Receptor Usage And Pathogenesis In Acute And Chronic Viral Infection

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Receptor usage and pathogenesis in acute and chronic viral infection

Author : Yasuko Tsunetsugu-Yokota
Publisher : Frontiers E-books
ISBN 13 : 2889190668
Total Pages : 89 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Receptor usage and pathogenesis in acute and chronic viral infection by : Yasuko Tsunetsugu-Yokota

Download or read book Receptor usage and pathogenesis in acute and chronic viral infection written by Yasuko Tsunetsugu-Yokota and published by Frontiers E-books. This book was released on with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first phase of the viral life cycle, the virus enters cells using a specific cell surface receptor. Many viruses use multiple receptors: some of which are unique to a certain cell type, while others are ubiquitous in many cell types. Depending on the receptors used, the viral cell tropism is determined, which may result in the characteristic distribution of virus- infected cells/tissues. Obviously, virus entry is not the whole story. After the virus enters, various cellular proteins interact with it – some support virus replication, while others inhibit it. The intrinsic anti-viral cellular machinery differs among cell types; thus, viral cell tropism based on the receptor usage plays an important role in the pathogenesis. For example, HIV-1 utilizes one of two co-receptors, CXCR4 or CCR5, in addition to a major receptor, CD4. CCR5 expression is restricted to a certain subset of memory CD4+T cells, while CXCR4 expression is rather ubiquitous among CD4+T cells. Therefore, the latent infection of CCR5-utilizing HIV-1 in resting memory (CCR5+) T cells would be largely responsible for intermittent virus blimps accompanied by immune activation during chronic HIV infection. This may explain why CCR5-utilizing HIV-1 is preferentially isolated in the early phase of HIV-1 infection, even when the HIV-1 transmitter carries CXCR4-utilizing HIV-1 in abundance. In the case of the measles virus, CD150 (Signaling Lymphocyte Activation Molecule: SLAM) is a major receptor, while vaccine strains utilize CD46 when CD150 is not available. The third possible entry receptor would also be utilized for the infection of lung epithelial cells. The impact of these receptor usages in vivo on the disease outcome is now under investigation. We also know that the distinct use of host cell sugar moieties mediates species tropism in the influenza virus, and that a mutant virus breaking the species barrier is highly pathogenic in humans. Thanks to the recent development of reverse genetics, it is now possible to visualize virus-infected cells, or even the virus itself, by using highly sensitive flow cytometery or microscopy. How viral cell tropism, determined by the receptor used, can affect the disease course of acute and chronic virus infection is an important question to address. In this Research Topic, we focus on studies connecting virus receptor usage and the pathogenesis of various viruses causing acute or chronic infection.

Receptor-independent/-associated viral tropism

Author : Akio Adachi
Publisher : Frontiers E-books
ISBN 13 : 288919048X
Total Pages : 97 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Receptor-independent/-associated viral tropism by : Akio Adachi

Download or read book Receptor-independent/-associated viral tropism written by Akio Adachi and published by Frontiers E-books. This book was released on with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important and outstanding characteristics of viruses is their cellular and host tropism. As parasitic entities, viruses have to compromise with numbers of positive and negative factors present in target cells for their survival. In the absence of an appropriate interaction with cells, they do not replicate at all. Viral tropism can be therefore determined at each replication step, from the entry to progeny production in target cells. There are two major types of viral tropism, that is, the receptor-dependent and -independent tropisms. Restriction of viral replication occurs on the cell surface (receptor-dependent viral entry step) and/or intracellularly (receptor-independent post-entry replication steps). Viruses have acquired some mechanisms through adaptive mutations and/or recombinations to counteract a wide variety of cellular restriction factors, or to correctly interact with numerous cellular factors necessary for replication. They thereby can replicate, spread and survive in certain cell lineages, tissues, organs and finally in host individuals. This evolutional process/pressure would have generated profound effects on the biological properties of viruses. Recently, many cellular anti-viral factors with unique action mechanisms in addition to co-viral factors have been discovered by extensive studies on molecular genetics of viruses. Researches of these factors would lead to the effective clinical applications, as well as the increase of basic biological knowledge. In this Research Topic, we focus on the receptor-independent and uniquely associated viral tropism other than the strictly receptor-dependent or -mediated one. By presenting a series of centered articles, we describe here the unique properties of various virus species. Any types of the tier 1 article would be accepted and included in this Topic.

Greene's Infectious Diseases of the Dog and Cat - E-Book

Author : Jane E. Sykes
Publisher : Elsevier Health Sciences
ISBN 13 : 0323509339
Total Pages : 1828 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Greene's Infectious Diseases of the Dog and Cat - E-Book by : Jane E. Sykes

Download or read book Greene's Infectious Diseases of the Dog and Cat - E-Book written by Jane E. Sykes and published by Elsevier Health Sciences. This book was released on 2022-06-24 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW! Improved format includes overarching information on diagnosis, treatment, and prevention in the first part of the book, followed by specific pathogens and clinical problems in the second and third parts of the book, respectively. NEW! Parasite section includes coverage of disease caused by nematodes, (including heartworm disease), cestodes, trematodes, mites, ticks, fleas, and biting flies. NEW! Renewed focus on clinical relevance is applied throughout the text. NEW! Updated clinical images, maps, and life-cycle drawings are included in every chapter. NEW! Expanded sections on public health for each pathogen emphasize the One Health approach, promoting the interrelationship of human, animal, and environmental health. NEW! Information on SARS-CoV-2 relates its importance and relevance to animal health. NEW! Updated information on vaccination recommendations for client-owned and shelter animals is included as an Appendix.

Humanized Mice for HIV Research

Author : Larisa Y. Poluektova
Publisher : Springer
ISBN 13 : 1493916556
Total Pages : 538 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Humanized Mice for HIV Research by : Larisa Y. Poluektova

Download or read book Humanized Mice for HIV Research written by Larisa Y. Poluektova and published by Springer. This book was released on 2015-02-18 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. An expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens.

Cell Entry by Non-Enveloped Viruses

Author : John E. Johnson
Publisher : Springer Science & Business Media
ISBN 13 : 3642133320
Total Pages : 230 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Cell Entry by Non-Enveloped Viruses by : John E. Johnson

Download or read book Cell Entry by Non-Enveloped Viruses written by John E. Johnson and published by Springer Science & Business Media. This book was released on 2010-09-30 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The means by which non-enveloped viruses penetrate cellular membranes during cell entry remain poorly defined. Recent findings indicate several members of this group share a common mechanism of membrane penetration in which the virus particle undergoes programmed conformational changes, leading to capsid disassembly and release of small membrane-interacting peptides. A complete understanding of host cell entry by this minimal system will help elucidate the mechanisms of non-enveloped virus membrane penetration in general

Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464949956
Total Pages : 28 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition by :

Download or read book Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Coronaviridae Infections in a compact format. The editors have built Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Coronaviridae Infections in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Coronaviridae Infections: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book

Author : John E. Bennett
Publisher : Elsevier Health Sciences
ISBN 13 : 0323263739
Total Pages : 5094 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book by : John E. Bennett

Download or read book Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases E-Book written by John E. Bennett and published by Elsevier Health Sciences. This book was released on 2014-09-02 with total page 5094 pages. Available in PDF, EPUB and Kindle. Book excerpt: After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to any questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you’ll find in any other ID resource. Apply the latest knowledge with updated diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on Influenza (new pandemic strains); New Middle East Respiratory Syndrome (MERS) Virus; Probiotics; Antibiotics for resistant bacteria; Antifungal drugs; New Antivirals for hepatitis B and C; Clostridium difficile treatment; Sepsis; Advances in HIV prevention and treatment; Viral gastroenteritis; Lyme Disease; Helicobacter pylori; Malaria; Infections in immunocompromised hosts; Immunization (new vaccines and new recommendations); and Microbiome. Benefit from fresh perspectives and expanded global insights from an expanded team of American and International contributors. Martin Blaser, MD, a leading expert and Muriel G. and George W. Singer Professional of Translational Medicine at New York University School of Medicine, joins veteran PPID editors John E. Bennett, MD, and Raphael Dolin, MD to continue a legacy of excellence. Find and grasp the information you need easily and rapidly with newly added chapter summaries.

Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases

Author : John E. Bennett, MD, MACP
Publisher : Elsevier Health Sciences
ISBN 13 : 1455748013
Total Pages : 5094 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases by : John E. Bennett, MD, MACP

Download or read book Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases written by John E. Bennett, MD, MACP and published by Elsevier Health Sciences. This book was released on 2014-08-28 with total page 5094 pages. Available in PDF, EPUB and Kindle. Book excerpt: After thirty five years, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. Get the answers to questions you have with more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than you'll find in any other infectious disease resource. Find the latest diagnoses and treatments for currently recognized and newly emerging infectious diseases, such as those caused by avian and swine influenza viruses. Put the latest knowledge to work in your practice with new or completely revised chapters on influenza (new pandemic strains); new Middle East respiratory syndrome (MERS) virus; probiotics; antibiotics for resistant bacteria; antifungal drugs; new antivirals for hepatitis B and C; Clostridium difficile treatment; sepsis; advances in HIV prevention and treatment; viral gastroenteritis; Lyme disease; Helicobacter pylori; malaria; infections in immunocompromised hosts; immunization (new vaccines and new recommendations); and microbiome. Benefit from fresh perspectives and global insights from an expanded team of international contributors. Find and grasp the information you need easily and rapidly with newly added chapter summaries. These bulleted templates include diagnosis, therapy, and prevention and are designed as a quick summary of the chapter and to enhance relevancy in search and retrieval on Expert Consult. Stay current on Expert Consult with a thorough and regularly scheduled update program that ensures access to new developments in the field, advances in therapy, and timely information. Access the information you need easily and rapidly with new succinct chapter summaries that include diagnosis, therapy, and prevention. Experience clinical scenarios with vivid clarity through a richly illustrated, full-color format that includes 1500 photographs for enhanced visual guidance.

Dynamics of Immune Activation in Viral Diseases

Author : Pallaval Veera Bramhachari
Publisher : Springer Nature
ISBN 13 : 9811510458
Total Pages : 283 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Dynamics of Immune Activation in Viral Diseases by : Pallaval Veera Bramhachari

Download or read book Dynamics of Immune Activation in Viral Diseases written by Pallaval Veera Bramhachari and published by Springer Nature. This book was released on 2020-02-24 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity. It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection. Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.

Pathologic Basis of Veterinary Disease E-BOOK

Author : James F. Zachary
Publisher : Elsevier Health Sciences
ISBN 13 : 0323713149
Total Pages : 2165 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Pathologic Basis of Veterinary Disease E-BOOK by : James F. Zachary

Download or read book Pathologic Basis of Veterinary Disease E-BOOK written by James F. Zachary and published by Elsevier Health Sciences. This book was released on 2021-12-15 with total page 2165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices. Clear, up-to-date illustrations and explanations of the macroscopic (gross) and microscopic lesions resulting from diseases occurring in domestic animals Complete coverage of both general pathology and the pathology of organ systems that includes the latest research, practice, and diagnostic information on disease mechanisms, pathogenesis, and lesions. Clear explanations of disease mechanisms that describe cell, tissue, and organ system responses to injury and infection. Easy-to-follow organization for each systemic disease chapter including a brief review of the study of diseases that occur in specific tissues, organs, and organ systems, with basic principles related to anatomy, structure, and function, followed by congenital and functional abnormalities and discussions of infectious disease responses, helping students apply principles to veterinary practice. More than 2,100 full-color illustrations featuring color photographs, schematics, flow charts, and diagrammatic representations of disease processes as well as summary tables and boxes, making it easier to understand difficult concepts. Content on cellular and organ system pathology updated throughout the book, with expanded coverage of genetics and disease. Key Readings Index in each chapter with page numbers for key topics. Essential Concept boxes in each General Pathology chapter break down complicated topics that are critical to understanding lesions and pathogeneses. More than 20 recognized experts deliver the most relevant information for the practitioner, student, or individual preparing for the American College of Veterinary Pathologists’ board examination. An enhanced eBook is included with new print purchase, featuring the complete, fully searchable text plus an image collection; the text, tables, and boxes linked to the website that are cited throughout the book; ten new appendices that focus on veterinary diagnostic pathology, postmortem examination, interpretation of lesions, and more; plus an established appendix of photographic techniques used in veterinary diagnostic pathology.

Stiehm's Immune Deficiencies

Author : Kathleen E. Sullivan
Publisher : Academic Press
ISBN 13 : 0128172959
Total Pages : 1334 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Stiehm's Immune Deficiencies by : Kathleen E. Sullivan

Download or read book Stiehm's Immune Deficiencies written by Kathleen E. Sullivan and published by Academic Press. This book was released on 2020-05-23 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stiehm’s Immune Deficiencies: Inborn Errors in Immunity, Second Edition, is ideal for physicians and other caregivers who specialize in immunology, allergies, infectious diseases and pulmonary medicine. It provides a validated source of information for care delivery to patients, covering approaches to diagnosis that use both new genetic information and emphasize screening strategies. Management has changed dramatically over the past five years, so approaches to infection and autoimmunity are emphasized in an effort to improve outcomes and disseminate new information on the uses of targeted therapy. Covers immune deficiencies that are presented in a practical way, providing helpful information for active clinicians Fills an increasingly deep gap in the information available to clinicians Presents both clinical management and scientific advances for immune deficiencies Provides a primary resource for physicians in the field of immunodeficiencies Includes website access to a range of videos relevant to the topics discussed

Regulation of Inflammation in Chronic Disease

Author : Jixin Zhong
Publisher : Frontiers Media SA
ISBN 13 : 2889459160
Total Pages : 580 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Regulation of Inflammation in Chronic Disease by : Jixin Zhong

Download or read book Regulation of Inflammation in Chronic Disease written by Jixin Zhong and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

National Institute of Allergy and Infectious Diseases, NIH

Author : Vassil St. Georgiev
Publisher : Springer Science & Business Media
ISBN 13 : 1597455695
Total Pages : 537 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis National Institute of Allergy and Infectious Diseases, NIH by : Vassil St. Georgiev

Download or read book National Institute of Allergy and Infectious Diseases, NIH written by Vassil St. Georgiev and published by Springer Science & Business Media. This book was released on 2008-08-22 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over 50 years, the mission of the National Institute of Allergy and Infectious Diseases (NIAID) has been to conduct and support basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases with the ultimate goal of improving the health of individuals in the United States and around the world. As part of its mission to foster biomedical discovery and to reduce the burden of human disease, NIAID is committed to encouraging the accelerated translation of biomedical discoveries into effective clinical care and public health practice throughout the world. In pursuit of this goal and its disease-specific scientific objectives, NIAID seeks to broaden research opportunities and collaborations involving scientists and institutions outside the United States. National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research contains presentations given at the 2006 NIAID Research Conference held in Opatija, Croatia which brought internationally known researchers from the United States and Central and Eastern Europe to focus together on shared interests in microbiology, infectious disease, HIV/AIDS, and basic and clinical immunology. Some of the topics covered include emerging and re-emerging infections, the development of infectious disease prophylactics and therapeutics, drug resistance, and various topics in immunomodulation, autoimmunity, infections and immunity, and the development of vaccines. Extensive and in-depth, National Institute of Allergy and Infectious Diseases, NIH: Volume 1, Frontiers in Research is a valuable, comprehensive guide to the state of research today.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 742 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1989 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemokine Networks and Altered Leukocyte Traffic in Acute Simian Immunodeficiency Virus Infection

Author : Candice Cynclare Clay
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (83 download)

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Book Synopsis Chemokine Networks and Altered Leukocyte Traffic in Acute Simian Immunodeficiency Virus Infection by : Candice Cynclare Clay

Download or read book Chemokine Networks and Altered Leukocyte Traffic in Acute Simian Immunodeficiency Virus Infection written by Candice Cynclare Clay and published by . This book was released on 2008 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Targeting the Immune System to Treat Hepatitis B Virus Infection

Author : Mengji Lu
Publisher : Frontiers Media SA
ISBN 13 : 2889748561
Total Pages : 186 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Targeting the Immune System to Treat Hepatitis B Virus Infection by : Mengji Lu

Download or read book Targeting the Immune System to Treat Hepatitis B Virus Infection written by Mengji Lu and published by Frontiers Media SA. This book was released on 2022-04-06 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C)

Author : Zisis Kozlakidis
Publisher : Frontiers Media SA
ISBN 13 : 2832522319
Total Pages : 694 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C) by : Zisis Kozlakidis

Download or read book Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response (volume I.C) written by Zisis Kozlakidis and published by Frontiers Media SA. This book was released on 2023-04-25 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume I.C An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.