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Author : Carsten Voß
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (837 download)
Download or read book Processes for the Production of Pharmaceutical Grade Plasmid DNA written by Carsten Voß and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Odalys Ruiz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)
Download or read book Scalable Technology to Produce Pharmaceutical Grade Plasmid DNA for Gene Therapy written by Odalys Ruiz and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Scalable Technology to Produce Pharmaceutical Grade Plasmid DNA for Gene Therapy.
Author : Odalys Ruiz
Publisher :
ISBN 13 : 9789533076171
Total Pages : pages
Book Rating : 4.0/5 (761 download)
Download or read book Scalable Technology to Produce Pharmaceutical Grade Plasmid DNA for Gene Therapy written by Odalys Ruiz and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Duarte Miguel F. Prazeres
Publisher : John Wiley & Sons
ISBN 13 : 1118002253
Total Pages : 465 pages
Book Rating : 4.1/5 (18 download)
Download or read book Plasmid Biopharmaceuticals written by Duarte Miguel F. Prazeres and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the basics, applications, and manufacturing of plasmid biopharmaceuticals. The survey of the most relevant characteristics of plasmids provides the basics for designing plasmid products (applications) and processes (manufacturing). Key features that the authors include in the book are: i) consistency and clear line of direction, ii) an extensive use of cross-referencing between the individual chapters, iii) a rational integration of chapters, iv) appellative figures, tables and schemes, and v) an updated, but selected choice of references, with a focus on key papers.
Author : Monica Rinaldi
Publisher : Humana
ISBN 13 : 9781493946532
Total Pages : 0 pages
Book Rating : 4.9/5 (465 download)
Download or read book DNA Vaccines written by Monica Rinaldi and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Vaccines: Methods and Protocols, Third Edition explores innovative approaches and technologies used to design, deliver, and enhance the efficacy of DNA vaccines. Featuring applications which should be of great value in moving vaccines from research to clinic, this detailed volume includes sections on DNA vaccine design and enhancement, delivery systems, production, purification, and quality, as well as chapters on new vaccine applications. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, DNA Vaccines: Methods and Protocols, Third Edition serves the important role of further documenting the potential of the DNA vaccination as a platform technology for treatment and prevention of human disease.
Author : Emily P. Wen
Publisher : John Wiley & Sons
ISBN 13 : 1118870905
Total Pages : 452 pages
Book Rating : 4.1/5 (188 download)
Download or read book Vaccine Development and Manufacturing written by Emily P. Wen and published by John Wiley & Sons. This book was released on 2014-10-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market
Author : Gail K. Sofer
Publisher : Academic Press
ISBN 13 : 1483289176
Total Pages : 89 pages
Book Rating : 4.4/5 (832 download)
Download or read book Process Chromatography written by Gail K. Sofer and published by Academic Press. This book was released on 2015-09-02 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research and development into biological products for therapeutic use has increased dramatically over the last 10 years. With this, strict regulatory requirements have been imposed by authorities such as the U.S. Food & Drug Administration, so that today validation has become a key issue in the biopharmaceutical industry.This concise book addresses validation issues in the chromatography of biotherapeutics. It covers process design, qualification and validation, including an overview of analytical techniques commonly used in the validation of processes. A concluding section comments on product changeover and presents four case studies.
Author : Ganapathy Subramanian
Publisher : John Wiley & Sons
ISBN 13 : 3527653112
Total Pages : 945 pages
Book Rating : 4.5/5 (276 download)
Download or read book Biopharmaceutical Production Technology written by Ganapathy Subramanian and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.
Author : Anurag Singh Rathore
Publisher : CRC Press
ISBN 13 : 1003805469
Total Pages : 413 pages
Book Rating : 4.0/5 (38 download)
Download or read book Process Validation in Manufacturing of Biopharmaceuticals written by Anurag Singh Rathore and published by CRC Press. This book was released on 2023-12-18 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of Process Validation in Manufacturing of Biopharmaceuticals is a practical and comprehensive resource illustrating the different approaches for successful validation of biopharmaceutical processes. A pivotal text in its field, this new edition provides guidelines and current practices, contains industrial case studies, and is expanded to include in-depth analysis of the new Process Validation (PV) guidance from the US FDA. Key Features: Offers readers a thorough understanding of the key concepts that form the basis of a good process validation program for biopharmaceuticals. Includes case studies from the various industry leaders that demonstrate application of these concepts. Discusses the use of modern tools such as multivariate analysis for facilitating a process validation exercise. Covers process characterization techniques for scaling down unit operations in biopharmaceutical manufacturing, including chromatography, chemical modification reactions, ultrafiltration, and microfiltration, and practical methods to test raw materials and in-process samples. Providing a thorough understanding of the key concepts that form the basis of a good process validation program, this book will help readers ensure that PV is carried out and exceeds expectations. Fully illustrated, this is a much-needed practical guide for biopharmaceutical manufacturers.
Author : Martin Schleef
Publisher : John Wiley & Sons
ISBN 13 : 3527670440
Total Pages : 373 pages
Book Rating : 4.5/5 (276 download)
Download or read book Minicircle and Miniplasmid DNA Vectors written by Martin Schleef and published by John Wiley & Sons. This book was released on 2013-02-14 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications. Written by the most prominent academic researchers in the field as well as by researchers at one of the world's leading companies in industrial production of minicircle DNA, this practical book is aimed at everyone who is directly or indirectly involved in the development of gene therapies.
Author : Ralf Pörtner
Publisher : Springer Nature
ISBN 13 : 3031456696
Total Pages : 497 pages
Book Rating : 4.0/5 (314 download)
Download or read book Biopharmaceutical Manufacturing written by Ralf Pörtner and published by Springer Nature. This book was released on 2024-02-11 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume “Cell Engineerring 11 - Biopharmaceutical Manufacturing: Progress, Trends and Challenges” is a source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation. The book comprises contributions of experts from academia and industry active in the field of cell culture development for the production of recombinant proteins, cell therapy and gene therapy, with consideration of Digital Twin ́s and facility design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. Inevitably, some omissions will occur in the test, but the authors have sought to avoid duplications by extensive cross-referencing to chapters in other volumes of this series and elsewhere. We hope the volume provides a useful compendium of techniques for scientists in industrial and research laboratories active in this field.
Author : Wolfgang Walther
Publisher : Springer Science & Business Media
ISBN 13 : 1592590861
Total Pages : 633 pages
Book Rating : 4.5/5 (925 download)
Download or read book Gene Therapy of Cancer written by Wolfgang Walther and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the molecular structure of genes and the unveiling of the molecular basis of numerous human diseases, scientists have been fas- nated with the possibility of treating certain diseases by transducing foreign DNA into the affected cells. Initially, it was proposed that the foreign DNA could either replace defective nonfunctional genes, or code for therapeutic proteins. This concept has evolved into the rapidly growing field of gene therapy. Even though surgery, radiotherapy, and chemotherapy are widely ava- able and routinely used for cancer treatment, these therapies fail to cure approximately 50 percent of cancer patients. Therefore, since it is a disease characterized by aberrant gene expression, cancer has been a target of gene therapy research since the inception of this treatment modality. Numerous cancer gene therapy strategies are currently being investigated, including gene replacement therapy, the regulation of gene expression to modulate immu- logical responses to tumors, the direct killing of tumor cells, and direct int- ference with tumor growth. In this context, gene transfer systems, tumor-specific expression vectors, and novel therapeutic genes have been extensively st- ied. All these strategies aim for the selective destruction of human malignant disease while circumventing the destruction of nonmalignant cells and tissues thereby minimizing toxicity to the patient.
Author : Kathy Barker
Publisher : CSHL Press
ISBN 13 : 9780879697082
Total Pages : 488 pages
Book Rating : 4.6/5 (97 download)
Download or read book At the Bench written by Kathy Barker and published by CSHL Press. This book was released on 2005 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A clue hidden in a toy ship leads Tintin on a dangerous treasure hunt.
Author : Didier Trono
Publisher : Springer Science & Business Media
ISBN 13 : 9783540421900
Total Pages : 276 pages
Book Rating : 4.4/5 (219 download)
Download or read book Lentiviral Vectors written by Didier Trono and published by Springer Science & Business Media. This book was released on 2001-12-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time a compilation of chapters that depict the biological bases underlying the development of lentiviral vectors, the techniques involved in the manufacture of this new gene delivery tool, and its most promising applications.
Author : David Summers
Publisher : John Wiley & Sons
ISBN 13 : 1444313738
Total Pages : 169 pages
Book Rating : 4.4/5 (443 download)
Download or read book The Biology of Plasmids written by David Summers and published by John Wiley & Sons. This book was released on 2009-07-17 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasmids are closed, circular pieces of DNA that are able to self-replicate and are carried by many bacteria. They provide unique functions for bacteria by allowing them to sexually replicate and to pass on genetic material between each other. Plasmids are also responsible for the genetic factors that give resistance to antibiotics, and provide the enzymes needed to break down poorly metabolised food resources. The author has provided an updated treatment of the structure, function and application of plasmids suitable for undergraduates and medical students. Employing an original teaching perspective--examining plasmids as living organisms with either a symbiotic or parasitic mode of survival--this text provides an important framework for understanding the structure and function of plasmids in an evolutionary context. The most up to date text on plasmids An innovative teaching perspective makes for easy student understanding Contains crucial chapters on the importance of plasmids for clinical and biological research
Author : Mark W. Saltzman
Publisher : Springer Science & Business Media
ISBN 13 : 1597451681
Total Pages : 382 pages
Book Rating : 4.5/5 (974 download)
Download or read book DNA Vaccines written by Mark W. Saltzman and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged. The conventional method of vaccination required delivery of whole pathogens or structural subunits, but in this new approach, DNA or genetic information was administered to elicit an immunological response. Once it was observed that plasmid DNA delivered in vivo led to production of an encoded transgene (1), two ground-breaking studies demonstrated that immunological responses could be generated against antigenic transgenes via plasmid DNA delivered by DNA vaccination (as this approach is called) (2,3). The appe- ance of this new vaccination strategy coincided with advances in molecular biology, which provided new tools to study and manipulate the basic elements of an organism’s genome and also could also be applied to the design and production of DNA vaccines. DNA Vaccines is a major updated and enhancement of the first edition. It reviews state-of-the-art methods in DNA vaccine technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current appli- tions, methods of production, and quality control. Consistent with the approach of the Methods in Molecular Medicine series, these chapters contain detailed practical procedures on the latest DNA vaccine technology. The enthusiasm for DNA vaccine technology is made clear by the number of research studies published on this topic since the mid-1990s.
Author : Daan J. A. Crommelin
Publisher : CRC Press
ISBN 13 : 9780415285018
Total Pages : 456 pages
Book Rating : 4.2/5 (85 download)
Download or read book Pharmaceutical Biotechnology written by Daan J. A. Crommelin and published by CRC Press. This book was released on 2002-11-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
