Phase Separated Biomolecular Condensates

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Phase-Separated Biomolecular Condensates

Author : Huan-Xiang Zhou
Publisher : Springer Nature
ISBN 13 : 1071626639
Total Pages : 454 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Phase-Separated Biomolecular Condensates by : Huan-Xiang Zhou

Download or read book Phase-Separated Biomolecular Condensates written by Huan-Xiang Zhou and published by Springer Nature. This book was released on 2022-10-13 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with a broad collection of theoretical, computational, and experimental methods to quantitatively study the properties of phase-separate biomolecular condensates in diverse systems. The chapters in this book cover topics such as theoretical and computational methods; methods for in vitro characterization of biomolecular condensates; and techniques that enable in-cell characterization of biomolecular condensates. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Phase-Separated Biomolecular Condensates: Methods and Protocols is a valuable resource that helps researchers learn and use established methods to study both biophysical properties and biological functions of biomolecular condensates.

Extracellular Matrix Degradation

Author : William C. Parks
Publisher : Springer Science & Business Media
ISBN 13 : 3642168612
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

The Mathematics of Diffusion

Author : John Crank
Publisher : Oxford University Press
ISBN 13 : 9780198534112
Total Pages : 428 pages
Book Rating : 4.5/5 (341 download)

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Book Synopsis The Mathematics of Diffusion by : John Crank

Download or read book The Mathematics of Diffusion written by John Crank and published by Oxford University Press. This book was released on 1979 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.

Tau oligomers

Author : Jesus Avila
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Tau oligomers by : Jesus Avila

Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.

Molecular Driving Forces

Author : Ken Dill
Publisher : Garland Science
ISBN 13 : 1136672990
Total Pages : 784 pages
Book Rating : 4.1/5 (366 download)

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Book Synopsis Molecular Driving Forces by : Ken Dill

Download or read book Molecular Driving Forces written by Ken Dill and published by Garland Science. This book was released on 2010-10-21 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Driving Forces, Second Edition E-book is an introductory statistical thermodynamics text that describes the principles and forces that drive chemical and biological processes. It demonstrates how the complex behaviors of molecules can result from a few simple physical processes, and how simple models provide surprisingly accurate insights into the workings of the molecular world. Widely adopted in its First Edition, Molecular Driving Forces is regarded by teachers and students as an accessible textbook that illuminates underlying principles and concepts. The Second Edition includes two brand new chapters: (1) "Microscopic Dynamics" introduces single molecule experiments; and (2) "Molecular Machines" considers how nanoscale machines and engines work. "The Logic of Thermodynamics" has been expanded to its own chapter and now covers heat, work, processes, pathways, and cycles. New practical applications, examples, and end-of-chapter questions are integrated throughout the revised and updated text, exploring topics in biology, environmental and energy science, and nanotechnology. Written in a clear and reader-friendly style, the book provides an excellent introduction to the subject for novices while remaining a valuable resource for experts.

Fuzziness

Author : Monika Fuxreiter
Publisher : Springer Science & Business Media
ISBN 13 : 1461406595
Total Pages : 210 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Fuzziness by : Monika Fuxreiter

Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Molecular Theory of Capillarity

Author : J. S. Rowlinson
Publisher : Courier Corporation
ISBN 13 : 0486317099
Total Pages : 354 pages
Book Rating : 4.4/5 (863 download)

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Book Synopsis Molecular Theory of Capillarity by : J. S. Rowlinson

Download or read book Molecular Theory of Capillarity written by J. S. Rowlinson and published by Courier Corporation. This book was released on 2013-04-26 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: History of surface phenomena offers critical and detailed examination and assessment of modern theories, focusing on statistical mechanics and application of results in mean-field approximation to model systems. 1989 edition.

The Immune Synapse

Author : Cosima T. Baldari
Publisher : Humana
ISBN 13 : 9781071631379
Total Pages : 0 pages
Book Rating : 4.6/5 (313 download)

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Book Synopsis The Immune Synapse by : Cosima T. Baldari

Download or read book The Immune Synapse written by Cosima T. Baldari and published by Humana. This book was released on 2024-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new collection features the most up-to-date essential protocols that are currently being used to study the immune synapse. Beginning with methods for making biophysical measurements, the volume continues by covering the cell biology of synapses, methods for advanced substrate engineering, mechanobiology topics, new technologies to describe and manipulate synaptic components, as well as methods related to sites of action and immunotherapy. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and fully updated, The Immune Synapse: Methods and Protocols, Second Edition serves as an ideal practical guide for researchers working in this dynamic field. Chapters 5, 11,18, 27, 30, and 32 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Phase Transitions in Cell Biology

Author : Gerald H. Pollack
Publisher : Springer Science & Business Media
ISBN 13 : 1402086512
Total Pages : 187 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Phase Transitions in Cell Biology by : Gerald H. Pollack

Download or read book Phase Transitions in Cell Biology written by Gerald H. Pollack and published by Springer Science & Business Media. This book was released on 2008-08-15 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase transitions occur throughout nature. The most familiar example is the one that occurs in water – the abrupt, discontinuous transition from a liquid to a gas or a solid, induced by a subtle environmental change. Practically magical, the ever-so-slight shift of temperature or pressure can induce an astonishing transition from one entity to another entity that bears little resemblance to the first. So "convenient" a feature is seen throughout the domains of physics and chemistry, and one is therefore led to wonder whether it might also be common to biology. Indeed, many of the most fundamental cellular processes are arguably attributable to radical structural shifts triggered by subtle changes that cross a critical threshold. These processes include transport, motion, signaling, division, and other fundamental aspects of cellular function. Largely on the basis of this radical concept, a symposium was organized in Poitiers, France, to bring together people who have additional evidence for the role of phase transitions in biology, and this book is a compendium of some of the more far-reaching of those presentations, as well as several others that seemed to the editors to be compelling. The book should be suitable for anyone interested in the nature of biological function, particularly those who tire of lumbering along well trodden pathways of pursuit, and are eager to hear something fresh. The book is replete with fresh interpretations of familiar phenomena, and should serve as an excellent gateway to deeper understanding.

The Nucleolus

Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
ISBN 13 : 1461405149
Total Pages : 434 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis The Nucleolus by : Mark O. J. Olson

Download or read book The Nucleolus written by Mark O. J. Olson and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Intrinsically Disordered Proteins

Author : Birthe B. Kragelund
Publisher : Humana
ISBN 13 : 9781071605264
Total Pages : 951 pages
Book Rating : 4.6/5 (52 download)

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Book Synopsis Intrinsically Disordered Proteins by : Birthe B. Kragelund

Download or read book Intrinsically Disordered Proteins written by Birthe B. Kragelund and published by Humana. This book was released on 2021-07-23 with total page 951 pages. Available in PDF, EPUB and Kindle. Book excerpt: The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Intrinsically Disordered Proteins: Methods and Protocols aims to help scientists with different backgrounds to further their investigations into these fascinating and dynamic molecules. Chapter 24 is available open access under a CC BY 4.0 license via link.springer.com. Chapters “40 and 42 ” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Author : Isabella C. Felli
Publisher : Springer
ISBN 13 : 3319201646
Total Pages : 428 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Intrinsically Disordered Proteins Studied by NMR Spectroscopy by : Isabella C. Felli

Download or read book Intrinsically Disordered Proteins Studied by NMR Spectroscopy written by Isabella C. Felli and published by Springer. This book was released on 2015-09-19 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in high-resolution studies of proteins, intrinsic protein disorder is now recognized as one of the key features for a large variety of cellular functions, where structural flexibility presents a functional advantage in terms of binding plasticity and promiscuity and this volume explores this exciting new research. Recent progress in the field has radically changed our perspective to study IDPs through NMR: increasingly complex IDPs can now be characterized, a wide range of observables can be determined reporting on the structural and dynamic properties, computational methods to describe the structure and dynamics are in continuous development and IDPs can be studied in environments as complex as whole cells. This volume communicates the new exciting possibilities offered by NMR and presents open questions to foster further developments. Intrinsically Disordered Proteins Studied by NMR Spectroscopy provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.

Tau Biology

Author : Akihiko Takashima
Publisher : Springer Nature
ISBN 13 : 9813293586
Total Pages : 405 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Tau Biology by : Akihiko Takashima

Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.

Scaling Concepts in Polymer Physics

Author : Pierre-Gilles de Gennes
Publisher : Cornell University Press
ISBN 13 : 9780801412035
Total Pages : 336 pages
Book Rating : 4.4/5 (12 download)

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Book Synopsis Scaling Concepts in Polymer Physics by : Pierre-Gilles de Gennes

Download or read book Scaling Concepts in Polymer Physics written by Pierre-Gilles de Gennes and published by Cornell University Press. This book was released on 1979 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first stage of the physics of long, flexible chains was pioneered by eminent scientists such as Debye, Kuhn, Kramers, and Flory, who formulated the basic ideas. In recent years, because of the availability of new experimental and theoretical tools, a second stage of the physics of polymers has evolved. In this book, a noted physicist explains the radical changes that have taken place in this exciting and rapidly developing field. Pierre-Gilles de Gennes points out the three developments that have been essential for recent advances in the study of large-scale conformations and motions of flexible polymers in solutions and melts. They are the advent of neutron-scattering experiments on selectively deuterated molecules; the availability of inelastic scattering of laser light, which allows us to study the cooperative motions of the chains; and the discovery of an important relationship between polymer statistics and critical phenomena, leading to many simple scaling laws. Until now, information relating to these advances has not been readily accessible to physical chemists and polymer scientists because of the difficulties in the new theoretical language that has come into use. Professor de Gennes bridges this gap by presenting scaling concepts in terms that will be understandable to students in chemistry and engineering as well as in physics.

Statistical Thermodynamics Of Surfaces, Interfaces, And Membranes

Author : Samuel Safran
Publisher : CRC Press
ISBN 13 : 0429976763
Total Pages : 204 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Statistical Thermodynamics Of Surfaces, Interfaces, And Membranes by : Samuel Safran

Download or read book Statistical Thermodynamics Of Surfaces, Interfaces, And Membranes written by Samuel Safran and published by CRC Press. This book was released on 2018-03-08 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the structural and thermodynamic properties of surfaces, interfaces, and membranes is important for both fundamental and practical reasons. Important applications include coatings, dispersants, encapsulating agents, and biological materials. Soft materials, important in the development of new materials and the basis of many biological systems, cannot be designed using trial and error methods due to the multiplicity of components and parameters. While these systems can sometimes be analyzed in terms of microscopic mixtures, it is often conceptually simpler to regard them as dispersions and to focus on the properties of the internal interfaces found in these systems. The basic physics centers on the properties of quasi-two-dimensional systems embedded in the three-dimensional world, thus exhibiting phenomena that do not exist in bulk materials. This approach is the basis behind the theoretical presentation of Statistical Thermodynamics of Surfaces, Interfaces, and Membranes. The approach adapted allows one to treat the rich diversity of phenomena investigated in the field of soft matter physics (including both colloid/interface science as well as the materials and macromolecular aspects of biological physics) such as interfacial tension, the roughening transition, wetting, interactions between surfaces, membrane elasticity, and self-assembly. Presented as a set of lecture notes, this book is aimed at physicists, physical chemists, biological physicists, chemical engineers, and materials scientists who are interested in the statistical mechanics that underlie the macroscopic, thermodynamic properties of surfaces, interfaces, and membranes. This paperback edition contains all the material published in the original hard-cover edition as well as additional clarifications and explanations.

Understanding DNA

Author : Chris R. Calladine
Publisher : Elsevier
ISBN 13 : 0080474667
Total Pages : 349 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Understanding DNA by : Chris R. Calladine

Download or read book Understanding DNA written by Chris R. Calladine and published by Elsevier. This book was released on 2004-03-13 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The functional properties of any molecule are directly related to, and affected by, its structure. This is especially true for DNA, the molecular that carries the code for all life on earth. The third edition of Understanding DNA has been entirely revised and updated, and expanded to cover new advances in our understanding. It explains, step by step, how DNA forms specific structures, the nature of these structures and how they fundamentally affect the biological processes of transcription and replication. Written in a clear, concise and lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry and genetics students, to newcomers to the field from other areas such as chemistry or physics, and even for seasoned researchers, who really want to understand DNA. - Describes the basic units of DNA and how these form the double helix, and the various types of DNA double helix - Outlines the methods used to study DNA structure - Contains over 130 illustrations, some in full color, as well as exercises and further readings to stimulate student comprehension

Air Pollution

Author : Bhola R. Gurjar
Publisher : CRC Press
ISBN 13 : 1439809631
Total Pages : 556 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Air Pollution by : Bhola R. Gurjar

Download or read book Air Pollution written by Bhola R. Gurjar and published by CRC Press. This book was released on 2010-06-22 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Air pollution is recognized as one of the leading contributors to the global environmental burden of disease, even in countries with relatively low concentrations of air pollution. Air Pollution: Health and Environmental Impacts examines the effect of this complex problem on human health and the environment in different settings around the world. I