Ion Channel Diseases

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Ion Channels and Disease

Author : Frances M. Ashcroft
Publisher : Academic Press
ISBN 13 : 0080535216
Total Pages : 505 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Ion Channels and Disease by : Frances M. Ashcroft

Download or read book Ion Channels and Disease written by Frances M. Ashcroft and published by Academic Press. This book was released on 1999-10-20 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

Ion Channel Diseases

Author :
Publisher : Academic Press
ISBN 13 : 9780080923109
Total Pages : 168 pages
Book Rating : 4.9/5 (231 download)

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Book Synopsis Ion Channel Diseases by :

Download or read book Ion Channel Diseases written by and published by Academic Press. This book was released on 2011-09-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component. This volume of Advances in Genetics presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Ion Channels in Health and Disease

Author : Geoffrey S. Pitt
Publisher : Academic Press
ISBN 13 : 0128020172
Total Pages : 392 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Ion Channels in Health and Disease by : Geoffrey S. Pitt

Download or read book Ion Channels in Health and Disease written by Geoffrey S. Pitt and published by Academic Press. This book was released on 2016-10-04 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

Handbook of Ion Channels

Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1466551429
Total Pages : 682 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Handbook of Ion Channels by : Jie Zheng

Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce

Channelopathies

Author : F. Lehmann-Horn
Publisher : Elsevier
ISBN 13 : 9780080528854
Total Pages : 384 pages
Book Rating : 4.5/5 (288 download)

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Book Synopsis Channelopathies by : F. Lehmann-Horn

Download or read book Channelopathies written by F. Lehmann-Horn and published by Elsevier. This book was released on 2000-11-16 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes human hereditary ion channel diseases of voltage- and ligand-gated ion channels covering the diverse fields of medicine myology, neurology, cardiology, and nephrology requiring a wide and interdisciplinary readership. Interesting parallels in pathogenetic mechanisms of disease are especially emphasized to interest even highly specialized readers in entities outside of their fields. Each author has written an objective overview of his or her particular subject in a way that should allow the reader within a short period of time to obtain a comprehensive picture of the present state of art.

Textbook of Ion Channels Volume III

Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1000857840
Total Pages : 246 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Textbook of Ion Channels Volume III by : Jie Zheng

Download or read book Textbook of Ion Channels Volume III written by Jie Zheng and published by CRC Press. This book was released on 2023-06-28 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors and researchers. Ion channels are mem- brane proteins that control the electrical properties of neurons and cardiac cells; medi- ate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs. Volume III includes coverage of key ion channel regulators and their mechanisms, the role of ion channels working in concert in selected physiological systems, and examples of ion channel mutations and dysfunction in a selection of diseases. Chapters on ion channel regulation include splice variants, calcium–calmodulin regulation, regulation by G pro- teins, and lipids. A selection of ion channels in physiological systems includes ion chan- nels of the heart, ion channels in immune cells and their role in pancreatic beta cells and regulation of insulin secretion, and the role of channels in sperm and eggs. While disease mechanisms are integrated into the chapters of Volume II, Volume III offers special consid- eration of ion channels in epilepsy, cystic fibrosis and pain syndromes. All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and includecoverage of key examples of regulatory, physiological, and disease roles for ion channels.

Ion Channels

Author : James N. C. Kew
Publisher :
ISBN 13 : 0199296758
Total Pages : 586 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Ion Channels by : James N. C. Kew

Download or read book Ion Channels written by James N. C. Kew and published by . This book was released on 2010 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are intimately involved in the everyday physiological functions that enable us to live a full and varied life. When disease strikes, malfunction of ion channels or their dependent is often involved, either as the cause or the effect of the illness. Thus, billions of dollars have been, and still are being, invested in research to understand the physiological and pathophysiological functions of ion channels in an attempt to develop novel therapeutic treatments for a wide range of diseases. This book provides a comprehensive overview of ion channel structure and function. It comprises two major parts. Part one is an introductory overview of the ion channel superfamily and the generic aspects of ion channel function. This part also reviews the methodologies by which ion channel function can be studied from the perspective of performing detailed biophysical characterization through to the deployment of high throughput approaches for identifying novel ion channel ligands. Part two of the book provides an in-depth review of the individual ion channel subfamilies and, as such, is subdivided into four broad sections: Voltage-Gated Ion Channels, Extracellular Ligand-Gated Ion Channels, Intracellular Ligand-Gated Ion Channels, and Polymodal-Gated Ion Channels, with each chapter focused on specific family members. These chapters have been written by world leading experts and provide a detailed overview of the structure, biophysics, localization, pharmacology, physiology, and disease relevance of each particular ion channel subfamily. Reviewing both the basic principles of ion channel function and providing a detailed up-to-date review of the phsyiological and pharmacological aspects of individual ion channel sub-families, this book constitutes both an excellent introduction to the field for non-specialists, as well as a highly valuable reference text for experienced researchers already working in the ion channel area.

Ion Channels

Author : David J. Aidley
Publisher : Cambridge University Press
ISBN 13 : 9780521498821
Total Pages : 324 pages
Book Rating : 4.4/5 (988 download)

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Book Synopsis Ion Channels by : David J. Aidley

Download or read book Ion Channels written by David J. Aidley and published by Cambridge University Press. This book was released on 1996-08-13 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are crucial components of living cells. Situated in the cell's membranes. they allow particular ions to pass from one side of the membrane to the other. In recent years the patch clamp technique has allowed the activity of individual channels to be measured, and recombinant DNA technology has led to fascinating detail on their structure. Together, these technical advances have produced a great flowering of knowledge and understanding about the subject, itself leading to further breakthroughs in science and medicine. Ion Channels provides an introduction to this scientific endeavour. It emphasises the molecular structure of channels as determined by gene cloning technology. This knowledge illuminates discussions of the permeability and selectivity of channels, their gating and modulation, their responses to drugs and toxins and the human diseases caused when they do not function properly.

Nonclassical Ion Channels in the Nervous System

Author : Xu Tian-le
Publisher : CRC Press
ISBN 13 : 1000403742
Total Pages : 341 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Nonclassical Ion Channels in the Nervous System by : Xu Tian-le

Download or read book Nonclassical Ion Channels in the Nervous System written by Xu Tian-le and published by CRC Press. This book was released on 2021-08-05 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Channelopathies in Heart Disease

Author : Dierk Thomas
Publisher : Springer
ISBN 13 : 9783030085483
Total Pages : 0 pages
Book Rating : 4.0/5 (854 download)

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Book Synopsis Channelopathies in Heart Disease by : Dierk Thomas

Download or read book Channelopathies in Heart Disease written by Dierk Thomas and published by Springer. This book was released on 2018-12-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.

Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics

Author : Elena Adinolfi
Publisher : Frontiers Media SA
ISBN 13 : 2889711242
Total Pages : 261 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics by : Elena Adinolfi

Download or read book Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics written by Elena Adinolfi and published by Frontiers Media SA. This book was released on 2021-08-02 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacology of Potassium Channels

Author : Nikita Gamper
Publisher : Springer Nature
ISBN 13 : 3030840522
Total Pages : 546 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Pharmacology of Potassium Channels by : Nikita Gamper

Download or read book Pharmacology of Potassium Channels written by Nikita Gamper and published by Springer Nature. This book was released on 2021-09-27 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.

Ion Channel Drug Discovery

Author : Brian Cox
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731861
Total Pages : 384 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Ion Channel Drug Discovery by : Brian Cox

Download or read book Ion Channel Drug Discovery written by Brian Cox and published by Royal Society of Chemistry. This book was released on 2014-09-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.

Ion Channels

Author : Bernard Fermini
Publisher : Springer Science & Business Media
ISBN 13 : 3540797297
Total Pages : 177 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Ion Channels by : Bernard Fermini

Download or read book Ion Channels written by Bernard Fermini and published by Springer Science & Business Media. This book was released on 2008-09-04 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.

Integrins and Ion Channels

Author : Andrea Becchetti
Publisher : Springer Science & Business Media
ISBN 13 : 144196066X
Total Pages : 124 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Integrins and Ion Channels by : Andrea Becchetti

Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer Science & Business Media. This book was released on 2010-12-28 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.

Disorders of Voluntary Muscle

Author : George Karpati
Publisher : Cambridge University Press
ISBN 13 : 9780521650625
Total Pages : 800 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Disorders of Voluntary Muscle by : George Karpati

Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Neuromuscular Disorders: Management and Treatment E-Book

Author : Tulio E. Bertorini
Publisher : Elsevier Health Sciences
ISBN 13 : 1437736408
Total Pages : 469 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Neuromuscular Disorders: Management and Treatment E-Book by : Tulio E. Bertorini

Download or read book Neuromuscular Disorders: Management and Treatment E-Book written by Tulio E. Bertorini and published by Elsevier Health Sciences. This book was released on 2010-09-08 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life. Effectively treat your patients using the latest management tools and targeted therapeutic strategies. Manage all neuromuscular disorders as well as resulting complications through comprehensive coverage of diagnosis and evaluations, treatments, and outcomes. Apply the multi-disciplinary approach of an expert in clinical neuromuscular care and a team of world-renown contributors. Easily refer to tools for diagnosis, treatment algorithms, and drug tables included throughout the text.