Piecewise Deterministic Processes In Biological Models

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Piecewise Deterministic Processes in Biological Models

Author : Ryszard Rudnicki
Publisher : Springer
ISBN 13 : 3319612956
Total Pages : 169 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Piecewise Deterministic Processes in Biological Models by : Ryszard Rudnicki

Download or read book Piecewise Deterministic Processes in Biological Models written by Ryszard Rudnicki and published by Springer. This book was released on 2017-07-20 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a concise introduction to piecewise deterministic Markov processes (PDMPs), with particular emphasis on their applications to biological models. Further, it presents examples of biological phenomena, such as gene activity and population growth, where different types of PDMPs appear: continuous time Markov chains, deterministic processes with jumps, processes with switching dynamics, and point processes. Subsequent chapters present the necessary tools from the theory of stochastic processes and semigroups of linear operators, as well as theoretical results concerning the long-time behaviour of stochastic semigroups induced by PDMPs and their applications to biological models. As such, the book offers a valuable resource for mathematicians and biologists alike. The first group will find new biological models that lead to interesting and often new mathematical questions, while the second can observe how to include seemingly disparate biological proc esses into a unified mathematical theory, and to arrive at revealing biological conclusions. The target audience primarily comprises of researchers in these two fields, but the book will also benefit graduate students.

Markov Renewal and Piecewise Deterministic Processes

Author : Christiane Cocozza-Thivent
Publisher : Springer Nature
ISBN 13 : 3030704475
Total Pages : 252 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Markov Renewal and Piecewise Deterministic Processes by : Christiane Cocozza-Thivent

Download or read book Markov Renewal and Piecewise Deterministic Processes written by Christiane Cocozza-Thivent and published by Springer Nature. This book was released on 2021-06-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed at researchers, graduate students and engineers who would like to be initiated to Piecewise Deterministic Markov Processes (PDMPs). A PDMP models a deterministic mechanism modified by jumps that occur at random times. The fields of applications are numerous : insurance and risk, biology, communication networks, dependability, supply management, etc. Indeed, the PDMPs studied so far are in fact deterministic functions of CSMPs (Completed Semi-Markov Processes), i.e. semi-Markov processes completed to become Markov processes. This remark leads to considerably broaden the definition of PDMPs and allows their properties to be deduced from those of CSMPs, which are easier to grasp. Stability is studied within a very general framework. In the other chapters, the results become more accurate as the assumptions become more precise. Generalized Chapman-Kolmogorov equations lead to numerical schemes. The last chapter is an opening on processes for which the deterministic flow of the PDMP is replaced with a Markov process. Marked point processes play a key role throughout this book.

Statistical Inference for Piecewise-deterministic Markov Processes

Author : Romain Azais
Publisher : John Wiley & Sons
ISBN 13 : 1119544092
Total Pages : 300 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Statistical Inference for Piecewise-deterministic Markov Processes by : Romain Azais

Download or read book Statistical Inference for Piecewise-deterministic Markov Processes written by Romain Azais and published by John Wiley & Sons. This book was released on 2018-07-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piecewise-deterministic Markov processes form a class of stochastic models with a sizeable scope of applications: biology, insurance, neuroscience, networks, finance... Such processes are defined by a deterministic motion punctuated by random jumps at random times, and offer simple yet challenging models to study. Nevertheless, the issue of statistical estimation of the parameters ruling the jump mechanism is far from trivial. Responding to new developments in the field as well as to current research interests and needs, Statistical inference for piecewise-deterministic Markov processes offers a detailed and comprehensive survey of state-of-the-art results. It covers a wide range of general processes as well as applied models. The present book also dwells on statistics in the context of Markov chains, since piecewise-deterministic Markov processes are characterized by an embedded Markov chain corresponding to the position of the process right after the jumps.

Methods and Models in Mathematical Biology

Author : Johannes Müller
Publisher : Springer
ISBN 13 : 3642272517
Total Pages : 721 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Methods and Models in Mathematical Biology by : Johannes Müller

Download or read book Methods and Models in Mathematical Biology written by Johannes Müller and published by Springer. This book was released on 2015-08-13 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models.

Stochastic Models in Biology

Author : Narendra S. Goel
Publisher : Elsevier
ISBN 13 : 1483278107
Total Pages : 282 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Stochastic Models in Biology by : Narendra S. Goel

Download or read book Stochastic Models in Biology written by Narendra S. Goel and published by Elsevier. This book was released on 2013-10-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic Models in Biology describes the usefulness of the theory of stochastic process in studying biological phenomena. The book describes analysis of biological systems and experiments though probabilistic models rather than deterministic methods. The text reviews the mathematical analyses for modeling different biological systems such as the random processes continuous in time and discrete in state space. The book also discusses population growth and extinction through Malthus' law and the work of MacArthur and Wilson. The text then explains the dynamics of a population of interacting species. The book also addresses population genetics under systematic evolutionary pressures known as deterministic equations and genetic changes in a finite population known as stochastic equations. The text then turns to stochastic modeling of biological systems at the molecular level, particularly the kinetics of biochemical reactions. The book also presents various useful equations such as the differential equation for generating functions for birth and death processes. The text can prove valuable for biochemists, cellular biologists, and researchers in the medical and chemical field who are tasked to perform data analysis.

Semigroups of Operators -Theory and Applications

Author : Jacek Banasiak
Publisher : Springer
ISBN 13 : 3319121456
Total Pages : 338 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Semigroups of Operators -Theory and Applications by : Jacek Banasiak

Download or read book Semigroups of Operators -Theory and Applications written by Jacek Banasiak and published by Springer. This book was released on 2014-11-20 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many results, both from semi group theory itself and from the applied sciences, are phrased in discipline-specific languages and hence are hardly known to a broader community. This volume contains a selection of lectures presented at a conference that was organised as a forum for all mathematicians using semi group theory to learn what is happening outside their own field of research. The collection will help to establish a number of new links between various sub-disciplines of semigroup theory, stochastic processes, differential equations and the applied fields. The theory of semigroups of operators is a well-developed branch of functional analysis. Its foundations were laid at the beginning of the 20th century, while the fundamental generation theorem of Hille and Yosida dates back to the forties. The theory was, from the very beginning, designed as a universal language for partial differential equations and stochastic processes, but at the same time it started to live as an independent branch of operator theory. Nowadays, it still has the same distinctive flavour: it develops rapidly by posing new ‘internal’ questions and in answering them, discovering new methods that can be used in applications. On the other hand, it is influenced by questions from PDEs and stochastic processes as well as from applied sciences such as mathematical biology and optimal control, and thus it continually gathers a new momentum. Researchers and postgraduate students working in operator theory, partial differential equations, probability and stochastic processes, analytical methods in biology and other natural sciences, optimization and optimal control will find this volume useful.

Statistical Inference for Piecewise-deterministic Markov Processes

Author : Romain Azais
Publisher : John Wiley & Sons
ISBN 13 : 1119544033
Total Pages : 300 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Statistical Inference for Piecewise-deterministic Markov Processes by : Romain Azais

Download or read book Statistical Inference for Piecewise-deterministic Markov Processes written by Romain Azais and published by John Wiley & Sons. This book was released on 2018-07-31 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piecewise-deterministic Markov processes form a class of stochastic models with a sizeable scope of applications: biology, insurance, neuroscience, networks, finance... Such processes are defined by a deterministic motion punctuated by random jumps at random times, and offer simple yet challenging models to study. Nevertheless, the issue of statistical estimation of the parameters ruling the jump mechanism is far from trivial. Responding to new developments in the field as well as to current research interests and needs, Statistical inference for piecewise-deterministic Markov processes offers a detailed and comprehensive survey of state-of-the-art results. It covers a wide range of general processes as well as applied models. The present book also dwells on statistics in the context of Markov chains, since piecewise-deterministic Markov processes are characterized by an embedded Markov chain corresponding to the position of the process right after the jumps.

Analytic Methods for Coagulation-Fragmentation Models, Volume I

Author : Jacek Banasiak
Publisher : CRC Press
ISBN 13 : 1351650467
Total Pages : 330 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Analytic Methods for Coagulation-Fragmentation Models, Volume I by : Jacek Banasiak

Download or read book Analytic Methods for Coagulation-Fragmentation Models, Volume I written by Jacek Banasiak and published by CRC Press. This book was released on 2019-09-04 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytic Methods for Coagulation-Fragmentation Models is a two-volume set that provides a comprehensive exposition of the mathematical analysis of coagulation-fragmentation models. Initially, an in-depth survey of coagulation-fragmentation processes is presented, together with an account of relevant early results obtained on the associated model equations. These provide motivation for the subsequent detailed treatment of more up-to-date investigations which have led to significant theoretical developments on topics such as solvability and the long-term behaviour of solutions. To make the account as self-contained as possible, the mathematical tools that feature prominently in these modern treatments are introduced at appropriate places. The main theme of Volume I is the analysis of linear fragmentation models, with Volume II devoted to processes that involve the nonlinear contribution of coagulation. Features of Volume I: The main models of the theory together with their derivations and early methods of solution A detailed presentation of the operator theoretical methods and semigroup theory that play an essential role in the theory of fragmentation processes A comprehensive theory of fragmentation processes, including fragmentation with growth and decay in both the discrete and continuous particle size cases An analytical explanation of the `pathologies’ of the fragmentation equation, such as the shattering phase transition and non-uniqueness of solutions An analysis of the long-term dynamics of the discrete size fragmentation equation with growth

Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology

Author : David Holcman
Publisher : Springer
ISBN 13 : 3319626272
Total Pages : 377 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology by : David Holcman

Download or read book Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology written by David Holcman and published by Springer. This book was released on 2017-10-04 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the modeling and mathematical analysis of stochastic dynamical systems along with their simulations. The collected chapters will review fundamental and current topics and approaches to dynamical systems in cellular biology. This text aims to develop improved mathematical and computational methods with which to study biological processes. At the scale of a single cell, stochasticity becomes important due to low copy numbers of biological molecules, such as mRNA and proteins that take part in biochemical reactions driving cellular processes. When trying to describe such biological processes, the traditional deterministic models are often inadequate, precisely because of these low copy numbers. This book presents stochastic models, which are necessary to account for small particle numbers and extrinsic noise sources. The complexity of these models depend upon whether the biochemical reactions are diffusion-limited or reaction-limited. In the former case, one needs to adopt the framework of stochastic reaction-diffusion models, while in the latter, one can describe the processes by adopting the framework of Markov jump processes and stochastic differential equations. Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology will appeal to graduate students and researchers in the fields of applied mathematics, biophysics, and cellular biology.

Stochastic Processes in Cell Biology

Author : Paul C. Bressloff
Publisher : Springer Nature
ISBN 13 : 3030725154
Total Pages : 773 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Stochastic Processes in Cell Biology by : Paul C. Bressloff

Download or read book Stochastic Processes in Cell Biology written by Paul C. Bressloff and published by Springer Nature. This book was released on 2022-01-04 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Stochastic Modelling for Systems Biology

Author : Darren J. Wilkinson
Publisher : CRC Press
ISBN 13 : 9781584885405
Total Pages : 296 pages
Book Rating : 4.8/5 (854 download)

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Book Synopsis Stochastic Modelling for Systems Biology by : Darren J. Wilkinson

Download or read book Stochastic Modelling for Systems Biology written by Darren J. Wilkinson and published by CRC Press. This book was released on 2006-04-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. The stochastic processes formalism provides a beautiful, elegant, and coherent foundation for chemical kinetics and there is a wealth of associated theory every bit as powerful and elegant as that for conventional continuous deterministic models. The time is right for an introductory text written from this perspective. Stochastic Modelling for Systems Biology presents an accessible introduction to stochastic modelling using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. He provides a comprehensive understanding of stochastic kinetic modelling of biological networks in the systems biology context. The text covers the latest simulation techniques and research material, such as parameter inference, and includes many examples and figures as well as software code in R for various applications. While emphasizing the necessary probabilistic and stochastic methods, the author takes a practical approach, rooting his theoretical development in discussions of the intended application. Written with self-study in mind, the book includes technical chapters that deal with the difficult problems of inference for stochastic kinetic models from experimental data. Providing enough background information to make the subject accessible to the non-specialist, the book integrates a fairly diverse literature into a single convenient and notationally consistent source.

Analysis and Design of Hybrid Systems 2006

Author : Christos Cassandras
Publisher : Elsevier
ISBN 13 : 0080475841
Total Pages : 437 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Analysis and Design of Hybrid Systems 2006 by : Christos Cassandras

Download or read book Analysis and Design of Hybrid Systems 2006 written by Christos Cassandras and published by Elsevier. This book was released on 2006-11-21 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of Analysis and Design of Hybrid Systems 2006: the 2nd IFAC Conference on Analysis and Design of Hybrid Systems, organized in Alghero (Italy) on June 7-9, 2006. ADHS is a series of triennial meetings that aims to bring together researchers and practitioners with a background in control and computer science to provide a survey of the advances in the field of hybrid systems, and of their ability to take up the challenge of analysis, design and verification of efficient and reliable control systems. ADHS'06 is the second Conference of this series after ADHS'03 in Saint Malo. 65 papers selected through careful reviewing process Plenary lectures presented by three distinguished speakers Featuring interesting new research topics

Stochastic Dynamics in Computational Biology

Author : Stefanie Winkelmann
Publisher : Springer Nature
ISBN 13 : 3030623874
Total Pages : 284 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Stochastic Dynamics in Computational Biology by : Stefanie Winkelmann

Download or read book Stochastic Dynamics in Computational Biology written by Stefanie Winkelmann and published by Springer Nature. This book was released on 2021-01-04 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide a well-structured and coherent overview of existing mathematical modeling approaches for biochemical reaction systems, investigating relations between both the conventional models and several types of deterministic-stochastic hybrid model recombinations. Another main objective is to illustrate and compare diverse numerical simulation schemes and their computational effort. Unlike related works, this book presents a broad scope in its applications, from offering a detailed introduction to hybrid approaches for the case of multiple population scales to discussing the setting of time-scale separation resulting from widely varying firing rates of reaction channels. Additionally, it also addresses modeling approaches for non well-mixed reaction-diffusion dynamics, including deterministic and stochastic PDEs and spatiotemporal master equations. Finally, by translating and incorporating complex theory to a level accessible to non-mathematicians, this book effectively bridges the gap between mathematical research in computational biology and its practical use in biological, biochemical, and biomedical systems.

Convergence of One-Parameter Operator Semigroups

Author : Adam Bobrowski
Publisher : Cambridge University Press
ISBN 13 : 1316552950
Total Pages : 453 pages
Book Rating : 4.3/5 (165 download)

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Book Synopsis Convergence of One-Parameter Operator Semigroups by : Adam Bobrowski

Download or read book Convergence of One-Parameter Operator Semigroups written by Adam Bobrowski and published by Cambridge University Press. This book was released on 2016-07-14 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a detailed and contemporary account of the classical theory of convergence of semigroups and its more recent development treating the case where the limit semigroup, in contrast to the approximating semigroups, acts merely on a subspace of the original Banach space (this is the case, for example, with singular perturbations). The author demonstrates the far-reaching applications of this theory using real examples from various branches of pure and applied mathematics, with a particular emphasis on mathematical biology. The book may serve as a useful reference, containing a significant number of new results ranging from the analysis of fish populations to signaling pathways in living cells. It comprises many short chapters, which allows readers to pick and choose those topics most relevant to them, and it contains 160 end-of-chapter exercises so that readers can test their understanding of the material as they go along.

Optimal Control Applied to Biological Models

Author : Suzanne Lenhart
Publisher : CRC Press
ISBN 13 : 1584886404
Total Pages : 272 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis Optimal Control Applied to Biological Models by : Suzanne Lenhart

Download or read book Optimal Control Applied to Biological Models written by Suzanne Lenhart and published by CRC Press. This book was released on 2007-05-07 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: From economics and business to the biological sciences to physics and engineering, professionals successfully use the powerful mathematical tool of optimal control to make management and strategy decisions. Optimal Control Applied to Biological Models thoroughly develops the mathematical aspects of optimal control theory and provides insight into the application of this theory to biological models. Focusing on mathematical concepts, the book first examines the most basic problem for continuous time ordinary differential equations (ODEs) before discussing more complicated problems, such as variations of the initial conditions, imposed bounds on the control, multiple states and controls, linear dependence on the control, and free terminal time. In addition, the authors introduce the optimal control of discrete systems and of partial differential equations (PDEs). Featuring a user-friendly interface, the book contains fourteen interactive sections of various applications, including immunology and epidemic disease models, management decisions in harvesting, and resource allocation models. It also develops the underlying numerical methods of the applications and includes the MATLAB® codes on which the applications are based. Requiring only basic knowledge of multivariable calculus, simple ODEs, and mathematical models, this text shows how to adjust controls in biological systems in order to achieve proper outcomes.

Density Evolution Under Delayed Dynamics

Author : Jérôme Losson
Publisher : Springer Nature
ISBN 13 : 1071610724
Total Pages : 138 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Density Evolution Under Delayed Dynamics by : Jérôme Losson

Download or read book Density Evolution Under Delayed Dynamics written by Jérôme Losson and published by Springer Nature. This book was released on 2020-10-23 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph has arisen out of a number of attempts spanning almost five decades to understand how one might examine the evolution of densities in systems whose dynamics are described by differential delay equations. Though the authors have no definitive solution to the problem, they offer this contribution in an attempt to define the problem as they see it, and to sketch out several obvious attempts that have been suggested to solve the problem and which seem to have failed. They hope that by being available to the general mathematical community, they will inspire others to consider–and hopefully solve–the problem. Serious attempts have been made by all of the authors over the years and they have made reference to these where appropriate.

Mathematical Modeling of Random and Deterministic Phenomena

Author : Solym Mawaki Manou-Abi
Publisher : John Wiley & Sons
ISBN 13 : 1119706912
Total Pages : 259 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Mathematical Modeling of Random and Deterministic Phenomena by : Solym Mawaki Manou-Abi

Download or read book Mathematical Modeling of Random and Deterministic Phenomena written by Solym Mawaki Manou-Abi and published by John Wiley & Sons. This book was released on 2020-02-19 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights mathematical research interests that appear in real life, such as the study and modeling of random and deterministic phenomena. As such, it provides current research in mathematics, with applications in biological and environmental sciences, ecology, epidemiology and social perspectives. The chapters can be read independently of each other, with dedicated references specific to each chapter. The book is organized in two main parts. The first is devoted to some advanced mathematical problems regarding epidemic models; predictions of biomass; space-time modeling of extreme rainfall; modeling with the piecewise deterministic Markov process; optimal control problems; evolution equations in a periodic environment; and the analysis of the heat equation. The second is devoted to a modelization with interdisciplinarity in ecological, socio-economic, epistemological, demographic and social problems. Mathematical Modeling of Random and Deterministic Phenomena is aimed at expert readers, young researchers, plus graduate and advanced undergraduate students who are interested in probability, statistics, modeling and mathematical analysis.