Receptor And Ion Channel Trafficking

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Receptor and Ion-channel Trafficking

Author : Stephen John Moss
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Receptor and Ion-channel Trafficking by : Stephen John Moss

Download or read book Receptor and Ion-channel Trafficking written by Stephen John Moss and published by . This book was released on 2002 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: A volume in the Molecular and Cellular Neurobiology series. This book reviews the recent advances in our understanding of the molecular and cellular mechanisms that control the assembly, transport, targeting and anchoring of the protein complexes making up the most important ion channels and receptor families, fundamental to synaptic function. Improved understanding of these processes is expected to reveal novel therapeutic targets relevant to a range of disease states. The first section of the book contains three chapters dealing with cation channels and provides an accessible, succinct and comprehensive account of what is known about the structures and the assembly and targeting of these multimeric proteins. The focus of the book then moves on to cover ligand-gated ion channels with two chapters on accetylcholine receptors. The final section of the book contains four chapters covering the excitatory and inhibitory amino acid receptors. Receptor and Ion-Channel Trafficking provides an integrated overview of the significant recent advances in the field of molecular neurobiology and will be essential reading for all researchers in neuroscience, neurobiology, biochemistry, cellular and molecular biology.

Receptor and Ion-channel Trafficking

Author : Stephen John Moss
Publisher :
ISBN 13 : 9780191724763
Total Pages : pages
Book Rating : 4.7/5 (247 download)

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Book Synopsis Receptor and Ion-channel Trafficking by : Stephen John Moss

Download or read book Receptor and Ion-channel Trafficking written by Stephen John Moss and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Trafficking of Cardiac Ion Channels

Author : Marcel Verges
Publisher : MDPI
ISBN 13 : 3039434721
Total Pages : 156 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Trafficking of Cardiac Ion Channels by : Marcel Verges

Download or read book Trafficking of Cardiac Ion Channels written by Marcel Verges and published by MDPI. This book was released on 2021-04-27 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein sorting and trafficking are regulated by well-conserved mechanisms. These allow a distinctive set of resident proteins to be present in the correct subcellular organelle, which is required for proper cell functioning. Voltage-gated ion channels, as responsible for cardiomyocyte action potential, must be properly localized. They participate in cell excitability and electrical coupling, ensuring uninterrupted and rhythmic heart beating. Ion channel complexes comprise one or more pore-forming α subunits, associated β subunits, and additional proteins. Channel localization and function are regulated by the β subunits and associated proteins, such as cytoskeletal elements, cell-adhesion molecules, and adaptors. These influence protein targeting, anchoring, and retention in specific surface domains along the cardiomyocyte sarcolemma, such as intercalated discs, T-tubules, or the lateral membrane. Alterations in ion channel trafficking are the cause of channelopathies associated with inherited arrhythmias leading to sudden death. An outstanding question is how these molecular alterations lead to disease. In this volume, scientists share their vision to understand how cardiac ion channel trafficking is regulated and how it may become altered, leading to channelopathies that often turn into deadly arrhythmias. Data generated can be translated to a clinical context, hopefully turning into approaches to help prevention and treatment, which is of utmost importance, both medically and socially.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 502 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system

Download The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system PDF Online Free

Author : Leigh Anne Swayne
Publisher : Frontiers Media SA
ISBN 13 : 2889194450
Total Pages : 161 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system by : Leigh Anne Swayne

Download or read book The truth in complexes: why unraveling ion channel multi-protein signaling nexuses is critical for understanding the function of the nervous system written by Leigh Anne Swayne and published by Frontiers Media SA. This book was released on 2015-04-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.

Textbook of Ion Channels Volume II

Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1000857743
Total Pages : 489 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Textbook of Ion Channels Volume II by : Jie Zheng

Download or read book Textbook of Ion Channels Volume II written by Jie Zheng and published by CRC Press. This book was released on 2023-06-28 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume II starts with ion channel taxonomy and features coverage of major ion channel families, and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology, and roles in dis- ease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium- activated potassium channels, cyclic nucleotide-gated channels, pacemaker ion channels, chloride channels, ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors, and proton channels. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; offer a modern guide to the properties of major ion channel families; and include coverage of key examples of regulatory, physiological and disease roles for ion channels.

Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function

Author :
Publisher : Academic Press
ISBN 13 : 0128239255
Total Pages : 454 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function by :

Download or read book Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function written by and published by Academic Press. This book was released on 2021-06-12 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels, Part C, Volume 653 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of topics, including Nonsense suppression in ion channels, Engineering Ion Channels Using Protein Trans-splicing, Probing Ion Channel Neighborhoods Using APEX, STX based probes for NaVs, ANAP: a versatile, fluorescent probe of ion channel gating and regulation, High Throughput Screens for Small Molecule Ion Channel Modulators, Using toxins to study ion channels, Re/de-constructing ubiquitin regulation of ion channels, Tethered Peptide Toxins for Ion Channels, Voltage-Sensing Phosphatase Molecular Engineering, and more. Additional chapters cover Engineering excitable cells, Stretch and Poke Stimulation of Mechanically-Activated Ion Channels, Optical Control of STIM Channels, High Throughput Electrophysiological Evaluation of Mutant Ion Channels, Evaluating BEST1 Mutations in RPE Stem Cells, Long Read Transcript Profiling of Ion Channel Splice Variants, Permeation of Connexin Channels, Ratiometric pH indicator for melanosomes and lysosomes, and Ion channels in the epithelial cells of the choroid plexus. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series

Ion Channels and Disease

Author : Frances M. Ashcroft
Publisher : Academic Press
ISBN 13 : 0080535216
Total Pages : 505 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Ion Channels and Disease by : Frances M. Ashcroft

Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Voltage Gated Sodium Channels

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Store-Operated Calcium Channels

Author :
Publisher : Academic Press
ISBN 13 : 0124079385
Total Pages : 307 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Store-Operated Calcium Channels by :

Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject

Ion Channel Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0080923100
Total Pages : 168 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Ion Channel Diseases by :

Download or read book Ion Channel Diseases written by and published by Academic Press. This book was released on 2011-09-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Ion Channel Pharmacology

Author : Bernat Soria
Publisher :
ISBN 13 :
Total Pages : 498 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Ion Channel Pharmacology by : Bernat Soria

Download or read book Ion Channel Pharmacology written by Bernat Soria and published by . This book was released on 1998 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.

Handbook of Ion Channels

Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1466551429
Total Pages : 682 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Handbook of Ion Channels by : Jie Zheng

Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Mammalian Transient Receptor Potential (TRP) Cation Channels

Author : Bernd Nilius
Publisher : Springer
ISBN 13 : 331905161X
Total Pages : 569 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Mammalian Transient Receptor Potential (TRP) Cation Channels by : Bernd Nilius

Download or read book Mammalian Transient Receptor Potential (TRP) Cation Channels written by Bernd Nilius and published by Springer. This book was released on 2014-06-24 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

Calcium Entry Channels in Non-Excitable Cells

Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak

Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Ion Channel Drug Discovery

Author : Brian Cox
Publisher : Royal Society of Chemistry
ISBN 13 : 1849735085
Total Pages : 385 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Ion Channel Drug Discovery by : Brian Cox

Download or read book Ion Channel Drug Discovery written by Brian Cox and published by Royal Society of Chemistry. This book was released on 2014-09-03 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

Biology of the NMDA Receptor

Author : Antonius M. VanDongen
Publisher : CRC Press
ISBN 13 : 142004415X
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen

Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written