Precision Medicine In Neurodegenerative Disorders

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Precision Medicine in Neurodegenerative Disorders

Author :
Publisher : Elsevier
ISBN 13 : 032390064X
Total Pages : 290 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Precision Medicine in Neurodegenerative Disorders by :

Download or read book Precision Medicine in Neurodegenerative Disorders written by and published by Elsevier. This book was released on 2023-02-14 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases. Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine. - Summarizes theory and research on precision medicine in neurodegenerative disorders - Covers basic biology, clinical trials and therapeutics - Includes disease mechanisms, genetic subtypes, and more

Precision Medicine and Neurodegenerative Disorders

Author :
Publisher : Elsevier
ISBN 13 : 9780323855556
Total Pages : 0 pages
Book Rating : 4.8/5 (555 download)

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Book Synopsis Precision Medicine and Neurodegenerative Disorders by :

Download or read book Precision Medicine and Neurodegenerative Disorders written by and published by Elsevier. This book was released on 2023-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine in Neurodegenerative Disorders, Part Two, Volume 194 discusses a major transformation fueled by the recognition that what has worked for developing symptomatic therapies doesn't necessarily work for developing disease modifying therapies. The former depends on addressing convergent, common denominators of disease, present in most of those affected. The latter on divergent biological signals, present in some but absent in most. This work encompasses two volumes separated into multiple sections, including conceptual frameworks, pitfalls in definitions, cohorts, and measures of progression, basic science development, and clinical trials and therapeutic approaches.

GeNeDis 2020

Author : Panayiotis Vlamos
Publisher : Springer Nature
ISBN 13 : 3030787710
Total Pages : 391 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis GeNeDis 2020 by : Panayiotis Vlamos

Download or read book GeNeDis 2020 written by Panayiotis Vlamos and published by Springer Nature. This book was released on 2022-01-01 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.

TDP-43 and Neurodegeneration

Author : Vijay Kumar
Publisher : Elsevier
ISBN 13 : 0128200669
Total Pages : 270 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis TDP-43 and Neurodegeneration by : Vijay Kumar

Download or read book TDP-43 and Neurodegeneration written by Vijay Kumar and published by Elsevier. This book was released on 2021-10-27 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43's structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside

Neurodegenerative Diseases

Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
ISBN 13 : 1461406536
Total Pages : 421 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad

Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Genomics in Precision Medicine

Author : Shiv Sanjeevi
Publisher : Delve Publishing
ISBN 13 : 9781774073445
Total Pages : 290 pages
Book Rating : 4.0/5 (734 download)

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Book Synopsis Genomics in Precision Medicine by : Shiv Sanjeevi

Download or read book Genomics in Precision Medicine written by Shiv Sanjeevi and published by Delve Publishing. This book was released on 2019-11 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics in Precision Medicine makes the people aware about the field of genomics and that of precision medicine, by taking the readers through all the details related to genomics and precision medicine. It also updates the readers about the various innovations that have taken place in the field of precision medicine and discusses the path that is to be followed further. Also discussed in the book is a review on the relation between the precision medicine and the mutations that drive it, delving on the various computational methods and conformational principles for the detection of the factors that drive cancer. It also discusses the various genetic mutations and epigenetic modifications and goes on to explore the various benefits and harms in the research on precision medicine.

Precision Medicine

Author : Hans-Peter Deigner
Publisher : Academic Press
ISBN 13 : 0128054336
Total Pages : 376 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Precision Medicine by : Hans-Peter Deigner

Download or read book Precision Medicine written by Hans-Peter Deigner and published by Academic Press. This book was released on 2018-02-15 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisites, causes and consequences is given. Unique to this book is a combined view on technical and data analysis aspects that is mandatory for obtaining and interpreting results. This book is a valuable source for researchers in medical and life sciences, physicians and students with an interest in this emerging field of precision medicine. - Provides technological aspects in precision medicine with aspects of modern statistical and bioinformatics models and methods - Brings timely reviews on status and chances in precision medicine and associated aspects of data analysis, statistics and data interpretation - Encompasses easy access to relevant approaches, interactions and original literature

Neuro-Geriatrics

Author : Babak Tousi
Publisher : Springer
ISBN 13 : 3319564846
Total Pages : 417 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Neuro-Geriatrics by : Babak Tousi

Download or read book Neuro-Geriatrics written by Babak Tousi and published by Springer. This book was released on 2017-12-06 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual takes a multidisciplinary approach to neurological disorders in the elderly. Comprehensive and practical, it includes the most recent diagnostic criteria and immediately accessible visual care paths including the latest pharmacologic and non-pharmacologic interventions. Covering a range of modalities, from the importance and impact of each disease to diagnostic criteria, genetics, laboratory and imaging findings, treatment and care paths, this book focuses on neurological conditions that occur commonly in older persons or which have a striking effect on their lives. The common types of dementias, Parkinson’s disease and related disorders, rapidly progressive diseases, seizure disorders and multiple sclerosis are covered. Issues commonly affecting this population, such as neurobehavioral symptoms and caregiver issues, are discussed. Neuro-Geriatrics: A Clinical Manual is aimed at any physician who treats the elderly with neurological disorders: neurologists, geriatricians and geriatric psychiatrists, both specialists and general practitioners.

Brain Fables

Author : Alberto Espay
Publisher : Cambridge University Press
ISBN 13 : 1108893597
Total Pages : 179 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Brain Fables by : Alberto Espay

Download or read book Brain Fables written by Alberto Espay and published by Cambridge University Press. This book was released on 2020-07-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 80 million people live with a neurodegenerative disease. That number is expected to increase rapidly as populations age, lifespans increase, and exposure to toxins rises. Despite decades of research and billions in funding, there are no medications that can slow, much less stop, the progress of these diseases. This is because diseases such as Parkinson's and Alzheimer's do not exist in biology. Yet, hundreds of clinical trials around the world are examining the potential of single therapies in thousands of people sharing one of these labels. Compounding the problem, these therapies were developed on evidence from models that do not come close to capturing the complexity of these diseases in the affected humans. These practices must end. Brain Fables is a call to refocus on understanding living and aging to create the personalized treatments each affected individual desperately needs.

The Road from Nanomedicine to Precision Medicine

Author : Shaker A. Mousa
Publisher : CRC Press
ISBN 13 : 1000021270
Total Pages : 681 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis The Road from Nanomedicine to Precision Medicine by : Shaker A. Mousa

Download or read book The Road from Nanomedicine to Precision Medicine written by Shaker A. Mousa and published by CRC Press. This book was released on 2020-01-17 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.

Precision Medicine in Oncology

Author : Bulent Aydogan
Publisher : John Wiley & Sons
ISBN 13 : 1119432448
Total Pages : 288 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Precision Medicine in Oncology by : Bulent Aydogan

Download or read book Precision Medicine in Oncology written by Bulent Aydogan and published by John Wiley & Sons. This book was released on 2020-11-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

The Spectrum of Hope

Author : Gayatri Devi
Publisher : Workman Publishing Company
ISBN 13 : 1523500581
Total Pages : 337 pages
Book Rating : 4.5/5 (235 download)

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Book Synopsis The Spectrum of Hope by : Gayatri Devi

Download or read book The Spectrum of Hope written by Gayatri Devi and published by Workman Publishing Company. This book was released on 2017-10-31 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imagine finding a glimmer of good news in a diagnosis of Alzheimer’s. And imagine how that would change the outlook of the 5 million Americans who suffer from Alzheimer’s disease and other dementias, not to mention their families, loved ones, and caretakers. A neurologist who’s been specializing in dementia and memory loss for more than 20 years, Dr. Gayatri Devi rewrites the story of Alzheimer’s by defining it as a spectrum disorder—like autism, Alzheimer’s is a disease that affects different people differently. She encourages people who are worried about memory impairment to seek a diagnosis, because early treatment will enable doctors and caregivers to manage the disease more effectively through drugs and other therapies. Told through the stories of Dr. Devi’s patients, The Spectrum of Hope humanizes the science, and offers equal parts practical advice and wisdom with skillful ease, along with real hope. Here are chapters on how to maintain independence and dignity; how to fight depression, anxiety, and apathy; how to communicate effectively with a person suffering from dementia. Plus chapters on sexuality, genetics, going public with the diagnosis, even putting together a bucket list—because through her practice, Dr. Devi knows that the majority of Alzheimer’s patients continue to live and work in their communities. They babysit their grandkids, drive to the store (or own the store), serve their clients, or otherwise live fulfilling lives. That’s news that 5 million people are waiting to hear.

Personalized Precision Medicine in Autism Spectrum Related Disorders

Author : Lidia V. Gabis
Publisher : Frontiers Media SA
ISBN 13 : 2889716775
Total Pages : 176 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Personalized Precision Medicine in Autism Spectrum Related Disorders by : Lidia V. Gabis

Download or read book Personalized Precision Medicine in Autism Spectrum Related Disorders written by Lidia V. Gabis and published by Frontiers Media SA. This book was released on 2022-02-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Preventive and Predictive Genetics: Towards Personalised Medicine

Author : Godfrey Grech
Publisher : Springer
ISBN 13 : 3319153447
Total Pages : 388 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Preventive and Predictive Genetics: Towards Personalised Medicine by : Godfrey Grech

Download or read book Preventive and Predictive Genetics: Towards Personalised Medicine written by Godfrey Grech and published by Springer. This book was released on 2015-06-24 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Personalized Psychiatry

Author : Bernhard Baune
Publisher : Academic Press
ISBN 13 : 0128131772
Total Pages : 594 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Personalized Psychiatry by : Bernhard Baune

Download or read book Personalized Psychiatry written by Bernhard Baune and published by Academic Press. This book was released on 2019-10-16 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Imaging in Neurodegenerative Disorders

Author : Luca Saba
Publisher : Oxford University Press, USA
ISBN 13 : 0199671613
Total Pages : 585 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Imaging in Neurodegenerative Disorders by : Luca Saba

Download or read book Imaging in Neurodegenerative Disorders written by Luca Saba and published by Oxford University Press, USA. This book was released on 2015 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.

Economic Dimensions of Personalized and Precision Medicine

Author : Ernst R. Berndt
Publisher : University of Chicago Press
ISBN 13 : 022661106X
Total Pages : 361 pages
Book Rating : 4.2/5 (266 download)

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Book Synopsis Economic Dimensions of Personalized and Precision Medicine by : Ernst R. Berndt

Download or read book Economic Dimensions of Personalized and Precision Medicine written by Ernst R. Berndt and published by University of Chicago Press. This book was released on 2019-04-22 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.