Phosphoinositides And Disease

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Phosphoinositides and Disease

Author : Marco Falasca
Publisher : Springer Science & Business Media
ISBN 13 : 9400750242
Total Pages : 322 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides and Disease by : Marco Falasca

Download or read book Phosphoinositides and Disease written by Marco Falasca and published by Springer Science & Business Media. This book was released on 2012-10-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.

Phosphoinositides I: Enzymes of Synthesis and Degradation

Author : Tamas Balla
Publisher : Springer Science & Business Media
ISBN 13 : 940073011X
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositides II: The Diverse Biological Functions

Author : Tamas Balla
Publisher : Springer Science & Business Media
ISBN 13 : 9400730152
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla

Download or read book Phosphoinositides II: The Diverse Biological Functions written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-02-28 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

Phosphoinositides I: Enzymes of Synthesis and Degradation

Author : Tamas Balla
Publisher : Springer
ISBN 13 : 9789400730113
Total Pages : 356 pages
Book Rating : 4.7/5 (31 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer. This book was released on 2012-03-14 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Phosphoinositide 3-kinase in Health and Disease

Author : Christian Rommel
Publisher : Springer Science & Business Media
ISBN 13 : 3642148166
Total Pages : 308 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Phosphoinositide 3-kinase in Health and Disease by : Christian Rommel

Download or read book Phosphoinositide 3-kinase in Health and Disease written by Christian Rommel and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

Phosphoinositide 3-kinase in Health and Disease

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (21 download)

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Book Synopsis Phosphoinositide 3-kinase in Health and Disease by :

Download or read book Phosphoinositide 3-kinase in Health and Disease written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phosphoinositides in Subcellular Targeting and Enzyme Activation

Author : Harald Stenmark
Publisher : Springer Science & Business Media
ISBN 13 : 3642188052
Total Pages : 215 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Phosphoinositides in Subcellular Targeting and Enzyme Activation by : Harald Stenmark

Download or read book Phosphoinositides in Subcellular Targeting and Enzyme Activation written by Harald Stenmark and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.

Phosphoinositide 3-kinase in Health and Disease

Author : Christian Rommel
Publisher : Springer
ISBN 13 : 9783642148156
Total Pages : 306 pages
Book Rating : 4.1/5 (481 download)

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Book Synopsis Phosphoinositide 3-kinase in Health and Disease by : Christian Rommel

Download or read book Phosphoinositide 3-kinase in Health and Disease written by Christian Rommel and published by Springer. This book was released on 2010-10-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target

Phosphoinositide 3-kinase in Health and Disease

Author : Christian Rommel
Publisher : Springer
ISBN 13 : 9783642136627
Total Pages : 0 pages
Book Rating : 4.1/5 (366 download)

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Book Synopsis Phosphoinositide 3-kinase in Health and Disease by : Christian Rommel

Download or read book Phosphoinositide 3-kinase in Health and Disease written by Christian Rommel and published by Springer. This book was released on 2010-10-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here

PI3K signalling

Author : Klaus Okkenhaug
Publisher : Frontiers Media SA
ISBN 13 : 2889194191
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis PI3K signalling by : Klaus Okkenhaug

Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.

Handbook of Cell Signaling

Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3188 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Cell Signaling by : Ralph A. Bradshaw

Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field

Cellular and Molecular Biology of Bone

Author : Masaki Noda
Publisher : Academic Press
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cellular and Molecular Biology of Bone by : Masaki Noda

Download or read book Cellular and Molecular Biology of Bone written by Masaki Noda and published by Academic Press. This book was released on 1993-09-13 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death and resorption.

Molecular Biology of the Male Reproductive System

Author : David de Kretser
Publisher : Elsevier
ISBN 13 : 008091764X
Total Pages : 502 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Molecular Biology of the Male Reproductive System by : David de Kretser

Download or read book Molecular Biology of the Male Reproductive System written by David de Kretser and published by Elsevier. This book was released on 2012-12-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. - Provides up-to-date reviews of the molecular and cellular biology of male reproduction - Includes chapters on the developmental biology of the testes - Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes

Pathogenic Bacteria

Author : Sahra Kırmusaoğlu
Publisher : BoD – Books on Demand
ISBN 13 : 1789859875
Total Pages : 248 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Pathogenic Bacteria by : Sahra Kırmusaoğlu

Download or read book Pathogenic Bacteria written by Sahra Kırmusaoğlu and published by BoD – Books on Demand. This book was released on 2020-12-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogenic bacteria are the main problem in hospital- and community-acquired infections. As bacteria continue to develop more resistance to antibiotics, it is imperative to develop antibacterial treatment strategies. Written by experts from all over the world, this book examines pathogenic bacteria and their link to multidrug resistance. Over thirteen chapters, it presents examples of pathogenesis, virulence factors, and treatment strategies.

Targeting Cellular Signalling Pathways in Lung Diseases

Author : Kamal Dua
Publisher : Springer Nature
ISBN 13 : 9813368276
Total Pages : 926 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Targeting Cellular Signalling Pathways in Lung Diseases by : Kamal Dua

Download or read book Targeting Cellular Signalling Pathways in Lung Diseases written by Kamal Dua and published by Springer Nature. This book was released on 2021-07-02 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases

Author :
Publisher : Academic Press
ISBN 13 : 0128205512
Total Pages : 232 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases by :

Download or read book Medicinal Chemistry Approaches to Malaria and Other Tropical Diseases written by and published by Academic Press. This book was released on 2019-10-25 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry Approaches to Malaria and Other Tropical Disease, Volume 53 in the Annual Reports in Medicinal Chemistry series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Annual Reports in Medicinal Chemistry series Includes the latest information on Medicinal Approaches to Malaria and Other Tropical Diseases

Lipid Metabolism in Signaling Systems

Author : John N. Fain
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.X/5 (2 download)

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Book Synopsis Lipid Metabolism in Signaling Systems by : John N. Fain

Download or read book Lipid Metabolism in Signaling Systems written by John N. Fain and published by . This book was released on 1993 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Major topics covered include: * Techniques for examining the role of phosphoinositides in signal transduction * Techniques related to protein kinase C * Analysis of inositol phosphates * Techniques to analyze phospholipid turnover in the brain