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Author : Andrea Jean VonTom
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.3/5 (129 download)
Download or read book Processivity of Mitochondrial DNA Polymerase from Drosophila Embryos written by Andrea Jean VonTom and published by . This book was released on 1994 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Catherine Marie Wernette
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.3/5 (129 download)
Download or read book Mitochondrial DNA Polymerase from Drosophila Melanogaster Embryos written by Catherine Marie Wernette and published by . This book was released on 1988 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew Wayne Olson
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.3/5 (129 download)
Download or read book 3'-5' Exonuclease in Drosophila Mitochondrial DNA Polymerase written by Matthew Wayne Olson and published by . This book was released on 1991 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carol Lynn Farr
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.3/5 (129 download)
Download or read book Drosophila Pol and Its Recombinant Catalytic and Accessory Subunits written by Carol Lynn Farr and published by . This book was released on 1997 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Stuart
Publisher : BoD – Books on Demand
ISBN 13 : 953510991X
Total Pages : 502 pages
Book Rating : 4.5/5 (351 download)
Download or read book The Mechanisms of DNA Replication written by David Stuart and published by BoD – Books on Demand. This book was released on 2013-02-20 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.
Author : Anita Göndör
Publisher : Academic Press
ISBN 13 : 0128034025
Total Pages : 496 pages
Book Rating : 4.1/5 (28 download)
Download or read book Chromatin Regulation and Dynamics written by Anita Göndör and published by Academic Press. This book was released on 2016-10-25 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes
Author : William C. Copeland
Publisher : Springer Science & Business Media
ISBN 13 : 1592592848
Total Pages : 415 pages
Book Rating : 4.5/5 (925 download)
Download or read book Mitochondrial DNA written by William C. Copeland and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease.
Author : David Lawrence Lewis
Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (129 download)
Download or read book A+T Regulatory Region of the Drosophila Melanogaster Mitochondrial Genome written by David Lawrence Lewis and published by . This book was released on 1994 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Giovanni Maga
Publisher : World Scientific
ISBN 13 : 9813226420
Total Pages : 398 pages
Book Rating : 4.8/5 (132 download)
Download or read book Human Dna Polymerases: Biology, Medicine And Biotechnology written by Giovanni Maga and published by World Scientific. This book was released on 2017-11-10 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, next generation sequencing, nucleic acids based diagnostics and in techniques to analyze ancient and otherwise damaged DNA (e.g. for forensic applications). Moreover, some diseases are related to DNA polymerase defects and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. This book focuses on (i) biology of DNA polymerases, (ii) medical aspects of DNA polymerases and (iii) biotechnological applications of DNA polymerases. It is intended for a wide audience from basic scientists, to diagnostic laboratories, to companies and to clinicians, who seek a better understanding and the practical use of these fascinating enzymes.
Author : Patrick Lestienne
Publisher : Springer Science & Business Media
ISBN 13 : 3642598846
Total Pages : 397 pages
Book Rating : 4.6/5 (425 download)
Download or read book Mitochondrial Diseases written by Patrick Lestienne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: For those like me who witnessed the beginning of the adventure of human mitochon drial pathology, one can only be astounded by the extent and unexpectedness of what the field has come to offer. Extent because nobody could have imagined the sheer size of the domain. Unexpectedness because hitherto it was impossible to imagine the clinical polymorphism that this pathology would represent. The starting point was clear. Initially, there was the exceptional, and for a long time unique, observation of euthyroidian hypermetabolism that Luft and colleagues analyzed remarkably in biochemical and clinical terms. Thereafter, there was the support provided by the electron microscopy studies of Afzelius, and the very first visualization of mitochondrial abnormalities. That was way back in 1958. A few years later, progress in the cytology and cytochemistry of skeletal muscle tissue was to provide the means of detecting such abnormalities by examining sections with light microscopy. The colorful term "ragged red fibers", coined by W. K. Engel, became uni versally accepted, and this typical aspect with Gomori trichrome stain was to throw light on the frequency with which these mitochondrial abnormalities could occur under pathological conditions which, until then, had remained a total mystery regard ing their mechanism: syndromes such as the ocular myopathies with their descending evolution and the oculocraniosomatic syndromes. We were at the beginning of the 1970s.
Author : Melvin L. DePamphilis
Publisher : CSHL Press
ISBN 13 : 9780879694593
Total Pages : 1080 pages
Book Rating : 4.6/5 (945 download)
Download or read book DNA Replication in Eukaryotic Cells written by Melvin L. DePamphilis and published by CSHL Press. This book was released on 1996 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.
Author : Giuseppe Gasparre
Publisher : Academic Press
ISBN 13 : 0128226420
Total Pages : 596 pages
Book Rating : 4.1/5 (282 download)
Download or read book The Human Mitochondrial Genome written by Giuseppe Gasparre and published by Academic Press. This book was released on 2020-07-23 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists
Author : Li Fan
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.3/5 (129 download)
Download or read book Homology Modeling of the Accessory Subunit of Drosophila Mitochondrial DNA Polymerase and Subunit Interaction Studies written by Li Fan and published by . This book was released on 2000 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1828 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 146144599X
Total Pages : 495 pages
Book Rating : 4.4/5 (614 download)
Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Author : Anthony Schapira
Publisher : Elsevier
ISBN 13 : 0080489079
Total Pages : 581 pages
Book Rating : 4.0/5 (84 download)
Download or read book Mitochondrial Function and Dysfunction written by Anthony Schapira and published by Elsevier. This book was released on 2003-01-10 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease. * Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases* Includes outstanding list of contributing authors
Author : Fumio Hanaoka
Publisher : Springer
ISBN 13 : 443155873X
Total Pages : 548 pages
Book Rating : 4.4/5 (315 download)
Download or read book DNA Replication, Recombination, and Repair written by Fumio Hanaoka and published by Springer. This book was released on 2016-01-22 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
