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Author : A. Douglas Kinghorn
Publisher :
ISBN 13 : 9783319049014
Total Pages : 260 pages
Book Rating : 4.0/5 (49 download)
Download or read book Progress in the Chemistry of Organic Natural Products 99 written by A. Douglas Kinghorn and published by . This book was released on 2014-08-31 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. D. Kinghorn
Publisher :
ISBN 13 : 9788875487065
Total Pages : 258 pages
Book Rating : 4.4/5 (87 download)
Download or read book Progress in the Chemistry of Organic Natural Products 99 written by A. D. Kinghorn and published by . This book was released on 2014 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author : A. D. Kinghorn
Publisher : Springer
ISBN 13 : 3319049003
Total Pages : 245 pages
Book Rating : 4.3/5 (19 download)
Download or read book Progress in the Chemistry of Organic Natural Products 99 written by A. D. Kinghorn and published by Springer. This book was released on 2014-08-11 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, Laszlo Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The series has featured contributions by seven Nobel laureates: D.H.R. Barton, D. Crowfoot Hodgkin, L. Pauling, K. Alder, O. Diels, P. Karrer, H. von Euler-Chelpin. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in the field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3709187591
Total Pages : 262 pages
Book Rating : 4.7/5 (91 download)
Download or read book Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030146324
Total Pages : 271 pages
Book Rating : 4.0/5 (31 download)
Download or read book Progress in the Chemistry of Organic Natural Products 110 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2019-10-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3031267680
Total Pages : 298 pages
Book Rating : 4.0/5 (312 download)
Download or read book Progress in the Chemistry of Organic Natural Products 122 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2023-07-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights some recent developments on plants used widely as botanical dietary supplements and herbal medicines, especially in terms of knowledge of the chemical types and diverse biological activities of their constituents, as well as laboratory approaches for their quality control and taxonomic identification. In the first chapter, the biologically active secondary metabolites are described of selected botanicals that have a wide current use in the United States, with recent information provided also on their in vitro and in vivo biological activities. The second chapter constitutes an updated survey of the different chromatographic, spectroscopic, and metabolomics techniques that can be utilized for the quality control of botanical products. The penultimate chapter covers different nomenclatural systems that are of use for the taxonomic identification of source plants used in botanical products. Finally, deoxyribonucleic acid molecular barcoding techniques for the identification for plants used as dietary supplements are covered.
Author : A. Andersen
Publisher : Springer Science & Business Media
ISBN 13 : 9783211828502
Total Pages : 382 pages
Book Rating : 4.8/5 (285 download)
Download or read book Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by A. Andersen and published by Springer Science & Business Media. This book was released on 1997-05-28 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author : A. D. Kinghorn
Publisher : Springer
ISBN 13 : 3319052756
Total Pages : 588 pages
Book Rating : 4.3/5 (19 download)
Download or read book Progress in the Chemistry of Organic Natural Products 100 written by A. D. Kinghorn and published by Springer. This book was released on 2014-11-17 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author : P. R. Ashurst
Publisher : Springer Science & Business Media
ISBN 13 : 370918164X
Total Pages : 362 pages
Book Rating : 4.7/5 (91 download)
Download or read book Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie Organischer Naturstoffe / Progrès dans la Chimie des Substances Organiques Naturelles written by P. R. Ashurst and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mit Beiträgen zahlreicher Fachwissenschaftler
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030805603
Total Pages : 265 pages
Book Rating : 4.0/5 (38 download)
Download or read book Progress in the Chemistry of Organic Natural Products 116 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2021-10-26 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes several highly diverse subjects: Chapter 1 explores marine biodiscovery of the North-eastern Atlantic off the coast of Ireland as a model for best practice in research. The second chapter investigates Brazilian Chemical Ecology and examples of insect-plant communication studies that are mediated by natural products demonstrate the beautiful interconnectedness of species in a biome. Our third chapter comprises the advances in the science of the sesquiterpene quinone, perezone, which in 1852 was the first natural product isolated in crystalline form in the New World. The last two chapters are from a Vietnamese group and the first of these follows the phytochemistry, pharmacology, and ethnomedical uses of the genus Xanthium, which produces interesting sulfur and nitrogen containing natural products. Finally, the genus Desmos is discussed, where an overview of its constituent natural products and their in vitro pharmacological potential is described.
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030594440
Total Pages : 341 pages
Book Rating : 4.0/5 (35 download)
Download or read book Progress in the Chemistry of Organic Natural Products 114 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2021-04-01 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes current understandings and recent progress in four areas: in the first one, the cytochalasans, a group of fungal derived natural products characterized by a perhydro-isoindolone core fused with a macrocyclic ring are shown to exhibit high structural diversity and a broad spectrum of bioactivities. The second one is dedicated to a description of bioactive compounds from the medicinal plants of Myanmar, the third one is dedicated to new structure elucidation techniques in the field of sesquiterpenes. The last one discusses the endogenous natural products that are produced by human cells including endogenous amines, steroids, and fatty acid derived natural products. The co-metabolism and natural product production of the human microbiome is also described including tryptophan, bile acids, choline, and cysteine.
Author : A. Douglas Kinghorn
Publisher : Springer Science & Business Media
ISBN 13 : 9783709107485
Total Pages : 254 pages
Book Rating : 4.1/5 (74 download)
Download or read book Progress in the Chemistry of Organic Natural Products Vol. 94 written by A. Douglas Kinghorn and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.
Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3319456180
Total Pages : 246 pages
Book Rating : 4.3/5 (194 download)
Download or read book Progress in the Chemistry of Organic Natural Products 104 written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-01-25 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available. Thus, the apolar compounds are divided in linear and branched alkanes followed by alicyclic compounds and aromatic and heterocyclic molecules, and, in particular, the geoporphyrins. The polar molecular fossils contain as functional groups or constituent units ethers, alcohols, phenols, carbonyl groups, flavonoids, quinones, and acids, or are polymers like kerogen, amber, melanin, proteins, or nucleic acids. The final sections discuss the methodology used and the fundamental processes encountered by the biomolecules described, including diagenesis, catagenesis, and metagenesis. The second contribution covers the distribution of phthalides in nature and the findings in the structural diversity, chemical reactivity, biotransformations, syntheses, and bioactivity of natural and semisynthetic phthalides.
Author : S. Hunek
Publisher : Springer Science & Business Media
ISBN 13 : 9783211835180
Total Pages : 348 pages
Book Rating : 4.8/5 (351 download)
Download or read book Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products written by S. Hunek and published by Springer Science & Business Media. This book was released on 2001-02-22 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.
Author : A. Douglas Kinghorn
Publisher : Springer
ISBN 13 : 3319331728
Total Pages : 252 pages
Book Rating : 4.3/5 (193 download)
Download or read book Progress in the Chemistry of Organic Natural Products 102 written by A. Douglas Kinghorn and published by Springer. This book was released on 2016-07-05 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030920305
Total Pages : 183 pages
Book Rating : 4.0/5 (39 download)
Download or read book Progress in the Chemistry of Organic Natural Products 118 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2022-04-13 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of several fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.
Author : A. Douglas Kinghorn
Publisher : Springer Nature
ISBN 13 : 3030529665
Total Pages : 212 pages
Book Rating : 4.0/5 (35 download)
Download or read book Progress in the Chemistry of Organic Natural Products 112 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-12-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter describes the oldest method of communication between living systems in Nature, the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process - allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely, kind of allelochemicals have been investigated, as well as their releasing mechanisms and their purpose, are described in this chapter. The second chapter is focused on the natural products obtained from Hypericum L., a genus of the family Hypericaceae within the dicotyledones. Hypericum has been valued for its important biological and chemical properties and its use in the treatment of depression and as an antibacterial has been well documented in primary literature and ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents and biological effects of this genus. A comprehensive account of the chemical constituents including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects. The third chapter addresses microtubule stabilizers, which are a mainstay in the treatment of many solid cancers and are often used in combination with molecularly targeted anticancer agents and immunotherapeutics. The taccalonolides are a unique class of such microtubule stabilizers isolated from plants of Tacca species that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule stabilizing activity of the taccalonolides is independent of direct tubulin binding, additional studies have found that potent C-22,23 epoxidated taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule stabilizing activity. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction and the opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.
