Peptides as Immunogens

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3642714404
Total Pages : 93 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Peptides as Immunogens by : Hilary Koprowski

Download or read book Peptides as Immunogens written by Hilary Koprowski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: The humoral response of the immune system to a foreign antigen usually requires the recognition of two antigenic determinants. The one, called the carrier, is recognized by T-Iymphocytes, the other, called the hapten, by B-Iympho cytes. As a consequence, T - and B-Iymphocytes proliferate, B-Iymphocytes produce hapten-specific antibodies, and the system develops memory to the antigens. It was long thought that antigens would form a bridge to mediate the cooperation of T - and B-Iymphocytes. However, it now appears that antigens are broken down to fragments which then act as carrier determinants for T -lymphocytes. The cells which originally process antigen are called an tigen-presenting cells. They have phagocytic properties. They can take up and degrade antigens, in the case of pro teins to peptides. The peptides of protein antigens reappear on the surface of the antigen-presenting cells, where they must become associated with membrane proteins encoded by genes of the major histocompatibility complex (MHC) in order to be recognized by T-Iymphocytes. To activate helper T-Iym phocytes which cooperate in antibody responses, MHC class II molecules have to be expressed on the surface of the antigen-presenting cells. Once T -lymphocytes have be come activated, they are ready to cooperate with B cells.

Synthetic Peptides as Antigens

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Author :
Publisher : Elsevier
ISBN 13 : 008085897X
Total Pages : 401 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Synthetic Peptides as Antigens by : S. Muller

Download or read book Synthetic Peptides as Antigens written by S. Muller and published by Elsevier. This book was released on 1999-11-25 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro. It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays. The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.

Peptide Antibodies

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Author :
Publisher : Humana
ISBN 13 : 9781493929986
Total Pages : 0 pages
Book Rating : 4.9/5 (299 download)

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Book Synopsis Peptide Antibodies by : Gunnar Houen

Download or read book Peptide Antibodies written by Gunnar Houen and published by Humana. This book was released on 2015-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study.

Janeway's Immunobiology

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Author :
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Immunobiology of Proteins and Peptides V

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Publisher : Springer Science & Business Media
ISBN 13 : 1475720467
Total Pages : 353 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Immunobiology of Proteins and Peptides V by : M. Atassi

Download or read book Immunobiology of Proteins and Peptides V written by M. Atassi and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Fifth International Symposium held in Alberta, Canada, Oct. 1988. Articles are focused on the field of vaccines against viral, bacterial, and parasitic agents. Topics include: cytotoxic and helper T-lymphocyte responses to antibody, the application of molecular biology to the deve

Immunobiology of Proteins and Peptides · I

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461588588
Total Pages : 501 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Immunobiology of Proteins and Peptides · I by : M. Zouhair Atassi

Download or read book Immunobiology of Proteins and Peptides · I written by M. Zouhair Atassi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the central questions in immunology is the understanding in molecular terms of antigen-antibody interactions and of the cellu lar recognition of antigens. It is hoped that this understanding will extend eventually to the immunobiological basis of host defense to infectious agents and of tissue damage or deranged cell functions which stem from these reactions. A variety of natural and artificial substances have been used as models for these studies. Emphasis was placed upon substances of known and relatively uncomplicated chemical structures. These included polysaccharides, amino acid polymers, nu cleic acids and haptens. On the other hand. until recently there has been very little information on protein antigens. The complexity of these molecules posed an immense chemical obstacle to precise immuno chemical analysis. Indeed, it is this difficulty with proteins that spurred the synthesis and immunological studies of amino acid poly mers. The control and normal regulation of the immune system at the cellular-molecular interface and the great majority of antigens asso ciated with immune disorders are attributed to protein molecules. In the last few years great advances have been made in the analysis and synthesis of the antigenic sites of some proteins. The entire antigenic structures of myoglobin and lysozyme and the partial anti genic structures of several other proteins have been determined. Moreover, in the past seven years several biological responses resulting from the reactions of proteins and their peptides with cells of the immune system were described.

Immunobiology of Proteins and Peptides-III

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Publisher : Springer Science & Business Media
ISBN 13 : 1468479741
Total Pages : 278 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Immunobiology of Proteins and Peptides-III by : M. Z. Atassi

Download or read book Immunobiology of Proteins and Peptides-III written by M. Z. Atassi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This symposia series, founded in 1976, is devoted to the advancement and dissemination of knowledge in the field in immunology, particularly as it relates to the immune recognition and responses to protein and peptide antigens. Leading investigators are convened every 2 or 3 years for the purpose of consolidating the research on protein and peptide antigens of defined structure and to focus on these findings in the context of contemporary immunology. Each symposium has focussed on a particular aspect of molecular and cellular immunology of proteins and peptides. It is extremely gratifying that, in the last 2-3 years, the scientific community has shown a heightened interest in the study and understanding of protein and peptide antigens. The third symposium was devoted to viral and bacterial antigens. Great advances have been made in recent years in the elucidation and synthesis of protein antigenic sites. These, together with advances in cloning, expression and sequencing of protein genes, have offered new avenues for the preparation of synthetic vaccines for viral, bacterial and other antigens. Such vaccines have been the aspiration of immunologists for over 20 years. The meeting has served to integrate and correlate the current knowledge of these systems with developing trends in immunology and to identify the most promising new directions for future investigations.

Vaccines97

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Publisher : CSHL Press
ISBN 13 : 9780879695163
Total Pages : 396 pages
Book Rating : 4.6/5 (951 download)

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Book Synopsis Vaccines97 by : Cold Spring Harbor Laboratory

Download or read book Vaccines97 written by Cold Spring Harbor Laboratory and published by CSHL Press. This book was released on 1997 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over its lifespan so far, this annual series has traced the state of the art of vaccination from empiricism to molecular design. In this work, the investigation of immunogens at a structural level is especially prominent, as is further exploration of DNA immunization.

Peptide Antigens

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Publisher : Irl Press
ISBN 13 : 9780199634521
Total Pages : 252 pages
Book Rating : 4.6/5 (345 download)

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Book Synopsis Peptide Antigens by : G. Brian Wisdom

Download or read book Peptide Antigens written by G. Brian Wisdom and published by Irl Press. This book was released on 1994 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide antigens and anti-peptide antibodies are widely used in biochemistry and molecular biology for the measurement, location, and purification of specific oligopeptides. More recently the application of these reagents has expanded, for example in the identification and mapping of the binding sites of antibodies and T-cell receptors and in the identification and characterization of proteins which are known only by their primary structure. This volume provides practical guidance to the major techniques used in the exploitation of peptide antigens and anti-peptide antibodies. The chapters give detailed protocols for the prediction of epitopes, peptides synthesis, the preparation of peptide immunogens, immunoaffinity chromatography, immunoassays, and the mapping of epitopes using both synthetic peptides and phage display systems. Peptide Antigens: A Practical Approach covers all practical aspects of this important and growing subject. It is a unique compendium of methods for workers in biochemistry, molecular biology, and immunology who need to use this technology in their research.

Molecular Biology of The Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Immunogenicity of Proteins Used as Therapeutics

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889662888
Total Pages : 328 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Immunogenicity of Proteins Used as Therapeutics by : Amy Rosenberg

Download or read book Immunogenicity of Proteins Used as Therapeutics written by Amy Rosenberg and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Susan Richards is an employee of Sanofi and owns stock in the corporation. Topic Editor Bernard Maillere declares economic support from pharmaceutical companies (Novartis, Sanofi, and UCB) in the frame of collaborations aiming to evaluate the recognition by human T cells of therapeutic proteins and antibodies.

Peptide Antibodies

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Author :
Publisher : Springer Nature
ISBN 13 : 1071639145
Total Pages : 270 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Peptide Antibodies by : Gunnar Houen

Download or read book Peptide Antibodies written by Gunnar Houen and published by Springer Nature. This book was released on with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthetic Peptides as Antigens

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Author :
Publisher : Elsevier Science
ISBN 13 : 9780444821751
Total Pages : 380 pages
Book Rating : 4.8/5 (217 download)

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Book Synopsis Synthetic Peptides as Antigens by : S. Muller

Download or read book Synthetic Peptides as Antigens written by S. Muller and published by Elsevier Science. This book was released on 1999-12-09 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newest edition to the Laboratory Techniques Series gives current state of the art use of synthetic peptides in molecular biology and practical protocols on how to conjugate peptides, immunize animals with peptides and monitor immune responses to peptides in vitro. It gives background information on antigenic specificity, prediction of antigenic sites in proteins and applications of peptides in immunology and virology, as probes in diagnosis and as vaccines. The book also describes antigenicity of proteins and methods to localize antigenic sites as well as methods for predicting epitoxes, and gives detailed protocols for peptide-carrier conjugation, immunization with peptides, and peptide immunoassays. The volume also describes typical use of antipeptide antibodies in molecular and cellular biology as well as the use of peptides in the diagnosis of viral infections and autoimmune diseases, and the use of peptides as potential synthetic vaccines. An excellent edition to an excellent series, available in hardbound and paperback.

Immunoinformatics

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387729682
Total Pages : 216 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Immunoinformatics by : Christian Schönbach

Download or read book Immunoinformatics written by Christian Schönbach and published by Springer Science & Business Media. This book was released on 2007-11-21 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Immunology

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Publisher : John Wiley & Sons
ISBN 13 : 1118396898
Total Pages : 432 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Immunology by : Richard Coico

Download or read book Immunology written by Richard Coico and published by John Wiley & Sons. This book was released on 2015-01-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs. This new edition of Immunology: A Short Course: • Has been fully revised and updated, with a brand new art program to help reinforce learning • Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area • Highlights important therapeutic successes resulting from targeted antibody therapies • Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications

Immunological Recognition of Peptides in Medicine and Biology

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Author :
Publisher : CRC Press
ISBN 13 : 9780849389672
Total Pages : 498 pages
Book Rating : 4.3/5 (896 download)

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Book Synopsis Immunological Recognition of Peptides in Medicine and Biology by : N. D. Zegers

Download or read book Immunological Recognition of Peptides in Medicine and Biology written by N. D. Zegers and published by CRC Press. This book was released on 1995-07-19 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.

Immunobiology of Proteins and Peptides VII

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Author :
Publisher : Springer
ISBN 13 : 9781461360308
Total Pages : 0 pages
Book Rating : 4.3/5 (63 download)

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Book Synopsis Immunobiology of Proteins and Peptides VII by : Zouhair Atassi

Download or read book Immunobiology of Proteins and Peptides VII written by Zouhair Atassi and published by Springer. This book was released on 2012-11-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this volume represent papers delivered by invited speakers at the 7th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic, and basic applications. This anticipated explosion has in fact since occurred and many applications of these peptides are now being realized. The seventh symposium focused on immune responses that have undesirable effects on the host, hence we named them unwanted immune responses. Two major aspects of unwanted immune responses were discussed at the symposium: Allergy and Autoimmunity.