Quantitative Biosciences Companion in MATLAB

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Publisher : Princeton University Press
ISBN 13 : 0691259623
Total Pages : 257 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Quantitative Biosciences Companion in MATLAB by : Joshua S. Weitz

Download or read book Quantitative Biosciences Companion in MATLAB written by Joshua S. Weitz and published by Princeton University Press. This book was released on 2024-01-09 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hands-on lab guide in the MATLAB programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in Python and R

Quantitative Biosciences Companion in R

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Author :
Publisher : Princeton University Press
ISBN 13 : 0691259607
Total Pages : 273 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Quantitative Biosciences Companion in R by : Joshua S. Weitz

Download or read book Quantitative Biosciences Companion in R written by Joshua S. Weitz and published by Princeton University Press. This book was released on 2024-01-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hands-on lab guide in the R programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in Python and MATLAB

Quantitative Biosciences Companion in Python

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Author :
Publisher : Princeton University Press
ISBN 13 : 0691259615
Total Pages : 273 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Quantitative Biosciences Companion in Python by : Joshua S. Weitz

Download or read book Quantitative Biosciences Companion in Python written by Joshua S. Weitz and published by Princeton University Press. This book was released on 2024-01-09 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A hands-on lab guide in the Python programming language that enables students in the life sciences to reason quantitatively about living systems across scales This lab guide accompanies the textbook Quantitative Biosciences, providing students with the skills they need to translate biological principles and mathematical concepts into computational models of living systems. This hands-on guide uses a case study approach organized around central questions in the life sciences, introducing landmark advances in the field while teaching students—whether from the life sciences, physics, computational sciences, engineering, or mathematics—how to reason quantitatively in the face of uncertainty. Draws on real-world case studies in molecular and cellular biosciences, organismal behavior and physiology, and populations and ecological communities Encourages good coding practices, clear and understandable modeling, and accessible presentation of results Helps students to develop a diverse repertoire of simulation approaches, enabling them to model at the appropriate scale Builds practical expertise in a range of methods, including sampling from probability distributions, stochastic branching processes, continuous time modeling, Markov chains, bifurcation analysis, partial differential equations, and agent-based simulations Bridges the gap between the classroom and research discovery, helping students to think independently, troubleshoot and resolve problems, and embark on research of their own Stand-alone computational lab guides for Quantitative Biosciences also available in R and MATLAB

So Simple a Beginning

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Publisher : Princeton University Press
ISBN 13 : 0691200408
Total Pages : 336 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis So Simple a Beginning by : Raghuveer Parthasarathy

Download or read book So Simple a Beginning written by Raghuveer Parthasarathy and published by Princeton University Press. This book was released on 2022-02-08 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: A biophysicist reveals the hidden unity behind nature’s breathtaking complexity The form and function of a sprinting cheetah are quite unlike those of a rooted tree. A human being is very different from a bacterium or a zebra. The living world is a realm of dazzling variety, yet a shared set of physical principles shapes the forms and behaviors of every creature in it. So Simple a Beginning shows how the emerging new science of biophysics is transforming our understanding of life on Earth and enabling potentially lifesaving but controversial technologies such as gene editing, artificial organ growth, and ecosystem engineering. Raghuveer Parthasarathy explains how four basic principles—self-assembly, regulatory circuits, predictable randomness, and scaling—shape the machinery of life on scales ranging from microscopic molecules to gigantic elephants. He describes how biophysics is helping to unlock the secrets of a host of natural phenomena, such as how your limbs know to form at the proper places, and why humans need lungs but ants do not. Parthasarathy explores how the cutting-edge biotechnologies of tomorrow could enable us to alter living things in ways both subtle and profound. Featuring dozens of original watercolors and drawings by the author, this sweeping tour of biophysics offers astonishing new perspectives on how the wonders of life can arise from so simple a beginning.

Nano Comes to Life

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Publisher : Princeton University Press
ISBN 13 : 0691206449
Total Pages : 232 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Nano Comes to Life by : Sonia Contera

Download or read book Nano Comes to Life written by Sonia Contera and published by Princeton University Press. This book was released on 2021-11-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology (such as the author herself), advances in nanoscience and technology are transforming how we think about life and treat human health. This is due to a convergence of size. To do medicine, one must understand and be able to reach the nanoscale environment of healthy cells in tissues and organs, as well as other nano-sized building blocks that constitute a living organism, such as proteins and DNA. The ground-breaking advances being made at the frontiers of nanoscience and -technology, specifically in the areas of biology and medicine, are the subject of this short, popular-level book. Chapter 1 describes how nanotechnology and quantitative methods in biology are progressively being deployed to embrace life in all its multiscale, hierarchical intricacy and multiplicity. Chapters 2 through 4 review how bioinspired and biomimetic nanostructures and nanomachines are being created and integrated into strategies aimed at solving specific medical problems. In particular, Chapter 2 summarizes how scientists are seeking to build artificial nanostructures using both biological molecules and the organizational principles of biology. Chapter 3 gives an account of how nanotechnology is being used to develop drug-delivery strategies that specifically target cancer cells and tumors to improve the efficacy of current cancer chemotherapies. Chapter 4 reviews the science of one of the most potentially transformative scientific fields: tissue engineering. In a concluding chapter (Chapter 5), Contera reviews how nanotechnology, biology, and medicine will continue fusing with other sciences and technologies - incorporating more mathematical and computational modelling, as well as AI and robotics. Nanoscale devices will be used to learn biology; and biology will be used to inspire increasingly sophisticated "transmaterial" devices that mimic some of the characteristics of biology and incorporate new features that are not available in the biological world. The effects on human health and longevity will be profound. In a more personal epilogue, Contera describes the crossroads at which we find ourselves. Accessing our own biology evokes a mixture of possibility and dread. However, Contera maintains that we can create a positive transmaterial world for the benefit of humankind, and she describes ways in which scientists are proactively engaging with the public, politicians, industry, and entrepreneurs, as well as the media and the arts, to communicate the power and risks of new advances and to influence the ways in which new technologies will affect our future"--

Solid Biomechanics

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Publisher : Princeton University Press
ISBN 13 : 0691135509
Total Pages : 266 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Solid Biomechanics by : Roland Ennos

Download or read book Solid Biomechanics written by Roland Ennos and published by Princeton University Press. This book was released on 2012 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a review of the biomechanical design of organisms, from bacteria onwards, this book shows how the bodies of animals & plants are masterpieces of engineering, enabling them to survive in a hostile world.

Biophysics

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Publisher : Princeton University Press
ISBN 13 : 1400845572
Total Pages : 653 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Biophysics by : William Bialek

Download or read book Biophysics written by William Bialek and published by Princeton University Press. This book was released on 2012-12-17 with total page 653 pages. Available in PDF, EPUB and Kindle. Book excerpt: A physicist's guide to the phenomena of life Interactions between the fields of physics and biology reach back over a century, and some of the most significant developments in biology—from the discovery of DNA's structure to imaging of the human brain—have involved collaboration across this disciplinary boundary. For a new generation of physicists, the phenomena of life pose exciting challenges to physics itself, and biophysics has emerged as an important subfield of this discipline. Here, William Bialek provides the first graduate-level introduction to biophysics aimed at physics students. Bialek begins by exploring how photon counting in vision offers important lessons about the opportunities for quantitative, physics-style experiments on diverse biological phenomena. He draws from these lessons three general physical principles—the importance of noise, the need to understand the extraordinary performance of living systems without appealing to finely tuned parameters, and the critical role of the representation and flow of information in the business of life. Bialek then applies these principles to a broad range of phenomena, including the control of gene expression, perception and memory, protein folding, the mechanics of the inner ear, the dynamics of biochemical reactions, and pattern formation in developing embryos. Featuring numerous problems and exercises throughout, Biophysics emphasizes the unifying power of abstract physical principles to motivate new and novel experiments on biological systems. Covers a range of biological phenomena from the physicist's perspective Features 200 problems Draws on statistical mechanics, quantum mechanics, and related mathematical concepts Includes an annotated bibliography and detailed appendixes

The R Book

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 9780470515068
Total Pages : 953 pages
Book Rating : 4.5/5 (15 download)

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Book Synopsis The R Book by : Michael J. Crawley

Download or read book The R Book written by Michael J. Crawley and published by John Wiley & Sons. This book was released on 2007-06-13 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high-level language of R is recognized as one of the mostpowerful and flexible statistical software environments, and israpidly becoming the standard setting for quantitative analysis,statistics and graphics. R provides free access to unrivalledcoverage and cutting-edge applications, enabling the user to applynumerous statistical methods ranging from simple regression to timeseries or multivariate analysis. Building on the success of the author’s bestsellingStatistics: An Introduction using R, The R Book ispacked with worked examples, providing an all inclusive guide to R,ideal for novice and more accomplished users alike. The bookassumes no background in statistics or computing and introduces theadvantages of the R environment, detailing its applications in awide range of disciplines. Provides the first comprehensive reference manual for the Rlanguage, including practical guidance and full coverage of thegraphics facilities. Introduces all the statistical models covered by R, beginningwith simple classical tests such as chi-square and t-test. Proceeds to examine more advance methods, from regression andanalysis of variance, through to generalized linear models,generalized mixed models, time series, spatial statistics,multivariate statistics and much more. The R Book is aimed at undergraduates, postgraduates andprofessionals in science, engineering and medicine. It is alsoideal for students and professionals in statistics, economics,geography and the social sciences.

Einstein's Other Theory

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Publisher : Princeton University Press
ISBN 13 : 0691216401
Total Pages : pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Einstein's Other Theory by : Donald W. Rogers

Download or read book Einstein's Other Theory written by Donald W. Rogers and published by Princeton University Press. This book was released on 2020-08-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Einstein's theories of relativity piqued public curiosity more than any other mathematical concepts since the time of Isaac Newton. Scientists and non-scientists alike struggled, not so much to grasp as to believe the weird predictions of relativity theory--shrinking space ships, bending light beams, and the like. People all over the world watched with fascination as Einstein's predictions were relentlessly and unequivocally verified by a hundred experiments and astronomical observations. In the last decade of the twentieth-century, another of Einstein's theories has produced results that are every bit as startling as the space-time contractions of relativity theory. This book addresses his other great theory, that of heat capacity and the Bose-Einstein condensate. In doing so, it traces the history of radiation and heat capacity theory from the mid-19th century to the present. It describes early attempts to understand heat and light radiation and proceeds through the theory of the heat capacity of solids. It arrives at the theory of superconductivity and superfluidity--the astonishing property of some liquids to crawl spontaneously up and out of their containers, and the ability of some gases to cause light to pause and take a moment's rest from its inexorable flight forward in time. Couched in the terminology of traditional physical chemistry, this book is accessible to chemists, engineers, materials scientists, mathematicians, mathematical biologists, indeed to anyone with a command of first-year calculus. In course work, it is a collateral text to third semester or advanced physical chemistry, introductory statistical mechanics, statistical thermodynamics, or introductory quantum chemistry. The book connects with mainstream physical chemistry by treating boson and fermion influences in molecular spectroscopy, statistical thermodynamics, molecular energetics, entropy, heat capacities (especially of metals), superconductivity, and superfluidity.

Kinetics of Heterogeneous Catalytic Reactions

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Publisher : Princeton University Press
ISBN 13 : 1400853338
Total Pages : 241 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Kinetics of Heterogeneous Catalytic Reactions by : Michel Boudart

Download or read book Kinetics of Heterogeneous Catalytic Reactions written by Michel Boudart and published by Princeton University Press. This book was released on 2014-07-14 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a critical account of the principles of the kinetics of heterogeneous catalytic reactions in the light of recent developments in surface science and catalysis science. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Transmission Electron Microscopy

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Publisher : Springer
ISBN 13 : 3319266519
Total Pages : 543 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Transmission Electron Microscopy by : C. Barry Carter

Download or read book Transmission Electron Microscopy written by C. Barry Carter and published by Springer. This book was released on 2016-08-24 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a companion volume to Transmission Electron Microscopy: A Textbook for Materials Science by Williams and Carter. The aim is to extend the discussion of certain topics that are either rapidly changing at this time or that would benefit from more detailed discussion than space allowed in the primary text. World-renowned researchers have contributed chapters in their area of expertise, and the editors have carefully prepared these chapters to provide a uniform tone and treatment for this exciting material. The book features an unparalleled collection of color figures showcasing the quality and variety of chemical data that can be obtained from today’s instruments, as well as key pitfalls to avoid. As with the previous TEM text, each chapter contains two sets of questions, one for self assessment and a second more suitable for homework assignments. Throughout the book, the style follows that of Williams & Carter even when the subject matter becomes challenging—the aim is always to make the topic understandable by first-year graduate students and others who are working in the field of Materials Science Topics covered include sources, in-situ experiments, electron diffraction, Digital Micrograph, waves and holography, focal-series reconstruction and direct methods, STEM and tomography, energy-filtered TEM (EFTEM) imaging, and spectrum imaging. The range and depth of material makes this companion volume essential reading for the budding microscopist and a key reference for practicing researchers using these and related techniques.

The Molecular Switch

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Publisher : Princeton University Press
ISBN 13 : 0691200246
Total Pages : 436 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis The Molecular Switch by : Rob Phillips

Download or read book The Molecular Switch written by Rob Phillips and published by Princeton University Press. This book was released on 2020-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Molecular Machines

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Publisher : Princeton University Press
ISBN 13 : 0691173869
Total Pages : 188 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Molecular Machines by : Giovanni Zocchi

Download or read book Molecular Machines written by Giovanni Zocchi and published by Princeton University Press. This book was released on 2018-07-10 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Machines presents a dynamic new approach to the physics of enzymes and DNA from the perspective of materials science. Unified around the concept of molecular deformability—how proteins and DNA stretch, fold, and change shape—this book describes the complex molecules of life from the innovative perspective of materials properties and dynamics, in contrast to structural or purely chemical approaches. It covers a wealth of topics, including nonlinear deformability of enzymes and DNA; the chemo-dynamic cycle of enzymes; supra-molecular constructions with internal stress; nano-rheology and viscoelasticity; and chemical kinetics, Brownian motion, and barrier crossing. Essential reading for researchers in materials science, engineering, and nanotechnology, the book also describes the landmark experiments that have established the materials properties and energy landscape of large biological molecules. Molecular Machines is also ideal for the classroom. It gives graduate students a working knowledge of model building in statistical mechanics, making it an essential resource for tomorrow's experimentalists in this cutting-edge field. In addition, mathematical methods are introduced in the bio-molecular context—for example, DNA conformational transitions are used to illustrate the transfer matrix formalism. The result is a generalized approach to mathematical problem solving that enables students to apply their findings more broadly. Molecular Machines represents the next leap forward in nanoscience, as researchers strive to harness proteins, enzymes, and DNA as veritable machines in medicine, technology, and beyond.

Functional Data Analysis with R and MATLAB

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Publisher : Springer Science & Business Media
ISBN 13 : 0387981853
Total Pages : 213 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Functional Data Analysis with R and MATLAB by : James Ramsay

Download or read book Functional Data Analysis with R and MATLAB written by James Ramsay and published by Springer Science & Business Media. This book was released on 2009-06-29 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides an application-oriented overview of functional analysis, with extended and accessible presentations of key concepts such as spline basis functions, data smoothing, curve registration, functional linear models and dynamic systems Functional data analysis is put to work in a wide a range of applications, so that new problems are likely to find close analogues in this book The code in R and Matlab in the book has been designed to permit easy modification to adapt to new data structures and research problems

Statistical Methods in Biology

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Publisher : CRC Press
ISBN 13 : 1439898057
Total Pages : 592 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Statistical Methods in Biology by : S.J. Welham

Download or read book Statistical Methods in Biology written by S.J. Welham and published by CRC Press. This book was released on 2014-08-22 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in simple language with relevant examples, this illustrative introductory book presents best practices in experimental design and simple data analysis. Taking a practical and intuitive approach, it only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R.

Text as Data

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Publisher : Princeton University Press
ISBN 13 : 0691207550
Total Pages : 360 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Text as Data by : Justin Grimmer

Download or read book Text as Data written by Justin Grimmer and published by Princeton University Press. This book was released on 2022-03-29 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide for using computational text analysis to learn about the social world From social media posts and text messages to digital government documents and archives, researchers are bombarded with a deluge of text reflecting the social world. This textual data gives unprecedented insights into fundamental questions in the social sciences, humanities, and industry. Meanwhile new machine learning tools are rapidly transforming the way science and business are conducted. Text as Data shows how to combine new sources of data, machine learning tools, and social science research design to develop and evaluate new insights. Text as Data is organized around the core tasks in research projects using text—representation, discovery, measurement, prediction, and causal inference. The authors offer a sequential, iterative, and inductive approach to research design. Each research task is presented complete with real-world applications, example methods, and a distinct style of task-focused research. Bridging many divides—computer science and social science, the qualitative and the quantitative, and industry and academia—Text as Data is an ideal resource for anyone wanting to analyze large collections of text in an era when data is abundant and computation is cheap, but the enduring challenges of social science remain. Overview of how to use text as data Research design for a world of data deluge Examples from across the social sciences and industry

On the Future

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Publisher : Princeton University Press
ISBN 13 : 0691231060
Total Pages : 280 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis On the Future by : Martin Rees

Download or read book On the Future written by Martin Rees and published by Princeton University Press. This book was released on 2021-10-05 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A provocative and inspiring look at the future of humanity and science from world-renowned scientist and bestselling author Martin Rees Humanity has reached a critical moment. Our world is unsettled and rapidly changing, and we face existential risks over the next century. Various outcomes—good and bad—are possible. Yet our approach to the future is characterized by short-term thinking, polarizing debates, alarmist rhetoric, and pessimism. In this short, exhilarating book, renowned scientist and bestselling author Martin Rees argues that humanity’s prospects depend on our taking a very different approach to planning for tomorrow. The future of humanity is bound to the future of science and hinges on how successfully we harness technological advances to address our challenges. If we are to use science to solve our problems while avoiding its dystopian risks, we must think rationally, globally, collectively, and optimistically about the long term. Advances in biotechnology, cybertechnology, robotics, and artificial intelligence—if pursued and applied wisely—could empower us to boost the developing and developed world and overcome the threats humanity faces on Earth, from climate change to nuclear war. At the same time, further advances in space science will allow humans to explore the solar system and beyond with robots and AI. But there is no “Plan B” for Earth—no viable alternative within reach if we do not care for our home planet. Rich with fascinating insights into cutting-edge science and technology, this accessible book will captivate anyone who wants to understand the critical issues that will define the future of humanity on Earth and beyond.