Pkd Journal

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Cystogenesis

Author : Jong Hoon Park
Publisher : Springer
ISBN 13 : 9811020418
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Cystogenesis by : Jong Hoon Park

Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Hereditary Kidney Diseases

Author : A. Sessa
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 9783805565516
Total Pages : 234 pages
Book Rating : 4.5/5 (655 download)

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Book Synopsis Hereditary Kidney Diseases by : A. Sessa

Download or read book Hereditary Kidney Diseases written by A. Sessa and published by Karger Medical and Scientific Publishers. This book was released on 1997-01-01 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: I would recommend this slim volume for geneticists with an interest in hereditary kidney diseases who would appreciate well written and referenced, up to date papers on the specific conditions included.' Journal of Medical Genetics

The Exegesis of Philip K Dick

Author : Philip K. Dick
Publisher : Houghton Mifflin Harcourt
ISBN 13 : 0547549253
Total Pages : 1003 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis The Exegesis of Philip K Dick by : Philip K. Dick

Download or read book The Exegesis of Philip K Dick written by Philip K. Dick and published by Houghton Mifflin Harcourt. This book was released on 2011-11-07 with total page 1003 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A great and calamitous sequence of arguments with the universe: poignant, terrifying, ludicrous, and brilliant. The Exegesis is the sort of book associated with legends and madmen, but Dick wasn't a legend and he wasn't mad. He lived among us, and was a genius."-Jonathan Lethem Based on thousands of pages of typed and handwritten notes, journal entries, letters, and story sketches, The Exegesis of Philip K. Dick is the magnificent and imaginative final work of an author who dedicated his life to questioning the nature of reality and perception, the malleability of space and time, and the relationship between the human and the divine. Edited and introduced by Pamela Jackson and Jonathan Lethem, this will be the definitive presentation of Dick's brilliant, and epic, final work. In The Exegesis, Dick documents his eight-year attempt to fathom what he called "2-3-74," a postmodern visionary experience of the entire universe "transformed into information." In entries that sometimes ran to hundreds of pages, Dick tried to write his way into the heart of a cosmic mystery that tested his powers of imagination and invention to the limit, adding to, revising, and discarding theory after theory, mixing in dreams and visionary experiences as they occurred, and pulling it all together in three late novels known as the VALIS trilogy. In this abridgment, Jackson and Lethem serve as guides, taking the reader through the Exegesis and establishing connections with moments in Dick's life and work.

Renal Fibrosis: Mechanisms and Therapies

Author : Bi-Cheng Liu
Publisher : Springer
ISBN 13 : 9811388717
Total Pages : 707 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Renal Fibrosis: Mechanisms and Therapies by : Bi-Cheng Liu

Download or read book Renal Fibrosis: Mechanisms and Therapies written by Bi-Cheng Liu and published by Springer. This book was released on 2019-08-09 with total page 707 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.

Kidney Development and Disease

Author : Rachel K. Miller
Publisher : Springer
ISBN 13 : 3319514369
Total Pages : 373 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Kidney Development and Disease by : Rachel K. Miller

Download or read book Kidney Development and Disease written by Rachel K. Miller and published by Springer. This book was released on 2017-04-13 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

The Cystic Kidney

Author : K.D. Gardner
Publisher : Springer Science & Business Media
ISBN 13 : 9400904576
Total Pages : 441 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Cystic Kidney by : K.D. Gardner

Download or read book The Cystic Kidney written by K.D. Gardner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about renal cysts and cystic kidneys. Its contributors have created a resource of current information in a field that once aroused only curiosity, but that now stands at the leading edge of molecular nephrology. Its authorship includes 'oldtimers', who bring the wisdom of experience, and 'newcomers', whose presence attests to the contributions made by the investigative and technological advances of the past decade. Its text is organized to carry the reader from renal cyst to cystic renal disease. Each of its chapters defines or explores a challenge or an advance. Cells that line renal cysts are diverse in structure, type, and perhaps function. The cysts themselves lie within an interstitium that is not normal and may influence cyst development and growth. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.

Pediatric Kidney Disease

Author : Denis F. Geary
Publisher : Springer
ISBN 13 : 3662529726
Total Pages : 1968 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Pediatric Kidney Disease by : Denis F. Geary

Download or read book Pediatric Kidney Disease written by Denis F. Geary and published by Springer. This book was released on 2017-02-16 with total page 1968 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this valuable clinical resource offers a state of the art, comprehensive review on every clinical condition encountered in pediatric nephrology. International experts present the latest knowledge on epidemiology, diagnosis, management, and prognosis in one concise, clinically focused text, in which care has been taken to couple just the right amount of "need-to-know" basic science with practical clinical guidance that will enable the reader to make efficient, informed decisions. The topics covered include: disorders of renal development, glomerular disorders, the kidney and systemic disease, renal tubular disorders, tubulointerstitial disease, urinary tract disorders, acute kidney injury, hypertension, chronic and end-stage renal disease, and renal replacement therapy. The full-color, highly visual, meticulously crafted format will ensure that the practitioner is able to source and apply information with remarkable ease.

Cilia and Flagella

Author :
Publisher : Academic Press
ISBN 13 : 0080859453
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Cilia and Flagella by :

Download or read book Cilia and Flagella written by and published by Academic Press. This book was released on 1995-08-31 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cilia and Flagella presents protocols accessible to all individuals working with eukaryotic cilia and flagella. These recipes delineate laboratory methods and reagents, as well as critical steps and pitfalls of the procedures. The volume covers the roles of cilia and flagella in cell assembly and motility, the cell cycle, cell-cell recognition and other sensory functions, as well as human diseases and disorders. Students, researchers, professors, and clinicians should find the book's combination of "classic" and innovative techniques essential to the study of cilia and flagella.Key Features* A complete guide containing more than 80 concise technical chapters friendly to both the novice and experienced researcher* Covers protocols for cilia and flagella across systems and species from Chlamydomonas and Euglena to mammals* Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time, including microscopy, electrophoresis, and PCR* Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes, who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Chronic Kidney Disease

Author : Thomas Rath
Publisher : BoD – Books on Demand
ISBN 13 : 953513843X
Total Pages : 307 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Chronic Kidney Disease by : Thomas Rath

Download or read book Chronic Kidney Disease written by Thomas Rath and published by BoD – Books on Demand. This book was released on 2018-02-21 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

Liver Diseases

Author : Florentina Radu-Ionita
Publisher : Springer Nature
ISBN 13 : 3030244326
Total Pages : 806 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Liver Diseases by : Florentina Radu-Ionita

Download or read book Liver Diseases written by Florentina Radu-Ionita and published by Springer Nature. This book was released on 2020-01-10 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an in-depth coverage not only of liver pathology but also of diagnosis of the numerous types of liver disease, placing specific emphasis on current treatments of liver pathology including the most up-to-date information on liver transplantation. The first part of provides an in-depth account of the liver pathology in different conditions such as Hepatits, liver ischaemia reperfusion injury, Lyme disease, cirrhotic cardiomyopathy and hepatocellular carcinoma. The second part provides a comprehensive overview of diagnostic methods. Of particular interest are chapters on the latest techniques in Patient-specific 3D printing and transient elastography (FibroScan). The final part focuses on treatment and provides a step-by step guide to the therapeutic management of liver diseases starting with pharmacological treatment and techniques including surgery and liver transplantation. This is an invaluable book for clinicians, practitioners including academics, scientists/researchers and postgraduates to provide the newest knowledge in the field of liver pathogenesis. It is written by a multidisciplinary team of experts in hepathology, gastroenterology, and surgery especially from liver transplantation.

Polycystic Kidney Disease

Author : Benjamin D. Cowley, Jr.
Publisher : Springer
ISBN 13 : 1493977849
Total Pages : 274 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Polycystic Kidney Disease by : Benjamin D. Cowley, Jr.

Download or read book Polycystic Kidney Disease written by Benjamin D. Cowley, Jr. and published by Springer. This book was released on 2018-05-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease. The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms. This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients. The final section covers current clinical trials and emerging therapies in PKD. Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.

Cooking Well

Author : Jacob Taylor
Publisher :
ISBN 13 : 9780692705582
Total Pages : pages
Book Rating : 4.7/5 (55 download)

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Book Synopsis Cooking Well by : Jacob Taylor

Download or read book Cooking Well written by Jacob Taylor and published by . This book was released on 2016-06-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cookbook tailored for those with Polycystic Kidney Disease

ABC of Pediatric Surgical Imaging

Author : Tracy Kilborn
Publisher : Springer Science & Business Media
ISBN 13 : 3540893857
Total Pages : 187 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis ABC of Pediatric Surgical Imaging by : Tracy Kilborn

Download or read book ABC of Pediatric Surgical Imaging written by Tracy Kilborn and published by Springer Science & Business Media. This book was released on 2010-02-05 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is intended for doctors working in this ? eld. It belongs to the pocket of a student, house of? cer, resident, medical of? cer or generalist consultant, who will ? rst see the patient. The clinician needs to suspect at least one disease process as a starting point, because the book is ordered alphabetically according to diagnoses. From this point there are both surgical and imaging differential diagnoses listed. These can also be looked at within the book. For the clinician there is a dedicated page to assist with clinical symptoms and signs, alternative diagnoses and urgency of the radiological investigation, based on important information that is needed from imaging. With regard to imaging, there is a list of primary, follow-on and alternative investi- tions appropriate for the suspected diagnosis. There are lists of imaging features with s- porting images, tips and radiological differential diagnoses. The alphabetic organization makes for a jump to the next suspected diagnosis with ease to ? nd something more suitable for the current patient’s needs.

The Man in the High Castle

Author : Philip K. Dick
Publisher : Houghton Mifflin Harcourt
ISBN 13 : 0547572484
Total Pages : 291 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis The Man in the High Castle by : Philip K. Dick

Download or read book The Man in the High Castle written by Philip K. Dick and published by Houghton Mifflin Harcourt. This book was released on 2011 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Slavery is back. America, 1962. Having lost a war, America finds itself under Nazi Germany and Japan occupation. A few Jews still live under assumed names. The 'I Ching' is prevalent in San Francisco. Science fiction meets serious ideas in this take on a possible alternate history.

Genetic Diseases of the Kidney

Author : Richard P. Lifton
Publisher : Academic Press
ISBN 13 : 0080924271
Total Pages : 895 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Genetic Diseases of the Kidney by : Richard P. Lifton

Download or read book Genetic Diseases of the Kidney written by Richard P. Lifton and published by Academic Press. This book was released on 2009-02-25 with total page 895 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease. More than 2,000 disease genes have been identified in the last 20 years, providing important new insight into the pathophysiology of diseases in every field of medicine. Genetic Diseases of the Kidney offers expert insight into the role of genetic abnormalities in the pathogenesis of abnormal kidney function and kidney disease. Genetic abnormalities are carefully presented within the appropriate physiologic context so that readers will understand not only which genes are linked to which diseases but also which pathways lead from a genetic "disturbance to the systemic appearance of disease. - Lays the essential foundation of mammalian genetics principles for medical professionals with little or no background in genetics - Analyzes specific renal diseases – both monogenic disorders confined to the kidney and systemic diseases with renal involvement – and explains their genetic causes - World-renowned editors and authors offer expert frameworks for understanding the links between genes and complex clinical disorders (i.e., lupus, diabetes, HIV, and hypertension)

The Divine Madness of Philip K. Dick

Author : Kyle Arnold
Publisher : Oxford University Press
ISBN 13 : 0199743258
Total Pages : 249 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis The Divine Madness of Philip K. Dick by : Kyle Arnold

Download or read book The Divine Madness of Philip K. Dick written by Kyle Arnold and published by Oxford University Press. This book was released on 2016 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Divine Madness of Philip K. Dick, written by a psychologist, investigates the inner world of the science fiction writer Philip K. Dick. In 1974, Dick was beset by religious visions, and warned police he was an android. The book explores whether Dick's experience was a spiritual awakening or caused by mental illness.

Combined Liver-kidney Transplantation

Author : Martin Erlichman
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Combined Liver-kidney Transplantation by : Martin Erlichman

Download or read book Combined Liver-kidney Transplantation written by Martin Erlichman and published by . This book was released on 1995 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: