Pathology Of Genetically Engineered And Other Mutant Mice

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Pathology of Genetically Engineered and Other Mutant Mice

Author : John P. Sundberg
Publisher : John Wiley & Sons
ISBN 13 : 1119624576
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Pathology of Genetically Engineered and Other Mutant Mice by : John P. Sundberg

Download or read book Pathology of Genetically Engineered and Other Mutant Mice written by John P. Sundberg and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.

Pathology of Genetically-Engineered Mice

Author : Jerrold M. Ward
Publisher : Wiley-Blackwell
ISBN 13 : 9780813825212
Total Pages : 520 pages
Book Rating : 4.8/5 (252 download)

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Book Synopsis Pathology of Genetically-Engineered Mice by : Jerrold M. Ward

Download or read book Pathology of Genetically-Engineered Mice written by Jerrold M. Ward and published by Wiley-Blackwell. This book was released on 2000-11-28 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the use of genetically-enigneered mice in the biomedical research revolution in technology, this book brings together the collective expertise of many specialists to cover the approaches to organ-specific evaluations, to provide examples of many currently available mutant mice, to illustrate how specific defects can be studied, and to present methods for evaluation of live mice. It will provide state-of-the art methods that can be used by pathologists, biologists, molecular biologists and other scientists.

Genetically Engineered Mice Handbook

Author : John P. Sundberg
Publisher : CRC Press
ISBN 13 : 1420039075
Total Pages : 337 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Genetically Engineered Mice Handbook by : John P. Sundberg

Download or read book Genetically Engineered Mice Handbook written by John P. Sundberg and published by CRC Press. This book was released on 2016-04-19 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book covers all aspects of the field of genetically engineered laboratory mice, including the creation of mutant mice through mouse models for developmental biology and the monitoring of laboratory mouse colonies. Written by leading biomedical investigators, pathologists, and clinicians, this book presents systematic approaches for analyzing mutant laboratory mice for specific medical applications. It provides a variety of methods for creating mutant mice, while covering legal aspects of mutant and inbred laboratory mice as well as the use and maintenance of international databases.

Pathology of the Developing Mouse

Author : Brad Bolon
Publisher : CRC Press
ISBN 13 : 1420070096
Total Pages : 446 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Pathology of the Developing Mouse by : Brad Bolon

Download or read book Pathology of the Developing Mouse written by Brad Bolon and published by CRC Press. This book was released on 2015-04-24 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Comparative Anatomy and Histology

Author : Piper M. Treuting
Publisher : Academic Press
ISBN 13 : 0123813611
Total Pages : 475 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Comparative Anatomy and Histology by : Piper M. Treuting

Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2012 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.

Animal Models of Cognitive Impairment

Author : Edward D. Levin
Publisher : CRC Press
ISBN 13 : 1420004336
Total Pages : 395 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Animal Models of Cognitive Impairment by : Edward D. Levin

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Safety of Genetically Engineered Foods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309166152
Total Pages : 254 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Safety of Genetically Engineered Foods by : National Research Council

Download or read book Safety of Genetically Engineered Foods written by National Research Council and published by National Academies Press. This book was released on 2004-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.

Mouse Models of Human Cancer

Author : Eric C. Holland
Publisher : John Wiley & Sons
ISBN 13 : 047144460X
Total Pages : 504 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Mouse Models of Human Cancer by : Eric C. Holland

Download or read book Mouse Models of Human Cancer written by Eric C. Holland and published by John Wiley & Sons. This book was released on 2004-08-27 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

Genetically Engineered Crops

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309437385
Total Pages : 607 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Genetically Engineered Crops by : National Academies of Sciences, Engineering, and Medicine

Download or read book Genetically Engineered Crops written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-01-28 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetically engineered (GE) crops were first introduced commercially in the 1990s. After two decades of production, some groups and individuals remain critical of the technology based on their concerns about possible adverse effects on human health, the environment, and ethical considerations. At the same time, others are concerned that the technology is not reaching its potential to improve human health and the environment because of stringent regulations and reduced public funding to develop products offering more benefits to society. While the debate about these and other questions related to the genetic engineering techniques of the first 20 years goes on, emerging genetic-engineering technologies are adding new complexities to the conversation. Genetically Engineered Crops builds on previous related Academies reports published between 1987 and 2010 by undertaking a retrospective examination of the purported positive and adverse effects of GE crops and to anticipate what emerging genetic-engineering technologies hold for the future. This report indicates where there are uncertainties about the economic, agronomic, health, safety, or other impacts of GE crops and food, and makes recommendations to fill gaps in safety assessments, increase regulatory clarity, and improve innovations in and access to GE technology.

The Laboratory Mouse

Author : Hans Hedrich
Publisher : Academic Press
ISBN 13 : 012382009X
Total Pages : 868 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Laboratory Mouse by : Hans Hedrich

Download or read book The Laboratory Mouse written by Hans Hedrich and published by Academic Press. This book was released on 2012-06-14 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916785X
Total Pages : 223 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by : National Research Council

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Handbook of Mouse Mutations with Skin and Hair Abnormalities

Author : John P. Sundberg
Publisher : CRC Press
ISBN 13 : 9780849383724
Total Pages : 582 pages
Book Rating : 4.3/5 (837 download)

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Book Synopsis Handbook of Mouse Mutations with Skin and Hair Abnormalities by : John P. Sundberg

Download or read book Handbook of Mouse Mutations with Skin and Hair Abnormalities written by John P. Sundberg and published by CRC Press. This book was released on 1994-05-19 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

Moyamoya Disease Explored Through RNF213

Author : Akio Koizumi
Publisher : Springer
ISBN 13 : 9811027110
Total Pages : 185 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Moyamoya Disease Explored Through RNF213 by : Akio Koizumi

Download or read book Moyamoya Disease Explored Through RNF213 written by Akio Koizumi and published by Springer. This book was released on 2017-02-21 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease.Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke.

What's Wrong With My Mouse?

Author : Jacqueline N. Crawley
Publisher : John Wiley & Sons
ISBN 13 : 0470119047
Total Pages : 544 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis What's Wrong With My Mouse? by : Jacqueline N. Crawley

Download or read book What's Wrong With My Mouse? written by Jacqueline N. Crawley and published by John Wiley & Sons. This book was released on 2007-05-11 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

Comparative Anatomy and Histology

Author : Piper M. Treuting
Publisher : Academic Press
ISBN 13 : 0128029196
Total Pages : 570 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Comparative Anatomy and Histology by : Piper M. Treuting

Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2017-08-29 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images

Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

Author :
Publisher : Academic Press
ISBN 13 : 9780123813275
Total Pages : 336 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors by :

Download or read book Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors written by and published by Academic Press. This book was released on 2010-11-20 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use. Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors Preclinical models in COMT inhibitor devlopment Transgenic COMT mice – latest information summarized Chemistry of COMT inhibitors and their design with molecular modelling COMT gene and its regulation and relation to dopamine related diseases Role of cofactor SAM regulation in relation to homocysteine Nonclinical and clinical safety of COMT inhibitors summarized Future prospects of COMT inhibitors in Parkinson’s disease