Recent Trends in Antifungal Agents and Antifungal Therapy

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Publisher : Springer
ISBN 13 : 8132227824
Total Pages : 254 pages
Book Rating : 4.1/5 (322 download)

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Book Synopsis Recent Trends in Antifungal Agents and Antifungal Therapy by : Amit Basak

Download or read book Recent Trends in Antifungal Agents and Antifungal Therapy written by Amit Basak and published by Springer. This book was released on 2016-09-21 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Antifungal Therapy

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Publisher : CRC Press
ISBN 13 : 0849387868
Total Pages : 484 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Antifungal Therapy by : Mahmoud Ghannoum

Download or read book Antifungal Therapy written by Mahmoud Ghannoum and published by CRC Press. This book was released on 2016-04-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Antifungal Drug Discovery: New Theories and New Therapies

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Publisher : Frontiers Media SA
ISBN 13 : 2889199509
Total Pages : 138 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Antifungal Drug Discovery: New Theories and New Therapies by : Chaminda Jayampath Seneviratne

Download or read book Antifungal Drug Discovery: New Theories and New Therapies written by Chaminda Jayampath Seneviratne and published by Frontiers Media SA. This book was released on 2016-09-13 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antibiotics in Laboratory Medicine

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781749831
Total Pages : 924 pages
Book Rating : 4.7/5 (498 download)

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Book Synopsis Antibiotics in Laboratory Medicine by : Victor Lorian

Download or read book Antibiotics in Laboratory Medicine written by Victor Lorian and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implement the most current science and practice in antimicrobial research. Now, find the newest approaches for evaluating the activity, mechanisms of action, and bacterial resistance to antibiotics with this completely updated, landmark reference. Turn to this comprehensive reference for groundbreaking evidence on the molecular link between chemical disinfectants, sterilants, and antibiotics. On the latest methods for detecting antibacterial resistance genes in the clinical laboratory, and antivirogram use to select the most active antiviral components against your patient's HIV.

Clinical Mycology

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Publisher : Elsevier Health Sciences
ISBN 13 : 1416056807
Total Pages : 702 pages
Book Rating : 4.4/5 (16 download)

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Book Synopsis Clinical Mycology by : Elias J. Anaissie

Download or read book Clinical Mycology written by Elias J. Anaissie and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book of its kind to focus on the diagnosis, prevention, and treatment of patients with fungal infections, this definitive reference returns in a completely revised, full-color new edition. It presents specific recommendations for understanding, controlling, and preventing fungal infections based upon underlying principles of epidemiology and infection control policy, pathogenesis, immunology, histopathology, and laboratory diagnosis and antifungal therapy. More than 560 photographs, illustrations, and tables depict conditions as they appear in real life and equip you to identify clinical manifestations with accuracy. Expanded therapy content helps you implement the most appropriate treatment quickly, and a bonus CD-ROM-featuring all of the images from the text-enables you to enhance your electronic presentations. Includes specific recommendations for diagnosing, preventing, and treating fungal infections in various patient populations based upon underlying principles of epidemiology and infection control policy, pathogenesis, immunology, histopathology, and laboratory diagnosis and antifungal therapy. Covers etiologic agents of disease, fungal infections in special hosts such as pediatric patients and patients with cancer and HIV, infections of specific organ systems, and more, to make you aware of the special considerations involved in certain cases. Features clinically useful and reader-friendly practical tools-including algorithms, slides, graphs, pictorials, photographs, and radiographs-that better illustrate and communicate essential points, promote efficient use in a variety of clinical and academic settings, and facilitate slide making for lectures and presentations. Offers a CD-ROM containing all of the book's images for use in your electronic presentations. Offers more clinically relevant images-more than 300 in full color for the first time-to facilitate diagnosis. Features expanded therapy-related content, including up-to-date treatment strategies and drug selection and dosing guidelines. Includes several new sections in the chapter on fungal infections in cancer patients that reflect the formidable clinical challenges these infections continue to present. Presents the work of additional international contributors who have defined many of the key issues in the field, providing more of a global perspective on the best diagnostic and management approaches. Uses a new, full-color design to enhance readability and ease of access to information.

Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts

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Publisher :
ISBN 13 : 9781562384692
Total Pages : 30 pages
Book Rating : 4.3/5 (846 download)

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Book Synopsis Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts by :

Download or read book Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts written by and published by . This book was released on 2002 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Fungal Cell Wall

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Publisher : Springer Nature
ISBN 13 : 3030499286
Total Pages : 374 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis The Fungal Cell Wall by : Jean-Paul Latgé

Download or read book The Fungal Cell Wall written by Jean-Paul Latgé and published by Springer Nature. This book was released on 2020-08-12 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.

Human Fungal Pathogen Identification

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Publisher : Humana
ISBN 13 : 9781493965137
Total Pages : 0 pages
Book Rating : 4.9/5 (651 download)

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Book Synopsis Human Fungal Pathogen Identification by : Thomas Lion

Download or read book Human Fungal Pathogen Identification written by Thomas Lion and published by Humana. This book was released on 2016-11-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume presents timely and authoritative content offering a comprehensive overview of the current state of the art in fungal diagnostics. Moreover, it addresses on-going developments expected to provide a basis for targeted treatment strategies resulting in improved outcome of invasive mycoses. The knowledge of host-related predisposing factors and stratified treatment options facilitating timely onset of adequate antifungal therapy are critical for successful clinical management and outcome of invasive fungal disease (IFD), requiring not only rapid diagnosis of a fungal infection and identification of the causative species, but also assessment of pathogen/host factors related to pathogenicity, susceptibility, and response to treatment. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Human Fungal Pathogen Identification: Methods and Protocols serves as an ideal reference for researchers investigating the ever-growing worldwide healthcare problems involving fungal infections.

Yeast Membrane Transport

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Publisher : Springer
ISBN 13 : 3319253042
Total Pages : 381 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Yeast Membrane Transport by : José Ramos

Download or read book Yeast Membrane Transport written by José Ramos and published by Springer. This book was released on 2015-12-31 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume reviews the recent progress in our understanding of membrane transport in yeast including both Saccharomyces cerevisiae and non-conventional yeasts. The articles provide a summary of the key transport processes and put these in a systems biology context of cellular regulation, signal reception and homeostasis. After a general introduction, readers will find review articles covering the mechanisms and regulation of transport for various substrates ranging from diverse nutrients to cations, water and protons. These articles are complemented by a chapter on extremophilic yeast, a chapter on the mathematical modelling of ion transport and two chapters on the role of transport in pathogenic yeasts and antifungal drug resistance. Each article provides both a general overview of the main transport characteristics of a specific substrate or group of substrates and the unique details that only an expert working in the field is able to transmit to the reader. Researchers and students of the topic will find this book to be a useful resource for membrane transport in yeast collecting information in one complete volume, which is otherwise scattered across many papers. This might also be interesting for scientists investigating other species in order to compare transport mechanisms with known functions in yeast with the cells on which they work.

Pathogenic Yeasts

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Publisher : Springer Science & Business Media
ISBN 13 : 3642031501
Total Pages : 367 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Pathogenic Yeasts by : Ruth Ashbee

Download or read book Pathogenic Yeasts written by Ruth Ashbee and published by Springer Science & Business Media. This book was released on 2009-10-27 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycological studies of yeasts are entering a new phase, with the sequencing of multiple fungal genomes informing our understanding of their ability to cause disease and interact with the host. At the same time, the ongoing use of traditional methods in many clinical mycology laboratories continues to provide information for the diagnosis and treatment of patients. This volume reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance. The importance of laboratory diagnosis, antifungal susceptibility testing, antifungal resistance and yeast diseases in animals are reviewed.

Medical Mycology

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Publisher : CRC Press
ISBN 13 : 1498714226
Total Pages : 440 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Medical Mycology by : Mehdi Razzaghi-Abyaneh

Download or read book Medical Mycology written by Mehdi Razzaghi-Abyaneh and published by CRC Press. This book was released on 2015-08-24 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of medically important fungi has been an important area of study that warrants further extensive research. The use oftraditional and molecular methods of identification, provides new insights into differentiation of species and ultimately the line of treatment can be determined. This book incorporates a diverse group of medically

Basic Biology and Applications of Actinobacteria

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Publisher : BoD – Books on Demand
ISBN 13 : 1789846145
Total Pages : 133 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Basic Biology and Applications of Actinobacteria by : Shymaa Enany

Download or read book Basic Biology and Applications of Actinobacteria written by Shymaa Enany and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actinobacteria have an extensive bioactive secondary metabolism and produce a huge amount of naturally derived antibiotics, as well as many anticancer, anthelmintic, and antifungal compounds. These bacteria are of major importance for biotechnology, medicine, and agriculture. In this book, we present the experience of worldwide specialists in the field of Actinobacteria, exploring their current knowledge and future prospects.

Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents

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Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents by : Robert A. Fromtling

Download or read book Recent Trends in the Discovery, Development and Evaluation of Antifungal Agents written by Robert A. Fromtling and published by . This book was released on 1987 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Trends in Human and Animal Mycology

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Publisher : Springer Nature
ISBN 13 : 9811394350
Total Pages : 289 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Recent Trends in Human and Animal Mycology by : Karuna Singh

Download or read book Recent Trends in Human and Animal Mycology written by Karuna Singh and published by Springer Nature. This book was released on 2019-11-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the reader’s convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.

Treating Infectious Diseases in a Microbial World

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Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Handbook of Antimicrobial Resistance

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Publisher : Springer
ISBN 13 : 9781493906932
Total Pages : 0 pages
Book Rating : 4.9/5 (69 download)

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Book Synopsis Handbook of Antimicrobial Resistance by : Matthias Gotte

Download or read book Handbook of Antimicrobial Resistance written by Matthias Gotte and published by Springer. This book was released on 2018-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: While many volumes have been written about various aspects of antimicrobial resistance, this book is a comprehensive reference work. All manifestations of resistance are addressed: viral; bacterial, parasitical and fungal are given dedicated sections. The underlining molecular mechanisms, which depend not only on the microbe but on the specific drug (target), are highly diverse. This work discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Combating Fungal Infections

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Publisher : Springer Science & Business Media
ISBN 13 : 364212173X
Total Pages : 549 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Combating Fungal Infections by : Iqbal Ahmad

Download or read book Combating Fungal Infections written by Iqbal Ahmad and published by Springer Science & Business Media. This book was released on 2010-08-03 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.