Pharmacological And Toxicological Screening Methods Ii

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PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS-II

Author : Dr. Trilochan Satapathy
Publisher : JEC PUBLICATION
ISBN 13 : 9361759019
Total Pages : 244 pages
Book Rating : 4.3/5 (617 download)

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Book Synopsis PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS-II by : Dr. Trilochan Satapathy

Download or read book PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS-II written by Dr. Trilochan Satapathy and published by JEC PUBLICATION. This book was released on with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete handbook on toxicology covers basic principles, regulatory criteria, and sophisticated methods for understanding and assuring the safety of varied chemicals in the following pages. Introduction to toxicology, "Toxicology Fundamentals and Regulatory Guidelines," covers broad overviews, mechanistic toxicology, regulatory frameworks, and descriptive toxicology. Focus is on OECD, ICH, EPA, and Schedule Y regulatory criteria, as well as the history and importance of Good Laboratory Practise (GLP) in drug development. As the book explores "Types of Toxicity Studies and Test Item Characterization," it examines acute, sub-acute, chronic, and particular acute investigations, including oral, cutaneous, and inhalational toxicity studies. Test item characterisation procedures are carefully explained, emphasising their importance in regulatory compliance and toxicity evaluation. This leads to "Advanced Toxicology Studies," which covers reproductive toxicology, genotoxicity, and in vivo carcinogenicity. These investigations provide a thorough view of possible dangers and evaluate drug safety. The book then discusses "IND Enabling Studies and Safety Pharmacology," which covers the necessary research for IND applications. Exploring regulatory settings, corporate views, and safety pharmacology in drug development provides a complete knowledge of experimental substance safety. The third part, "Toxicokinetic and Alternatives to Animal Testing," emphasises toxicokinetic assessment and discusses new methods. Following the evolution of safety assessment practises, these options are investigated for ethical and regulatory consequences. Students, researchers, and professionals traversing toxicology's difficult landscape may find this book invaluable. Its extensive coverage, from basic concepts to sophisticated approaches, makes it an important tool for protecting humans and ecosystems in the dynamic pharmaceuticals and beyond industries.

Pharmacological Screening Methods & Toxicology

Author : Avanapu Srinivasa Srinivasa Rao
Publisher :
ISBN 13 : 9789391910549
Total Pages : 398 pages
Book Rating : 4.9/5 (15 download)

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Book Synopsis Pharmacological Screening Methods & Toxicology by : Avanapu Srinivasa Srinivasa Rao

Download or read book Pharmacological Screening Methods & Toxicology written by Avanapu Srinivasa Srinivasa Rao and published by . This book was released on 2021-11 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacological Screening Methods and Toxicology

Author : A Srinivasa Rao
Publisher :
ISBN 13 : 9789385433818
Total Pages : 356 pages
Book Rating : 4.4/5 (338 download)

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Book Synopsis Pharmacological Screening Methods and Toxicology by : A Srinivasa Rao

Download or read book Pharmacological Screening Methods and Toxicology written by A Srinivasa Rao and published by . This book was released on 2016 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Book covers all steps of drug discovery like lead synthesis, preclinical studies, FDA requirements and clinical studies and also about High Throughput Screening. It also covers about all aspects about experimental animals.

Screening Methods in Pharmacology

Author : Robert A. Turner
Publisher : Elsevier
ISBN 13 : 1483264238
Total Pages : 308 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Screening Methods in Pharmacology by : Robert A. Turner

Download or read book Screening Methods in Pharmacology written by Robert A. Turner and published by Elsevier. This book was released on 2016-01-26 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for alpha and beta Adrenergic blocking agents; compounds for antianginal activity; topical products for excessive eccrine sweating; antidepressant agents; and agents with analgesic and analgesic antagonist activity. Pharmacologists, pharmacists, researchers, and physicians will find this book a good source of information.

Introduction to Toxicological Screening Methods and Good Laboratory Practice

Author : Saravana Babu Chidambaram
Publisher : Springer Nature
ISBN 13 : 9811660921
Total Pages : 205 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Introduction to Toxicological Screening Methods and Good Laboratory Practice by : Saravana Babu Chidambaram

Download or read book Introduction to Toxicological Screening Methods and Good Laboratory Practice written by Saravana Babu Chidambaram and published by Springer Nature. This book was released on 2022-02-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.

PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS - I

Author : Dr. Trilochan Satapathy
Publisher : JEC PUBLICATION
ISBN 13 : 9361752359
Total Pages : 254 pages
Book Rating : 4.3/5 (617 download)

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Book Synopsis PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS - I by : Dr. Trilochan Satapathy

Download or read book PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS - I written by Dr. Trilochan Satapathy and published by JEC PUBLICATION. This book was released on with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sciences of pharmacology and toxicology are strongly intertwined. The former focuses on how medications function in live beings, while the latter focuses on the bad effects of drugs and chemicals and how to treat them. Both fields are concerned with the behaviour of drugs and chemicals in living organisms. This book provides a detailed illustration of the most important concepts that are involved in pharmacology and the medical sciences that are related to it. The title opens with a discussion of the historical elements of drug creation, including up-to-date information about Nobel Laureates in pharmacology and toxicology and the key discoveries they made. Following this, it conducts an analysis of the fundamental concepts of pharmacology, including pharmacokinetics and pharmacodynamics, as well as providing comprehensive information on drug transporters and interactions. The subsequent chapters of the book are dedicated to covering a comprehensive assortment of subjects that provide vital knowledge on the fundamental principles of pharmacology and the manner in which these concepts are used for the clinical treatment of disorders.

Screening Methods in Pharmacology

Author : Robert Arnold Turner
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (12 download)

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Book Synopsis Screening Methods in Pharmacology by : Robert Arnold Turner

Download or read book Screening Methods in Pharmacology written by Robert Arnold Turner and published by . This book was released on 1971 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Screening Methods in Pharmacology

Author : Robert A. Turner
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (258 download)

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Book Synopsis Screening Methods in Pharmacology by : Robert A. Turner

Download or read book Screening Methods in Pharmacology written by Robert A. Turner and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Screening Methods in Pharmacology, V.2

Author : R. A. H. Turner
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Screening Methods in Pharmacology, V.2 by : R. A. H. Turner

Download or read book Screening Methods in Pharmacology, V.2 written by R. A. H. Turner and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Screening Methods in Pharmacology

Author : Robert A. Turner
Publisher :
ISBN 13 :
Total Pages : 332 pages
Book Rating : 4.:/5 (379 download)

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Book Synopsis Screening Methods in Pharmacology by : Robert A. Turner

Download or read book Screening Methods in Pharmacology written by Robert A. Turner and published by . This book was released on 1979 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Comprehensive Guide to Toxicology in Preclinical Drug Development

Author : Ali S. Faqi
Publisher : Academic Press
ISBN 13 : 0123878152
Total Pages : 904 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-11-02 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --

Drug Screening Methods

Author : Suresh Kumar Gupta
Publisher : Anshan Pub
ISBN 13 :
Total Pages : 532 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Drug Screening Methods by : Suresh Kumar Gupta

Download or read book Drug Screening Methods written by Suresh Kumar Gupta and published by Anshan Pub. This book was released on 2005 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Screening Methods in Pharmacology

Author : N. S. Parmar
Publisher : Alpha Science International, Limited
ISBN 13 : 9781842653463
Total Pages : 452 pages
Book Rating : 4.6/5 (534 download)

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Book Synopsis Screening Methods in Pharmacology by : N. S. Parmar

Download or read book Screening Methods in Pharmacology written by N. S. Parmar and published by Alpha Science International, Limited. This book was released on 2006 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Screening Methods in Pharmacology provides an up to-date and concise account of in vivo methods used in the pharmacological screening of important categories of clinically useful drugs. It also encompasses the basic principles of animal experimentation and current advances leading to the use of transgenic animals, combinatorial chemistry, high throughout screening, pharmacogenomics, proteomics and array technology. The methods used for the detection of pharmacological effects of potential drugs on the CNS, CVS, endocrines, respiratory tract and immunomodulation have been described in adequate details with cross references for further studies and comprehension. The book is expected to be extremely useful for postgraduates in pharmacology from all disciplines and for the scientists engaged in the drug discovery research programmes.

Screening Methods in Pharmacology

Author : Rao Muralidhar
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (898 download)

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Book Synopsis Screening Methods in Pharmacology by : Rao Muralidhar

Download or read book Screening Methods in Pharmacology written by Rao Muralidhar and published by . This book was released on 2023-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the essential topics related to drug discovery and development, with a particular focus on the care, handling, and breeding techniques of laboratory animals, toxicity testing, and screening methods for pharmacological activity. Designed for M.Pharm Pharmacology and B.Pharm students, as well as anyone involved in drug discovery and development, this book covers the following topics: Care, handling, and breeding techniques of laboratory animals, along with alternative methods to animal studies OECD guidelines and the determination of LD50, acute, sub-acute, and chronic toxicity studies Organization of screening for pharmacological activity of new substances, with a particular emphasis on the evaluation of antipsychotics, antiepileptics, and antidepressants Screening methods for anti-diabetic, antiulcer, CHF, and anti-hypertensive drugs, as well as screening methods for anti-inflammatory, analgesics, and antipyretic drugs Throughout the book, the importance of preclinical studies in drug development and the role of screening methods in identifying potential drug candidates are emphasized. The ethical considerations related to animal experimentation are also discussed in detail. This book is a valuable resource for anyone involved in drug discovery and development, providing a comprehensive overview of the essential topics related to pharmacology.

Principles of Safety Pharmacology

Author : Michael K. Pugsley
Publisher : Springer
ISBN 13 : 366246943X
Total Pages : 481 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Principles of Safety Pharmacology by : Michael K. Pugsley

Download or read book Principles of Safety Pharmacology written by Michael K. Pugsley and published by Springer. This book was released on 2015-06-19 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.

Drug Discovery and Evaluation

Author : Hans G. Vogel
Publisher : Springer Science & Business Media
ISBN 13 : 366203333X
Total Pages : 790 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Drug Discovery and Evaluation by : Hans G. Vogel

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

Author : Ali S. Faqi
Publisher : Elsevier
ISBN 13 : 0323984622
Total Pages : 1074 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi

Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology