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Author : Harry V. Gelboin
Publisher :
ISBN 13 : 9780122792038
Total Pages : 0 pages
Book Rating : 4.7/5 (92 download)
Download or read book Polycyclic Hydrocarbons and Cancer written by Harry V. Gelboin and published by . This book was released on 1978 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harry Victor Gelboin
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (78 download)
Download or read book Polycyclic Hydrocarbons and Cancer: Molecular and cell biology written by Harry Victor Gelboin and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : POP TS'O (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book POLYCYCLIC HYDROCARBONS AND CANCER; Volume 2: Molecular and Cell Biology written by POP TS'O (Ed) and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: VOLUME 1, ENVIRONMENT, CHEMISTRY AND METABOLISM. VOLUME 2,
Author : Harry Gelboin
Publisher : Elsevier
ISBN 13 : 0323149065
Total Pages : 475 pages
Book Rating : 4.3/5 (231 download)
Download or read book Molecular and Cell Biology written by Harry Gelboin and published by Elsevier. This book was released on 2012-12-02 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polycyclic Hydrocarbons and Cancer, Volume 2: Molecular and Cell Biology explores the link between polycyclic aromatic hydrocarbons (PAHs) and cancer from the viewpoint of molecular and cell biology. This volume consists of 26 chapters divided into eight sections based on the following themes: DNA and Chromatin Interactions; Microbial Mutagenesis; Mammalian Mutagenesis; DNA Repair; Transformation of Cells in Culture; Animal and Human Models; Genetics; and Comments and Observations. The discussion begins with an analysis of the interactions of PAHs with cellular macromolecules and with DNA of mammalian cells in culture. The following chapters focus on microbial and mammalian mutagenesis by PAHs; mechanisms of DNA excision repair in human cells; effect of DNA repair on the cytotoxicity and mutagenicity of PAH metabolites in human cells; and oncogenic transformation of cell cultures by PAHs and their derivatives. The final chapter makes the case for the establishment of a system for conducting quantitative assessments of biomedical risk presented by many types of environmental perturbants such as PAHs. This monograph will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in the field of molecular and cell biology.
Author : POP TS'O (Ed)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book POLYCYCLIC HYDROCARBONS AND CANCER; Volume 1: Environment, Chemistry, and Metabolism written by POP TS'O (Ed) and published by . This book was released on 1978 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: VOLUME 1, ENVIRONMENT, CHEMISTRY AND METABOLISM. VOLUME 2, MOLECULAR AND CELL BIOLOGY.
Author : Harry Gelboin
Publisher : Elsevier
ISBN 13 : 032315056X
Total Pages : 433 pages
Book Rating : 4.3/5 (231 download)
Download or read book Environment, Chemistry, and metabolism written by Harry Gelboin and published by Elsevier. This book was released on 2012-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polycyclic Hydrocarbons and Cancer, Volume 1: Environment, Chemistry, and Metabolism brings together information from many diverse disciplines in the environmental, chemical, biological, and medical sciences to provide a comprehensive account of the link between polycyclic aromatic hydrocarbons (PAHs) and cancer. This volume consists of 19 chapters divided into seven sections based on the following themes: Energy Sources; Environmental Occurrence and Monitoring; Tobacco Carcinogenesis; Chemistry, Carcinogenicity, and Theory; Metabolism and Activation; Enzymology; and Pharmacokinetics. The first three chapters focus on the energy sources, occurrence and surveillance, and environmental monitoring of PAHs. The discussion then turns to the link between smoking and cancer; the carcinogenicity of 5-methylchrysene; synthesis and reactions of diol epoxides and related metabolites of carcinogenic hydrocarbons; and enzymes of oxygenation. The final chapter is devoted to the pharmacokinetics of chemically reactive metabolites. This book will be of interest to investigators and educators concerned with scientific aspects of PAH research; government officials and elected representatives as well as industry leaders who must confront and solve the problems related to PAHs; and others in various fields such as chemistry, environmental science, biochemistry and enzymology, pharmacology, molecular and cell biology, and genetics.
Author :
Publisher :
ISBN 13 :
Total Pages : 16 pages
Book Rating : 4.:/5 (3 download)
Download or read book ICRDB Cancergram written by and published by . This book was released on 1986 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harry Victor Gelboin
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.0/5 ( download)
Download or read book Polycyclic Hydrocarbons and Cancer: Molecular and cell biology written by Harry Victor Gelboin and published by . This book was released on 1978 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Harry Victor Gelboin
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)
Download or read book Polycyclic Hydrocarbons and Cancer written by Harry Victor Gelboin and published by . This book was released on 1978 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polycyclic hydrocarbons and cancer ...
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Trevor M. Penning
Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)
Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Author :
Publisher : World Health Organization
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.:/5 (1 download)
Download or read book WHO Guidelines for Indoor Air Quality written by and published by World Health Organization. This book was released on 2010 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.
Author :
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.3/5 (91 download)
Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Warshawsky
Publisher : CRC Press
ISBN 13 : 9780203503430
Total Pages : 602 pages
Book Rating : 4.5/5 (34 download)
Download or read book Molecular Carcinogenesis and the Molecular Biology of Human Cancer written by David Warshawsky and published by CRC Press. This book was released on 2005-10-31 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: To gain a complete overview of what is presently known about molecular carcinogenesis would prove to be a very daunting task for those not already steeped in this complex subject. Fortunately, David Warshawsky and Joseph Landolph Jr., both highly respected for their own contributions to the field, know exactly whom to call upon to fulfill the need
Author : Ronald G. Harvey
Publisher :
ISBN 13 :
Total Pages : 424 pages
Book Rating : 4.3/5 (91 download)
Download or read book Polycyclic Hydrocarbons and Carcinogenesis written by Ronald G. Harvey and published by . This book was released on 1985 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Author : Wing-Sum Tsang
Publisher : Elsevier
ISBN 13 : 1483280675
Total Pages : 134 pages
Book Rating : 4.4/5 (832 download)
Download or read book Metabolic Activation of Polynuclear Aromatic Hydrocarbons written by Wing-Sum Tsang and published by Elsevier. This book was released on 2014-05-09 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Activation of Polynuclear Aromatic Hydrocarbons deals with the metabolic activation of polynuclear aromatic hydrocarbons and covers topics ranging from the cytotoxic, mutagenic, and carcinogenic effects of arene oxides to the role of secondary metabolites as ultimate carcinogens. The mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites is also discussed. This book begins with a brief review of the early work on the mechanism of chemical carcinogenesis by polynuclear hydrocarbons, followed by a detailed survey of pertinent literature in the field. The cytotoxic, mutagenic, and carcinogenic effects of arene oxides are analyzed, along with the solvolytic and nucleophilic reactions of benzo[a]pyrene (BaP) diol epoxides. The discussion then turns to the carcinogenicity, mutagenicity, and cytotoxicity of BaP metabolites; the "Bay-region" theory of carcinogenic activity and perturbational molecular orbital theory; and the mechanism of binding of metabolites derived from polynuclear hydrocarbons to key cellular sites. Research on polycyclic aromatic hydrocarbons pertaining to the "Bay-region" theory is also presented. This monograph will be of interest to chemists, biochemists, and oncologists.
Author : Andreas Luch
Publisher : World Scientific
ISBN 13 : 1783260874
Total Pages : 514 pages
Book Rating : 4.7/5 (832 download)
Download or read book The Carcinogenic Effects Of Polycyclic Aromatic Hydrocarbons written by Andreas Luch and published by World Scientific. This book was released on 2005-08-22 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview on the molecular mode of action of carcinogenic polycyclic aromatic hydrocarbons (PAHs). PAHs are by-products arising from incomplete combustion of organic matter that are frequently released into our environment, and thus are ubiquitously detectable. Many PAHs are strong carcinogens in rodent bioassays and have been linked to increased incidences of various types of cancer in humans. The present book covers all aspects of PAH-induced carcinogenesis; it is a collection of articles written by some of the most recognizable PAH researchers, reviewing the present knowledge in this field. The topics include: exposure to and biomonitoring of PAHs in the human population; metabolic activation of PAHs; genotoxicity and repair of PAH-induced DNA damage; and factors modulating individual susceptibility to the deleterious effects of PAHs.
