Predictions for 2013-2014

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Publisher : AuthorHouse
ISBN 13 : 146709420X
Total Pages : 88 pages
Book Rating : 4.4/5 (67 download)

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Book Synopsis Predictions for 2013-2014 by : Kurt B. Bakley

Download or read book Predictions for 2013-2014 written by Kurt B. Bakley and published by AuthorHouse. This book was released on 2011-11-21 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictions for 2013-2014 Will two great earthquakes and tidal waves strike on August 10, 2013 and August 10, 2014, plus or minus three days, or in July- August of 2013-2014? Will wars, terrorist attacks, storms, attacks and volcano eruptions hit at or near those dates and/or July-August of 2013-2014 and 2018-2019? And in December into January, or March-September of 2014-2015 will we see a great flu outbreak and/or a epidemic that kills with sores and fever caused by animals or birds or flying insects? Will there be an airplane crash with the U.S. President in it caused by an accident that happens in July-August or March-April of 2013- 2014, or 2015-2019? Or will airplanes again be used in terrorist attacks flying into buildings in New York City, Philadelphia, Chicago, Los Angeles, Miami or the White House? Some exact dates are given from codes as to exactly when these predictions of these events will happen. In this book you will read about all the documentation of ancient prophecies that predicted these events using codes found in chapter 7 of this book. This book was written by August 29, 2011.

Predictions for 2011-2019

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Publisher : AuthorHouse
ISBN 13 : 1468557599
Total Pages : 110 pages
Book Rating : 4.4/5 (685 download)

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Book Synopsis Predictions for 2011-2019 by : Kurt B. bakley

Download or read book Predictions for 2011-2019 written by Kurt B. bakley and published by AuthorHouse. This book was released on 2012-03-20 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictions for 2011-2019 In this book you will read exactly what the ancient prophecies are predicting for the dates March 12, 2016, March 12, 2017 and March 12, 2018, plus or minus 30 days. Or in July-August of 2011-2019 the predictions could come true noted in this book or my other books. Certain dates of December 4-16, 20-25, January 1-4, 14-24, February 14, 26-29, March-April 12,1, 6, 9-10, 14- 15, 19- 20, 21, 24-25, May 9-10, 19-20, June 9-12, 20-25, 29, 9th of Av, August 2, 10-11, 28-29, September 7-8, 19, 26-27, October 15, 22, 31, November 1-2, 11, 28, Thanksgiving, Hanukah, Purim, Passover, Pentecost, Rosh Hashanah, Yom Kippur, Feast of Tabernacles of 2011-2019 might be exact dates when Israel and the U.S. attacks Iran and Iran attacks back or Iran attacks them. They are all documented by using codes found in my book Predictions for 2013-2014 in chapter seven called The Codes. Will storms, earthquakes, wars, volcano eruptions and tidal waves play apart for the years 2011-2019? Will the years 2014-2016 see Florida again be hit by four storms or one great one like in 1992 and 2004? Are there predictions of great storms, earthquakes, attacks, wars and volcano eruptions, comet or asteroid impacts and tidal waves and commotion's to happen on March 12-April 12, 2016-2018, plus or minus three days or the other dates above in 2011-2019? This book was written by February 14, 2012.

Nostradamus 2014: Prediction, Modeling and Analysis of Complex Systems

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Publisher : Springer
ISBN 13 : 3319074016
Total Pages : 463 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Nostradamus 2014: Prediction, Modeling and Analysis of Complex Systems by : Ivan Zelinka

Download or read book Nostradamus 2014: Prediction, Modeling and Analysis of Complex Systems written by Ivan Zelinka and published by Springer. This book was released on 2014-06-09 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prediction of behavior of complex systems, analysis and modeling of its structure is a vitally important problem in engineering, economy and generally in science today. Examples of such systems can be seen in the world around us (including our bodies) and of course in almost every scientific discipline including such “exotic” domains as the earth’s atmosphere, turbulent fluids, economics (exchange rate and stock markets), population growth, physics (control of plasma), information flow in social networks and its dynamics, chemistry and complex networks. To understand such complex dynamics, which often exhibit strange behavior, and to use it in research or industrial applications, it is paramount to create its models. For this purpose there exists a rich spectrum of methods, from classical such as ARMA models or Box Jenkins method to modern ones like evolutionary computation, neural networks, fuzzy logic, geometry, deterministic chaos amongst others. This proceedings book is a collection of accepted papers of the Nostradamus conference that has been held in Ostrava, Czech Republic in June 2014. This book also includes outstanding keynote lectures by distinguished guest speakers: René Lozi (France), Ponnuthurai Nagaratnam Suganthan (Singapore) and Lars Nolle (Germany). The main aim of the conference was to create a periodical possibility for students, academics and researchers to exchange their ideas and novel research methods. This conference establishes a forum for presentation and discussion of recent research trends in the area of applications of various predictive methods.

Seasonal to Decadal Prediction of Marine Ecosystems: Opportunities, Approaches, and Applications

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Publisher : Frontiers Media SA
ISBN 13 : 2889458814
Total Pages : 136 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Seasonal to Decadal Prediction of Marine Ecosystems: Opportunities, Approaches, and Applications by : Mark R. Payne

Download or read book Seasonal to Decadal Prediction of Marine Ecosystems: Opportunities, Approaches, and Applications written by Mark R. Payne and published by Frontiers Media SA. This book was released on 2019-06-28 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tremendous advances in oceanographic observing and modeling systems over the last decade have led to unprecedented developments in the nature of information available to marine science. While improvements in observational technologies and networks have garnered much attention, remarkable developments in forecasting the ocean have received much less focus. Exploiting this new predictive skill to improve scientific understanding, generate advice and aid in the management of marine resources, is emerging as one of the new challenges of marine science. Translating predictions of the physical environment into biological outcomes, however, is not straightforward. Fisheries scientists, for example, have been trying to understand the links between physics and biology, and generate predictions of variables such as recruitment, for close to a century, with limited success. Nevertheless, spatial distributions and the timing of key events, which have received less focus, are often tightly linked to the physical environment and may have management-relevant applications. The first-such forecasts based on this skill are now starting to emerge. This Frontiers in Marine Science Research Topic provides a snapshot of the state-of-the-art in Marine Ecological Prediction. It covers the opportunities for developing such forecasts, technical approaches that could be employed, and examples where the technology is already being applied. This body of work therefore marks an important milestone on the route to developing this new and exciting field of marine science.

End Time Signs

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Publisher : AuthorHouse
ISBN 13 : 147723702X
Total Pages : 160 pages
Book Rating : 4.4/5 (772 download)

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Book Synopsis End Time Signs by : Kurt B. Bakley

Download or read book End Time Signs written by Kurt B. Bakley and published by AuthorHouse. This book was released on 2012-07-27 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Will Israel and the U.S. be destroyed or partially destroyed in 2012-2019 or 2026-2030 and beyond and Muslims, Catholics and communism take over most of the world? Were there strange things going around the sun, the moon changing degrees and phases, stars that aren't where there suppose to be and the magnetic poles changing mostly reported secretly in 2001-2011? Did NASA or scientists and astronomers brush the pictures of them away so not to scare people? Did the Bible Code predict strange behavior of the moon in 2011? Will a great tidal wave hit the U.S. East Coast in 2012-2019 and Yellowstone Park super volcano erupt or a comet or asteroid hits the earth or Ocean in 2026-2030 and utterly destroy the entire United States if it still around after the war of 2012-2019? Will the Muslims, communism and Catholics persecute Christians, Americans and Jews all over the world bringing them before Kings and have them sent to prisons and torture and killed if they don't deny Christ and convert to Islam? Will Muslims and people all over the world begin to mock and scoff at Christians and the Bible because Israel and the U.S. are destroyed and no Rapture or end or Second Coming of Christ happened? Several of the Bible prophecies predict God will not make a full end of the U.S., Israel and the world at this time and pockets of people and nations may or may not survive. God may save the U.S., Israel and the world if the people repent and turn from their sins and begin to humble themselves and heed the harbingers. But if they don't then these events may start to happen. This book was written by June 12, 2012.

Computational Science and Its Applications – ICCSA 2021

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Publisher : Springer Nature
ISBN 13 : 3030869792
Total Pages : 752 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Computational Science and Its Applications – ICCSA 2021 by : Osvaldo Gervasi

Download or read book Computational Science and Its Applications – ICCSA 2021 written by Osvaldo Gervasi and published by Springer Nature. This book was released on 2021-09-11 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​The ten-volume set LNCS 12949 – 12958 constitutes the proceedings of the 21st International Conference on Computational Science and Its Applications, ICCSA 2021, which was held in Cagliari, Italy, during September 13 – 16, 2021. The event was organized in a hybrid mode due to the Covid-19 pandemic.The 466 full and 18 short papers presented in these proceedings were carefully reviewed and selected from 1588 submissions. Part VI of the set includes the proceedings of the following workshops: ​International Workshop on Digital Transformation and Smart City (DIGISMART 2021); International Workshop on Econometrics and Multidimensional Evaluation in Urban Environment (EMEUE 2021); International Workshop on Transformational Urban Mobility: Challenges and Opportunities During and Post COVID Era (FURTHER2021); International Workshop on Geodesign in Decision Making: meta planning and collaborative design for sustainable and inclusive development (GDM 2021);11th International Workshop on Future Computing System Technologies and Applications (FiSTA 2021); International Workshop on Geographical Analysis, Urban Modeling, Spatial Statistics (GEOG-AND-MOD 2021).

Predictions for 2015

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Publisher : Author House
ISBN 13 : 1496961382
Total Pages : 275 pages
Book Rating : 4.4/5 (969 download)

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Book Synopsis Predictions for 2015 by : Kurt B. Bakley

Download or read book Predictions for 2015 written by Kurt B. Bakley and published by Author House. This book was released on 2015-01-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictions for 2015 Revised Edition Will two great tidal waves, earthquakes, storms, volcano eruptions, terrorist attacks and wars hit the U.S. Eastern Coast Line or Western Coast Line or Mid-West on September 27, 2015? Will Billy Graham and Pat Robertson die on this same date or near it? Will on this same date the earth stop rotating causing three days of darkness then it starts again only to have Venus (=life) to rotate counterclockwise opposite what it rotates now making long life for everyone and the curse of the ground and animals will be gone. Will there be an evil rapture at this time taking every evil person off the earth and their bodies lay on the ground for eagles and vultures to eat? Will massive amounts of gold and oil be found in the U.S. and prospers everyone in the world? Demons and satan will be bound up in hell and/or the U.S. or Iraq for a 1000 years and good angels possess people souls bringing good health of mind, body and soul for a 1000 years. Half of this book was written by November 11, 2011 (11-11-11) and the last three chapters were written by February 14, 2015.

The Experiment at Philadelphia

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Publisher : AuthorHouse
ISBN 13 : 1524622230
Total Pages : 1379 pages
Book Rating : 4.5/5 (246 download)

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Book Synopsis The Experiment at Philadelphia by : Kurt B. Bakley

Download or read book The Experiment at Philadelphia written by Kurt B. Bakley and published by AuthorHouse. This book was released on 2016-08-29 with total page 1379 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Experiment at Philadelphia Did Einstein discover God? If God created all things, then who Created God? What Was and Happened Before the Big-Bang. The Philadelphia Experiment was Einsteins experiment in which he had not only discovered, in 1943, the way to make things invisible and transport them at great speeds but also positively proven scientifically, physically, and spiritually that the Almighty God exists! He had literally discovered God! That question, is there a god? Thats been going through peoples minds for so long, was discussed on the street corner, talked about on the porch on a hot summers night, and is now a proven fact. Yes, there is a god! Did Einstein in the Philadelphia Experiment make contact with UFO beings, who gave him advance knowledge of all things, which Einstein later destroyed, fearing what the world would do with that knowledge? Are the first fourteen chapters of this book about the advance knowledge Einstein received? Does it reveal the deepest, darkest secrets of God and Satan and how the universe works? Does it answer these questions? Many have asked since the beginning of the world: Which is known as the mystery of God? Why am I here? Whats the true meaning of life? How was everything created? Who are God and the devil? If God created all, who created God? If he is the first in creation, where and how did he come into existence? Why does God allow evil in the world? Why do good things happen to bad people and bad things to good people? Whyif we all came from Adam and Eve, who were Jewishare there Gentiles? Are Gentiles children of devils? Is that why the Jews are Gods chosen race? Why in the Garden of Eden was the knowledge of good on the tree forbidden? How old is the earth? Why is God known as the Trinity? Why have religions, down through the ages, done such evil? What, when, and how did the big bang start? What happened to Satan? Who is he really, and what did he do in the past? What are his beliefs and ways? What is he and God literally made of? What is the meaning of the great pyramids and the sphinx? Is there scientific proof that God exists? Read this whole book for the answers to all these tough questions, and be sure to read the introduction first before reading the rest of this book. It will help you better understand this whole book.

Indecision in American Legislatures

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Publisher : University of Michigan Press
ISBN 13 : 0472124269
Total Pages : 209 pages
Book Rating : 4.4/5 (721 download)

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Book Synopsis Indecision in American Legislatures by : Justin Howard Kirkland

Download or read book Indecision in American Legislatures written by Justin Howard Kirkland and published by University of Michigan Press. This book was released on 2018-08-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lawmaking provides many opportunities for proposals to be altered, amended, tabled, or stopped completely. The ideal legislator should assess evidence, update his or her beliefs with new information, and sometimes be willing to change course. In practice, however, lawmakers face criticism from the media, the public, and their colleagues for “flip-flopping.” Legislators may also only appear to change positions in some cases as a means of voting strategically. This book presents a systematic examination of legislative indecision in American politics. This might occur via “waffling”—where a legislator cosponsors a bill, then votes against it at roll call. Or it might occur when a legislator votes one way on a bill, then switches her vote to the other side. In Indecision in American Legislatures, Jeffrey J. Harden and Justin H. Kirkland develop a theoretical framework to explain indecision itself, as well as the public’s attitudes toward indecision. They test their expectations with data sources from American state legislatures, the U.S. Congress, and survey questions administered to American citizens. Understanding legislative indecision from both the legislator and citizen perspectives is important for discussions about the quality of representation in American politics.

Global Monsoon System, The: Research And Forecast (Third Edition)

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Publisher : World Scientific
ISBN 13 : 9813200928
Total Pages : 396 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Global Monsoon System, The: Research And Forecast (Third Edition) by : Chih-pei Chang

Download or read book Global Monsoon System, The: Research And Forecast (Third Edition) written by Chih-pei Chang and published by World Scientific. This book was released on 2017-01-25 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third edition of a book series on the state of the science of monsoon research and forecasting. The series is updated approximately every five years based on the invited reviews of the World Meteorological Organization's International Workshop on Monsoons (IWM). The third edition is an outgrowth of the reviews initially presented in late 2013 at IWM-V, with manuscripts revised and updated through 2015 and early 2016. As in previous editions, the book builds on the concept that the monsoon in various parts of the globe can be viewed as components of an integrated global monsoon system, while also emphasizing that significant region-specific characteristics are present in individual monsoon regions. In addition to the regional monsoons, the current volume covers contemporary topics with emphasis on intraseasonal oscillations, extreme weather, decadal variability, climate change, and summary of recent field experiments including CINDY/DYNAMO in the Indian Ocean and the Asian Monsoon Years.World Scientific Series on Asia-Pacific Weather and Climate is indexed in SCOPUS.

Computational Prediction of Protein Complexes from Protein Interaction Networks

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Publisher : Morgan & Claypool
ISBN 13 : 1970001534
Total Pages : 297 pages
Book Rating : 4.9/5 (7 download)

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Book Synopsis Computational Prediction of Protein Complexes from Protein Interaction Networks by : Sriganesh Srihari

Download or read book Computational Prediction of Protein Complexes from Protein Interaction Networks written by Sriganesh Srihari and published by Morgan & Claypool. This book was released on 2017-05-30 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complexes of physically interacting proteins constitute fundamental functional units that drive almost all biological processes within cells. A faithful reconstruction of the entire set of protein complexes (the "complexosome") is therefore important not only to understand the composition of complexes but also the higher level functional organization within cells. Advances over the last several years, particularly through the use of high-throughput proteomics techniques, have made it possible to map substantial fractions of protein interactions (the "interactomes") from model organisms including Arabidopsis thaliana (a flowering plant), Caenorhabditis elegans (a nematode), Drosophila melanogaster (fruit fly), and Saccharomyces cerevisiae (budding yeast). These interaction datasets have enabled systematic inquiry into the identification and study of protein complexes from organisms. Computational methods have played a significant role in this context, by contributing accurate, efficient, and exhaustive ways to analyze the enormous amounts of data. These methods have helped to compensate for some of the limitations in experimental datasets including the presence of biological and technical noise and the relative paucity of credible interactions. In this book, we systematically walk through computational methods devised to date (approximately between 2000 and 2016) for identifying protein complexes from the network of protein interactions (the protein-protein interaction (PPI) network). We present a detailed taxonomy of these methods, and comprehensively evaluate them for protein complex identification across a variety of scenarios including the absence of many true interactions and the presence of false-positive interactions (noise) in PPI networks. Based on this evaluation, we highlight challenges faced by the methods, for instance in identifying sparse, sub-, or small complexes and in discerning overlapping complexes, and reveal how a combination of strategies is necessary to accurately reconstruct the entire complexosome.

Cybercrime and Digital Forensics

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Publisher : Routledge
ISBN 13 : 1317694775
Total Pages : 400 pages
Book Rating : 4.3/5 (176 download)

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Book Synopsis Cybercrime and Digital Forensics by : Thomas J. Holt

Download or read book Cybercrime and Digital Forensics written by Thomas J. Holt and published by Routledge. This book was released on 2015-02-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of the World Wide Web, smartphones, and Computer-Mediated Communications (CMCs) profoundly affect the way in which people interact online and offline. Individuals who engage in socially unacceptable or outright criminal acts increasingly utilize technology to connect with one another in ways that are not otherwise possible in the real world due to shame, social stigma, or risk of detection. As a consequence, there are now myriad opportunities for wrongdoing and abuse through technology. This book offers a comprehensive and integrative introduction to cybercrime. It is the first to connect the disparate literature on the various types of cybercrime, the investigation and detection of cybercrime and the role of digital information, and the wider role of technology as a facilitator for social relationships between deviants and criminals. It includes coverage of: key theoretical and methodological perspectives, computer hacking and digital piracy, economic crime and online fraud, pornography and online sex crime, cyber-bulling and cyber-stalking, cyber-terrorism and extremism, digital forensic investigation and its legal context, cybercrime policy. This book includes lively and engaging features, such as discussion questions, boxed examples of unique events and key figures in offending, quotes from interviews with active offenders and a full glossary of terms. It is supplemented by a companion website that includes further students exercises and instructor resources. This text is essential reading for courses on cybercrime, cyber-deviancy, digital forensics, cybercrime investigation and the sociology of technology.

Social Computing, Behavioral-Cultural Modeling and Prediction

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Author :
Publisher : Springer
ISBN 13 : 3319055798
Total Pages : 435 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Social Computing, Behavioral-Cultural Modeling and Prediction by : William G. Kennedy

Download or read book Social Computing, Behavioral-Cultural Modeling and Prediction written by William G. Kennedy and published by Springer. This book was released on 2014-03-14 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 7th International Conference on Social Computing, Behavioral-Cultural Modeling, and Prediction, SBP 2014, held in Washington, DC, USA, in April 2014. The 51 full papers presented were carefully reviewed and selected from 101 submissions. The SBP conference provides a forum for researchers and practitioners from academia, industry, and government agencies to exchange ideas on current challenges in social computing, behavioral-cultural modeling and prediction, and on state-of-the-art methods and best practices being adopted to tackle these challenges. The topical areas addressed by the papers are social and behavioral sciences, health sciences, military science, and information science.

Hydrologic Modeling

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Publisher : Springer
ISBN 13 : 9811058016
Total Pages : 718 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Hydrologic Modeling by : Vijay P Singh

Download or read book Hydrologic Modeling written by Vijay P Singh and published by Springer. This book was released on 2018-01-19 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains seven parts. The first part deals with some aspects of rainfall analysis, including rainfall probability distribution, local rainfall interception, and analysis for reservoir release. Part 2 is on evapotranspiration and discusses development of neural network models, errors, and sensitivity. Part 3 focuses on various aspects of urban runoff, including hydrologic impacts, storm water management, and drainage systems. Part 4 deals with soil erosion and sediment, covering mineralogical composition, geostatistical analysis, land use impacts, and land use mapping. Part 5 treats remote sensing and geographic information system (GIS) applications to different hydrologic problems. Watershed runoff and floods are discussed in Part 6, encompassing hydraulic, experimental, and theoretical aspects. Water modeling constitutes the concluding Part 7. Soil and Water Assessment Tool (SWAT), Xinanjiang, and Soil Conservation Service-Curve Number (SCS-CN) models are discussed. The book is of interest to researchers and practitioners in the field of water resources, hydrology, environmental resources, agricultural engineering, watershed management, earth sciences, as well as those engaged in natural resources planning and management. Graduate students and those wishing to conduct further research in water and environment and their development and management find the book to be of value.

Sub-seasonal to Seasonal Prediction

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Publisher : Elsevier
ISBN 13 : 012811715X
Total Pages : 588 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Sub-seasonal to Seasonal Prediction by : Andrew Robertson

Download or read book Sub-seasonal to Seasonal Prediction written by Andrew Robertson and published by Elsevier. This book was released on 2018-10-19 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Gap Between Weather and Climate Forecasting: Sub-seasonal to Seasonal Prediction is an ideal reference for researchers and practitioners across the range of disciplines involved in the science, modeling, forecasting and application of this new frontier in sub-seasonal to seasonal (S2S) prediction. It provides an accessible, yet rigorous, introduction to the scientific principles and sources of predictability through the unique challenges of numerical simulation and forecasting with state-of-science modeling codes and supercomputers. Additional coverage includes the prospects for developing applications to trigger early action decisions to lessen weather catastrophes, minimize costly damage, and optimize operator decisions. The book consists of a set of contributed chapters solicited from experts and leaders in the fields of S2S predictability science, numerical modeling, operational forecasting, and developing application sectors. The introduction and conclusion, written by the co-editors, provides historical perspective, unique synthesis and prospects, and emerging opportunities in this exciting, complex and interdisciplinary field. - Contains contributed chapters from leaders and experts in sub-seasonal to seasonal science, forecasting and applications - Provides a one-stop shop for graduate students, academic and applied researchers, and practitioners in an emerging and interdisciplinary field - Offers a synthesis of the state of S2S science through the use of concrete examples, enabling potential users of S2S forecasts to quickly grasp the potential for application in their own decision-making - Includes a broad set of topics, illustrated with graphic examples, that highlight interdisciplinary linkages

Computational Systems Biology of Pathogen-Host Interactions

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Publisher : Frontiers Media SA
ISBN 13 : 2889198219
Total Pages : 200 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Computational Systems Biology of Pathogen-Host Interactions by : Saliha Durmuş

Download or read book Computational Systems Biology of Pathogen-Host Interactions written by Saliha Durmuş and published by Frontiers Media SA. This book was released on 2016-05-30 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough understanding of pathogenic microorganisms and their interactions with host organisms is crucial to prevent infectious threats due to the fact that Pathogen-Host Interactions (PHIs) have critical roles in initiating and sustaining infections. Therefore, the analysis of infection mechanisms through PHIs is indispensable to identify diagnostic biomarkers and next-generation drug targets and then to develop strategic novel solutions against drug-resistance and for personalized therapy. Traditional approaches are limited in capturing mechanisms of infection since they investigate hosts or pathogens individually. On the other hand, the systems biology approach focuses on the whole PHI system, and is more promising in capturing infection mechanisms. Here, we bring together studies on the below listed sections to present the current picture of the research on Computational Systems Biology of Pathogen-Host Interactions: - Computational Inference of PHI Networks using Omics Data - Computational Prediction of PHIs - Text Mining of PHI Data from the Literature - Mathematical Modeling and Bioinformatic Analysis of PHIs Computational Inference of PHI Networks using Omics Data Gene regulatory, metabolic and protein-protein networks of PHI systems are crucial for a thorough understanding of infection mechanisms. Great advances in molecular biology and biotechnology have allowed the production of related omics data experimentally. Many computational methods are emerging to infer molecular interaction networks of PHI systems from the corresponding omics data. Computational Prediction of PHIs Due to the lack of experimentally-found PHI data, many computational methods have been developed for the prediction of pathogen-host protein-protein interactions. Despite being emerging, currently available experimental PHI data are far from complete for a systems view of infection mechanisms through PHIs. Therefore, computational methods are the main tools to predict new PHIs. To this end, the development of new computational methods is of great interest. Text Mining of PHI Data from Literature Despite the recent development of many PHI-specific databases, most data relevant to PHIs are still buried in the biomedical literature, which demands for the use of text mining techniques to unravel PHIs hidden in the literature. Only some rare efforts have been performed to achieve this aim. Therefore, the development of novel text mining methods specific for PHI data retrieval is of key importance for efficient use of the available literature. Mathematical Modeling and Bioinformatic Analysis of PHIs After the reconstruction of PHI networks experimentally and/or computationally, their mathematical modeling and detailed computational analysis is required using bioinformatics tools to get insights on infection mechanisms. Bioinformatics methods are increasingly applied to analyze the increasing amount of experimentally-found and computationally-predicted PHI data.

Advances in Computational and Bio-Engineering

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Author :
Publisher : Springer Nature
ISBN 13 : 3030469395
Total Pages : 650 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Advances in Computational and Bio-Engineering by : S. Jyothi

Download or read book Advances in Computational and Bio-Engineering written by S. Jyothi and published by Springer Nature. This book was released on 2020-07-19 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers state-of-the-art research in computational engineering and bioengineering to facilitate knowledge exchange between various scientific communities. Computational engineering (CE) is a relatively new discipline that addresses the development and application of computational models and simulations often coupled with high-performance computing to solve complex physical problems arising in engineering analysis and design in the context of natural phenomena. Bioengineering (BE) is an important aspect of computational biology, which aims to develop and use efficient algorithms, data structures, and visualization and communication tools to model biological systems. Today, engineering approaches are essential for biologists, enabling them to analyse complex physiological processes, as well as for the pharmaceutical industry to support drug discovery and development programmes.