Psp94 What Is It Good For Third Edition

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PSP94, what is it good for? (third edition)

Author : Martin Laurence
Publisher : Shipshaw Labs
ISBN 13 : 1482745844
Total Pages : 198 pages
Book Rating : 4.4/5 (827 download)

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Book Synopsis PSP94, what is it good for? (third edition) by : Martin Laurence

Download or read book PSP94, what is it good for? (third edition) written by Martin Laurence and published by Shipshaw Labs. This book was released on 2013-04-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews the literature linking prostate secretory protein 94 (PSP94) to prostate cancer and benign prostatic hyperplasia (BPH). It reveals four important insights not previously reported in the scientific literature: PSP94 is fungicidal within epithelial cells that synthesize it, but it is not fungicidal extracellularly due to inhibition by calcium ions. Prostatic epithelial cells of BPH men secrete an incomplete version of PSP94 which is not fungicidal; non-BPH men only secrete the fungicidal version. Epidemiological data indicate that a yet-to-be-identified sexually transmissible infection is causing prostate cancer, BPH and non-bacterial prostatitis. The gene responsible for the synthesis of PSP94 is expressed in all late onset cancers sites, representing 75% of all cancer cases in developed countries; it is not expressed in any early onset cancer sites of unknown etiology. The etiologies of prostate cancer and BPH are not known. Prostatic inflammation can be observed in 80% of elderly men. Epidemiologists have been predicting for more than a decade that a yet-to-be-identified sexually transmissible infection is causing prostate cancer. The search for prostatic pathogens has resulted in dozens of studies, yet a disease causing agent still eludes researchers. Research has focused on known sexually transmissible infections and bacteria. Two 2008 genome wide association studies reported that a single-nucleotide polymorphism near the PSP94 gene was associated with a 1.6x increase in risk of prostate cancer: the risk allele causes reduced synthesis of PSP94 in the prostate. Taken together, these facts suggest that PSP94's primary purpose is to defend epithelial cells from an intracellular pathogen which is causing prostate cancer and BPH, and possibly other diseases. Though this hypothesis is fully consistent with the current scientific literature, additional studies are necessary. Might this hypothesis be correct or not, understanding the mechanisms behind PSP94's protective properties for prostate cancer and its role in other late onset cancers should be given high priority in cancer research.

Cellular and Molecular Neurophysiology

Author : Constance Hammond
Publisher : Elsevier
ISBN 13 : 0323986137
Total Pages : 602 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Cellular and Molecular Neurophysiology by : Constance Hammond

Download or read book Cellular and Molecular Neurophysiology written by Constance Hammond and published by Elsevier. This book was released on 2024-06-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques

Hypercalcemia of Malignancy

Author : Friedhelm Raue
Publisher : Springer Science & Business Media
ISBN 13 : 3642850731
Total Pages : 211 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Hypercalcemia of Malignancy by : Friedhelm Raue

Download or read book Hypercalcemia of Malignancy written by Friedhelm Raue and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.

Cancer Epigenetics

Author : Mukesh Verma
Publisher : Humana
ISBN 13 : 9781493948949
Total Pages : 0 pages
Book Rating : 4.9/5 (489 download)

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Book Synopsis Cancer Epigenetics by : Mukesh Verma

Download or read book Cancer Epigenetics written by Mukesh Verma and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

Precision Medicine for Investigators, Practitioners and Providers

Author : Joel Faintuch
Publisher : Academic Press
ISBN 13 : 0128191791
Total Pages : 640 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Precision Medicine for Investigators, Practitioners and Providers by : Joel Faintuch

Download or read book Precision Medicine for Investigators, Practitioners and Providers written by Joel Faintuch and published by Academic Press. This book was released on 2019-11-16 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Anatomy for Urologic Surgeons in the Digital Era

Author : Emre Huri
Publisher : Springer Nature
ISBN 13 : 3030594793
Total Pages : 358 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Anatomy for Urologic Surgeons in the Digital Era by : Emre Huri

Download or read book Anatomy for Urologic Surgeons in the Digital Era written by Emre Huri and published by Springer Nature. This book was released on 2021-11-01 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical guide in the use of imaging and visualization technologies in urology. It details how output from diagnostic systems, can be represented through synthetic, virtual and augmented reality tools, such as holograms and three dimensional (3D) modelling and how they can improve everyday surgical procedures including laparoscopic, robotic-assisted, open, endoscopic along with the latest and most innovative approaches. Anatomy for Urologic Surgeons in the Digital Era: Scanning, Modelling and 3D Printing systematically reviews diagnostic imaging, visualization tools available in urology and is a valuable resource for all practicing and in-training urological surgeons.

From Molecules to Networks

Author : Ruth Heidelberger
Publisher : Academic Press
ISBN 13 : 9780080920832
Total Pages : 656 pages
Book Rating : 4.9/5 (28 download)

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Book Synopsis From Molecules to Networks by : Ruth Heidelberger

Download or read book From Molecules to Networks written by Ruth Heidelberger and published by Academic Press. This book was released on 2009-01-27 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. • Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook • Discusses emerging new understanding of non-classical molecules that affect neuronal signaling • Full colour, professional graphics throughout • Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

Viruses and Human Disease

Author : Ellen G. Strauss
Publisher : Elsevier
ISBN 13 : 9780080553160
Total Pages : 480 pages
Book Rating : 4.5/5 (531 download)

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Book Synopsis Viruses and Human Disease by : Ellen G. Strauss

Download or read book Viruses and Human Disease written by Ellen G. Strauss and published by Elsevier. This book was released on 2007-09-21 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text

Models for Prostate Cancer

Author : Gerald Patrick Murphy
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Models for Prostate Cancer by : Gerald Patrick Murphy

Download or read book Models for Prostate Cancer written by Gerald Patrick Murphy and published by . This book was released on 1980 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Urologic Surgical Pathology E-Book

Author : Liang Cheng
Publisher : Elsevier Health Sciences
ISBN 13 : 0323076149
Total Pages : 1037 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Urologic Surgical Pathology E-Book by : Liang Cheng

Download or read book Urologic Surgical Pathology E-Book written by Liang Cheng and published by Elsevier Health Sciences. This book was released on 2008-06-25 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised with practical guidance in daily urological pathology sign-out and the latest recommended diagnostic approaches, the new edition of this comprehensive reference equips you to accurately diagnose specimens of the entire urinary tract and male reproductive system plus the adrenal glands. It begins with a look at normal anatomy and histology for each organ system...followed by discussions of the pathology of congenital anomalies, inflammations, non-neoplastic diseases and neoplasia. An emphasis on clinicopathologic and radiographic-pathologic correlations makes this a true diagnostic decision-making guide. A consistent format enables you to locate critical information quickly, and morethan 1500 high-quality illustrations — most in full color — make diagnosis even easier. Presents the practice-proven experience of today’s authorities to enable you to diagnose with confidence. Limits coverage of general mechanisms of disease and anatomy to the most relevant information needed to fully comprehend the clinical picture. Includes boxed lists of types and causes of diseases, differential diagnosis, characteristic features of diseases, complications, classifications, and staging that help you quickly locate the specific information you need. Presents two brand-new chapters covering urinary cytology and fine needle aspiration to keep you up to date. Covers newly described entities and application of ancillary study for precise diagnosis. Features integration of new molecular techniques and immunohistochemical analysis for differential diagnosis. Equips you with the latest recommended diagnostic approaches help you make the most informed decisions. Provides you with a critical review of the current classifications of cancer and disease. Features more than 1500 high-quality illustrations-in full color—providing a complete visual perspective of the conditions encountered in pathology.

Mouse Models of Human Cancer

Author : Eric C. Holland
Publisher : John Wiley & Sons
ISBN 13 : 047144460X
Total Pages : 504 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Mouse Models of Human Cancer by : Eric C. Holland

Download or read book Mouse Models of Human Cancer written by Eric C. Holland and published by John Wiley & Sons. This book was released on 2004-08-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Essentials of Medical Biochemistry

Author : Chung-Eun Ha
Publisher : Academic Press
ISBN 13 : 9780080916880
Total Pages : 600 pages
Book Rating : 4.9/5 (168 download)

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Book Synopsis Essentials of Medical Biochemistry by : Chung-Eun Ha

Download or read book Essentials of Medical Biochemistry written by Chung-Eun Ha and published by Academic Press. This book was released on 2011-01-28 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert biochemist N.V. Bhagavan’s new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor. * Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts * Interactive multiple-choice questions to prep for USMLE exams * Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases * Instructional overview figures, flowcharts, and tables to enhance understanding

Handbook of Satisfiability

Author : A. Biere
Publisher : IOS Press
ISBN 13 : 1643681613
Total Pages : 1486 pages
Book Rating : 4.6/5 (436 download)

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Book Synopsis Handbook of Satisfiability by : A. Biere

Download or read book Handbook of Satisfiability written by A. Biere and published by IOS Press. This book was released on 2021-05-05 with total page 1486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Propositional logic has been recognized throughout the centuries as one of the cornerstones of reasoning in philosophy and mathematics. Over time, its formalization into Boolean algebra was accompanied by the recognition that a wide range of combinatorial problems can be expressed as propositional satisfiability (SAT) problems. Because of this dual role, SAT developed into a mature, multi-faceted scientific discipline, and from the earliest days of computing a search was underway to discover how to solve SAT problems in an automated fashion. This book, the Handbook of Satisfiability, is the second, updated and revised edition of the book first published in 2009 under the same name. The handbook aims to capture the full breadth and depth of SAT and to bring together significant progress and advances in automated solving. Topics covered span practical and theoretical research on SAT and its applications and include search algorithms, heuristics, analysis of algorithms, hard instances, randomized formulae, problem encodings, industrial applications, solvers, simplifiers, tools, case studies and empirical results. SAT is interpreted in a broad sense, so as well as propositional satisfiability, there are chapters covering the domain of quantified Boolean formulae (QBF), constraints programming techniques (CSP) for word-level problems and their propositional encoding, and satisfiability modulo theories (SMT). An extensive bibliography completes each chapter. This second edition of the handbook will be of interest to researchers, graduate students, final-year undergraduates, and practitioners using or contributing to SAT, and will provide both an inspiration and a rich resource for their work. Edmund Clarke, 2007 ACM Turing Award Recipient: "SAT solving is a key technology for 21st century computer science." Donald Knuth, 1974 ACM Turing Award Recipient: "SAT is evidently a killer app, because it is key to the solution of so many other problems." Stephen Cook, 1982 ACM Turing Award Recipient: "The SAT problem is at the core of arguably the most fundamental question in computer science: What makes a problem hard?"

Genetic Diagnosis of Endocrine Disorders

Author : Roy E. Weiss
Publisher : Academic Press
ISBN 13 : 0128011343
Total Pages : 472 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genetic Diagnosis of Endocrine Disorders by : Roy E. Weiss

Download or read book Genetic Diagnosis of Endocrine Disorders written by Roy E. Weiss and published by Academic Press. This book was released on 2015-10-09 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing

Cellular Endocrinology in Health and Disease

Author : Alfredo Ulloa-Aguirre
Publisher : Academic Press
ISBN 13 : 0128198028
Total Pages : 488 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Cellular Endocrinology in Health and Disease by : Alfredo Ulloa-Aguirre

Download or read book Cellular Endocrinology in Health and Disease written by Alfredo Ulloa-Aguirre and published by Academic Press. This book was released on 2021-02-02 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

The Great Prostate Hoax

Author : Richard J. Ablin
Publisher : Macmillan
ISBN 13 : 1137278749
Total Pages : 274 pages
Book Rating : 4.1/5 (372 download)

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Book Synopsis The Great Prostate Hoax by : Richard J. Ablin

Download or read book The Great Prostate Hoax written by Richard J. Ablin and published by Macmillan. This book was released on 2014-03-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reveals how fear-based and inaccurate testing is resulting in unnecessary high-risk surgeries, arguing that the PSA test was never intended for prostate cancer screening while sharing the stories of patients who have suffered from damaging procedures. 35,000 first printing.

Strength and Weakness

Author : William F. Stone
Publisher : Springer Science & Business Media
ISBN 13 : 1461391806
Total Pages : 277 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Strength and Weakness by : William F. Stone

Download or read book Strength and Weakness written by William F. Stone and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book had its origins in conversations held at various meetings of the International Society of Political Psychology. The editors and con tributors are grateful for the forum that has given us the opportunity to discuss these topics over the last 10 years. We are most grateful to our contributors both for their chapters and for the intellectual stimulation they have given us. Jos Meloen in particular has been free with his time, advice, and enthusiasm. Although he declined to contribute a chapter, Bob Altemeyer has been a source of encouragement and a ready adviser on any question we have asked. The staff of Springer-Verlag has been most patient in adapting to our schedule. We are indebted to the secretarial staff at the University of Maine, and especially to Kathy McAuliffe, who has put in many extra hours above and beyond the call of duty. Finally, we dedicate this book to our departed friend and colleague, Silvan Tomkins, with whom we conversed at length about these and other topics, and from whom we received inspiration and diversion. William F. Stone Gerda Lederer Richard Christie v Contents Preface. . . .. . . . . . . . . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . .. . . . . v Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix . . . . . . . . . . . . . . . Part I Overview 1 Introduction: Strength and Weakness ........................ 3 WILLIAM F. STONE, GERDA LEDERER, and RICHARD CHRISTIE 2 The Authoritarian Character from Berlin to Berkeley and Beyond: The Odyssey of a Problem. . . . . . . . . . . . . . . . . .. . . 22 . . . . . .