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Plague Formation And Progression In Atherosclerosis And Inflammation And Stroke In Sickle Cell Disease
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Book Synopsis Plague Formation and Progression in Atherosclerosis, and Inflammation and Stroke in Sickle Cell Disease by : Felicia Vivienne Schwab-Doyle
Download or read book Plague Formation and Progression in Atherosclerosis, and Inflammation and Stroke in Sickle Cell Disease written by Felicia Vivienne Schwab-Doyle and published by . This book was released on 2003 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intracranial Atherosclerosis by : Jong S. Kim
Download or read book Intracranial Atherosclerosis written by Jong S. Kim and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracranial atherosclerosis is the dominant cause of stroke inover 70% of the world’s population. Globalization is leadingto an increasingly heterogeneous society everywhere. Advances inimaging techinology allow this previously inaccessible pathology tobe clinically studied. Edited by internationally renowned clinicians, IntracranialAtherosclerosis is the first book to examine intracranialcauses of stroke. Clinical practice is allied with basic science toguide all those with an interest in stroke on the diagnosis andmanagement of intracranial atherosclerosis.
Download or read book Stroke Genetics written by Hugh S. Markus and published by Oxford Medical Publications. This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. Anincreasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke.Stroke Genetics provides an up-to-date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemicstroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggest that genetic factors are also important for the much more common multifactorial stroke; this evidence isreviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing apractical approach to investigating patients with stroke for underlying genetic disorders. Also included is a list of useful websites.
Book Synopsis The Stroke Book by : Michel T. Torbey
Download or read book The Stroke Book written by Michel T. Torbey and published by Cambridge University Press. This book was released on 2013-07-18 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.
Download or read book Balance, Gait, and Falls written by and published by Elsevier. This book was released on 2018-11-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Balance, Gait, and Falls, Volume 159 presents the latest information on sensorimotor anatomy, sensory integration, gravity and verticality, standing balance, balance perturbations, voluntary stepping and gait initiation, gait and gait adaptability, disorders of balance and gait that result from aging and neurological diseases. The book provides a brief overview of age-related changes in the structure and function of sensorimotor and central processes, with sections specifically devoted to Parkinson’s disease, parkinsonism, cerebellar ataxia, stroke, corticobasal degeneration, multiple sclerosis, Huntington’s disease, dystonia, tremor, Alzheimer’s disease, frontotemporal dementia, cerebral palsy, polio, motor neuron disease, brainstem lesions, spinal lesions, peripheral nerve disease, and psychogenic conditions. Diseases covered have a common structure comprising background and epidemiology, pathology, balance disorders, gait disorders, falls, therapies (including fall prevention), and future directions. Covers all aspects of basic and clinical research on disorders of balance and gait in neurological disease Presents a multidisciplinary review of balance and gait physiology, the epidemiology and natural history of balance and gait impairments in aging, and a broad range of neurological diseases Addresses impairments of balance and gait for basic and clinical researchers in neuroscience, human movement science, physiotherapy and exercise physiology
Book Synopsis Textbook of Stroke Medicine by : Michael Brainin
Download or read book Textbook of Stroke Medicine written by Michael Brainin and published by Cambridge University Press. This book was released on 2014-09-11 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully revised throughout, the new edition of this concise textbook is aimed at doctors preparing to specialize in stroke care.
Book Synopsis Companion to Psychiatric Studies by : Eve C. Johnstone
Download or read book Companion to Psychiatric Studies written by Eve C. Johnstone and published by . This book was released on 2004 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and authoritative resource thoroughly covers the basic science of psychiatry as well as its clinical practice. It succinctly presents all of the information needed for psychiatric certification. The 7th Edition features a new soft-cover binding and a more user-friendly format, as well as an increased focus on evidence-based medicine.
Book Synopsis Transient Ischemic Attack and Stroke by : Sarah T. Pendlebury
Download or read book Transient Ischemic Attack and Stroke written by Sarah T. Pendlebury and published by Cambridge University Press. This book was released on 2009-02-19 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accessible handbook covering the investigation, diagnosis and management of transient ischemic attacks and minor strokes.
Book Synopsis Acute Ischemic Stroke by : R. Gilberto González
Download or read book Acute Ischemic Stroke written by R. Gilberto González and published by Springer Science & Business Media. This book was released on 2010-10-05 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.
Book Synopsis Molecular Basis of Health and Disease by : Undurti N. Das
Download or read book Molecular Basis of Health and Disease written by Undurti N. Das and published by Springer Science & Business Media. This book was released on 2011-04-02 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
Book Synopsis Red Blood Cell Aggregation by : Oguz Baskurt
Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans—and most other mammals—have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses—the bridging model and the depletion model—that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
Book Synopsis Uncommon Causes of Stroke by : Julien Bogousslavsky
Download or read book Uncommon Causes of Stroke written by Julien Bogousslavsky and published by Cambridge University Press. This book was released on 2001-05-24 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
Book Synopsis Oxford Textbook of Stroke and Cerebrovascular Disease by : Bo Norrving
Download or read book Oxford Textbook of Stroke and Cerebrovascular Disease written by Bo Norrving and published by Oxford University Press, USA. This book was released on 2014 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Oxford Textbooks in Clinical Neurology (OTCN) series, this practical volume covers the current pedagogic principles of stroke disease and care, including the acute hospital phase, public health issues, prevention, long-term management, and silent vascular disease.
Book Synopsis Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies by : Mauro Perretti
Download or read book Resolution Pharmacology - Innovative Therapeutic Approaches Based on the Biology of Resolution to Control Chronic Diseases of Western Societies written by Mauro Perretti and published by Frontiers Media SA. This book was released on 2019-11-04 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this eBook, we have grouped together 16 original contributions which have addressed the translational potential for therapeutics developed on the conceptual framework of the resolution of inflammation. The take home message of our effort, and the efforts of our colleagues who wrote these pieces, is that completely different drugs can be designed and modelled on the mediators and targets of resolution. By implementing this 180° shift in the way we plan the drug development programme (that is by focusing on agonists and/or promoting the actions of pro-resolution agonists) we can offer a fresh approach to the clinical management of chronic diseases that affect the modern society. With this series of articles we foresee the birth of Resolution Pharmacology. The 16 contributions presented herein confirm the broad relevance of pro-resolving physio-pharmacology with the description of pro-resolving mechanisms in distinct diseases, from atherosclerosis and heart infarct, to cystic fibrosis and diabetes. This testifies on one hand the fundamental role that inflammatory mechanisms play in virtually all pathological settings and, on the other hand, the great potential that a novel approach to anti-inflammatory therapy by exploiting resolution mediators and targets may have. Thus, while there is broad recognition that evidence-based interventions have transformed cardiovascular, inflammation and endocrine care, new therapies are still needed for growing numbers of patients with unmet needs. As an example, an estimated 17 million people world-wide die annually of cardiovascular diseases, particularly heart attacks and strokes. Cardiovascular diseases occur almost equally in men and women and are the leading cause of death and morbidity worldwide. It is estimated that only 1/1,000 compounds entering preclinical testing are then trialled in man and the actual cost of developing a new therapeutic into clinical practice has grown exponentially over the past two decades (estimated $1.2B). Over the last 20 years or more, scientists have appreciated the biology of the resolution of inflammation, which provides a new paradigm in our understanding of the inflammatory process with the appreciation of genetic, molecular and cellular mechanisms that are engaged to actively resolve inflammation. The ‘resolution of acute inflammation’ is enabled by counter-regulatory checkpoints to terminate the host reaction while at the same time promoting healing and repair. The potential of lipid mediators to enact pro-resolving effects in the context of cystic fibrosis is presented by Recchiuti et al., while Fredman reasons on the potential for these molecules in atherosclerosis. This resonates well with the contributions from Bäck and colleagues who have focused on pro-resolving receptors to offer vasculo-protection in intimal hyperplasia and more generally in cardiovascular disease. On the same vein is the scholar contribution of Leoni and Soehnlein who focus on heart disease, with Qin et al. presenting the latest findings on the effect of an Annexin A1-derived peptide in myocardial infarction. Hansen et al. and de Gaetano et al. bring in the complexity of diabetes and associated morbidity with a focus on specialised pro-resolving lipid mediators but also introducing the potential of dietary approaches. As the western diet favours disease, an omega-3 rich diet can lead to higher availability of lipid mediators to afford tissue protection if not reverting its pathological status. Docosahexaenoic acid and its bioactive derivatives are endowed with potent anti-nociceptive properties following bone fracture, as shown by Zhang et al. The broad relevance of the pharmacological approach reaches the skin with Resolvin D1 protecting against UV irradiation (Saito et al.). Reduced skin inflammation is also achieved with an Annexin A1 peptide that impacts on the outcome of heterologous transplantation (Lacerda et al.). Indeed, modulating the phenotype of immune cells can provide long lasting beneficial outcomes, as attained with CDK inhibitors (Cartwright et al.) and PI3K inhibitors in experimental gout (Galvao et al.). Such an effect is also achieved with a third group of pro-resolving therapeutics, the melanocortin receptor agonists, with important modulation of macrophage reactivity (Patruno et al.) with Spana et al., providing new pharmacology following selective activation of the MC1 receptor. Finally, Hopkin et al. discuss the potential for targeting immune cell trafficking as a way to control immune mediated diseases, bringing in not only pro-resolving mediator agonists, but also approaches to reduce chemo/cytokine gradients or modulating S1P and 11-beta hydroxysteroid dehydrogenase. Finally, we wish to highlight that this wealth of science has also bought to the forefront specific pro-resolving receptors (including FPR2/ALX, GPR32, ChemR23 and MC1), all G protein coupled receptors that are therefore amenable to pharmacological exploitation for drug discovery programmes. We see that not only agonists to the receptors can be developed, some of them modelled on the natural ligands (e.g. resolvins, lipoxins, Annexin A1-derived peptides or melanocortin peptides), but also that the creativity of this pharmacology can be attained through biased ligands and positive allosteric modulators. Deep knowledge of pro-resolving receptor biology and their cell-specific signalling can accelerate the generation of novel anti-inflammatory depicted on the resolution of inflammation. In conclusion, with this eBook, we propose time is ready to exploit the concepts of resolution and use its targets and mediators for the identification of better drugs to establish ‘Resolution Pharmacology’. We predict Resolution Pharmacology will represent an important innovation in the way common diseases will be treated in the next decades of this millennium.
Book Synopsis Clinical Significance of C-reactive Protein by : Waliza Ansar
Download or read book Clinical Significance of C-reactive Protein written by Waliza Ansar and published by Springer Nature. This book was released on 2020-12-17 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology. Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.
Book Synopsis Stroke Syndromes, 3ed by : Louis R. Caplan
Download or read book Stroke Syndromes, 3ed written by Louis R. Caplan and published by Cambridge University Press. This book was released on 2012-07-12 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of dysfunction due to stroke, this revised edition remains the definitive guide to stroke patterns and syndromes.
Book Synopsis Sickle Cell Anemia by : Fernando Ferreira Costa
Download or read book Sickle Cell Anemia written by Fernando Ferreira Costa and published by Springer. This book was released on 2016-03-29 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.