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Principles And Procedures For Evaluating The Toxicity Of Household Substances
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Author :National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances Publisher : ISBN 13 : Total Pages :148 pages Book Rating :4.1/5 (384 download)
Book Synopsis Principles and Procedures for Evaluating the Toxicity of Household Substances by : National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances
Download or read book Principles and Procedures for Evaluating the Toxicity of Household Substances written by National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances and published by . This book was released on 1977 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis PRINCIPLES AND PROCEDURES FOR EVALUATING THE TOXICITY OF HOUSEHOLD SUBSTANCES. by :
Download or read book PRINCIPLES AND PROCEDURES FOR EVALUATING THE TOXICITY OF HOUSEHOLD SUBSTANCES. written by and published by . This book was released on 1977 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Principles and Procedures for Evaluating the Toxicity of Household Substances by : National Research Council (U.S.). Committee on Toxicology
Download or read book Principles and Procedures for Evaluating the Toxicity of Household Substances written by National Research Council (U.S.). Committee on Toxicology and published by . This book was released on 1964 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academy of Sciences, United States. National Research Council. Committee on Toxicology Publisher : ISBN 13 : Total Pages :35 pages Book Rating :4.:/5 (16 download)
Book Synopsis Principles and Procedures for Evaluating the Toxicity of Household Substances by : National Academy of Sciences, United States. National Research Council. Committee on Toxicology
Download or read book Principles and Procedures for Evaluating the Toxicity of Household Substances written by National Academy of Sciences, United States. National Research Council. Committee on Toxicology and published by . This book was released on 1964 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Principles and Methods of Toxicology, Fifth Edition by : A. Wallace Hayes
Download or read book Principles and Methods of Toxicology, Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Download or read book Code of Federal Regulations written by and published by . This book was released on 2002 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Special edition of the Federal Register, containing a codification of documents of general applicability and future effect ... with ancillaries.
Book Synopsis Hayes' Principles and Methods of Toxicology by : A. Wallace Hayes
Download or read book Hayes' Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Book Synopsis The Code of Federal Regulations of the United States of America by :
Download or read book The Code of Federal Regulations of the United States of America written by and published by . This book was released on 1994 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Code of Federal Regulations is the codification of the general and permanent rules published in the Federal Register by the executive departments and agencies of the Federal Government.
Book Synopsis Integrated Safety and Risk Assessment for Medical Devices and Combination Products by : Shayne C. Gad
Download or read book Integrated Safety and Risk Assessment for Medical Devices and Combination Products written by Shayne C. Gad and published by Springer Nature. This book was released on 2020-02-24 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the safety assessment (“biocompatibility”) of medical devices has been focused on issues of local tissue tolerance (irritation, sensitization, cytotoxicity) and selected quantal effects (genotoxicity and acute lethality) since first being regulated in the late 1950s, this has changed as devices assumed a much more important role in healthcare and became more complex in both composition and in their design and operation. Add to this that devices now frequently serve as delivery systems for drugs, and that drugs may be combined with devices to improve device performance, and the problems of ensuring patient safety with devices has become significantly more complex. A part of this, requirements for ensuring safety (once based on use of previously acceptable materials – largely polymers and metals) have come to requiring determining which chemical entities are potentially released from a device into patients (and how much is released). Then an appropriate and relevant (yet also conservative) risk assessment must be performed for each identified chemical structure. The challenges inherent in meeting the current requirements are multifold, and this text seeks to identify, understand, and solve all of them. • Identify and verify the most appropriate available data. • As in most cases such data is for a different route of exposure, transform it for use in assessing exposure by the route of interest. • As the duration (and rate) of exposure to moieties released from a device are most frequently different (longer) than what available data speaks to, transformation across tissue is required. • As innate and adaptive immune responses are a central part of device/patient interaction, assessing potential risks on this basis are required. • Incorporating assessments for special populations such as neonates. • Use of (Q)SAR (Quantitative Structure Activity Relationships) modeling in assessments. • Performance and presentation of integrative assessments covering all potential biologic risks. Appendices will contain summarized available biocompatibility data for commonly used device materials (polymers and metals) and safety assessments on the frequently seen moieties in extractions from devices.
Book Synopsis DERMATOTOXICOLOGY 4ED by : Francis Nicholas Marzulli
Download or read book DERMATOTOXICOLOGY 4ED written by Francis Nicholas Marzulli and published by CRC Press. This book was released on 1991-06-01 with total page 1978 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the field of dermatotoxicology. This edition includes fundamental information on the mechanisms of action of toxic substances on skin as well as practical information on the varied responses of skin to specific toxic substances and approaches to evaluating dermal toxicity. Other topics discussed include: hostile natural elements, such as ultraviolet radiation, poisonous plants, man-made detergents and chemicals; problems associated with chronic occupational skin exposure to toxic chemicals; animal alternative research programmes; carcinogenic and Photo Carcinogenic Potential Of Xenobiotic Chemicals; Oculotoxicity; Risk assessment and management; and cosmetic safety. Anatomical factors affecting barrier functions/ lipids of the permeability barrier/the skin immune system.
Download or read book Federal Register written by and published by . This book was released on 1979-07 with total page 2204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Product Safety Evaluation Handbook, Second Edition by : Shayne C. Gad
Download or read book Product Safety Evaluation Handbook, Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 1999-07-02 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides comprehensive, single-source coverage of the latest toxicity testing requirements and methods for personal care products, industrial and agricultural chemicals, and consumer goods. Second Edition, contains a new chapter on toxicokinetic testing and modeling, offers the latest solutions to common problems in testing and risk assessment, supplies an updated bibliography and more than 1300 references-over 100 new to this edition, and more."
Book Synopsis Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards by : K.S. Khera
Download or read book Interpretation and Extrapolation of Reproductive Data to Establish Human Safety Standards written by K.S. Khera and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (!LSI) is a scientific foundation that addresses critical health and safety issues of national and international con cern. ILSI promotes international cooperation by providing the mechanism for scientists from government, industry, and universities to work together on cooperative programs to generate and disseminate scientific data. The mem bers and trustees of the institute believe that questions regarding health and safety are best resolved when scientists can examine and discuss issues as an independent body separate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refine ment of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have mainly been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results to humans. Publicity surrounding toxicologic issues makes it difficult for governments to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government, and industry with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.
Book Synopsis Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants by : Rhoda G.M. Wang
Download or read book Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants written by Rhoda G.M. Wang and published by CRC Press. This book was released on 2017-11-22 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.
Book Synopsis Handbook of Developmental Toxicology by : Ronald D. Hood
Download or read book Handbook of Developmental Toxicology written by Ronald D. Hood and published by CRC Press. This book was released on 1996-10-23 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 410: Repeated Dose Dermal Toxicity: 21/28-day Study written by OECD and published by OECD Publishing. This book was released on 1981-05-12 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance. This method is composed of two tests: the main test and the limit test. This Test Guideline is intended for use with the adult rat ...
Author :United States. Environmental Protection Agency. Library Systems Branch Publisher : ISBN 13 : Total Pages :702 pages Book Rating :4.3/5 (121 download)
Book Synopsis U.S. Environmental Protection Agency Library System Book Catalog Holdings as of July 1973 by : United States. Environmental Protection Agency. Library Systems Branch
Download or read book U.S. Environmental Protection Agency Library System Book Catalog Holdings as of July 1973 written by United States. Environmental Protection Agency. Library Systems Branch and published by . This book was released on 1974 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:
