Population Genetics, Molecular Evolution, and the Neutral Theory

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Publisher : University of Chicago Press
ISBN 13 : 9780226435633
Total Pages : 736 pages
Book Rating : 4.4/5 (356 download)

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Book Synopsis Population Genetics, Molecular Evolution, and the Neutral Theory by : Motoo Kimura

Download or read book Population Genetics, Molecular Evolution, and the Neutral Theory written by Motoo Kimura and published by University of Chicago Press. This book was released on 1994 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of this century's leading evolutionary biologists, Motoo Kimura revolutionized the field with his random drift theory of molecular evolution—the neutral theory—and his groundbreaking theoretical work in population genetics. This volume collects 57 of Kimura's most important papers and covers forty years of his diverse and original contributions to our understanding of how genetic variation affects evolutionary change. Kimura's neutral theory, first presented in 1968, challenged the notion that natural selection was the sole directive force in evolution. Arguing that mutations and random drift account for variations at the level of DNA and amino acids, Kimura advanced a theory of evolutionary change that was strongly challenged at first and that eventually earned the respect and interest of evolutionary biologists throughout the world. This volume includes the seminal papers on the neutral theory, as well as many others that cover such topics as population structure, variable selection intensity, the genetics of quantitative characters, inbreeding systems, and reversibility of changes by random drift. Background essays by Naoyuki Takahata examine Kimura's work in relation to its effects and recent developments in each area.

The Neutral Theory of Molecular Evolution

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Publisher : Cambridge University Press
ISBN 13 : 9780521317931
Total Pages : 388 pages
Book Rating : 4.3/5 (179 download)

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Book Synopsis The Neutral Theory of Molecular Evolution by : Motoo Kimura

Download or read book The Neutral Theory of Molecular Evolution written by Motoo Kimura and published by Cambridge University Press. This book was released on 1983 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first comprehensive treatment of this subject.

The Neutral Theory of Molecular Evolution

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Publisher : Cambridge University Press
ISBN 13 : 1139935674
Total Pages : 506 pages
Book Rating : 4.1/5 (399 download)

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Book Synopsis The Neutral Theory of Molecular Evolution by : Motoo Kimura

Download or read book The Neutral Theory of Molecular Evolution written by Motoo Kimura and published by Cambridge University Press. This book was released on 1985-01-10 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motoo Kimura, as founder of the neutral theory, is uniquely placed to write this book. He first proposed the theory in 1968 to explain the unexpectedly high rate of evolutionary change and very large amount of intraspecific variability at the molecular level that had been uncovered by new techniques in molecular biology. The theory - which asserts that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants - has caused controversy ever since. This book is the first comprehensive treatment of this subject and the author synthesises a wealth of material - ranging from a historical perspective, through recent molecular discoveries, to sophisticated mathematical arguments - all presented in a most lucid manner.

Theoretical Population Genetics

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Publisher : Springer Science & Business Media
ISBN 13 : 9400903871
Total Pages : 428 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Theoretical Population Genetics by : J.S. Gale

Download or read book Theoretical Population Genetics written by J.S. Gale and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise of the neutral theory of molecular evolution seems to have aroused a renewed interest in mathematical population genetics among biologists, who are primarily experimenters rather than theoreticians. This has encouraged me to set out the mathematics of the evolutionary process in a manner that, I hope, will be comprehensible to those with only a basic knowledge of calculus and matrix algebra. I must acknowledge from the start my great debt to my students. Equipped initially with rather limited mathematics, they have pursued the subject with much enthusiasm and success. This has enabled me to try a number of different approaches over the years. I was particularly grateful to Dr L. J. Eaves and Professor W. E. Nance for the opportunity to give a one-semester course at the Medical College of Virginia, and I would like to thank them, their colleagues and their students for the many kindnesses shown to me during my visit. I have concentrated almost entirely on stochastic topics, since these cause the greatest problems for non-mathematicians. The latter are particularly concerned with the range of validity of formulae. A sense of confidence in applying these formulae is, almost certainly, best gained by following their derivation. I have set out proofs in fair detail, since, in my experience, minor points of algebraic manipulation occasionally cause problems. To avoid loss of continuity, I have sometimes put material in notes at the end of chapters.

A Primer of Molecular Population Genetics

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Publisher : Oxford University Press, USA
ISBN 13 : 0198838948
Total Pages : 266 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis A Primer of Molecular Population Genetics by : Asher D. Cutter

Download or read book A Primer of Molecular Population Genetics written by Asher D. Cutter and published by Oxford University Press, USA. This book was released on 2019 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics.

Bioinformatics for Beginners

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Publisher : Elsevier
ISBN 13 : 0124105106
Total Pages : 238 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Bioinformatics for Beginners by : Supratim Choudhuri

Download or read book Bioinformatics for Beginners written by Supratim Choudhuri and published by Elsevier. This book was released on 2014-05-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. Avoids non-essential coverage, yet fully describes the field for beginners Explains the molecular basis of evolution to place bioinformatic analysis in biological context Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools Contains over 100 figures that aid in concept discovery and illustration

My Thoughts on Biological Evolution

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Publisher : Springer Nature
ISBN 13 : 9811561656
Total Pages : 159 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis My Thoughts on Biological Evolution by : Motoo Kimura

Download or read book My Thoughts on Biological Evolution written by Motoo Kimura and published by Springer Nature. This book was released on 2020-07-29 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by Motoo Kimura (1924–94), is a classic in evolutionary biology. In 1968, Kimura proposed the “neutral theory of molecular evolution”, which became the theoretical basis of modern evolutionary studies. After publishing his work in 1983 in the book “Neutral Theory of Molecular Evolution”, Kimura wrote this book in 1988 for the general public. It was originally written in Japanese and is translated here for the first time. In the book, Kimura first summarizes the development of evolutionary theory since Lamarck and Darwin. He then shows how the search for mechanisms of evolution developed into population genetics and describes how the study of molecular evolution matured by taking in the fruits of molecular biology. Kimura proceeds to carefully explain his neutral evolution theory at the molecular level. Finally, he presents his view of the world from an evolutionary perspective. The book has long served as an in-depth introduction to evolutionary biology for students and young researchers in Japan. There has been remarkably rapid progress in the field of bioscience at the molecular level over the past 30 years. Nevertheless, the book remains an important contribution that laid the foundations for what followed in molecular evolutionary studies.

The Causes of Molecular Evolution

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Publisher : Oxford University Press
ISBN 13 : 0195357744
Total Pages : 351 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis The Causes of Molecular Evolution by : John H. Gillespie

Download or read book The Causes of Molecular Evolution written by John H. Gillespie and published by Oxford University Press. This book was released on 1994-05-26 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.

Mutation and Evolution

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Publisher : Springer Science & Business Media
ISBN 13 : 9401152101
Total Pages : 561 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Mutation and Evolution by : Ronny C. Woodruff

Download or read book Mutation and Evolution written by Ronny C. Woodruff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although debated since the time of Darwin, the evolutionary role of mutation is still controversial. In over 40 chapters from leading authorities in mutation and evolutionary biology, this book takes a new look at both the theoretical and experimental measurement and significance of new mutation. Deleterious, nearly neutral, beneficial, and polygenic mutations are considered in their effects on fitness, life history traits, and the composition of the gene pool. Mutation is a phenomenon that draws attention from many different disciplines. Thus, the extensive reviews of the literature will be valuable both to established researchers and to those just beginning to study this field. Through up-to-date reviews, the authors provide an insightful overview of each topic and then share their newest ideas and explore controversial aspects of mutation and the evolutionary process. From topics like gonadal mosaicism and mutation clusters to adaptive mutagenesis, mutation in cell organelles, and the level and distribution of DNA molecular changes, the foundation is set for continuing the debate about the role of mutation, fitness, and adaptability. It is a debate that will have profound consequences for our understanding of evolution.

Data Analysis in Molecular Biology and Evolution

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Publisher : Springer Science & Business Media
ISBN 13 : 030646893X
Total Pages : 280 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Data Analysis in Molecular Biology and Evolution by : Xuhua Xia

Download or read book Data Analysis in Molecular Biology and Evolution written by Xuhua Xia and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Analysis in Molecular Biology and Evolution introduces biologists to DAMBE, a proprietary, user-friendly computer program for molecular data analysis. The unique combination of this book and software will allow biologists not only to understand the rationale behind a variety of computational tools in molecular biology and evolution, but also to gain instant access to these tools for use in their laboratories. Data Analysis in Molecular Biology and Evolution serves as an excellent resource for advanced level undergraduates or graduates as well as for professionals working in the field.

Mutation-Driven Evolution

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Publisher : OUP Oxford
ISBN 13 : 0199661731
Total Pages : 261 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Mutation-Driven Evolution by : Masatoshi Nei

Download or read book Mutation-Driven Evolution written by Masatoshi Nei and published by OUP Oxford. This book was released on 2013-05-02 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.

Non-Neutral Evolution

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Publisher : Springer Science & Business Media
ISBN 13 : 1461523834
Total Pages : 261 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Non-Neutral Evolution by : Brian Golding

Download or read book Non-Neutral Evolution written by Brian Golding and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: All organisms--from the AIDS virus, to bacteria, to fish, to humans--must evolve to survive. Despite the central place of evolution within biology, there are many things that are still poorly understood. For Charles Darwin, the driving force behind all evolution was natural selection. More recently, evolutionary biologists have considered that many mutations are essentially neutral with respect to natural selection. Many questions remain. Are molecular differences between species adaptive? Are differences within species adaptive? Modern biotechnology has enabled us to identify precisely the actual DNA structure from many individuals within a population, and thus to see how these DNA sequences have changed over time and to answer some of these questions. At the same time, this knowledge poses new challenges to our ability to understand the observed patterns. This exciting volume outlines the biological problems, provides new perspectives on theoretical treatments of the consequences of natural selection, examines the consequences of molecular data, and relates molecular events to speciation. Every evolutionary biologist will find it of interest.

Theoretical Aspects of Population Genetics

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Publisher : Princeton University Press
ISBN 13 : 9780691080987
Total Pages : 236 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Theoretical Aspects of Population Genetics by : Motoo Kimura

Download or read book Theoretical Aspects of Population Genetics written by Motoo Kimura and published by Princeton University Press. This book was released on 1971-10-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: To show the importance of stochastic processes in the change of gene frequencies, the authors discuss topics ranging from molecular evolution to two-locus problems in terms of diffusion models. Throughout their discussion, they come to grips with one of the most challenging problems in population genetics--the ways in which genetic variability is maintained in Mendelian populations. R.A. Fisher, J.B.S. Haldane, and Sewall Wright, in pioneering works, confirmed the usefulness of mathematical theory in population genetics. The synthesis their work achieved is recognized today as mathematical genetics, that branch of genetics whose aim is to investigate the laws governing the genetic structure of natural populations and, consequently, to clarify the mechanisms of evolution. For the benefit of population geneticists without advanced mathematical training, Professors Kimura and Ohta use verbal description rather than mathematical symbolism wherever practicable. A mathematical appendix is included.

A Primer of Molecular Population Genetics

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Publisher : Oxford University Press
ISBN 13 : 0192575546
Total Pages : 266 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis A Primer of Molecular Population Genetics by : Asher D. Cutter

Download or read book A Primer of Molecular Population Genetics written by Asher D. Cutter and published by Oxford University Press. This book was released on 2019-06-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics.

The Unified Neutral Theory of Biodiversity and Biogeography (MPB-32)

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Publisher : Princeton University Press
ISBN 13 : 1400837529
Total Pages : 390 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis The Unified Neutral Theory of Biodiversity and Biogeography (MPB-32) by : Stephen P. Hubbell

Download or read book The Unified Neutral Theory of Biodiversity and Biogeography (MPB-32) written by Stephen P. Hubbell and published by Princeton University Press. This book was released on 2011-06-27 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite its supreme importance and the threat of its global crash, biodiversity remains poorly understood both empirically and theoretically. This ambitious book presents a new, general neutral theory to explain the origin, maintenance, and loss of biodiversity in a biogeographic context. Until now biogeography (the study of the geographic distribution of species) and biodiversity (the study of species richness and relative species abundance) have had largely disjunct intellectual histories. In this book, Stephen Hubbell develops a formal mathematical theory that unifies these two fields. When a speciation process is incorporated into Robert H. MacArthur and Edward O. Wilson's now classical theory of island biogeography, the generalized theory predicts the existence of a universal, dimensionless biodiversity number. In the theory, this fundamental biodiversity number, together with the migration or dispersal rate, completely determines the steady-state distribution of species richness and relative species abundance on local to large geographic spatial scales and short-term to evolutionary time scales. Although neutral, Hubbell's theory is nevertheless able to generate many nonobvious, testable, and remarkably accurate quantitative predictions about biodiversity and biogeography. In many ways Hubbell's theory is the ecological analog to the neutral theory of genetic drift in genetics. The unified neutral theory of biogeography and biodiversity should stimulate research in new theoretical and empirical directions by ecologists, evolutionary biologists, and biogeographers.

Population Genetics

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Publisher : JHU Press
ISBN 13 : 0801880084
Total Pages : 263 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Population Genetics by : John H. Gillespie

Download or read book Population Genetics written by John H. Gillespie and published by JHU Press. This book was released on 2004-08-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Molecular Population Genetics

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Publisher : Sinauer Associates, Incorporated
ISBN 13 : 9780878939657
Total Pages : 334 pages
Book Rating : 4.9/5 (396 download)

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Book Synopsis Molecular Population Genetics by : Matthew William Hahn

Download or read book Molecular Population Genetics written by Matthew William Hahn and published by Sinauer Associates, Incorporated. This book was released on 2018 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published by Sinauer Associates, an imprint of Oxford University Press. Provides descriptions of the methods and tools used in molecular population genetics, which has combined advances in molecular biology and genomics with mathematical and empirical findings to uncover the history of natural selection and demographic shifts in many organisms.