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Perspectives On Biologically Based Cancer Risk Assessment
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Author :Vincent James Cogliano Publisher :Springer Science & Business Media ISBN 13 :1461547415 Total Pages :329 pages Book Rating :4.4/5 (615 download)
Book Synopsis Perspectives on Biologically Based Cancer Risk Assessment by : Vincent James Cogliano
Download or read book Perspectives on Biologically Based Cancer Risk Assessment written by Vincent James Cogliano and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first meeting of the NATO/CCMS Pilot Study "Dose-Response Analysis and Biologically-Based Risk assessment for Initiator and Promoter Carcinogens" was held in Rome, Italy, in the spring of 1991, and was followed by annual or bi-annual meetings held in Germany, Greece, Netherlands, Portugal, USA, up to the end of 1995; in large part supported by NATO/CCMS grants or fellowships, and organized by Pilot Study participants. The Pilot Study activity has been characterized by a higly collaborative atmosphere, which was essential for a deep and detailed analysis of a problem on which different points of view, methodological approaches and regulations exist in the various member countries. The Pilot Study was aimed at proposing a carcinogenic risk assessment procedure which is based on a detailed analysis of the relevant biological processes, and may also consent the verification of hypotheses. The specific form of theoretical and mathe matical models is identified by considering and using the whole set of objective data available. The multidisciplinary approach of the pilot study is reflected by the struc ture of this book. Each chapter is the result of the cooperation of several authors from to produce a comprehensive manual that includes different countries; its objective was both theoretical and practical information.
Book Synopsis Biologically Based Methods for Cancer Risk Assessment by : Curtis Travis
Download or read book Biologically Based Methods for Cancer Risk Assessment written by Curtis Travis and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Biologically Based Methods for Cancer Risk Assessment", an Advanced Research Workshop, (ARW) sponsored by the North Atlantic Treaty Organization (NATO) was held in Corfu, Greece in June, 1989. The intent of the workshop was to survey available pharmacokinetic and pharmacodynamic methods in cancer risk assessment and identify methodological gaps and research needs for biologically based methods in cancer risk assessment. Incorporation of such methods represents one of the most challenging areas for risk assessment. The workshop included an international group of invited experts in the field and provided for a dynamic exchange of ideas and accomplishments. Some of the major topics discussed were: * Inventory of available pharmacokinetic and pharmacodynamic methods for cancer risk assessment. * Identification of methodology gaps and research needs in biologically based methods in cancer risk assessment. * Development of a general framework to guide future cancer risk assessment research. This book is a compilation of the papers presented at the workshop and is intended to provide guidance for future research to reduce uncertainties in the cancer risk assessment process. The primary sponsorship of this ARW by NATO and the advice and cooperation of Dr. C. Sinclair of the Scientific affairs Division are gratefully acknowledged. Acknowledgement is also given to the National Science Foundation for its support. The organization of the ARW and the preparation of this book have required considerable help from many other sources.
Book Synopsis Cancer Risk Assessment by : Ching-Hung Hsu
Download or read book Cancer Risk Assessment written by Ching-Hung Hsu and published by John Wiley & Sons. This book was released on 2010-12-08 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
Author :Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation Publisher :National Academies Press ISBN 13 :0309133343 Total Pages :422 pages Book Rating :4.3/5 (91 download)
Book Synopsis Health Risks from Exposure to Low Levels of Ionizing Radiation by : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation
Download or read book Health Risks from Exposure to Low Levels of Ionizing Radiation written by Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and published by National Academies Press. This book was released on 2006-03-23 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Book Synopsis Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment by : Lutz Edler
Download or read book Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment written by Lutz Edler and published by John Wiley & Sons. This book was released on 2005-12-13 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry. Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems. Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian). Includes an extensive introduction and discussion to each chapter. Features detailed studies of risk assessments using biologically-based modelling approaches. Discusses the varying computational aspects of the methods proposed. Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries. Features an extensive bibliography with links to relevant background information within each chapter. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies.
Book Synopsis Volume 159: Biologically Based Methods for Cancer Risk Assessment by : CC Travis (Ed)
Download or read book Volume 159: Biologically Based Methods for Cancer Risk Assessment written by CC Travis (Ed) and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Research Needs for Biologically Based Risk Assessment; Multistage Models for Cancer Risk Assessment; Understanding Multistage Carcinogenesis at the Molecular Level - Notes on Recent Progress; The Use of Enzyme-Altered Foci for Risk Assessment of Hepatocarcinogens; Pathogenic Interrelationship of Focal Lesions, Nodules, Adenomas and Carcinomas in the Multistage Evolution of Azaserine-Induced Rat Pancreas Carcinogenesis; Phenotypic Cellular Changes in Multistage Carcinogenesis; Interspecies Extrapolation; Comparative Carcinogenesis, Is There a Theoretical Approach to Interspecies Similarity; Biological Basis for Interspecies Extrapolation of Halogenated Solvents and of 1,3-Butadiene; Species Specific Inhalation Pharmacokinetics of 2-Nitropropane, Methyl Ethyl Ketone, and n-Hexane; Overview of Promotion as a Mechanism in Carcinogenesis; Hepatocarcinogenesis by Non-Genotoxic Compounds; The Role of Inhibited Intercellular Communication in Carcinogenesis - Implications for Risk Assessment From Exposure to Chemicals; Comparative Analyses of the Timing and Magnitude of Genotoxic and Nongenotoxic Cellular Effects in Urinary Bladder Carcinogenesis; Alterations in Gene Expression in Mouse Hepatocarcinogenesis; Medium Term Bioassay Models for Environmental Carcinogens - Two - Step Liver and Multi-Organ Carcinogenesis Protocols; The Use of Aldh Induction as a Carcinogenic Risk Marker in Comparison With Typical in Vitro Mutagenicity System; Expression of Inducible Cytochrome P-450 mRNAs During Promotion of Experimental Chemical Hepatocarcinogenesis; An In Vitro Approach for Interspecies Extrapolation Using Animal and Human Airway Epithelial Cell Culture; Assessment of Low-Exposure Risk from Carcinogens, Implication of the Knudson-Moolgavkar Two-Critical Mutation Theory; A Biological Data Base for Methylene Chloride Risk Assessment; Computer Simulation of Chemical Carcinogenesis; Determination of Carcinogen Exposure by Immunological Techniques; Risk Estimation for Leukemogenic Drugs.
Book Synopsis Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment by : Lutz Edler
Download or read book Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment written by Lutz Edler and published by John Wiley & Sons. This book was released on 2005-05-27 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human health risk assessment involves the measuring of risk of exposure to disease, with a view to improving disease prevention. Mathematical, biological, statistical, and computational methods play a key role in exposure assessment, hazard assessment and identification, and dose-response modelling. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment is a comprehensive text that accounts for the wealth of new biological data as well as new biological, toxicological, and medical approaches adopted in risk assessment. It provides an authoritative compendium of state-of-the-art methods proposed and used, featuring contributions from eminent authors with varied experience from academia, government, and industry. Provides a comprehensive summary of currently available quantitative methods for risk assessment of both cancer and non-cancer problems. Describes the applications and the limitations of current mathematical modelling and statistical analysis methods (classical and Bayesian). Includes an extensive introduction and discussion to each chapter. Features detailed studies of risk assessments using biologically-based modelling approaches. Discusses the varying computational aspects of the methods proposed. Provides a global perspective on human health risk assessment by featuring case studies from a wide range of countries. Features an extensive bibliography with links to relevant background information within each chapter. Recent Advances in Quantitative Methods in Cancer and Human Health Risk Assessment will appeal to researchers and practitioners in public health & epidemiology, and postgraduate students alike. It will also be of interest to professionals working in risk assessment agencies.
Book Synopsis Endocrine Disrupters and Carcinogenic Risk Assessment by : Lech Chyczewski
Download or read book Endocrine Disrupters and Carcinogenic Risk Assessment written by Lech Chyczewski and published by IOS Press. This book was released on 2002 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is devoted to the study of the endocrine-related effects on human health with special reference to carcinogenesis, and to the assessment of carcinogenic risk. After providing basic information at the general, cellular and molecular levels, the contents focus on the paradigm of biologically-based risk assessment, as developed form physiologically-based toxicokinetic models. The analysis of this material is proposed as the novel parameters for developing biologically-based models of carcinogenesis, considered to be more relevant to risk assessment than traditional approaches.
Book Synopsis Statistical Modelling and Risk Analysis by : Christos P. Kitsos
Download or read book Statistical Modelling and Risk Analysis written by Christos P. Kitsos and published by Springer Nature. This book was released on 2024-01-13 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest results on novel methods in Risk Analysis and assessment, with applications in Biostatistics (which is providing food for thought since the first ICRAs, covering traditional areas of RA, until now), Engineering Reliability, the Environmental Sciences and Economics. The contributions, based on lectures given at the 9th International Conference on Risk Analysis (ICRA 9), at Perugia, Italy, May 2022, detail a wide variety of daily risks, building on ideas presented at previous ICRA conferences. Working within a strong theoretical framework, supporting applications, the material describes a modern extension of the traditional research of the 1980s. This book is intended for graduate students in Mathematics, Statistics, Biology, Toxicology, Medicine, Management, and Economics, as well as quantitative researchers in Risk Analysis.
Book Synopsis Statistical Advances in the Biomedical Sciences by : Atanu Biswas
Download or read book Statistical Advances in the Biomedical Sciences written by Atanu Biswas and published by John Wiley & Sons. This book was released on 2007-12-14 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.
Book Synopsis Toxicology and Risk Assessment by : Helmut Greim
Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2018-08-22 with total page 862 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
Book Synopsis Human and Ecological Risk Assessment by : Dennis J. Paustenbach
Download or read book Human and Ecological Risk Assessment written by Dennis J. Paustenbach and published by John Wiley & Sons. This book was released on 2017-05-22 with total page 1476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human and Ecological Risk Assessment: Theory and Practice assembles the expertise of more than fifty authorities from fifteen different fields, forming a comprehensive reference and textbook on risk assessment. Containing two dozen case studies of environmental or human health risk assessments, the text not only presents the theoretical underpinnings of the discipline, but also serves as a complete handbook and "how-to" guide for individuals conducting or interpreting risk assessments. In addition, more than 4,000 published papers and books in the field are cited. Editor Dennis Paustenbach has assembled chapters that present the most current methods for conducting hazard identification, dose-response and exposure assessment, and risk characterization components for risk assessments of any chemical hazard to humans or wildlife (fish, birds, and terrestrials). Topics addressed include hazards posed by: Air emissions Radiological hazards Contaminated soil and foods Agricultural hazards Occupational hazards Consumer products and water Hazardous waste sites Contaminated air and water The bringing together of so many of the world's authorities on these topics, plus the comprehensive nature of the text, promises to make Human and Ecological Risk Assessment the text against which others will be measured in the coming years.
Book Synopsis Mindful Topics on Risk Analysis and Design of Experiments by : Jürgen Pilz
Download or read book Mindful Topics on Risk Analysis and Design of Experiments written by Jürgen Pilz and published by Springer Nature. This book was released on 2022-05-20 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the role of statistics in Risk Analysis, by addressing theory, methodology and applications covering the broad scope of risk assessment in life sciences and public health, environmental science as well as in economics and finance. Experimental Design plays a key role in many of these areas, therefore there is special attention paid to joining Risk Analysis and Experimental Design topics. The contributions of this volume originate from the 8th International Conference on Risk Analysis (23-26 April, 2019, Vienna). The conference brought together researchers and practitioners working in the field of Risk Analysis. The most important contributions at the conference have been refereed and developed into chapters to show the latest developments in the field.
Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Book Synopsis Science and Judgment in Risk Assessment by : National Research Council
Download or read book Science and Judgment in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1994-01-01 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The public depends on competent risk assessment from the federal government and the scientific community to grapple with the threat of pollution. When risk reports turn out to be overblownâ€"or when risks are overlookedâ€"public skepticism abounds. This comprehensive and readable book explores how the U.S. Environmental Protection Agency (EPA) can improve its risk assessment practices, with a focus on implementation of the 1990 Clean Air Act Amendments. With a wealth of detailed information, pertinent examples, and revealing analysis, the volume explores the "default option" and other basic concepts. It offers two views of EPA operations: The first examines how EPA currently assesses exposure to hazardous air pollutants, evaluates the toxicity of a substance, and characterizes the risk to the public. The second, more holistic, view explores how EPA can improve in several critical areas of risk assessment by focusing on cross-cutting themes and incorporating more scientific judgment. This comprehensive volume will be important to the EPA and other agencies, risk managers, environmental advocates, scientists, faculty, students, and concerned individuals.
Author :Larry W. Robertson, Larry G. Hansen Publisher :University Press of Kentucky ISBN 13 :9780813130545 Total Pages :506 pages Book Rating :4.1/5 (35 download)
Book Synopsis PCBs: Recent Advances in Environmental Toxicology and Health Effects by : Larry W. Robertson, Larry G. Hansen
Download or read book PCBs: Recent Advances in Environmental Toxicology and Health Effects written by Larry W. Robertson, Larry G. Hansen and published by University Press of Kentucky. This book was released on 2001 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: In April 2000 researchers from around the world met in Lexington, Kentucky to bring together the very latest information on the chemistry and biological effects of the environmental pollutants known as Polychlorinated Biphenyls (PCBs). The result is a comprehensive and extensive treatment of the very latest findings on all significant subjects relating to PCBs and their health risks. The thorough introduction and sixty-two scientific papers presented here represent the most up-to-date research by scientists in government, private industry, and academia.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt:
