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Progress Toward The Total Synthesis Of Paecilospirone
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Book Synopsis Progress Toward the Total Synthesis of Paecilospirone by : Matthew Leo Landry
Download or read book Progress Toward the Total Synthesis of Paecilospirone written by Matthew Leo Landry and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Further Progress Towards the Total Synthesis of Paecilospirone by : Victoria Chung
Download or read book Further Progress Towards the Total Synthesis of Paecilospirone written by Victoria Chung and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Synthetic Approach Towards Paecilospirone by : G. Leslie Burnett IV
Download or read book A Synthetic Approach Towards Paecilospirone written by G. Leslie Burnett IV and published by . This book was released on 2013 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our research focuses on the total synthesis of naturally occurring highly oxidized and densely functionalized carbon skeletons. The generation of dearomatized intermediates and o-quinone methides enable the rapid manipulation and derivatization of aromatic cores. o-Quinone methides in particular undergo a variety of reactions, but in the presence of enol ethers cycloaddition reactions predominate, which enable access to complex spiroketal derivatives. The use of this technology enables the generation of spiroketals in a kinetic fashion, not possible through traditional thermodynamic ketalizations. Herein, we will overview our studies towards finding an appropriate o-quinone methide precursor and demonstrate the application of this methodology towards the total synthesis of paecilospirone, a marine natural product whose unique chroman spiroketal core had not previously been encountered in nature prior to its isolation.
Book Synopsis The Total Synthesis of (-)-paspaline and Progress Toward the Total Synthesis of (+)-paspalicine by : Tamara L. Leenay
Download or read book The Total Synthesis of (-)-paspaline and Progress Toward the Total Synthesis of (+)-paspalicine written by Tamara L. Leenay and published by . This book was released on 1988 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Total Synthesis of the Antimitotic Agent Paecilospirone by : Tsz Ying Yuen
Download or read book Enantioselective Total Synthesis of the Antimitotic Agent Paecilospirone written by Tsz Ying Yuen and published by . This book was released on 2011 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This thesis describes the first, enantioselective total synthesis of the marine natural product paecilospirone (1). Paecilospirone is a polyketide derived metabolite isolated from the marine fungus Paecilomyces sp. collected off the coast of Yap Island, Federated States of Micronesia. Structural assignment following anticancer bioassay subsequently revealed a novel spiro[chroman-2,1(3H)- isobenzofuran] core where an -hydroxyl group occupies the unusual axial position of the sixmembered tetrahydropyran ring. An efficient and flexible strategy was developed to provide access to the [5,6]-bisbenzannulated spiroacetal in a convergent manner. Three key fragments, bromide 162, aldehyde 120 and ketone 92, were synthesised using readily available starting materials. In particular, ketone 92 was obtained from the chiral pool, thus allowing the facile incorporation of enantioselectivity into the synthesis. The fragments were successfully coupled together using an aryllithiation addition and a diasteresoselective, anti-boron aldol reaction. Initial attempts at the late stage spiroacetalisation reaction focused on the acid-mediated cyclisation of MOM-protected ketone 112. However, upon spirocyclisation, 113 readily underwent elimination to afford the corresponding dehydrated products. The problem was exacerbated by the axial orientation of the oxygenated group positioned to the spirocentre and anti to a vicinal hydrogen atom, thus a revision in protecting group strategy was enforced whereby access to the spiroacetal core was envisioned using pH neutral conditions. Attention therefore focused on the model study of a dihydroxyketone equivalent (123) in which the alcohol groups were protected as allyl ethers. Accordingly, treatment of 123 with Pd(PPh3)4 in the presence of a range of silane addictives successfully furnished the desired spiroacetal 124, clearly demonstrating the synthetic utility of this method for the preparation of sensitive spiroacetal systems. Subjection of bis-allyl ketone 166 to the established reaction conditions ultimately led to the completion of the total synthesis of paecilospirone 1"--Abstract.
Book Synopsis Further Progress Toward the Total Synthesis of Paeoniflorigenone by : Jared Nathaniel Cumming
Download or read book Further Progress Toward the Total Synthesis of Paeoniflorigenone written by Jared Nathaniel Cumming and published by . This book was released on 1992 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis I. Progress Towards the Asymmetric Synthesis of Α-methylasparagine ; II. Progress Towards the Total Synthesis of Diazonamide A by : Todd Ritsema
Download or read book I. Progress Towards the Asymmetric Synthesis of Α-methylasparagine ; II. Progress Towards the Total Synthesis of Diazonamide A written by Todd Ritsema and published by . This book was released on 1999 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Toward the Total Synthesis of Superstolide A by : Jennifer A. Champoux
Download or read book Progress Toward the Total Synthesis of Superstolide A written by Jennifer A. Champoux and published by . This book was released on 1996 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part 1: Progress Toward the Total Synthesis of Platensimycin. Part 2: Aromatic Ions: Carbon-Based Nucleofuges and Chiral Cyclopropenones and Formamides by : Ethan Lawrence Fisher
Download or read book Part 1: Progress Toward the Total Synthesis of Platensimycin. Part 2: Aromatic Ions: Carbon-Based Nucleofuges and Chiral Cyclopropenones and Formamides written by Ethan Lawrence Fisher and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The third chapter describes the synthesis of chiral cyclopropenones and their use in the kinetic resolution of alcohols by chlorodehydration. Chiral formamides are also studied for their use in chlorodehydration. Transition states for enantiodifferentiation are proposed.
Book Synopsis Progress Towards the Total Synthesis of Sorangicin by : Kumeneger Debalike Belayneh
Download or read book Progress Towards the Total Synthesis of Sorangicin written by Kumeneger Debalike Belayneh and published by Kumeneger Belayneh. This book was released on 2012 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Toward the Total Synthesis of Salvadione-A and Related Diterpenoids by : Blake Bennet Greene
Download or read book Progress Toward the Total Synthesis of Salvadione-A and Related Diterpenoids written by Blake Bennet Greene and published by . This book was released on 2004 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis of Ingenol and Jatrophatrione by : Scott Douglas Edmondson
Download or read book Progress Towards the Total Synthesis of Ingenol and Jatrophatrione written by Scott Douglas Edmondson and published by . This book was released on 1996 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Toward the Total Synthesis of 14-isoazacamptothecin and Synthesis of Substituted Quinoline by : Ibrahim Danlami Bori
Download or read book Progress Toward the Total Synthesis of 14-isoazacamptothecin and Synthesis of Substituted Quinoline written by Ibrahim Danlami Bori and published by . This book was released on 2008 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Catalytic Asymmetric Synthesis of the Chiral Tetraene Acyl Side Chain of Papulacandins by : Huanyan Cao
Download or read book Catalytic Asymmetric Synthesis of the Chiral Tetraene Acyl Side Chain of Papulacandins written by Huanyan Cao and published by . This book was released on 2005 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress in Heterocyclic Chemistry by : Gordon Gribble
Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2019-10-24 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Heterocyclic Chemistry, Volume 31 is the latest release in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature and articles on developing topics in heterocyclic chemistry. Chapters in this new release are written by leading researchers in their field and constitute a systematic survey of the important original material reported in the literature in of heterocyclic in 2018. As with previous volumes in the series, this updated volume will enable academics, industrial chemists and advanced students stay abreast of developments in heterocyclic chemistry. - Recognized as the premiere review of heterocyclic chemistry - Includes contributions from leading researchers in the field - Provides a systematic survey of the important 2018 heterocyclic chemistry literature - Presents articles on new and developing topics of interest to heterocyclic chemists
Book Synopsis Progress Towards the Total Synthesis of Apoptolidin by : Bohan Jin
Download or read book Progress Towards the Total Synthesis of Apoptolidin written by Bohan Jin and published by . This book was released on 2002 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis of Chlorothricolide by : Steven Edward Hall
Download or read book Progress Towards the Total Synthesis of Chlorothricolide written by Steven Edward Hall and published by . This book was released on 1982 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: