Progress In The Chemistry Of Organic Natural Products 115

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Progress in the Chemistry of Organic Natural Products 115

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030648532
Total Pages : 214 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 115 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 115 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2021-04-02 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca2+ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

Progress in the Chemistry of Organic Natural Products 124

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 303159567X
Total Pages : 239 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 124 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 124 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Progress in the Chemistry of Organic Natural Products

Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3709168872
Total Pages : 508 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products by :

Download or read book Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this ASI was to bring together specialists in several complex variables (many of whom have contributed to complex potential theory) and specialists in potential theory (all of whom have contributed to several complex variables) together with young researchers and graduate students for an interchange of ideas and techniques. Not only was the status of current research presented, but also the relevant background, much of which is not yet available in books. The following topics and interconnections among them were discussed: 1. Real and Complex Potential Theory. Capacity and approximation, basic prop erties of plurisubharmonic functions and methods to manipulate their singularities and study their growth, Green functions, Chebyshev-type quadratures, electrostatic fields and potentials, propagation of smallness. 2. Complex Dynamics. Review of complex dynamics in one variable, Julia sets, Fatou sets, background in several variables, Henon maps, ergodicity, use of potential theory and multifunctions. 3. Banach Algebras and Infinite Dimensional Holomorphy. Analytic multi functions, spectral theory, analytic functions on a Banach space, semigroups of holomor phic isometries, Pick interpolation on uniform algebras and Von Neumann inequalities for operators on a Hilbert space. The basic notion of complex potential theory is that of a plurisubharmonic function.

Progress in the Chemistry of Organic Natural Products 118

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030920305
Total Pages : 183 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 118 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 118 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2022-04-13 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of several fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.

Progress in the Chemistry of Organic Natural Products 111

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030378659
Total Pages : 158 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 111 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 111 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-02-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.

Progress in the Chemistry of Organic Natural Products 110

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030146324
Total Pages : 274 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 110 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 110 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2019-10-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.

Progress in the Chemistry of Organic Natural Products Vol. 94

Author : A. Douglas Kinghorn
Publisher : Springer Science & Business Media
ISBN 13 : 3709107482
Total Pages : 269 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products Vol. 94 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products Vol. 94 written by A. Douglas Kinghorn and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.

Progress in the Chemistry of Organic Natural Products 114

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030594440
Total Pages : 341 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 114 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 114 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2021-04-01 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.

Progress in the Chemistry of Organic Natural Products 100

Author : A. D. Kinghorn
Publisher : Springer
ISBN 13 : 3319052756
Total Pages : 602 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 100 by : A. D. Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 100 written by A. D. Kinghorn and published by Springer. This book was released on 2014-11-17 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Progress in the Chemistry of Organic Natural Products 107

Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3319935062
Total Pages : 168 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 107 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 107 written by A. Douglas Kinghorn and published by Springer. This book was released on 2018-09-03 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first review describes examples of very promising compounds discovered from plants acquired from Africa, Southeast Asia, the Americas, and the Caribbean region with potential anticancer activity. These include plant secondary metabolites of the diphyllin lignan, penta[b]benzofuran, triterpenoid, and tropane alkaloid types. The second review presents 40 more erythrinan alkaloids, which were either new or were missed out in the last major reviews, bringing to a total of 154 known erythrinan alkaloids known to date. The reported pharmacological activities of the new and known alkaloids showed a greater bias towards central nervous system and related activities. Other prominent activities reported were antifeedant or insecticidal, cytotoxicity/antitumor/anticancer/estrogenic, antiprotozoal, antiinflammatory, antioxidant, antifungal and antiviral activities.

Progress in the Chemistry of Organic Natural Products 112

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030529665
Total Pages : 212 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 112 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 112 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-12-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter describes the oldest method of communication between living systems in Nature, the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process - allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely, kind of allelochemicals have been investigated, as well as their releasing mechanisms and their purpose, are described in this chapter. The second chapter is focused on the natural products obtained from Hypericum L., a genus of the family Hypericaceae within the dicotyledones. Hypericum has been valued for its important biological and chemical properties and its use in the treatment of depression and as an antibacterial has been well documented in primary literature and ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents and biological effects of this genus. A comprehensive account of the chemical constituents including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects. The third chapter addresses microtubule stabilizers, which are a mainstay in the treatment of many solid cancers and are often used in combination with molecularly targeted anticancer agents and immunotherapeutics. The taccalonolides are a unique class of such microtubule stabilizers isolated from plants of Tacca species that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule stabilizing activity of the taccalonolides is independent of direct tubulin binding, additional studies have found that potent C-22,23 epoxidated taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule stabilizing activity. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction and the opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.

Progress in the Chemistry of Organic Natural Products 99

Author : A. D. Kinghorn
Publisher : Springer
ISBN 13 : 3319049003
Total Pages : 258 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 99 by : A. D. Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 99 written by A. D. Kinghorn and published by Springer. This book was released on 2014-08-11 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Progress in the Chemistry of Organic Natural Products 104

Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3319456180
Total Pages : 252 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 104 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 104 written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-01-25 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.

Progress in the Chemistry of Organic Natural Products 108

Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3030010996
Total Pages : 301 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 108 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 108 written by A. Douglas Kinghorn and published by Springer. This book was released on 2019-03-28 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories. The most relevant phytochemical and pharmacological profiles of a selected group of plants used widely for treating major national health problems are described. The second contribution provides a detailed survey of the so far reported literature data on the capacities of selected oxyprenylated phenylpropanoids and polyketides to trigger receptors, enzymes, and other types of cellular factors for which they exhibit a high degree of affinity and therefore evoke specifice responses. And the third contribution discusses aspects of endophytic actinobacterial biology and chemistry, including biosynthesis and total synthesis of secondary metabolites produced in culture. It also presents perspectives fo the future of microbial biodiscovery, with emphasis on the seondary metabolism of endophytic actinobacteria.

Progress in the Chemistry of Organic Natural Products 106

Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3319595423
Total Pages : 309 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 106 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 106 written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-07-30 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution presents coumarins, the largest group of 1-benzopyran derivatives found in plants. Coumarin chemistry remains one of the major interest areas of phytochemists, especially because of their structural diversity and medicinal properties, along with the wide-ranging bioactivities of these compounds, inclusive of analgesic, anticoagulant anti-HIV, anti-inflammatory, antimicrobial, antineoplastic, antioxidant, and immunomodulatory effects. The second contribution presents a comprehensive survey of the many aspects of PAD biochemistry and physiology. The third contribution gives a comprehensive overview of secondary metabolites from higher fungi, with more than 700 references highlighting the isolation, structure elucidation, biological activities, chemical synthesis, and biosynthesis of pigments, nitrogen-containing compounds, and terpenoids from mushrooms.

Progress in the Chemistry of Organic Natural Products 122

Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3031267680
Total Pages : 298 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 122 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 122 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2023-07-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights some recent developments on plants used widely as botanical dietary supplements and herbal medicines, especially in terms of knowledge of the chemical types and diverse biological activities of their constituents, as well as laboratory approaches for their quality control and taxonomic identification. In the first chapter, the biologically active secondary metabolites are described of selected botanicals that have a wide current use in the United States, with recent information provided also on their in vitro and in vivo biological activities. The second chapter constitutes an updated survey of the different chromatographic, spectroscopic, and metabolomics techniques that can be utilized for the quality control of botanical products. The penultimate chapter covers different nomenclatural systems that are of use for the taxonomic identification of source plants used in botanical products. Finally, deoxyribonucleic acid molecular barcoding techniques for the identification for plants used as dietary supplements are covered.

Progress in the Chemistry of Organic Natural Products 105

Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 331949712X
Total Pages : 221 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products 105 by : A. Douglas Kinghorn

Download or read book Progress in the Chemistry of Organic Natural Products 105 written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-02-13 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.