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Potassium Channel Modulators
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Book Synopsis Potassium Channels And Their Modulators by : John M Evans
Download or read book Potassium Channels And Their Modulators written by John M Evans and published by CRC Press. This book was released on 2003-09-02 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
Book Synopsis Potassium Channel Modulators by : AH Weston
Download or read book Potassium Channel Modulators written by AH Weston and published by Wiley-Blackwell. This book was released on 1993-01-18 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines
Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Book Synopsis Synthesis and Development of Potassium Channel Modulators by : Noel John Chambers
Download or read book Synthesis and Development of Potassium Channel Modulators written by Noel John Chambers and published by . This book was released on 1994 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Branch Publisher : ISBN 13 : Total Pages :26 pages Book Rating :4.:/5 (327 download)
Book Synopsis Anticonvulsant Screening Project by : National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Branch
Download or read book Anticonvulsant Screening Project written by National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Branch and published by . This book was released on 1978 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacology of Potassium Channels by : Nikita Gamper
Download or read book Pharmacology of Potassium Channels written by Nikita Gamper and published by Springer Nature. This book was released on 2021-09-27 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
Book Synopsis Characteristics of the Effects of Potassium Channel Modulators on Murine Gastrointestinal Smooth Muscle by : Chi-Kong Yeung
Download or read book Characteristics of the Effects of Potassium Channel Modulators on Murine Gastrointestinal Smooth Muscle written by Chi-Kong Yeung and published by . This book was released on 1997 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this work was to investigate the actions of potassium channel modulating agents on the motility of the gastrointestinal tract of mice in vitro and in vivo. .....
Book Synopsis Potassium Channels by : Simone Furini
Download or read book Potassium Channels written by Simone Furini and published by Springer Nature. This book was released on with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Voltage-Gated Ion Channels as Drug Targets by : David J. Triggle
Download or read book Voltage-Gated Ion Channels as Drug Targets written by David J. Triggle and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Book Synopsis The Influence of Potassium Channel Modulators on Proliferation and Cycling in Human Keratinocytes by : Deirdre Catherine McCarthy
Download or read book The Influence of Potassium Channel Modulators on Proliferation and Cycling in Human Keratinocytes written by Deirdre Catherine McCarthy and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulators of Small and Intermediate Conductance Calcium-activated Potassium Channel by : David Paul Jenkins
Download or read book Modulators of Small and Intermediate Conductance Calcium-activated Potassium Channel written by David Paul Jenkins and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels generate the electrical signaling activity essential for complex life forms. Of prime importance, potassium channels establish and maintain the resting membrane potentials upon which cellular signaling dynamics are based. Potassium channels are the most diverse group of ion channels, offering great potential for selective interventions. Understanding the molecular, cellular and integrative physiology of potassium channels is critical for developing novel therapeutics. This dissertation examines the physiological roles of small- and intermediate-conductance calcium-activated potassium channels (K[subscript Ca]2/3) and the effects of their pharmacological modulation. Using a progressive chimeric approach and point-mutations, we delineated the site-of-action of NS8593, a selective negative gating modulator of K[subscript Ca]2 channels. Two residues, Ser-507 and Ala-532, adjacent to the cytoplasmic side of the selectivity filter mediate the action of NS8593. This demonstrates a site-of-action distinct from the positive gating modulators and suggests that negative gating modulation may result from a direct interaction with the physical gate of K[subscript Ca]2 channels. It further suggests that this type of gating modulation should be possible in other potassium and possibly in the related sodium and calcium channels. We identified and characterized a novel and structurally unique K[subscript Ca]3.1 blocker, NS6180, which compares favorably with the widely used TRAM-34. In heterologous expression systems and in native tissues, NS6180 inhibits K[subscript Ca]3.1 as potently (10-20 nM) as standard K[subscript Ca]3.1 blocker TRAM-34, and shares the same site-of-action, Thr-250 and Val-275. Despite these similarities, NS6180 has a distinct selectivity profile from TRAM-34, particularly showing significantly less inhibition of K[subscript V]7.2+7.3 channels. Finally, NS6180 produces immunosuppressive and anti-inflammatory effects in isolated splenocytes and DNBS induced rat colitis, demonstrating its promise for future development as a treatment of intestinal inflammation. Using optical mapping, we investigated the effects of NS8593 on action potential duration (APD) and effective refractory period (ERP) in isolated right atria from rabbits with chronic heart failure (CHF). APD was significantly decreased in CHF atria, while ERP was increased. NS8593 did not significantly affect ERP; however, it completely reversed the effects of CHF, restoring APD to control values. We have demonstrated that shortening of atrial action potentials secondary to chronic heart failure can be reversed by inhibition of K[subscript Ca]2 channels with the negative gating modulator, NS8593.
Book Synopsis Ion Channel Drug Discovery by : Brian Cox
Download or read book Ion Channel Drug Discovery written by Brian Cox and published by Royal Society of Chemistry. This book was released on 2014-09-03 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Book Synopsis Potassium Channels as a Target for Clinical Therapeutics by : Ivan Kocić
Download or read book Potassium Channels as a Target for Clinical Therapeutics written by Ivan Kocić and published by Bentham Science Publishers. This book was released on 2012-04-12 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This e-book presents an overview of the different substances capable of modulating potassium channels in relation to various clinical indications in cardiology, pulmonology, endocrinology and neurology. The possible benefits and side effects of potassium "
Book Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Book Synopsis Potassium Channel Modulators by : A.H. Weston
Download or read book Potassium Channel Modulators written by A.H. Weston and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inwardly Rectifying Potassium Channels—Advances in Research and Application: 2012 Edition by :
Download or read book Inwardly Rectifying Potassium Channels—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inwardly Rectifying Potassium Channels—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Inwardly Rectifying Potassium Channels in a compact format. The editors have built Inwardly Rectifying Potassium Channels—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Inwardly Rectifying Potassium Channels in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Inwardly Rectifying Potassium Channels—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
