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Quantitative Biology Of Metabolism
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Book Synopsis Quantitative Biology of Metabolism by : Alfred Locker
Download or read book Quantitative Biology of Metabolism written by Alfred Locker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of the life sciences may be said to have effected a gradual transition from a more or less intuitive prescientific approach based on crude observation, via a more refined type of observation to experimentation and hence to the level of formal theories. Quantitative methods are introduced at the second level; they comprise: (a) quantitative design of experiments; (b) regrouping of experimental results; (c) evalua tion of results by means of mathematical or special statistical techniques. The last step implies the introduction of theoretical concepts, but we are not justified in speaking of theoretical science unless true theoretical con siderations-models or hypotheses-precede experiment, and this is then followed by an attempt to link results with theory so as to verify the theory. Biology at present seems to lie somewhere between the second and third level mentioned above, not yet having achieved the status of a theoretical science in all its branches. Thus, though the need for quantification and mathematical formulation is widely recognized, many biologists still believe that e.g. general systems theory is too abstract to be of use in handling concrete problems. Those, however, who look critically at the present state of affairs cannot adopt this attitude.
Author :International symposium on quantitative biology of metabolism, 3rd (helgoland, 1967) Publisher : ISBN 13 : Total Pages :0 pages Book Rating :4.:/5 (141 download)
Book Synopsis Quantitative Biology of Metabolism: Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control: Symposium [sponsored by The] Biologische Anstalt Helgoland... by : International symposium on quantitative biology of metabolism, 3rd (helgoland, 1967)
Download or read book Quantitative Biology of Metabolism: Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control: Symposium [sponsored by The] Biologische Anstalt Helgoland... written by International symposium on quantitative biology of metabolism, 3rd (helgoland, 1967) and published by . This book was released on 1968 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Biology of Metabolism by : A. Locker
Download or read book Quantitative Biology of Metabolism written by A. Locker and published by . This book was released on 1968 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Biology of Metabolism by :
Download or read book Quantitative Biology of Metabolism written by and published by . This book was released on 1968 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Systems Biology of Metabolic and Signaling Networks by : Miguel A. Aon
Download or read book Systems Biology of Metabolic and Signaling Networks written by Miguel A. Aon and published by Springer Science & Business Media. This book was released on 2013-10-22 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.
Book Synopsis A Systems Biology Approach to Study Metabolic Syndrome by : Matej Orešič
Download or read book A Systems Biology Approach to Study Metabolic Syndrome written by Matej Orešič and published by Springer Science & Business Media. This book was released on 2013-09-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS. In particular, the aims are: (1) to provide an introduction to the key biological processes involved in the pathophysiology of MetS; (2) through the use of specific examples, provide an introduction to the latest technologies that use a systems biology approach to study MetS; and (3) to give an overview of the mathematical modeling approaches for studying MetS. The clearly written chapters by leading experts in the field provides detailed descriptions crucial for the unique position of this book and its focus on the application of systems biology to tackle specific pathophysiologically relevant aspects of MetS and provides a valuable practical guide to this research community.
Book Synopsis Genetics Meets Metabolomics by : Karsten Suhre
Download or read book Genetics Meets Metabolomics written by Karsten Suhre and published by Springer Science & Business Media. This book was released on 2012-06-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written by leading researchers in the fields about the intersection of genetics and metabolomics which can lead to more comprehensive studies of inborn variation of metabolism.
Book Synopsis Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology by : Kumar Selvarajoo
Download or read book Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology written by Kumar Selvarajoo and published by Springer Nature. This book was released on 2022-10-13 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides protocols for computational, statistical, and machine learning methods that are mainly applied to the study of metabolic engineering, synthetic biology, and disease applications. These techniques support the latest progress in cross-disciplinary research that integrates the different scales of biological complexity. The topics covered in this book are geared toward researchers with a background in engineering, computational analytical, and modeling experience and cover a broad range of topics in computational and machine learning approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Computational Biology and Machine Learning for Metabolic Engineering and Synthetic Biology is a valuable resource for any researcher or scientist who wants to learn more about the latest computational methods and how they are applied toward the understanding and prediction of complex biology.
Book Synopsis Computational Systems Biology by : Hans V. Westerhoff
Download or read book Computational Systems Biology written by Hans V. Westerhoff and published by Elsevier Inc. Chapters. This book was released on 2013-11-26 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology brings the potential to discover fundamental principles of Life that cannot be discovered by considering individual molecules. This chapter discusses a number of early, more recent, and upcoming discoveries of such network principles. These range from the balancing of fluxes through metabolic networks, the potential of those networks for truly individualized medicine, the time dependent control of fluxes and concentrations in metabolism and signal transduction, the ways in which organisms appear to regulate metabolic processes vis-à-vis limitations therein, tradeoffs in robustness and fragility, and a relation between robustness and time dependences in the cell cycle. The robustness considerations will lead to the issue whether and how evolution has been able to put in place design principles of control engineering such as infinite robustness and perfect adaptation in the hierarchical biochemical networks of cell biology.
Author :Seetharaman Vaidyanathan Publisher :Springer Science & Business Media ISBN 13 :0387252401 Total Pages :396 pages Book Rating :4.3/5 (872 download)
Book Synopsis Metabolome Analyses: by : Seetharaman Vaidyanathan
Download or read book Metabolome Analyses: written by Seetharaman Vaidyanathan and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.
Download or read book Metabolomics written by M. Tomita and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Book Synopsis Introduction To Metabolic And Cellular Engineering, An (Second Edition) by : Cortassa Sonia Del Carmen
Download or read book Introduction To Metabolic And Cellular Engineering, An (Second Edition) written by Cortassa Sonia Del Carmen and published by World Scientific. This book was released on 2011-12-28 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic and Cellular Engineering (MCE) is more than an exciting scientific enterprise. It has become the cornerstone for coping with the challenges ahead of mankind. Continuous developments, new concepts, and technological innovations will enable us to deal with emerging challenges, and solve problems once thought impossible ten years ago. Challenges in MCE are broad- from unraveling fundamental aspects of cellular function to meeting unsatiated energy and food demands that are rising in parallel with population growth.In charting the progress of MCE during the last decade, we could not help but feel in awe of the enormous strides of progress made from the nascent Metabolic Engineering to the Systems Bioengineering of today. The burgeoning availability of genomic sequences from diverse species has been spectacular. It has become the engine that drives the genetic means for the modification of existing organisms and the generation of synthetic, man-made ones. From the initial attempts at purposeful genetic modification of a cell for the production of valuable compounds, we have now moved on to changing microbes genetically or metabolically.The arsenal of experimental and theoretical tools available for Metabolic and Cellular Engineering has expanded enormously, driven by the re-emergence of Physiology as Systems Biology. The revival of the concept of networks fueled by new developments has become central to Systems Biology. Networks represent an integrative vision of how processes of disparate nature relate to each other, and as such is becoming a key analytical and conceptual tool for MCE. This book reflects and addresses all these ongoing changes while providing the essential conceptual and analytical tools needed to understand and work in the MCE research field.
Book Synopsis Correlation-based network analysis of cancer metabolism by : Emily G. Armitage
Download or read book Correlation-based network analysis of cancer metabolism written by Emily G. Armitage and published by Springer. This book was released on 2014-05-12 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.
Book Synopsis Quantitative Elements of General Biology by : Ivan Maly
Download or read book Quantitative Elements of General Biology written by Ivan Maly and published by Springer Nature. This book was released on 2021-08-28 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph sketches out a broad spectrum of problems (from evolution and metabolism to morphogenesis and biogeographical dynamics) whose solution has been impacted by mathematical models. Each of the selected examples has led to the recognition—and set direction to further study—of certain fundamental but unintuitive properties of biological systems, such as the making and breaking of specific symmetries that underlie morphogenesis. Whether they are long-established or only recently accepted, these models are selected for being thought-provoking and illuminating both the achievements and the gaps in our current understanding of the given area of biology. The selection of models is also meant to bring to the fore the existing degree of unity in the quantitative approach to diverse general-biological questions and in the systems-level properties that are discovered across the levels of biological organization. It is the thesis of this book that further cultivation of such unity is a way forward as we progress toward a general theory of living matter. This is an ideal book for students (in the broadest sense) of biology who wish to learn from this attempt to present the exemplary models, their methodological lessons, and the outline of a unified theory of living matter that is now beginning to emerge. In addition to a doctoral student preparing for quantitative biology research, this reader could also be an interdisciplinary scientist transitioning to biology. The latter—for example, a physicist or an engineer—may be comfortable with the mathematical apparatus and prepared to quickly enter the intended area of work, but desires a broader foundation in biology from the quantitative perspective.
Download or read book Metabolomics written by Ron Wehrens and published by CRC Press. This book was released on 2019-08-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics is the scientific study of the chemical processes in a living system, environment and nutrition. It is a relatively new omics science, but the potential applications are wide, including medicine, personalized medicine and intervention studies, food and nutrition, plants, agriculture and environmental science. The topics presented and discussed in this book are based on the European Molecular Biology Organization (EMBO) practical courses in metabolomics bioinformatics taught to those working in the field, from masters to postgraduate students, PhDs, postdoctoral and early PIs. The book covers the basics and fundamentals of data acquisition and analytical technologies, but the primary focus is data handling and data analysis. The mentioning and usage of a particular data analysis tool has been avoided; rather, the focus is on the concepts and principles of data processing and analysis. The material has been class-tested and includes lots of examples, computing and exercises. Key Features: Provides an overview of qualitative /quantitative methods in metabolomics Offers an introduction to the key concepts of metabolomics, including experimental design and technology Covers data handling, processing, analysis, data standards and sharing Contains lots of examples to illustrate the topics Includes contributions from some of the leading researchers in the field of metabolomics with extensive teaching experiences
Download or read book Metabolomics written by Jens Nielsen and published by Springer Science & Business Media. This book was released on 2007-09-19 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giving a fresh, substantial and in-depth overview of the topic, this book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it helps to significantly broaden our perspective on the principles and strategies underpinning this emerging field.
Book Synopsis Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer by : Osbaldo Resendis-Antonio
Download or read book Systems Biology and the Challenge of Deciphering the Metabolic Mechanisms Underlying Cancer written by Osbaldo Resendis-Antonio and published by Frontiers Media SA. This book was released on 2017-11-23 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options. Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current “omics” technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell’s metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.
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