Progress Toward The Total Synthesis Of Terpenoid Natural Products

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Progress Toward the Total Synthesis of Terpenoid Natural Products

Author : Jessica Louise Wood
Publisher :
ISBN 13 :
Total Pages : 426 pages
Book Rating : 4.:/5 (785 download)

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Book Synopsis Progress Toward the Total Synthesis of Terpenoid Natural Products by : Jessica Louise Wood

Download or read book Progress Toward the Total Synthesis of Terpenoid Natural Products written by Jessica Louise Wood and published by . This book was released on 2011 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress has been made toward the total synthesis of a diverse array of natural products. Chapter 1 begins by introducing the isolation, bioactivity, and biosynthesis of the neomangicol and mangicol sesterterpenoids. Subsequent to that introduction, a summary of previous synthetic approaches to these natural products is presented. In the third section, our synthetic approaches are detailed, beginning with a first generation synthesis of the ABD tricycle, followed by a description of our revised route to the neomangicol tetracyclic core and our work toward the rearrangement of that core to the mangicol spirocyclic core. This chapter concludes with a summary of our accomplishments in this natural product area and outlines several strategies to achieve the desired rearrangement. The last section also includes our initial studies into the formation of the mangicol core. Preliminary work toward the synthesis of the ABD tricycle was performed by Dr. Brian Pujanauski. Chapter 2 details our work in the area of the yohimbine alkaloids. It begins with an introduction to these pentacyclic indole-containing natural products, discussing their isolation, proposed biosynthesis and giving a brief overview of the rich bioactivity that has been ascertained for these molecules. Closely related synthetic approaches are also described. Finally, our divergent approach to the synthesis of several yohimbine alkaloids, as well as strategic analogs, is delineated. Our proposal for rendering this route enantioselective is also detailed. This work was done in collaboration with Dr. Terry Lebold and Josh Deitch.

Synthesis of Marine Natural Products 1

Author : K.F. Albizati
Publisher : Springer Science & Business Media
ISBN 13 : 3642768350
Total Pages : 292 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Synthesis of Marine Natural Products 1 by : K.F. Albizati

Download or read book Synthesis of Marine Natural Products 1 written by K.F. Albizati and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes five and six of Bioorganic Marine Chemistry differ from their predecessors in two respects - they deal exclusively with labor atory synthesis of marine natural products and they represent the effort of a single author and his associates. The rationale for these departures is readily perceived. For several decades organic synthesis has without doubt been the most spectacular branch of organic chemistry. While the late R.B. Woodward's dictum - organic compounds can undergo only four basic reactions: they can gain electrons; they can lose electrons; they can be transformed with acid or with base - is still true, the wealth and variety of available reagents which will accomplish chemical transformations has reached staggering proportions. Little wonder then, that synthetic methodology has achieved a high degree of predictability and total synthesis of natural products has been successfully directed toward ever more challenging targets. As for the second point, that of single authorship, multiple authorship would invariably have led to gaps and overlaps, thus making it difficult to assemble and assess recent research in a systematic and comprehens ive fashion.

Towards The Total Synthesis Of Terpenoid Natural Products

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (656 download)

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Book Synopsis Towards The Total Synthesis Of Terpenoid Natural Products by :

Download or read book Towards The Total Synthesis Of Terpenoid Natural Products written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The construction of diverse molecular architecture conceived and created by Nature, continues to be the most exiting and challenging task to the practitioners of organic synthesis. As a result of refinement in isolation and purification techniques, recent advances in the spectroscopic methods particularly two-dimensional NMR spectroscopy and routine use of single crystal X-ray crystallography, the isolation and structural elucidation of the complex natural products has become a routine exercise. Even those natural products which are present in minute quantity, are being unraveled from the newer and exotic sources such as marine flora and fauna, microbial organisms and insect world. This has been a big boon for the synthetic organic chemists, providing them with increasing number of exciting objectives. The recent advances in the field of natural product synthesis testify to the organic chemists endeavors to meet these emerging challenges. Nature's expertise and virtuosity in creating a phenomenal array of carbocyclic frameworks is most notably highlighted in the terpenoid group of natural products. Indeed, the number and type of carbocyclic skeleta among terpenes continues to grow unabated as more and more natural products are being routinely isolated from the various sources. Thus, various polycyclic natural products bearing new and novel fused assemblies of five, six, seven and eight membered rings and replete with dense functionalization and stereogenic centers are being regularly encountered. The present investigation represents synthetic efforts towards some novel and recently isolated terpenoid natural products. Two main themes have been pursued. The first involves the construction of a functionalized hydroazulene framework employing RCM as the key step and its further elaboration to the 5,7,6-tricyclic framework present in diterpene guanacastepene-A and 5,11-fused bicyclic system present in neodolabellane diterpenes. The second theme explores the synthetic ve.

Total Synthesis of Natural Products

Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3642340652
Total Pages : 292 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Total Synthesis of Natural Products by : Jie Jack Li

Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Efforts Toward the Total Synthesis of Comlex Terpene Natural Products

Author : Jillian Elyse Spangler
Publisher :
ISBN 13 :
Total Pages : 518 pages
Book Rating : 4.:/5 (756 download)

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Book Synopsis Efforts Toward the Total Synthesis of Comlex Terpene Natural Products by : Jillian Elyse Spangler

Download or read book Efforts Toward the Total Synthesis of Comlex Terpene Natural Products written by Jillian Elyse Spangler and published by . This book was released on 2011 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthetic Studies on Terpene Natural Products

Author : Dennis Christian Johannes Waalboer
Publisher :
ISBN 13 : 9789090259659
Total Pages : 142 pages
Book Rating : 4.2/5 (596 download)

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Book Synopsis Synthetic Studies on Terpene Natural Products by : Dennis Christian Johannes Waalboer

Download or read book Synthetic Studies on Terpene Natural Products written by Dennis Christian Johannes Waalboer and published by . This book was released on 2011 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Glycoscience

Author : Bertram O. Fraser-Reid
Publisher : Springer Science & Business Media
ISBN 13 : 3540361545
Total Pages : 2847 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Glycoscience by : Bertram O. Fraser-Reid

Download or read book Glycoscience written by Bertram O. Fraser-Reid and published by Springer Science & Business Media. This book was released on 2008-04-14 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.

A Fragrant Introduction to Terpenoid Chemistry

Author : Charles S. Sell
Publisher : Royal Society of Chemistry
ISBN 13 : 9780854046812
Total Pages : 432 pages
Book Rating : 4.0/5 (468 download)

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Book Synopsis A Fragrant Introduction to Terpenoid Chemistry by : Charles S. Sell

Download or read book A Fragrant Introduction to Terpenoid Chemistry written by Charles S. Sell and published by Royal Society of Chemistry. This book was released on 2003 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Terpenoids play an important part in all our lives, from Vitamin A and hormones to perfumes and pharmaceuticals. This book provides an introduction to terpenoid chemistry, concentrating on the lower terpenoids, but the basic principles taught are also the foundation for the chemistry of the higher terpenoids. Coverage includes: the biogenesis of terpenoids; some of the history of the field; the principles of structural determination; and the importance of stereochemistry and stereoselective synthesis. Carbocation chemistry is introduced, as are the principles of total and partial synthesis. Finally, industrial chemistry (both discovery chemistry and chemical process development) is discussed, using the volatile terpenoids of perfumery to illustrate basic concepts. Ideal as both an introduction to terpenoid chemistry and as a refresher course, A Fragrant Introduction to Terpenoid Chemistry, with its real-life problems and appreciation of the relevance of chemistry to everyday life, will prove invaluable to students, lecturers and industrialists alike.

The Total Synthesis of Natural Products, Volumes 10 and 11, 2 Volume Set

Author : David Goldsmith
Publisher : Wiley-Interscience
ISBN 13 : 9780471194071
Total Pages : 0 pages
Book Rating : 4.1/5 (94 download)

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Book Synopsis The Total Synthesis of Natural Products, Volumes 10 and 11, 2 Volume Set by : David Goldsmith

Download or read book The Total Synthesis of Natural Products, Volumes 10 and 11, 2 Volume Set written by David Goldsmith and published by Wiley-Interscience. This book was released on 1999-06-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The indispensable reference for the twenty-first century chemist... A fascinating and comprehensive look into one of chemistry's fastest growing specialties--sesquiterpene synthesis--Volume Ten of The Total Synthesis of Natural Products focuses on acyclic and monocyclic compounds and sheds light on the structure and makeup of this important class of hydrocarbons. A useful and practical tool for researchers interested in locating any of the major classes of sesquiterpene compounds, the author will also provide, if needed, a database to the more than 1,600 articles on sesquiterpene synthesis. The ultimate index to the newest experimental work in synthetic chemistry, this latest volume in The Total Synthesis of Natural Products series is also a glossary to the new language of chemistry in the next century. Look for the following related title in the series: THE TOTAL SYNTHESIS OF NATURAL PRODUCTS, Volume Eleven Volume Eleven continues the authoritative coverage on sesquiterpene synthesis begun in Volume Ten, examining compounds with bicyclic and tricyclic ring structures., 1997 (0-471-18874-3) The research on the synthesis of sesquiterpenes, derivatives of terpenes, a class of hydrocarbons commonly found in oils, resins, and balsams, has grown exponentially over the past fifteen years. With over 500 sesquiterpene syntheses already developed, the literature on this experimental specialty is voluminous, now encompassing over 1,600 re-search papers. Volume Ten in The Total Synthesis of Natural Products provides a systematic and comprehensive look at acyclic and monocyclic compounds in sesquiterpene synthesis. Reflecting one of the significant changes in sesquiterpene re-search, that is, the increase in compound targets prepared in an optically active form, the present volume includes their absolute configurations, signs of optical rotation, or both. This newest volume in The Total Synthesis of Natural Products series is an "A-to-Z" look at acyclic and monocyclic compounds in sesquiterpene synthesis, one of the most dynamic areas in the ongoing revolution in chemical synthesis, and is a must for the chemical professional.

Synthetic Studies on Terpenoids, Total Synthesis of the Marine Natural Product Nanaimoal

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis Synthetic Studies on Terpenoids, Total Synthesis of the Marine Natural Product Nanaimoal by :

Download or read book Synthetic Studies on Terpenoids, Total Synthesis of the Marine Natural Product Nanaimoal written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Two-phase Approach to Terpene Total Synthesis: Demonstration of a ʺcyclase-phaseʺ Synthesis of the Eudesmane and Taxane Families

Author : Yoshihiro Ishihara
Publisher :
ISBN 13 : 9781267909152
Total Pages : 470 pages
Book Rating : 4.9/5 (91 download)

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Book Synopsis A Two-phase Approach to Terpene Total Synthesis: Demonstration of a ʺcyclase-phaseʺ Synthesis of the Eudesmane and Taxane Families by : Yoshihiro Ishihara

Download or read book A Two-phase Approach to Terpene Total Synthesis: Demonstration of a ʺcyclase-phaseʺ Synthesis of the Eudesmane and Taxane Families written by Yoshihiro Ishihara and published by . This book was released on 2012 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Terpenes are primary constituents of plant oils and have long held importance as flavors and fragrances, as well as poisons and medicines. Isolation, structural elucidation, total synthesis and occasional structural revision of these omnipresent natural products have long been conducted, providing constant challenges to chemists and thus allowing for a continuous development of the field. In particular, advances in analytical techniques and the development of retrosynthetic analysis have led to a dramatic increase in the number of isolated terpenes and the ability to execute their total synthesis. While total synthesis has conquered some extremely complex terpenes, only milligram quantities are typically prepared after many years of effort; in contrast, Nature seemingly generates terpenes with ease. Therefore, organic chemistry still needs to improve dramatically in order to match the efficiency of Nature. The main difficulty in the total synthesis of terpenes is that there are no general rules for their construction, and molecules must be retrosynthetically evaluated on a case-by-case basis. A solution to this problem perhaps lies in mimicking Nature, as the awe-inspiring efficiency of biosynthesis suggests that there might be certain advantages to conducting terpene synthesis in a similar manner. Nature creates its library of terpenes in a unified fashion by a two-phase approach: a cyclase phase that uses a small number of functional groups to cyclize and rearrange carboskeleton frameworks, and an oxidase phase that builds diversity by using a variety of cytochrome P450 enzymes to achieve C-H oxidation. Similarly, a laboratory two-phase synthesis of terpenes would involve first a "cyclase phase" with the aim to synthesize a lowly oxidized target of a particular terpene family in an enantioselective and scalable manner, followed by an "oxidase phase" that would divergently access various members of a given terpene family using C-H functionalization methods. In this thesis, two terpene families are chosen as platforms for discovery in total synthesis: the eudesmane family of sesquiterpenes and the taxane family of diterpenes. Execution of the "cyclase phase" in the eudesmane and taxane families is described through the scalable and enantioselective total syntheses of dihydrojunenol and "taxadienone."

Towards the Total Synthesis of Natural Products (-)-Englerin A and Crotogoudin

Author : Dmitry B. Ushakov
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (118 download)

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Book Synopsis Towards the Total Synthesis of Natural Products (-)-Englerin A and Crotogoudin by : Dmitry B. Ushakov

Download or read book Towards the Total Synthesis of Natural Products (-)-Englerin A and Crotogoudin written by Dmitry B. Ushakov and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Approaches to the Total Synthesis of Terpenoids

Author : Jutiwongse, Saowaros
Publisher :
ISBN 13 :
Total Pages : 70 pages
Book Rating : 4.:/5 (29 download)

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Book Synopsis Approaches to the Total Synthesis of Terpenoids by : Jutiwongse, Saowaros

Download or read book Approaches to the Total Synthesis of Terpenoids written by Jutiwongse, Saowaros and published by . This book was released on 1972 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemical Catalysts for Biomass Upgrading

Author : Mark Crocker
Publisher : John Wiley & Sons
ISBN 13 : 3527344667
Total Pages : 634 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Chemical Catalysts for Biomass Upgrading by : Mark Crocker

Download or read book Chemical Catalysts for Biomass Upgrading written by Mark Crocker and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference to the use of innovative catalysts and processes to turn biomass into value-added chemicals Chemical Catalysts for Biomass Upgrading offers detailed descriptions of catalysts and catalytic processes employed in the synthesis of chemicals and fuels from the most abundant and important biomass types. The contributors?noted experts on the topic?focus on the application of catalysts to the pyrolysis of whole biomass and to the upgrading of bio-oils. The authors discuss catalytic approaches to the processing of biomass-derived oxygenates, as exemplified by sugars, via reactions such as reforming, hydrogenation, oxidation, and condensation reactions. Additionally, the book provides an overview of catalysts for lignin valorization via oxidative and reductive methods and considers the conversion of fats and oils to fuels and terminal olefins by means of esterification/transesterification, hydrodeoxygenation, and decarboxylation/decarbonylation processes. The authors also provide an overview of conversion processes based on terpenes and chitin, two emerging feedstocks with a rich chemistry, and summarize some of the emerging trends in the field. This important book: -Provides a comprehensive review of innovative catalysts, catalytic processes, and catalyst design -Offers a guide to one of the most promising ways to find useful alternatives for fossil fuel resources -Includes information on the most abundant and important types of biomass feedstocks -Examines fields such as catalytic cracking, pyrolysis, depolymerization, and many more Written for catalytic chemists, process engineers, environmental chemists, bioengineers, organic chemists, and polymer chemists, Chemical Catalysts for Biomass Upgrading presents deep insights on the most important aspects of biomass upgrading and their various types.

Synthesis and Functionalization of Highly Biologically Active Terpene Natural Products − Total Synthesis of (+)-Darwinolide and Semisynthesis of (−)-Englerin A and Structure-activity Relationship Studies of Analogs

Download Synthesis and Functionalization of Highly Biologically Active Terpene Natural Products − Total Synthesis of (+)-Darwinolide and Semisynthesis of (−)-Englerin A and Structure-activity Relationship Studies of Analogs PDF Online Free

Author : Thomas Siemon
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (114 download)

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Book Synopsis Synthesis and Functionalization of Highly Biologically Active Terpene Natural Products − Total Synthesis of (+)-Darwinolide and Semisynthesis of (−)-Englerin A and Structure-activity Relationship Studies of Analogs by : Thomas Siemon

Download or read book Synthesis and Functionalization of Highly Biologically Active Terpene Natural Products − Total Synthesis of (+)-Darwinolide and Semisynthesis of (−)-Englerin A and Structure-activity Relationship Studies of Analogs written by Thomas Siemon and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Terpenes and Terpenoids

Author : Shagufta Perveen
Publisher : BoD – Books on Demand
ISBN 13 : 1789847761
Total Pages : 154 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Terpenes and Terpenoids by : Shagufta Perveen

Download or read book Terpenes and Terpenoids written by Shagufta Perveen and published by BoD – Books on Demand. This book was released on 2018-12-19 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Terpenes belong to the diverse class of chemical constituents isolated from materials found in nature (plants, fungi, insects, marine organisms, plant pathogens, animals and endophytes). These metabolites have simple to complex structures derived from Isopentyl diphosphate (IPP), dimethyl allyl diphosphate (DMAPP), mevalonate and deoxyxylulose biosynthetic pathways. Terpenes play a very important role in human health and have significant biological activities (anticancer, antimicrobial, anti-inflammatory, antioxidant, antiallergic, skin permeation enhancer, anti-diabetic, immunomodulatory, anti-insecticidal). This book gives an overview and highlights recent research in the phytochemical and biological understanding of terpenes and terpenoid and explains the most essential functions of these kinds of secondary metabolites isolated from natural sources.

The Total Synthesis of Natural Products, Volume 10, Part A

Author : Michael C. Pirrung
Publisher : Wiley-Interscience
ISBN 13 : 9780471596790
Total Pages : 0 pages
Book Rating : 4.5/5 (967 download)

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Book Synopsis The Total Synthesis of Natural Products, Volume 10, Part A by : Michael C. Pirrung

Download or read book The Total Synthesis of Natural Products, Volume 10, Part A written by Michael C. Pirrung and published by Wiley-Interscience. This book was released on 1997-04-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The indispensable reference for the twenty-first century chemist... A fascinating and comprehensive look into one of chemistry's fastest growing specialties--sesquiterpene synthesis--Volume Ten of The Total Synthesis of Natural Products focuses on acyclic and monocyclic compounds and sheds light on the structure and makeup of this important class of hydrocarbons. A useful and practical tool for researchers interested in locating any of the major classes of sesquiterpene compounds, the author will also provide, if needed, a database to the more than 1,600 articles on sesquiterpene synthesis. The ultimate index to the newest experimental work in synthetic chemistry, this latest volume in The Total Synthesis of Natural Products series is also a glossary to the new language of chemistry in the next century. Look for the following related title in the series: THE TOTAL SYNTHESIS OF NATURAL PRODUCTS, Volume Eleven Volume Eleven continues the authoritative coverage on sesquiterpene synthesis begun in Volume Ten, examining compounds with bicyclic and tricyclic ring structures., 1997 (0-471-18874-3) The research on the synthesis of sesquiterpenes, derivatives of terpenes, a class of hydrocarbons commonly found in oils, resins, and balsams, has grown exponentially over the past fifteen years. With over 500 sesquiterpene syntheses already developed, the literature on this experimental specialty is voluminous, now encompassing over 1,600 re-search papers. Volume Ten in The Total Synthesis of Natural Products provides a systematic and comprehensive look at acyclic and monocyclic compounds in sesquiterpene synthesis. Reflecting one of the significant changes in sesquiterpene re-search, that is, the increase in compound targets prepared in an optically active form, the present volume includes their absolute configurations, signs of optical rotation, or both. This newest volume in The Total Synthesis of Natural Products series is an "A-to-Z" look at acyclic and monocyclic compounds in sesquiterpene synthesis, one of the most dynamic areas in the ongoing revolution in chemical synthesis, and is a must for the chemical professional.