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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Douglas R. Green
Publisher :
ISBN 13 : 9781621822141
Total Pages : 0 pages
Book Rating : 4.8/5 (221 download)
Download or read book Cell Death written by Douglas R. Green and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A million cells in our bodies die every second--they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer. In this second edition of Douglas Green's essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer. The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.
Author : Michael D. Jacobson
Publisher : Frontiers in Molecular Biology
ISBN 13 : 9780199638499
Total Pages : 366 pages
Book Rating : 4.6/5 (384 download)
Download or read book Apoptosis written by Michael D. Jacobson and published by Frontiers in Molecular Biology. This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of cells within the human body is very tightly regulated: too many and we can develop cancer, too few and we may lose cells that we cannot replace. The number of cells is controlled by several different mechanisms in different tissues, but all are triggered to commit suicide should too many be in one place at one time, or become damaged. This book examines how this process of cell suicide (apoptosis) is regulated, and how our understanding of this process may lead to novel treatments for a wide variety of human diseases.
Author : James A. Radosevich
Publisher : John Wiley & Sons
ISBN 13 : 1119432359
Total Pages : 768 pages
Book Rating : 4.1/5 (194 download)
Download or read book Apoptosis and Beyond written by James A. Radosevich and published by John Wiley & Sons. This book was released on 2018-09-18 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.
Author : Yusuf Tutar
Publisher : BoD – Books on Demand
ISBN 13 : 1789235006
Total Pages : 162 pages
Book Rating : 4.7/5 (892 download)
Download or read book Current Understanding of Apoptosis written by Yusuf Tutar and published by BoD – Books on Demand. This book was released on 2018-08-29 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is an essential biochemical process in cell turnover, development, and chemical-induced cell death. Current knowledge and ongoing research of apoptosis highlight our understanding in designing the therapeutic approaches for several diseases. This book covers four main sections: "Apoptosis and Necrosis," "Apoptosis Inducers," "Proteasome and Signaling Pathways in Apoptosis," and "Radiation-Based Apoptosis." The first section implicitly describes the differences between apoptosis and necrosis processes. The following section elaborates the small molecule-induced apoptosis. Then, the third section deals with proteasome and signaling pathways and finally, resistance to chemotherapy and electromagnetic radiation is covered in the last section. Overall, the book deals with pathways for manipulating apoptosis and provides a unique perspective to the scientists.
Author : C. S. Potten
Publisher : Cambridge University Press
ISBN 13 : 9780521626798
Total Pages : 240 pages
Book Rating : 4.6/5 (267 download)
Download or read book Apoptosis written by C. S. Potten and published by Cambridge University Press. This book was released on 2004-08-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.
Author : Shigekazu Nagata
Publisher : Springer
ISBN 13 : 3319239139
Total Pages : 186 pages
Book Rating : 4.3/5 (192 download)
Download or read book Apoptotic and Non-apoptotic Cell Death written by Shigekazu Nagata and published by Springer. This book was released on 2017-04-07 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.
Author : Carlos López-Larrea
Publisher : Springer Science & Business Media
ISBN 13 : 1461416809
Total Pages : 338 pages
Book Rating : 4.4/5 (614 download)
Download or read book Self and Nonself written by Carlos López-Larrea and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.
Author : John Gray
Publisher : Wiley-Blackwell
ISBN 13 : 9781841274201
Total Pages : 287 pages
Book Rating : 4.2/5 (742 download)
Download or read book Programmed Cell Death in Plants written by John Gray and published by Wiley-Blackwell. This book was released on 2004 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recognition of cell death as an active process has changed the way in which biologists view living things. Geneticists re-evaluate long known mutants, research strategies are redesigned, and new model systems are sought. This volume reviews our new understanding of programmed cell death as it applies to plants. The book draws comparisons with programmed cell death in animals and unicellular organisms. The book is directed at researchers and professionals in plant cell biology, biochemistry, physiology, developmental biology and genetics.
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Arunika N. Gunawardena
Publisher : Springer
ISBN 13 : 3319210335
Total Pages : 306 pages
Book Rating : 4.3/5 (192 download)
Download or read book Plant Programmed Cell Death written by Arunika N. Gunawardena and published by Springer. This book was released on 2015-10-08 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Programmed cell death (PCD) is a genetically encoded, active process which results in the death of individual cells, tissues, or whole organs. PCD plays an essential role in plant development and defense, and occurs throughout a plant’s lifecycle from the death of the embryonic suspensor to leaf and floral organ senescence. In plant biology, PCD is a relatively new research area, however, as its fundamental importance is further recognized, publications in the area are beginning to increase significantly. The field currently has few foundational reference books and there is a critical need for books that summarizes recent findings in this important area. This book contains chapters written by several of the world’s leading researchers in PCD. This book will be invaluable for PhD or graduate students, or for scientists and researchers entering the field. Established researchers will also find this timely work useful as an up-to-date overview of this fascinating research area.
Author : Richard A. Lockshin
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 578 pages
Book Rating : 4.3/5 (91 download)
Download or read book When Cells Die II written by Richard A. Lockshin and published by Wiley-Liss. This book was released on 2004 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers the most thorough, cutting-edge coverage of the field of cell death since publication of the first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised, this new edition features relavant discussions of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; and evolution of mechanisms.
Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)
Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author : Christopher D. Gregory
Publisher : Springer
ISBN 13 : 3319394061
Total Pages : 260 pages
Book Rating : 4.3/5 (193 download)
Download or read book Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy written by Christopher D. Gregory and published by Springer. This book was released on 2016-08-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : Han-Ming Shen
Publisher : Springer Science & Business Media
ISBN 13 : 1461482208
Total Pages : 402 pages
Book Rating : 4.4/5 (614 download)
Download or read book Necrotic Cell Death written by Han-Ming Shen and published by Springer Science & Business Media. This book was released on 2014-03-29 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
Author : Seamus J. Martin
Publisher : R G Landes Company
ISBN 13 : 9781570594526
Total Pages : 265 pages
Book Rating : 4.5/5 (945 download)
Download or read book Apoptosis and Cancer written by Seamus J. Martin and published by R G Landes Company. This book was released on 1997 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
