Introduction to Basics of Pharmacology and Toxicology

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Author :
Publisher : Springer Nature
ISBN 13 : 9813360097
Total Pages : 1156 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Abialbon Paul

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Abialbon Paul and published by Springer Nature. This book was released on 2021-03-13 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Comprehensive Natural Products III

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Author :
Publisher : Elsevier
ISBN 13 : 0081026919
Total Pages : 4266 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Comprehensive Natural Products III by :

Download or read book Comprehensive Natural Products III written by and published by Elsevier. This book was released on 2020-07-22 with total page 4266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience

Prostaglandins: Chemical and Biochemical Aspects

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9401196486
Total Pages : 239 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Prostaglandins: Chemical and Biochemical Aspects by : S. M. M. Karim

Download or read book Prostaglandins: Chemical and Biochemical Aspects written by S. M. M. Karim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second in a series of three books on advances in prostaglandin research. In recent years there has been an unparalleled interest in these compounds and as a result a vast amount of research data has accumulated since the publication of my earlier book in 1972. At that time it was possible to present a fairly comprehensive review of the various aspects of prosta glandin research in one volume. This is no longer possible and the contents are divided into three volumes; the first one dealing with prostaglandins and reproduction was published in October 1975; the present volume dealing with chemical and biochemical aspects of prostaglandin research, to be published in April 1976 and the third book dealing with physiological, pharmacological and pathological aspects of prostaglandin research wiII be published in May 1976. The authorship represents international scientists consisting of physiolo-. gists, pharmacologists, chemists, biochemists, veterinary scientists and obstetrician gynaecologists actively engaged in different areas of prosta glandin research. An attempt has been made to provide a total coverage of advances relating to prostaglandins. For the sake of completeness and continuity, material covered in the 1972 book is either briefly summarised or reference made to that edition. In recent years there have been notable advances in the chemical and biochemical aspects of prostaglandin research and these are discussed by various authorities in the chapters that follow.

The Eicosanoids

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Publisher : John Wiley & Sons
ISBN 13 : 047002061X
Total Pages : 654 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Eicosanoids by : Peter Curtis-Prior

Download or read book The Eicosanoids written by Peter Curtis-Prior and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide. This book satisfies a surge of interest in prostaglandins—NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Encyclopedia of Medical Immunology

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Author :
Publisher :
ISBN 13 : 9781461492092
Total Pages : pages
Book Rating : 4.4/5 (92 download)

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Book Synopsis Encyclopedia of Medical Immunology by : Ian R. Mackay

Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Strategies for Organic Drug Synthesis and Design

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 9780470399590
Total Pages : 700 pages
Book Rating : 4.3/5 (995 download)

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Book Synopsis Strategies for Organic Drug Synthesis and Design by : Daniel Lednicer

Download or read book Strategies for Organic Drug Synthesis and Design written by Daniel Lednicer and published by John Wiley & Sons. This book was released on 2009-03-04 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

Fluorine and Health

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Publisher : Elsevier
ISBN 13 : 0080558119
Total Pages : 821 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Fluorine and Health by : Alain Tressaud

Download or read book Fluorine and Health written by Alain Tressaud and published by Elsevier. This book was released on 2008-06-06 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Prostaglandins

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Author :
Publisher : Nova Science Publishers
ISBN 13 : 9781616682729
Total Pages : 0 pages
Book Rating : 4.6/5 (827 download)

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Book Synopsis Prostaglandins by : Gillian M. Goodwin

Download or read book Prostaglandins written by Gillian M. Goodwin and published by Nova Science Publishers. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring. They are mediators that participate in the regulation of multiple biological processes, both in health and disease. Prostaglandins contribute to the regulation of vascular tone, platelet function, and fertility. They also play key roles as inflammatory mediators and modulators of tumor biology. Although they are technically hormones, they are rarely classified as such. This book examines the biological role of prostaglandins in drug discovery, and on immune cells; the prostaglandin interchange; and the roles of prostaglandin E2 in inflammation-related cardiovascular disease as well as other related topics of import.

Inflammation and Natural Products

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Author :
Publisher : Academic Press
ISBN 13 : 0128192194
Total Pages : 420 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Inflammation and Natural Products by : Sreeraj Gopi

Download or read book Inflammation and Natural Products written by Sreeraj Gopi and published by Academic Press. This book was released on 2021-01-19 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Approx.446 pagesApprox.446 pages

Bioactive Carboxylic Compound Classes

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Publisher : John Wiley & Sons
ISBN 13 : 3527339477
Total Pages : 528 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Bioactive Carboxylic Compound Classes by : Clemens Lamberth

Download or read book Bioactive Carboxylic Compound Classes written by Clemens Lamberth and published by John Wiley & Sons. This book was released on 2016-08-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the successful and proven concept used in "Bioactive Heterocyclic Compound Classes" by the same editors, this book is the first to present approved pharmaceutical and agrochemical compounds classified by their carboxylic acid functionality in one handy volume. Each of the around 40 chapters describes one or two typical syntheses of a specific compound class and provides concise information on the history of development, mode of action, biological activity and field of application, as well as structure-activity relationships. In addition, similarities and differences between pharmaceuticals and agrochemicals are discussed in the introduction. Written by a team of experts in the field, this is a useful reference for researchers in academia and chemical or pharmaceutical companies working in the field of total synthesis and natural product chemistry, drug development, and crop protection research.

Prostaglandins and Related Substances

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Author :
Publisher : Elsevier
ISBN 13 : 008086063X
Total Pages : 251 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Prostaglandins and Related Substances by :

Download or read book Prostaglandins and Related Substances written by and published by Elsevier. This book was released on 1983-01-01 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostaglandins and Related Substances

Gas Chromatography and Mass Spectrometry: A Practical Guide

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Publisher : Academic Press
ISBN 13 : 0080920152
Total Pages : 633 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Gas Chromatography and Mass Spectrometry: A Practical Guide by : O. David Sparkman

Download or read book Gas Chromatography and Mass Spectrometry: A Practical Guide written by O. David Sparkman and published by Academic Press. This book was released on 2011-05-17 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. - Covers the practical instruction necessary for successful operation of GC/MS equipment - Reviews the latest advances in instrumentation, ionization methods, and quantitation - Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner - A true benchtop reference - A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) - Quick References to data interpretation - Ready source for information on new analyses

Immunobiology of the Macrophage

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Publisher : Academic Press
ISBN 13 : 1483274772
Total Pages : 652 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Immunobiology of the Macrophage by : David S. Nelson

Download or read book Immunobiology of the Macrophage written by David S. Nelson and published by Academic Press. This book was released on 2014-06-28 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book's contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.

Prostacyclin and Its Stable Analogue, Iloprost

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Prostacyclin and Its Stable Analogue, Iloprost by : Ryszard Gryglewski

Download or read book Prostacyclin and Its Stable Analogue, Iloprost written by Ryszard Gryglewski and published by Springer. This book was released on 1987 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstrated by its unusual feature of being chemically and meta bolically unstable when compared to other prostanoids and known amine or peptide mediators. Although physiologically essential, the chemical instability of prostacyclin poses a serious drawback in laboratory and clinical studies. It is one of the genuine objectives of pharmaceutical research to supply synthetic compounds which overcome the inherent drawbacks - considering investigational and therapeutic use - of endogenous compounds. Whereas metabolic instability in certain cases could be of advantage, chemical instability definitely is not. With Iloprost, a molecule has been designed which - according to all data so far available - pertains high receptor affinity, metabolic instability (clinically this equates with a fine control of Iloprost's effects) while chemical stability has been achieved. By virtue of these characteristics Iloprost can be considered as one step towards specific interaction within the arachidonic acid cascade, namely the prostacyclin receptor. The aim of the symposium was to provide a critical experimental appraisal concerning the biochemical mode of action and pharmacological properties of prostacyclin and Iloprost.

Lipid Metabolism

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Publisher : Elsevier
ISBN 13 : 0323144276
Total Pages : 628 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Lipid Metabolism by : Salih Wakil

Download or read book Lipid Metabolism written by Salih Wakil and published by Elsevier. This book was released on 2012-12-02 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Metabolism focuses on the regulation and metabolism of lipids. This book is composed of 10 chapters that specifically deal with fatty acids, prostaglandins, glycerides, glycerophosphates, cholesterol, isoprenoids, and aromatic compounds. This text starts with an overview of fatty acid metabolism and its controlling factors. This topic is followed by discussions on the physiochemical aspects of oxidative metabolism of fatty acids, with a special emphasis on the role of carnitine in this process. A chapter highlights the several important aspects of higher plant lipid metabolism. Other chapters are devoted to the structures, biosynthesis, and metabolism of prostaglandins, bacterial lipids, phospholipids, glycerides, and steroids. The final chapters describe the biogenesis of aromatic substances through the polyketide path, including polyisoprenoid quinines and related compounds.

Biomarkers in Toxicology

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Publisher : Academic Press
ISBN 13 : 0124046495
Total Pages : 1149 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Biomarkers in Toxicology by : Ramesh C Gupta

Download or read book Biomarkers in Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2014-01-25 with total page 1149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. - Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers - Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes - Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

Prostaglandins and Related Compounds

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Author :
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781702386
Total Pages : 616 pages
Book Rating : 4.7/5 (23 download)

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Book Synopsis Prostaglandins and Related Compounds by : Bengt Samuelsson

Download or read book Prostaglandins and Related Compounds written by Bengt Samuelsson and published by Lippincott Williams & Wilkins. This book was released on 1995 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: