 download)

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Book Synopsis Methods in Protein Structure and Stability Analysis: NMR and EPR spectroscopies, mass-spectrometry, and protein imaging by : Vladimir N. Uversky

Download or read book Methods in Protein Structure and Stability Analysis: NMR and EPR spectroscopies, mass-spectrometry, and protein imaging written by Vladimir N. Uversky and published by Nova Science Publishers. This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.

Drug-Induced Liver Injury

Author :
Publisher : Academic Press
ISBN 13 : 0128173173
Total Pages : 288 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug-Induced Liver Injury by :

Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Antibodies in Diagnosis and Therapy

Author : Matzku
Publisher : Routledge
ISBN 13 : 1351466364
Total Pages : 328 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Antibodies in Diagnosis and Therapy by : Matzku

Download or read book Antibodies in Diagnosis and Therapy written by Matzku and published by Routledge. This book was released on 2019-06-14 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.

Bispecific Antibodies

Author : Roland E. Kontermann
Publisher : Springer
ISBN 13 : 9783642209093
Total Pages : 373 pages
Book Rating : 4.2/5 (9 download)

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Book Synopsis Bispecific Antibodies by : Roland E. Kontermann

Download or read book Bispecific Antibodies written by Roland E. Kontermann and published by Springer. This book was released on 2011-07-21 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.

Monoclonal Antibody Production

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309064473
Total Pages : 74 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Monoclonal Antibody Production by : National Research Council

Download or read book Monoclonal Antibody Production written by National Research Council and published by National Academies Press. This book was released on 1999-06-06 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.