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Author : Misako Nakashima
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)
Download or read book Pulp Regeneration by Harnessing Dental Pulp Stem Cells written by Misako Nakashima and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulp Regeneration by Harnessing Dental Pulp Stem Cells.
Author : Barbara Zavan
Publisher : Humana Press
ISBN 13 : 3319332996
Total Pages : 288 pages
Book Rating : 4.3/5 (193 download)
Download or read book Dental Stem Cells: Regenerative Potential written by Barbara Zavan and published by Humana Press. This book was released on 2016-07-25 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.
Author : Sibel Yildirim
Publisher : Springer Science & Business Media
ISBN 13 : 146145686X
Total Pages : 89 pages
Book Rating : 4.4/5 (614 download)
Download or read book Dental Pulp Stem Cells written by Sibel Yildirim and published by Springer Science & Business Media. This book was released on 2012-10-15 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell technology is moving forward at a tremendous rate. Recent discoveries have surprised even the most expert researchers. While every piece of new data broadens the current knowledge and contributes to this moving forward, the new data also serve as paradigm shifters of fundamental knowledge of cell biology. While the question ‘What is a Stem Cell’ may now seem to basic to even discuss, there are still some discrepancies, however, between groups in terms of their functional roles. Teeth develop from the ectoderm of the first branchial arch and the ectomesenchyme of the neural crest. Deciduous teeth start to form between the sixth and eighth weeks, and permanent teeth begin to form in the twentieth weeks. Several studies have demonstrated that the pulp from both adult teeth and deciduous teeth contains dental pulp stem cells. Several factors have made them very attractive as a model system for many researchers; they are multipotent, ethically and non-controversially available in large numbers, immuno-compatible, developmentally primitive, easy to isolate and have high expansion potential in vitro. However, many controversies still exist in the field. There are several unanswered questions in the biology of dental pulp and odontoblasts. This new volume in the SpringerBriefs in Stem Cells series presents an evaluation of stem cells from human dental pulp as a reliable stem cell source for cell-based therapy to stimulate tissue regeneration.
Author : Fikrettin Şahin
Publisher : Springer
ISBN 13 : 3319289470
Total Pages : 322 pages
Book Rating : 4.3/5 (192 download)
Download or read book Dental Stem Cells written by Fikrettin Şahin and published by Springer. This book was released on 2016-06-08 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.
Author :
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (927 download)
Download or read book Effect of Small Molecules on Dental Pulp Stem Cells Properties and Pulp Regeneration written by and published by . This book was released on 2015 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Douglas Herrera
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783659438363
Total Pages : 124 pages
Book Rating : 4.4/5 (383 download)
Download or read book Dental Pulp Tissue Regeneration, a Promising Future written by Douglas Herrera and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The trend for the future of Root Canal Therapy is leaning towards dental pulp tissue regeneration using tissue engineering principles, stem cells, growth factors and scaffolds. Ideally, Root Canal Therapy would involve the removal of diseased pulp tissue and its permanent replacement with healthy pulp to revitalize teeth. Traditionally, during a Root Canal Therapy, the diseased pulp has been removed and replaced by a biocompatible synthetic material. This book presents the concepts and foundations of this new trend. It also presents the results of an in vitro tissue constructs study and the results of pre-clinical trials of dental pulp tissue regeneration in teeth of non-human primates. This study tested the fundamental principles of dental pulp tissue regeneration, as it is now envisioned, using stem cells, growth factors and scaffolds. The aim is to develop a reliable and reproducible protocol that will always give the same result, the revitalization of teeth by the regeneration of dental pulp tissue.
Author : Giovanna Orsini
Publisher : Frontiers Media SA
ISBN 13 : 2889199843
Total Pages : 248 pages
Book Rating : 4.8/5 (891 download)
Download or read book Dental and Periodontal Tissues Formation and Regeneration: Current Approaches and Future Challenges written by Giovanna Orsini and published by Frontiers Media SA. This book was released on 2016-10-07 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequential and reciprocal interactions between oral epithelial and cranial neural crest-derived mesenchymal cells give rise to the teeth and periodontium. Teeth are vital organs containing a rich number of blood vessels and nerve fibers within the dental pulp and periodontium. Teeth are composed by unique and specific collagenous (dentin, fibrillar cementum) and non-collagenous (enamel) highly mineralized extracellular matrices. Alveolar bone is another collagenous hard tissue that supports tooth stability and function through its close interaction with the periodontal ligament. Dental hard tissues are often damaged after infection or traumatic injuries that lead to the partial or complete destruction of the functional dental and supportive tissues. Well-established protocols are routinely used in dental clinics for the restoration or replacement of the damaged tooth and alveolar bone areas. Recent progress in the fields of cell biology, tissue engineering, and nanotechnology offers promising opportunities to repair damaged or missing dental tissues. Indeed, pulp and periodontal tissue regeneration is progressing rapidly with the application of stem cells, biodegradable scaffolds, and growth factors. Furthermore, methods that enable partial dental hard tissue repair and regeneration are being evaluated with variable degrees of success. However, these cell-based therapies are still incipient and many issues need to be addressed before any clinical application. The understanding of tooth and periodontal tissues formation would be beneficial for improving regenerative attempts in dental clinics. In the present e-book we have covered the various aspects dealing with dental and periodontal tissues physiology and regeneration in 6 chapters: 1. General principles on the use of stem cells for regenerating craniofacial and dental tissues 2. The roles of nerves, vessels and stem cell niches in tissue regeneration 3. Dental pulp regeneration and mechanisms of various odontoblast functions 4. Dental root and periodontal physiology, pathology and regeneration 5. Physiology and regeneration of the bone using various scaffolds and stem cell populations 6. Physiology, pathology and regeneration of enamel using dental epithelial stem cells
Author : Muhammad Fawwaz Abdullah
Publisher : Penerbit USM
ISBN 13 : 9838619310
Total Pages : 72 pages
Book Rating : 4.8/5 (386 download)
Download or read book Dental Stem Cells Culturing for the Future (Penerbit USM) written by Muhammad Fawwaz Abdullah and published by Penerbit USM. This book was released on 2016 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of stem cells for various treatment purposes came to be realized after the advent of its prolific research. Stem cells are being popularly harvested from many sources such as embryo and bone marrow. However, harvesting and reaping the beneficial effects of stem cells from dental pulp is still cradling in its infancy. Indeed, there is a dearth of information on the detailed procedure of harvesting the stem cells from the dental pulp. This book is a compendium which highlights on the procedures of harvesting the stem cells from dental pulp and its characterization, with the aim to trigger the interests of the readers who are keen to venture further in this field. Keywords: Universiti Sains Malaysia, Penerbit Universiti Sains Malayia, Penerbit USM
Author : Rachel J. Waddington
Publisher : John Wiley & Sons
ISBN 13 : 1118741072
Total Pages : 418 pages
Book Rating : 4.1/5 (187 download)
Download or read book Tissue Engineering and Regeneration in Dentistry written by Rachel J. Waddington and published by John Wiley & Sons. This book was released on 2016-11-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue Engineering and Regeneration in Dentistry: Current Strategies presents a thorough update on the current advances, methods and understanding in tissue engineering in dentistry. It offers invaluable tools, case studies, and methodologies for undertaking research, including important biological and practical considerations to facilitate successful migration of research from the bench to the clinic. Offers detailed coverage of the basic underlying principles and scientific evidence, and includes protocols to highlight practical applications Written by an internationally renowned team of expert contributors A must-have read for researchers and specialist clinicians in tissue engineering, oral biology, dental materials science, periodontology and oral surgery
Author : Waruna Lakmal Dissanayaka
Publisher : Open Dissertation Press
ISBN 13 : 9781361337455
Total Pages : pages
Book Rating : 4.3/5 (374 download)
Download or read book Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration written by Waruna Lakmal Dissanayaka and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration" by Waruna Lakmal, Dissanayaka, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Regeneration of the tissues to replace diseased, missing and traumatized dentin/pulp requires combining the recent progress in stem cell and tissue engineering research. Dental pulp stem cells (DPSCs) are considered as a promising population of cells in regenerative dentistry and shown to be able to produce dentin/pulp-like tissues following implantation in-vivo. Securing a good blood supply is critical in pulp regeneration, however, this is a challenging task due to the unique structure of the tooth, the anatomy of which permits only a microcirculatory system via a very small apical opening (In this study, for the first time, synergistic effects of DPSCs and human umbilical vein endothelial cells (HUVECs) on osteo/odontogenic differentiation and angiogenesis were investigated using two-dimensional and three-dimensional direct co-culture systems. Furthermore, the potential of three-dimensional DPSC constructs prevascularized with HUVECs in dental pulp regeneration in-vivo was exmined. HUVECs promoted odonto/osteogenic differentiation of DPSCs in direct two-dimensional co-cultures in-vitro. Further, addition of DPSCs stabilized the pre-existing vessel-like structures formed by HUVECs and increased the longevity of these structures on matrigel in-vitro. Using two different systems, scaffold-free self-assembling microtissue spheroids and peptide hydrogel scaffold, the interactions of DPSCs and HUVECs in three-dimensional cultures were investigated. The results demonstrated that DPSCs can self assemble into three-dimensional microtissue spheroids when cultured alone or with HUVECs. DPSCs promoted survival and vascular structure formation by HUVECs both in scaffold-free microtissue spheroids and peptide hydrogel scaffold. In contrast, HUVECs, when cultured alone, neither formed vascular structures nor survived in either of the 3D systems. The latter phenomenon was attributable to vascular endothelial growth factor secreted by DPSCs, a major factor responsible for endothelial function. Co-cultures also showed enhanced odonto/osteogenic differentiation in both three-dimensional microtissue spheroid and peptide hydrogel scaffold systems. Following implantation of tooth-root fragments filled with three-dimensional DPSC constructs into the subcutaneous space of immunodefficient mice, vascularised pulp-like tissue was regenerated within the root canals. Compared to DPSC-only group, DPSC/HUVEC co-culture groups showed higher vascularisation, extracellular matrix formation and mineralization in regenerated tissue. More importantly, HUVEC-lined vascular lumens were observed in regenerated tissues suggesting the successful integration of in-vitro formed pre-vascular structures to the host vasculature. In summary, the findings suggest that DPSCs and HUVECs display significant synergy during odonto/osteogenic differentiation and ang
Author : Waruna Lakmal Dissanayaka
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (88 download)
Download or read book Synergistic Effects of Dental Pulp Stem Cells and Endothelial Cells in Pulp Regeneration written by Waruna Lakmal Dissanayaka and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yuan Liu
Publisher : Open Dissertation Press
ISBN 13 : 9781361371244
Total Pages : pages
Book Rating : 4.3/5 (712 download)
Download or read book Regulation of Dental Pulp Stem Cell's Anti-Apoptotic Ability and Proliferation Through Over-Expression of Bcl-2 written by Yuan Liu and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Regulation of Dental Pulp Stem Cell's Anti-apoptotic Ability and Proliferation Through Over-expression of Bcl-2" by Yuan, Liu, 刘源, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The pulp organ is retained in the pulp chamber of teeth and maintains the biological and physiological vitality of the surrounding dentin. It works as a biosensor and generates secondary dentine and tertiary dentine to resist tooth abrasion and pathogenic stimuli (Zhang and Yelick, 2010). However, dental pulp is vulnerable to injury (Smulson and Sieraski, 1989). Most people experience some irreversible pulpal diseases during their lifetime. Hence, pulp regeneration is one of the research tasks in dentistry that attracts much attention. Stem cell transplantation is a plausible strategy for the regeneration of dental pulp organ. Dental pulp stem cells (DPSCs)derived from heavy or inflamed dental pulps have the natural advantage in pulp regeneration due to its dentinogenic potentiality (Huang et al., 2009). DPSCs are delivered into prepared root canal, which then differentiate into odontoblasts, fibroblasts, and other kinds of cells. It was shown that these transplanted DPSCs were able to produce dentin and formed a dentin-pulp like tissue both in vitro and in vivo(Huang, 2009).However, low survival rate of the transplanted cells is a common problem in pulp regeneration. Overexpression of Bcl-2 could enhance cell anti-apoptotic ability. Studies of many kinds of cell transplantation showed that a large number of cells died upon grafting and a large proportion of cell death seemed to have occurred due to apoptosis (Liu et al., 2013; Zhang et al., 2001).The aim of this study was to improve cell survival through making DPSCs overexpress lymphoma 2 (Bcl-2) protein.Bcl-2 is a proto-oncogene which playsa significant role in (anti) apoptosis. Former studies in the literature have provided evidences that overexpressing Bcl-2 could reduce cell apoptosis. However, this strategy has not been studied in the modification of DPSCs. In this study, DPSCs were isolated from discarded third molars of adults and manipulated to overexpressing Bcl-2. Proliferation of modified DPSCs was analyzed by static batch culture, CCK-8 test and BrdU based proliferation test. Apoptosis of modified DPSCs was analyzed by measuring DNA fragments in the cells. Modified DPSCs generated a higher maximum cell population during static batch culture and showed higher viability (the ratio of live cells to total cells). CCK-8 test showed that the population of modified DPSCs increased faster than control group cells and wild type cells. Modified DPSCs were not better than the other cells in proliferative ability, but had lower apoptosis level when culturing in serum free medium. Hence, overexpressing Bcl-2 could increase cell population, the mechanism is to help DPSCs survival rather than promote the proliferative ability of cells. DOI: 10.5353/th_b5435671 Subjects: Dental pulp Stem cells - Transplantation
Author : Mikihito Kajiya
Publisher : Frontiers Media SA
ISBN 13 : 2889744760
Total Pages : 178 pages
Book Rating : 4.8/5 (897 download)
Download or read book Stem Cells in Oral Cavity: From Development to Regeneration written by Mikihito Kajiya and published by Frontiers Media SA. This book was released on 2022-02-22 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : 朱丽芳
Publisher :
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.:/5 (1 download)
Download or read book The Involvement of Dental Pulp Stem Cells in Inflammation and Regeneration written by 朱丽芳 and published by . This book was released on 2017 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Weibo Zhang
Publisher :
ISBN 13 : 9789090221564
Total Pages : 208 pages
Book Rating : 4.2/5 (215 download)
Download or read book Stem Cells Derived from Dental Pulp and Their Application Potential on Tissue Regeneration written by Weibo Zhang and published by . This book was released on 2007 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Evgeny Kushnerev
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Dental Pulp Stem Cells written by Evgeny Kushnerev and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alisina Karimi
Publisher : Book Rivers
ISBN 13 : 9355151233
Total Pages : 86 pages
Book Rating : 4.3/5 (551 download)
Download or read book Stem Cells in Dentistry written by Alisina Karimi and published by Book Rivers. This book was released on 2022-02-02 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological solutions to biological problems are emerging as a new paradigm in dentistry and medicine. Diagnosis, treatment, therapeutics and biomaterials are all becoming biological and gene-based. We are on the verge of shifting or evolving from mechanical (e.g. surgical) to biological solutions for health promotion, risk assessment, diagnostics, treatments, therapeutics, and health care outcomes.(
