Receptor Localization

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Receptor Localization

Author : Marjorie Ariano
Publisher : John Wiley & Sons
ISBN 13 : 9780471195245
Total Pages : 276 pages
Book Rating : 4.1/5 (952 download)

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Book Synopsis Receptor Localization by : Marjorie Ariano

Download or read book Receptor Localization written by Marjorie Ariano and published by John Wiley & Sons. This book was released on 1998-07-16 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detection of neurotransmitter receptor locations and distribution densities within the central nervous system and peripheral tissues is receiving intense attention within the neuroscience research community. Neurotransmitter receptors, which receive the chemical signals sent from one neuron to another, are critical links in a highly complex information-processing chain. Pinpointing receptor sites and systems is crucial for understanding neurological function as well as dysfunction. It is also essential for understanding how receptors process information when impacted by such substances as heroin or nicotine, or when affected by neurodegenerative disease. Receptor Localization: Laboratory Methods and Procedures is the first user-friendly guide to the latest techniques and approaches being employed to examine the localization of neurotransmitter receptors in the central nervous system and peripheral tissues. It covers detection methods that are applicable to a wide variety of receptor systems, ranging from genes and ligands to in vito receptors in individuals; and to numerous receptor subtypes, such as nicotine, muscarine, tackykinins, dopamine, adenosine, and GABA. The standard laboratory "recipes" or "tricks" employed in these detection methods are fully discussed, as are the advantages and limitations of each procedure. With contributions from leading experts and extensively illustrated, this book: * Discusses receptor ligand binding methods using irreversible and reversible compounds * Presents antireceptor antisera technology using synthetic peptides and fusion proteins at both the cellular and subcellular resolution levels * Examines molecular assessments of receptors * Describes in situ hybridization, reverse transcriptase-PCR, and fluorescent in situ transcription * Covers new visualization paradigms * Includes physiological analysis of receptor function, cellular detection in the brain slice, and cultured neurons * Discusses the use of PET and SPECT to assess in vivo receptor distributions in animals and humans Receptor Localization: Laboratory Methods and Procedures is an invaluable guide for researchers in the related fields of neurology, biochemistry, and pharmacology. Its lucid descriptions of new detection methods, inclusion of experimental examples, and emphasis on how these experimental approaches are applicable to particular research areas will appeal to both the experienced researcher and novice investigator.

Receptor Localization

Author : Frances M. Leslie
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Receptor Localization by : Frances M. Leslie

Download or read book Receptor Localization written by Frances M. Leslie and published by . This book was released on 1988 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Serotonin Receptors in Neurobiology

Author : Amitabha Chattopadhyay
Publisher : CRC Press
ISBN 13 : 9781420005752
Total Pages : 224 pages
Book Rating : 4.0/5 (57 download)

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Book Synopsis Serotonin Receptors in Neurobiology by : Amitabha Chattopadhyay

Download or read book Serotonin Receptors in Neurobiology written by Amitabha Chattopadhyay and published by CRC Press. This book was released on 2007-05-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of developments spanning a multitude of techniques makes this an exciting time for research in serotonin receptors. A comprehensive review of the subject from a multidisciplinary perspective, Serotonin Receptors in Neurobiology is among the first books to include information on serotonin receptor knockout studies. With contributions from leading experts in their fields, the book explores serotonin receptors from a broad-based, multidisciplinary approach. The approaches described vary from molecular biological techniques to fluorescence microscopy and imaging, to genetic manipulation in animal models, providing a wide range of tools to study serotonergic phenomena. While each of these approaches has its own advantages and limitations, the synthesis of information and knowledge achieved from studies using multiple approaches will result in a comprehensive understanding of the underlying complex phenomena involved in serotonergic signaling and its implications in health and disease. The book provides an overall understanding of these receptors based on currently used methodologies and techniques. It describes specific experimental procedures that will be of use to researchers interested in addressing similar problems involving other G-protein-coupled receptor signaling systems.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 9781420044157
Total Pages : 350 pages
Book Rating : 4.0/5 (441 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written by one of the world’s leading authorities on NMDA receptors, Biology of the NMDA Receptor brings together virtually all the players in this important field.

Toll-Like Receptors (TLRs) and Innate Immunity

Author : Stefan Bauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540721673
Total Pages : 240 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer and published by Springer Science & Business Media. This book was released on 2007-12-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Localization Of Putative Steroid Receptors

Author : Pertschuk
Publisher : CRC Press
ISBN 13 : 1351082604
Total Pages : 183 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Localization Of Putative Steroid Receptors by : Pertschuk

Download or read book Localization Of Putative Steroid Receptors written by Pertschuk and published by CRC Press. This book was released on 2018-02-01 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. Some physician authors have applied many of the new methodologies in clinical research projects deisgned to improve medical practice, and these attempts have been placed in Volume II. The Background and recent advances presented here are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.

Localization Of Putative Steroid Receptors

Author : Louis P. Pertschuk
Publisher : CRC Press
ISBN 13 : 1351091042
Total Pages : 419 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Localization Of Putative Steroid Receptors by : Louis P. Pertschuk

Download or read book Localization Of Putative Steroid Receptors written by Louis P. Pertschuk and published by CRC Press. This book was released on 2019-07-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes represent the "state-of-the-art" in morphological methods for detection of steroid receptors. In Volume I we have attempted to collect current available methods and experimental approahes which might be useful in solving present enigmas. The background and recent advances presented are intended to stimulate further experimentation and new innovations, and spur clinical trials by all investigators with an interest in steroid hormones, cell biology, and clinical oncology.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 467 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Encyclopedia of Pain

Author : G.F. Gebhart
Publisher : Springer
ISBN 13 : 9783642287527
Total Pages : 0 pages
Book Rating : 4.2/5 (875 download)

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Book Synopsis Encyclopedia of Pain by : G.F. Gebhart

Download or read book Encyclopedia of Pain written by G.F. Gebhart and published by Springer. This book was released on 2013-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Pain includes more than 3,000 entries and provides clear, detailed and up-to-date coverage of the current state of research, and treatment of pain. In addition, detailed essays provide in-depth information on all aspects of nociception and pain, including substrates, causes, pathophysiology, symptoms and signs, diagnoses and treatment. A thousand color figures enhance understanding of this too-little-understood topic. The book is available in print, in online only form, or in a print-online bundle.

The Neurobiology of Drug and Alcohol Addiction

Author : Peter W. Kalivas
Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.X/5 (2 download)

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Book Synopsis The Neurobiology of Drug and Alcohol Addiction by : Peter W. Kalivas

Download or read book The Neurobiology of Drug and Alcohol Addiction written by Peter W. Kalivas and published by . This book was released on 1992 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers of a conference on [title] held by the New York Academy of Sciences, July 1991, in Spokane, Washington. No index. Annotation copyrighted by Book News, Inc., Portland, OR

Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309212243
Total Pages : 74 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System by : Institute of Medicine

Download or read book Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

The Orexin/Hypocretin System

Author : Seiji Nishino
Publisher : Springer Science & Business Media
ISBN 13 : 1592599508
Total Pages : 390 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis The Orexin/Hypocretin System by : Seiji Nishino

Download or read book The Orexin/Hypocretin System written by Seiji Nishino and published by Springer Science & Business Media. This book was released on 2007-11-22 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Impairment of orexin/hypocretin signaling causes narcolepsy-cataplexy in animals and humans. Most human narcolepsy-cataplexy cases are associated with orexin/hypocretin ligand deficiency, which can be detected clinically using cerebrospinal orexin/hypocretin measures and may lead to future treatments with orexin/hypocretin replacement therapy. In The Orexin/Hypocretin System: Physiology and Pathophysiology, leading researchers and clinicians review these exciting developments to set the stage for further research on the loss of orexin/hypocretin neurons in humans, regulation of sleep and wakefulness by the orexin/hypocretin system, and the role of the orexin/hypocretin system in many other physiological processes, including feeding, autonomic regulation, and neuroendocrine regulation. Topics of interest include an assessment of the functions and the physiology of orexin/hypocretin, its pathophysiology in human narcolepsy-cataplexy, and possible pharmacological treatments. The authors also introduce several experimental methods for orexin/hypocretin research, and, using multidisciplinary approaches, explain their uses and limitations. Authoritative and state-of-the-art, The Orexin/Hypocretin System: Physiology and Pathophysiology will aid scientists in the search for novel bioactive peptides and their receptors, as well as novel physiological insights and opportunities for the clinical treatment of not only narcolepsy, but also a broad range of diseases associated with endocrine, feeding, and body weight regulation.

Nuclear Localization of Growth Factors and of Monoclonal Antibodies

Author : Ewa Rakowicz-Szulczynska
Publisher : CRC Press
ISBN 13 : 9780849347139
Total Pages : 224 pages
Book Rating : 4.3/5 (471 download)

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Book Synopsis Nuclear Localization of Growth Factors and of Monoclonal Antibodies by : Ewa Rakowicz-Szulczynska

Download or read book Nuclear Localization of Growth Factors and of Monoclonal Antibodies written by Ewa Rakowicz-Szulczynska and published by CRC Press. This book was released on 1993-10-13 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Localization of Growth Factors and of Monoclonal Antibodies focuses on how an additional class of chromatin receptors is directly involved in mediation of the action of growth factors on the gene regulation level. The book describes a new intracellular pathway of growth factors and presents methods for identifying nuclear antigens with an epitopic homology of the cell surface antigens. It teaches how to distinguish monoclonal antibodies that penetrate the cell and localize in the nucleus from those that act only on the cell surface. New light is shed on the mechanisms of malignant transformation, and new approaches to developing anti-cancer and anti-HIV drugs are covered. The book will be important for oncologists, biochemists, cell biologists, pharmaceutical researchers, investigative pathologists, neurochemists, and immunologists.

The Cardiac Renin-angiotensin System

Author : Klaus Lindpaintner
Publisher : Wiley-Blackwell
ISBN 13 : 9780879935719
Total Pages : 366 pages
Book Rating : 4.9/5 (357 download)

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Book Synopsis The Cardiac Renin-angiotensin System by : Klaus Lindpaintner

Download or read book The Cardiac Renin-angiotensin System written by Klaus Lindpaintner and published by Wiley-Blackwell. This book was released on 1994-01-01 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential significance of the cardiac renin–angiotensin system is indicated by the beneficial effects of angiotensin–converting enzyme inhibitors in the treatment of congestive heart failure and regional myocardial ischemia. It has become clear that the cardiac renin–angiotensin system may contribute to post–myocardial infarction ventricular remodeling. This book details the cardiac renin–angiotensin system and its importance as the key to new therapeutic strategies. It will be an important addition to the library of any physician who is involved with the treatment of hypertension or congestive heart failure

Drug Localization in Tissues and Cells

Author : Walter E. Stumpf
Publisher : Iddc Press
ISBN 13 : 9780974051505
Total Pages : 170 pages
Book Rating : 4.0/5 (515 download)

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Book Synopsis Drug Localization in Tissues and Cells by : Walter E. Stumpf

Download or read book Drug Localization in Tissues and Cells written by Walter E. Stumpf and published by Iddc Press. This book was released on 2003-01-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ethylene in Plant Biology

Author : Frederick Abeles
Publisher : Elsevier
ISBN 13 : 0323156460
Total Pages : 312 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Ethylene in Plant Biology by : Frederick Abeles

Download or read book Ethylene in Plant Biology written by Frederick Abeles and published by Elsevier. This book was released on 2012-12-02 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ethylene in Plant Biology focuses on the role of ethylene in plant physiology and the interrelationship between ethylene, fruit ripening, and respiration. It summarizes the physiology, biochemistry, production, regulation, plant effects, metabolism, and mechanism of action of ethylene. This book presents an introduction to basic chemistry of ethylene and available techniques for its sampling and analysis. Then, it discusses the rate, environmental conditions, and reactions involved in ethylene production. Chapter 4 examines the effects of herbicides and hormones, such as auxin, gibberellins, cytokinins, and abscisic acid, on ethylene production. Meanwhile, the next chapter studies the so-called stress ethylene phenomenon in plants. In particular, this book examines the role of insects, temperature, water, gamma-irradiation, and mechanical and chemical stimuli in stress ethylene. The biochemical aspects of ethylene are covered in the subsequent chapters. These include its role in growth and development of plant, phytogerontological activity, role in ethylene synthesis, respiration, pigmentation, and hormone regulation. Chapter 9 presents the activity of ethylene relative to other hydrocarbon analogs and dose-response relationships for a number of ethylene-mediated processes. The concluding chapters tackle the attachment of ethylene to its site of action, including epinasty, root initiation, intumescence formation, and floral initiation. A discussion on the issue of ethylene air pollution is included. This book will be useful to both undergraduate students and professional workers, especially those who have background in plant anatomy, plant physiology, or biochemistry.