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Author : William Wei Shen
Publisher :
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.F/5 ( download)
Download or read book Polymer-supported Biomimetic Lipid Bilayers on Solid Substrates written by William Wei Shen and published by . This book was released on 2002 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lisa Yoonjoo Hwang
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.F/5 ( download)
Download or read book Creating Well-defined, Tailorable Polymer-tethered Biomimetic Lipid Bilayers written by Lisa Yoonjoo Hwang and published by . This book was released on 2006 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fatma N. Kök
Publisher : Springer
ISBN 13 : 3030115968
Total Pages : 306 pages
Book Rating : 4.0/5 (31 download)
Download or read book Biomimetic Lipid Membranes: Fundamentals, Applications, and Commercialization written by Fatma N. Kök and published by Springer. This book was released on 2019-04-16 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the fundamentals, applications and viable product strategies of biomimetic lipid membranes into a single, comprehensive source. It broadens its perspective to interdisciplinary realms incorporating medicine, biology, physics, chemistry, materials science, as well as engineering and pharmacy at large. The book guides readers from membrane structure and models to biophysical chemistry and functionalization of membrane surfaces. It then takes the reader through a myriad of surface-sensitive techniques before delving into cutting-edge applications that could help inspire new research directions. With more than half the world's drugs and various toxins targeting these crucial structures, the book addresses a topic of major importance in the field of medicine, particularly biosensor design, diagnostic tool development, vaccine formulation, micro/nano-array systems, and drug screening/development. Provides fundamental knowledge on biomimetic lipid membranes; Addresses some of biomimetic membrane types, preparation methods, properties and characterization techniques; Explains state-of-art technological developments that incorporate microfluidic systems, array technologies, lab-on-a-chip-tools, biosensing, and bioprinting techniques; Describes the integration of biomimetic membranes with current top-notch tools and platforms; Examines applications in medicine, pharmaceutical industry, and environmental monitoring.
Author : Chenyue Xing
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (469 download)
Download or read book How Solid Substrates Affect a Lipid Bilayer written by Chenyue Xing and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We use Molecular Dynamics (MD) simulations to investigate how solid substrates interact with a dipalmitoylphosphatidylcholine (DPPC) lipid bilayer and how substrates affect the lipid membrane structurally and dynamically. Supported lipid bilayers are extensively used in experiments as a simplified model for cell membranes. Few simulations of supported bilayers have been performed. We use the MARTINI coarse-grained model to study the supported bilayer computationally. When a lipid bilayer is deposited on the solid substrate, the undulation of the proximal leaflet is suppressed to a higher extent than that of the distal leaflet. Properties of the bilayer including density profiles and lateral mobility exhibit heterogeneity. The proximal leaflet is ordered under the influence of a smooth surface, while the distal leaflet remains the similar to the leaflets in a free-standing bilayer. The lateral pressure profile of the supported bilayer is also different from that of a free-standing bilayer. Membrane proteins undergo undesired conformational changes due to the change in the lateral pressure profile. We study in particular the high local pressure in the proximal leaflet and estimate the interfacial energy associated with it. The interfacial energy falls in the range of activation energy barriers of the large mechanosensative channel (MscL) and may contribute to the opening of MscL without external pressure. Experiencing the strong inwards tension, the proximal leaflet prefers a smaller area per molecule than the distal leaflet and free-standing bilayers. We employ the umbrella sampling technique to calculate the potential of mean force (PMF) of lipid translocation. The free energy difference given by the PMF of various supported bilayer systems indicate that the proximal leaflet needs more lipids than the distal leaflet. The equilibrium density imbalance between two leaflets in the supported bilayer is roughly 4-7%. In addition, the equilibrium area per molecule of the proximal leaflet is estimated to be around 58 Å2, about 4 Å2 smaller than that of the free-standing bilayer. The lipid flip-flop rate in a supported bilayer with the same number of lipids in both leaflets is higher than in the free-standing bilayer, because the energy barrier of flip-flop is lowered by a few kBT.
Author : C.G. Gebelein
Publisher : Springer Science & Business Media
ISBN 13 : 1461306574
Total Pages : 297 pages
Book Rating : 4.4/5 (613 download)
Download or read book Biomimetic Polymers written by C.G. Gebelein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term biomimetic is comparatively new on the chemical scene, but the concept has been utilized by chemists for many years. Furthermore, the basic idea of making a synthetic material that can imitate the func tions of natural materials probably could be traced back into antiquity. From the dawn of creation, people have probably attempted to duplicate or modify the activities of the natural world. (One can even find allusions to these attempts in the Bible; e. g. , Genesis 30. ) The term "mimetic" means to imitate or mimic. The word "mimic" means to copy closely, or to imitate accurately. Biomimetic, which has not yet entered most dictionaries, means to imitate or mimic some specific bio logical function. Usually, the objective of biomimetics is to form some useful material without the need of utilizing living systems. In a simi lar manner, the term biomimetic polymers means creating synthetic poly mers which imitate the activity of natural bioactive polymers. This is a major advance in polymer chemistry because the natural bioactive polymers are the basis of life itself. Thus, biomimetic polymers imitate the life process in many ways. This present volume delineates some of the recent progress being made in this vast field of biomimetic polymers. Chemists have been making biomimetic polymers for more than fifty years, although this term wasn't used in the early investigations.
Author : Donald Martin
Publisher : Springer Science & Business Media
ISBN 13 : 0387377409
Total Pages : 183 pages
Book Rating : 4.3/5 (873 download)
Download or read book Nanobiotechnology of Biomimetic Membranes written by Donald Martin and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the current state of research and development in biomimetic membranes for nanobiotechnology applications. It takes an international perspective on the issue of developing biotechnology applications from an understanding of the biomimetic membrane at the nanoscale. The success of these applications relies on a good understanding of the interaction and incorporation of macromolecules in membranes and the fundamental properties of the membrane itself.
Author : Aleš Iglič︎
Publisher : Academic Press
ISBN 13 : 0123910714
Total Pages : 329 pages
Book Rating : 4.1/5 (239 download)
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by Aleš Iglič︎ and published by Academic Press. This book was released on 2011-09-19 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field. - Incorporates contributions from newcomers and established and experienced researchers - Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives - Serves as an indispensable source of information for new scientists
Author : Caroline Youjung Kim
Publisher :
ISBN 13 : 9781267240583
Total Pages : pages
Book Rating : 4.2/5 (45 download)
Download or read book Diffusion of Supported Lipid Bilayers on PH Responsive Polymer Cushions Characterized by Fluorescence Recovery After Photobleaching written by Caroline Youjung Kim and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological membranes are extremely complex, highly organized, responsive thin films composed of a myriad of lipids and proteins. Due to their complexity, supported lipid bilayers have been used as alternates to living cell membranes for study of membrane dynamics, membrane structure, and lipid-protein interactions, among other topics. The tools of modern genetic engineering and bioorganic chemistry allow us to couple many types of biomolecule to supported membranes. This results in wide variety of interfaces that can be used to control, organize and study the properties and function of membranes and membrane-associated proteins. The overarching goal has been to develop robust and easily fabricated biomimetic membrane platforms to facilitate the study of transmembrane proteins for sensing applications.Despite the large volume of research, development of solid supported membrane bilayers that recreate the proper environment has proven to be difficult. Some fundamental drawbacks have been protein substrate interactions leading to premature denaturing of the protein and minimal-to-no mobility within the membrane. To ameliorate these issues, polymer supported lipid bilayers are widely used. One of the main attractions for using polymeric cushions is to mimic thermodynamic and structural properties of free bilayer more specifically the cytoskeleton and extra cellular matrix, which is an important feature of the native cellular environment.Chapter 1 describes the fabrication and characterization of polymer supported bilayers and reviews the lateral mobility of the lipids and proteins on various types of polymer supports. Also presented are potential practical applications including biosensors and future directions of development of polymer supported lipid bilayers. Chapter 2 provides the mobility of a polymer supported lipid bilayer with a polymer cushion that is pH responsive and structurally tunable in order to provide an environmentally sensitive interface. In details, the simple preparation of poly(acrylic acid) (PAA) cushioned membranes is described. The PAA cushion provides a tunable, water rich environment for supported lipid membrane applications. Conveniently the thickness of the PAA cushion can be controlled by manipulating the pH of the surrounding aqueous solution and the concentration of the spin-coating solution. As demonstrated in this work, the structure and continuity of cushioned membranes remains intact and this approach offers a robust and facile means to fabricate biological membranes for biophysical studies and sensing applications.
Author : Artur Motheo
Publisher : BoD – Books on Demand
ISBN 13 : 9535103857
Total Pages : 224 pages
Book Rating : 4.5/5 (351 download)
Download or read book Aspects on Fundaments and Applications of Conducting Polymers written by Artur Motheo and published by BoD – Books on Demand. This book was released on 2012-01-20 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the establishment of the conductive properties of intrinsic conductive polymers, a huge variety of basic and applied research has been carried out, involving different polymers, copolymers, blends, mixtures and composites. Thus, fundamental understanding of physical and chemical properties of these materials has been sought, while the applied aspects have advanced very rapidly, crossing the boundaries between disciplines. Today, the applications of conducting polymers in various fields such as neuroscience, nanotechnology and green chemistry, are easily found. This development is dynamic and it needs to be updated and hence the motivation for the set of results presented in this book; which provides information about the development of fundamentals, and about some applications of conductive polymers.
Author : Rolando Guidelli
Publisher : John Wiley & Sons
ISBN 13 : 1119278406
Total Pages : 360 pages
Book Rating : 4.1/5 (192 download)
Download or read book Bioelectrochemistry of Biomembranes and Biomimetic Membranes written by Rolando Guidelli and published by John Wiley & Sons. This book was released on 2016-09-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invaluable to biochemists, biophysicists, and pharmacological scientists; this book provides insights into the essential principles required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes. • Describes the essential electrochemical basics required to understand why and how electrochemical and electrophysiological tools are fundamental in elucidating the mode of ion transport across biomembranes • Requires only basic physical chemistry and mathematics to be understood, without intermediate stumbling blocks that would discourage the reader from proceeding further • Develops contents in a step-by-step approach that encourages students and researchers to read from beginning to end
Author : Chen Ma
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (66 download)
Download or read book Lifting-up of Supported Lipid Bilayers on Layer-by-layer Polyion/alkylthiol Cushions written by Chen Ma and published by . This book was released on 2002 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Helena S. Azevedo
Publisher : Woodhead Publishing
ISBN 13 : 0081020120
Total Pages : 614 pages
Book Rating : 4.0/5 (81 download)
Download or read book Self-assembling Biomaterials written by Helena S. Azevedo and published by Woodhead Publishing. This book was released on 2018-04-17 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials
Download or read book Design and Construction of Phospholipid Membrane Bilayer Biomimetic Devices for Fundamental Understanding of Physical and Chemical Membrane Processes written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, the scientific community has spent a great deal of effort trying to understand the cellular membrane bilayer on an intimate level. Langmuir deposition and vesicle fusion has provided a means to deposit membrane bilayers atop solid inorganic supports. These simple membranes remain fluid in nature due to a 10-30 Å water cushion that rests between the membrane and the solid substrate. Although these mimetic templates are ideal for simple lipid membrane, placement of membrane proteins into these systems results in loss of membrane fluidity, and the proteins often become denatured. It has been suggested that portions of the embedded protein extend beyond the vertical length of the membrane and water cushion, and negatively interact with the inorganic support. Due to these substrate-protein interactions, polymeric cushions and tethers have been used to adjust the vertical distance between the membrane and solid support. Poly(ethylene glycol) (PEG) amphiphiles were one of the first polymers used to remedy the substrate-protein interactions because of its hydrophilic and bioinert qualities. It was found that membranes tethered with PEG amphiphiles actually have up to three different motilities within a single system. There has been much speculation as to why these systems contain different motilities, but no real studies have been conducted to assess the issue. One focus of this dissertation was to study PEG-amphiphile/lipid interactions at the air-water interface. During the process of characterizing these binary mixtures, an interesting meta-stable domain changing phenomena was found to occur at low surface pressures within a narrow concentration regime in these mixtures. These serendipitous results will be described. Due to the different mobile fractions within a single PEG cushioned/tethered membrane system, other polymers have been explored. In this work the development of pH responsive, hydrophilic, and cross-linked poly (acrylic acid) (PAA) based cushioned membrane bilayers are also depicted. The cellular membranes own cushion inspired the design of these cushions; the cytoskeleton, which is a netted network that is able to change shape, based on environmental changes. In addition Gramicidin A transmembrane protein was embedded into PAA cushioned membrane bilayers.
Author : Georg Pabst
Publisher : CRC Press
ISBN 13 : 1466507098
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)
Download or read book Liposomes, Lipid Bilayers and Model Membranes written by Georg Pabst and published by CRC Press. This book was released on 2014-03-04 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a result of their unique physical properties, biological membrane mimetics, such as liposomes, are used in a broad range of scientific and technological applications. Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine. Written by leading researchers in their fields, this book describes basic and applied research, and serves as a useful reference for both the novice and the expert. Part one covers a range of basic research topics, from theory and computational simulations to some of the most up-to-date experimental research. Topics discussed include soft matter physics of membranes, nonlamellar phases, extraction of molecules by amphiphiles, lipid models for membrane rafts, membrane dynamics, nanodiscs, microemulsions, active membranes, as well as interactions of bilayers with drugs or DNA to treat disease or for gene transfer, respectively. Part two of the book focuses on technological applications of amphiphiles, such as liposome-based nanoparticles for drug delivery, formulation of liposomes for prolonged in vivo circulation and functionalization for medical purposes, novel drug delivery systems for increased drug loading, and the use of tethered membranes for bio-sensing applications. Chapters also describe the use of liposomes in textile dyeing and how lipidic nanoparticles are used by the food industry.
Author : Cyrus R. Safinya
Publisher : CRC Press
ISBN 13 : 1466555734
Total Pages : 371 pages
Book Rating : 4.4/5 (665 download)
Download or read book Handbook of Lipid Membranes written by Cyrus R. Safinya and published by CRC Press. This book was released on 2021-09-14 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology. Key Features: Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution Covers advanced X-ray and force measurement techniques Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.
Author :
Publisher : Gulf Professional Publishing
ISBN 13 : 9780126908510
Total Pages : 354 pages
Book Rating : 4.9/5 (85 download)
Download or read book Advances in Planar Lipid Bilayers and Liposomes: Supported lipid bilayers for the detection of hormone-receptor interactions written by and published by Gulf Professional Publishing. This book was released on 2005 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amira Abdelrasoul
Publisher : BoD – Books on Demand
ISBN 13 : 9535136615
Total Pages : 236 pages
Book Rating : 4.5/5 (351 download)
Download or read book Biomimetic and Bioinspired Membranes for New Frontiers in Sustainable Water Treatment Technology written by Amira Abdelrasoul and published by BoD – Books on Demand. This book was released on 2017-12-06 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomimetic and bioinspired membranes are the most promising type of membrane for multiple usage scenarios, including commercial separation applications as well as water and wastewater treatment technologies. In recent years, aquaporin biomimetic membranes (ABMs) for water purification have raised considerable interest. These membranes display uniquely favorable properties and outstanding performances, such as diverse interactions, varied selective transport mechanisms, superior stability, high resistance to membrane fouling, and distinct adaptability. Biomimetic membranes would make a significant contribution to alleviate water stress, environmental threats, and energy consumption.
