Purines Basic And Clinical Aspects

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Purines: Basic and Clinical Aspects

Author : T.W. Stone
Publisher : Springer Science & Business Media
ISBN 13 : 9401139113
Total Pages : 265 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Purines: Basic and Clinical Aspects by : T.W. Stone

Download or read book Purines: Basic and Clinical Aspects written by T.W. Stone and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many groups of biologically important compounds experience cycles of furious research activity and near oblivion. The purines however seem not to be falling into such a pattern. Interest seems to be continuing almost exponentially with no sign of diminution. The result is a frighteningly extensive literature and an increas ing demand for international conferences and symposia. Unfortunately meetings such as these also spawn increasingly voluminous proceedings and it becomes more and more difficult for a newcomer to the area, or a non specialist, to obtain the general introductory survey he needs. This volume therefore is not intended to be comprehensive - far from it. We have tried to be selective in the material presented and the references quoted. They should provide a quick guide and access to key works in the literature which can be expanded by library or computerised searching. We hope that our efforts will widen the appreciation of purines as biologically important substances and will herald the day when more purine related drugs than the handful currently available are used for the selective treatment of disease. We are grateful to the many authors and publishers who have given permission to reproduce figures or quote unpublished results, and to Anne Stone for her patient typing of the manuscript.

Gout

Author : David S. Newcombe
Publisher : Springer Science & Business Media
ISBN 13 : 1447142640
Total Pages : 410 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Gout by : David S. Newcombe

Download or read book Gout written by David S. Newcombe and published by Springer Science & Business Media. This book was released on 2012-10-12 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout: Basic Science and Clinical Practice is a thoroughly researched comprehensive text which covers all important aspects of gout, including its genetics, pathophysiology, diagnosis, and management. Gout is probably the most common rheumatic disease after osteoarthritis and is becoming more common with the prevalence of the metabolic syndrome in the US, and in many other countries. Only about 10% of patients with gout are treated by rheumatologists and this often leads to inadequate diagnosis and treatment in general medical practice. Written by an expert in the field this book is valuable reference for rheumatologists and others in the medical profession who are interested in understanding and managing this important disease.

Basic Neurochemistry

Author : R. Wayne Albers
Publisher : Academic Press
ISBN 13 : 0080959016
Total Pages : 1121 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Basic Neurochemistry by : R. Wayne Albers

Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Academic Press. This book was released on 2011-11-02 with total page 1121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism

Author : Ursula Gresser
Publisher : Springer Science & Business Media
ISBN 13 : 3642849628
Total Pages : 188 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism by : Ursula Gresser

Download or read book Molecular Genetics, Biochemistry and Clinical Aspects of Inherited Disorders of Purine and Pyrimidine Metabolism written by Ursula Gresser and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inherited disorders of purine and pyrimidine metabolism in man lead to severe diseases. At the 2nd M}nchner Adventssymposium the state of the art as to the genetic basis, clinical aspects, and the biochemical basis has been given by leading experts in the fields concerning the following diseases: Hypoxanthine phosphoribosyltransferase deficiency (HGPRT-deficieny), adenine phosphoribosyltransferase deficiency (APRT-deficiency), hyperuricemia and gout, adenosine deaminase deficiency (ADA-deficiency, purine nucleoside phosphorylase deficiency (PNP-deficiency). All contributions of the symposium are published within this volume thus giving and overview of this most interesting field.

Steroid Hormone Receptors: Basic and Clinical Aspects

Author : V. K. Moudgil
Publisher : Springer Science & Business Media
ISBN 13 : 1461598494
Total Pages : 519 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Steroid Hormone Receptors: Basic and Clinical Aspects by : V. K. Moudgil

Download or read book Steroid Hormone Receptors: Basic and Clinical Aspects written by V. K. Moudgil and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have witnessed the emergence of steroid hormones as the wonder molecules which generate as much discussion in the scientific literature as they do in a typical living room. This transition has been a result of the tremendous public and scientific interest in the normal functioning of the hor mones as well their suggested involvement in several clinical conditions. In the recent past, notable scientific and technological advances have been made in the areas of contraception and regulation of fertility. Steroid receptors are the indis pensable mediators of hormonal responses and are complex protein molecules which appear to exist in association with other, yet undefined, proteins and/or factors. Receptors for vitamin D, retinoic acid and the thyroid hormones share structural similarities with steroid receptors, and the roster of this superfamily is still expanding. While our knowledge of the diversity and magnitude of steroid effects has advanced, the precise mode of steroid hormone action has alluded investigators. This volume brings together an international team of prominent investigators who discuss their most recent work on the basic and clinical aspects of steroid/nuclear receptors. The contributions represent updated versions of the invited presentations made at The Second Meadow Brook Conference on Steroid Receptors in Health and Disease. I am grateful to my colleagues on the Scientific Committee: Etienne Baulieu, Jack Gorski, Benita Katzenellenbogen, David Toft and James WittJiff, who provided the vision and guidance in formulating an out standing program.

Developments in Tryptophan and Serotonin Metabolism

Author : Graziella Allegri
Publisher : Springer Science & Business Media
ISBN 13 : 1461501350
Total Pages : 736 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Developments in Tryptophan and Serotonin Metabolism by : Graziella Allegri

Download or read book Developments in Tryptophan and Serotonin Metabolism written by Graziella Allegri and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the Tenth International Meeting of the International Study Group for Tryptophan Research (ISTR V), held at the University of Padova, Padova, Italy, from 25-29 June, 2002 under the auspices of the Ministry of Education, University and Research (MIUR) in Roma, the University of Padova, the Italian Chemical Society - Division of Pharmaceutical Chemistry, the Veneto Region and the City of Padova. The meeting was organized to cover the recent developments in the field of tryptophan research. Weare very honoured that so many speakers accepted our invitation to give plenary lectures which, with the other communications, demonstrated the high scientific value of the Meeting. The publications in this volume are subdivided into nine main chapters, and cover all the major aspects in immunology, neurobiology, psychiatry, pathology, clinics, metabolism, enzymology, pharmacology, toxicology, melatonin, exercise and analytical chemistry. The volume includes the contributions of 325 scientists from 24 countries, and the Musajo Memorial Lecture delivered by Prof. Osamu Hayaishi during the Opening Ceremony.

Science and Technology in Medicine

Author : Andras Gedeon
Publisher : Springer Science & Business Media
ISBN 13 : 9780387278742
Total Pages : 562 pages
Book Rating : 4.2/5 (787 download)

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Book Synopsis Science and Technology in Medicine by : Andras Gedeon

Download or read book Science and Technology in Medicine written by Andras Gedeon and published by Springer Science & Business Media. This book was released on 2006-02-16 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history and evolution of the fields of science and medicine are symbiotically linked and thus are mutually dependent. Discoveries in one domain have allowed for progress in the other, and it is nearly impossible to study one area in isolation. The influence of science and technologic discoveries on medicine has profoundly impacted the way physicians practice and has resulted in an extended life expectancy and quality of life that our ancestors never dreamed possible. Science and Technology in Medicine is a collection of 99 essays based on landmark publications that have appeared in the medical literature over the past 500 years. Each essay includes a summary of the article or chapter; text and images reproduced directly from the original source; a short biography of the author(s); and a discussion about the significance of the discovery and its subsequent influence on later developments. Original material by the likes of Dürer, Bernoulli, Doppler, Pasteur, Trendelenburg, Curie and Röntgen offers readers a rare glimpse at publications housed in archives around the world, beautifully reproduced in one fascinating volume.

From Messengers to Molecules

Author : Gernot Riedel
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478628
Total Pages : 646 pages
Book Rating : 4.4/5 (786 download)

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Book Synopsis From Messengers to Molecules by : Gernot Riedel

Download or read book From Messengers to Molecules written by Gernot Riedel and published by Springer Science & Business Media. This book was released on 2004-11-03 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: The decade of the brain has brought us a few steps closer to some of the key questions in neuroscience. The complexity of memory is seen on the systems and cellular level, and different types of memory are implemented in several cellular changes that can interact, or work independently. From Messengers to Molecules: Memories are Made of These, follows the arguments from different research teams for their particular area of expertise. All chapters are written to stand-alone and provide an up-to-date introduction to the topic for both specialists and novices alike. As a result, a comprehensive compendium covering cellular mechanisms contributing to memory formation in an unusual breadth has emerged. This books will be of interest to researchers working on the pharmacology, physiology and genetics of memory formation, clinicians memory disorders, industry and students in advanced courses in Neuroscience or Pharmacology.

Basic Neurochemistry

Author : R. Wayne Albers
Publisher : Elsevier
ISBN 13 : 0080472079
Total Pages : 1020 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Basic Neurochemistry by : R. Wayne Albers

Download or read book Basic Neurochemistry written by R. Wayne Albers and published by Elsevier. This book was released on 2005-11-11 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education. Completely updated with 60% new authors and material, and entirely new chapters Over 400 fully revised figures in splendid color

Urology at a Glance

Author : Axel S. Merseburger
Publisher : Springer
ISBN 13 : 3642548598
Total Pages : 359 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Urology at a Glance by : Axel S. Merseburger

Download or read book Urology at a Glance written by Axel S. Merseburger and published by Springer. This book was released on 2014-10-21 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations are also included. This book will be a great asset for urologists and practitioners in related disciplines.

Diet and Health

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309039940
Total Pages : 765 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Diet and Health by : National Research Council

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Retinal Degenerations

Author : Matthew M LaVail
Publisher : Springer Science & Business Media
ISBN 13 : 9780306477812
Total Pages : 490 pages
Book Rating : 4.4/5 (778 download)

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Book Synopsis Retinal Degenerations by : Matthew M LaVail

Download or read book Retinal Degenerations written by Matthew M LaVail and published by Springer Science & Business Media. This book was released on 2003-10-31 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.

Medical Biochemistry: The Big Picture

Author : Lee W. Janson
Publisher : McGraw Hill Professional
ISBN 13 : 0071637923
Total Pages : 431 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Medical Biochemistry: The Big Picture by : Lee W. Janson

Download or read book Medical Biochemistry: The Big Picture written by Lee W. Janson and published by McGraw Hill Professional. This book was released on 2012-03-25 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the BIG PICTURE of Medical Biochemistry – and target what you really need to know to ace the course exams and the USMLE Step 1 300 FULL-COLOR ILLUSTRATIONS Medical Biochemistry: The Big Picture is a unique biochemistry review that focuses on the medically applicable concepts and techniques that form the underpinnings of the diagnosis, prognosis, and treatment of medical conditions. Those preparing for the USMLE, residents, as well as clinicians who desire a better understanding of the biochemistry behind a particular pathology will find this book to be an essential reference. Featuring succinct, to-the-point text, more than 300 full-color illustrations, and a variety of learning aids, Medical Biochemistry: The Big Picture is designed to make complex concepts understandable in the shortest amount of time possible. This full-color combination text and atlas features: Progressive chapters that allow you to build upon what you’ve learned in a logical, effective manner Chapter Overviews that orient you to the important concepts covered in that chapter Numerous tables and illustrations that clarify and encapsulate the text Sidebars covering a particular disease or treatment add clinical relevance to topic discussed Essay-type review questions at the end of each chapter allow you to assess your comprehension of the major topics USMLE-style review questions at the end of each section Three appendices, including examples of biochemically based diseases, a review of basic biochemical techniques, and a review of organic chemistry/biochemistry

Purines and Myocardial Protection

Author : Anwar-Saad A. Abd-Elfattah
Publisher : Springer Science & Business Media
ISBN 13 : 1461304555
Total Pages : 565 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Purines and Myocardial Protection by : Anwar-Saad A. Abd-Elfattah

Download or read book Purines and Myocardial Protection written by Anwar-Saad A. Abd-Elfattah and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical review of the most up-to-date research on purines and myocardial protection. The role of purines in reversible `myocardial stunning' and irreversible (myocardial infarction) ischemic injury, ventricular arrhythmias, and ischemic preconditioning is discussed in detail, by experts. All reviews address recent and rather controversial issues on purines and myocardial protection. Mechanisms of cardioprotection of exogenous versus endogenous purines are discussed in detail. The contribution of internationally recognized experts in the field of purines and cardiovascular physiology and in myocardial protection makes this a unique and interesting book for clinicians, basic scientists and students.

Purines in Cellular Signaling

Author : Kenneth A. Jacobson
Publisher : Springer Science & Business Media
ISBN 13 : 146123400X
Total Pages : 459 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Purines in Cellular Signaling by : Kenneth A. Jacobson

Download or read book Purines in Cellular Signaling written by Kenneth A. Jacobson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on purine derivatives as potent and selective modulators of physiologic functions has moved to center stage. This volume covers the biology and chemistry of purines and of their receptors broadly under these section headings: - Adenosine Receptors and Effector Systems - Adenine Nucleotide Receptors and Effector Systems - Phosphodiesterase Enzymes and Inhibitors The presentations focus on the potential development of clinically useful drugs and powerful agents that activate or block purinergic receptors or that inhibit phosphodiesterases. Xanthines (caffeine and theophylline) represent one class of such agents. This volume is for pharmacologists, biochemists, and medical chemists in research labs of universities, gov- ernment, and the pharmaceutical industry.

Purine and Pyrimidine Metabolism in Man VII

Author : R. Angus Harkness
Publisher : Springer Science & Business Media
ISBN 13 : 1461577039
Total Pages : 395 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Purine and Pyrimidine Metabolism in Man VII by : R. Angus Harkness

Download or read book Purine and Pyrimidine Metabolism in Man VII written by R. Angus Harkness and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes record the scientific and clinical work presented at the VIIth International and 3rd European joint symposium on purine and pyrimidine metabolism in man held at the Bournemouth International Conference Centre, Bournemouth, UK, from 30th June to 5th July 1991. The series of international meetings at three yearly intervals have previously been held initially in 1973 in Israel, then Austria, Spain, the Netherlands, USA and Japan. The European Society for the Study of Purine and pyrimidine Metabolism in Man (ESSPPM) which has its own executive and some finance first met in switzerland in 1987, then in Germany in 1989. The steady evolution of the science in this series of meetings is intellectually satisfying; the subsequent clinical progress is emotionally and economically reassuring. As befits the position of purines and pyrimidines at the centre of biochemistry, there has been steady scientific development into molecular genetics and now onto developmental controls and biochemical pharmacology. The complexities of the immune system are being unravelled but an understanding of the human brain largely eludes us. Laboratory based scientists now predominate over those who work as clinical specialists in VIi rheumatology, immunology, oncology and paediatrics. However, there continue to be major clinical objectives since large sections are concerned with major causes of death like ATP depletion, cancer and now AIDS; the laboratory work is providing clinical solutions.

Oxford Textbook of Clinical Nephrology Volume 2

Author : Alex M. Davison
Publisher : Oxford University Press, USA
ISBN 13 : 0198567979
Total Pages : 1132 pages
Book Rating : 4.1/5 (985 download)

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Book Synopsis Oxford Textbook of Clinical Nephrology Volume 2 by : Alex M. Davison

Download or read book Oxford Textbook of Clinical Nephrology Volume 2 written by Alex M. Davison and published by Oxford University Press, USA. This book was released on 2005 with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative, well-written, and comprehensive textbook of clinical nephrology, combining the clinical aspects of renal disease important for daily clinical practice while giving extensive information about the underlying basic science and current evidence available. This new edition highlights the numerous changes in clinical management that have arisen as a result of recently concluded clinical trials and there are now specific formal guidelines for optimal treatment of patients. Each section of the textbook has been critically and comprehensively edited under the auspices of one of the leading experts in the field. The emphasis throughout is on marrying advances in scientific research with clinical managment. Where possible treatment algorithms are included to aid patient care.