Gnotobiotics

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Gnotobiotics

Author : Trenton R Schoeb
Publisher : Academic Press
ISBN 13 : 0128045833
Total Pages : 428 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Gnotobiotics by : Trenton R Schoeb

Download or read book Gnotobiotics written by Trenton R Schoeb and published by Academic Press. This book was released on 2017-08-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility

Gnotobiotics

Author : Trenton R Schoeb
Publisher : Academic Press
ISBN 13 : 9780128045619
Total Pages : 0 pages
Book Rating : 4.0/5 (456 download)

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Book Synopsis Gnotobiotics by : Trenton R Schoeb

Download or read book Gnotobiotics written by Trenton R Schoeb and published by Academic Press. This book was released on 2017-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource.

Germfree and Gnotobiotic Animal Models

Author : Bernard S. Wostmann
Publisher : CRC Press
ISBN 13 : 9780849340086
Total Pages : 206 pages
Book Rating : 4.3/5 (4 download)

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Book Synopsis Germfree and Gnotobiotic Animal Models by : Bernard S. Wostmann

Download or read book Germfree and Gnotobiotic Animal Models written by Bernard S. Wostmann and published by CRC Press. This book was released on 1996-06-19 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.

Vaccine Efficacy Evaluation

Author : Lijuan Yuan
Publisher : CRC Press
ISBN 13 : 1000565998
Total Pages : 207 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis Vaccine Efficacy Evaluation by : Lijuan Yuan

Download or read book Vaccine Efficacy Evaluation written by Lijuan Yuan and published by CRC Press. This book was released on 2022-04-19 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing the immunogenicity, protective efficacy and safety in animal models is a crucial step in vaccine development. Pigs raised in germ-free environments, called gnotobiotic (Gn) pigs, are one of the most useful animal models for testing vaccines. The Gn pig model is a widely accepted model for studying pathogenesis and immunity and an ideal model for pre-clinical testing for the safety and efficacy of enteric viral vaccines. Through these studies and others, the Gn pig model has been established as the most reliable animal model for pre-clinical evaluation of human rotavirus and norovirus vaccines. This book provides detailed information on establishing Gn pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection. Key Features Provides a natural history of human rotavirus and norovirus infection in Gn pigs Establishes the optimal virus challenge doses in Gn pigs for vaccine evaluation Evaluates various candidate rotavirus and norovirus vaccines Discusses human gut microbiota transplanted Gn pig models Documents the role of probiotics and rice bran as prophylactics and vaccine adjuvants

Gnotobiotic Mouse Technology

Author : Chriss J. Vowles
Publisher : CRC Press
ISBN 13 : 1498736335
Total Pages : 237 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Gnotobiotic Mouse Technology by : Chriss J. Vowles

Download or read book Gnotobiotic Mouse Technology written by Chriss J. Vowles and published by CRC Press. This book was released on 2016-01-05 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of establishing and operating a germ-free mouse research facility, from basic principles and equipment to detailed instructions for assembling and maintaining isolators, sterilizing supplies, handling animals, and monitoring sterility. The book breaks down techniques and procedures into modules, each of which contains a step-by-step practical and visual guide to a set of related procedures. Each description consists of a materials list, introduction, and general overview, followed by a thoroughly illustrated walkthrough of the steps for each procedure. The descriptions end with troubleshooting tips. Technical chapters are heavily illustrated and include notations of potential pitfalls and alternatives. Other chapters discuss management procedures and practices such as the hiring and training of personnel, setting fee schedules, and record keeping. This book is a landmark resource for establishing and maintaining a facility for germ-free mouse research. Useful to both technicians and investigators, it presents every step necessary to establish a successful facility. It also gives direction in expanding multi-user facilities and applying new technologies to your current practices.

Guide for the Care and Use of Laboratory Animals

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309154006
Total Pages : 246 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Guide for the Care and Use of Laboratory Animals by : National Research Council

Download or read book Guide for the Care and Use of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 2011-01-27 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Laboratory Animal Medicine

Author : James G. Fox
Publisher : Academic Press
ISBN 13 : 1483269167
Total Pages : 766 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Laboratory Animal Medicine by : James G. Fox

Download or read book Laboratory Animal Medicine written by James G. Fox and published by Academic Press. This book was released on 2013-10-02 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals.

The Human Microbiome, Diet, and Health

Author : Food Forum
Publisher : National Academies Press
ISBN 13 : 030926586X
Total Pages : 197 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Human Microbiome, Diet, and Health by : Food Forum

Download or read book The Human Microbiome, Diet, and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

The Microbiota in Gastrointestinal Pathophysiology

Author : Martin H. Floch
Publisher : Academic Press
ISBN 13 : 0128040629
Total Pages : 442 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Microbiota in Gastrointestinal Pathophysiology by : Martin H. Floch

Download or read book The Microbiota in Gastrointestinal Pathophysiology written by Martin H. Floch and published by Academic Press. This book was released on 2016-11-16 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects Explores the gut microbiota as a therapeutic target Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field Serves as a ‘one-stop’ shop for a topic that’s currently spread across a number of various journals

Developments in Industrial Microbiology

Author : Saul Rich
Publisher : Springer
ISBN 13 : 1489950737
Total Pages : 270 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Developments in Industrial Microbiology by : Saul Rich

Download or read book Developments in Industrial Microbiology written by Saul Rich and published by Springer. This book was released on 2013-11-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methods in Protein Biochemistry

Author : Harald Tschesche
Publisher : Walter de Gruyter
ISBN 13 : 3110252368
Total Pages : 379 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Methods in Protein Biochemistry by : Harald Tschesche

Download or read book Methods in Protein Biochemistry written by Harald Tschesche and published by Walter de Gruyter. This book was released on 2011-12-23 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a survey of recent developments in protein biochemistry. Top researchers in the field of protein biochemistry describe modern methods to address the challenges of protein purification by three-phase partitioning, and their folding and degradation by the functions of chaperones. The significance of peptide purity for fibril formation is addressed as well as the use of target oriented peptide arrays in palliative approaches in mucoviszidose. The design and application of protein epitope mimetics just as the structural resolving of the misfolding of various mutant proteins in serpinopathies enlarge our tools in resolving pathophysiological imbalances.

Environmental Chemicals, the Human Microbiome, and Health Risk

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309468698
Total Pages : 123 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Environmental Chemicals, the Human Microbiome, and Health Risk by : National Academies of Sciences, Engineering, and Medicine

Download or read book Environmental Chemicals, the Human Microbiome, and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

The Mouse in Biomedical Research

Author :
Publisher : Elsevier
ISBN 13 : 0080469078
Total Pages : 829 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis The Mouse in Biomedical Research by :

Download or read book The Mouse in Biomedical Research written by and published by Elsevier. This book was released on 2006-12-15 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.

The Laboratory Rat

Author : Henry J. Baker
Publisher :
ISBN 13 : 9780120749010
Total Pages : 464 pages
Book Rating : 4.7/5 (49 download)

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Book Synopsis The Laboratory Rat by : Henry J. Baker

Download or read book The Laboratory Rat written by Henry J. Baker and published by . This book was released on 1979 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aquaculture Nutrition

Author : Daniel L. Merrifield
Publisher : John Wiley & Sons
ISBN 13 : 1118897277
Total Pages : 488 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Aquaculture Nutrition by : Daniel L. Merrifield

Download or read book Aquaculture Nutrition written by Daniel L. Merrifield and published by John Wiley & Sons. This book was released on 2014-08-13 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manipulation of the microbial gut content of farmed fishes andcrustaceans can have a marked effect on their general health,growth, and quality. Expertly covering the science behind the useof prebiotics and probiotics this landmark book explains how thecorrect manipulation of the gut flora of farmed fishes andcrustaceans can have a positive effect on their health, growthrates, feed utilization, and general wellbeing. Aquaculture Nutrition: Gut Health, Probioticsand Prebiotics provides a comprehensive overview of the currentknowledge of the gut microbiomes of fish and their importance withrespect to host-fish health and performance, providing in-depth, cutting-edge fundamental and applied information. Written by many of the world’s leading authorities andedited by Dr Daniel Merrifield and Professor Einar Ringø, thisimportant book discusses in detail the common mechanisms formodulating microbiomes, particularly at the gut level (e.g.probiotics, prebiotics and synbiotics). The book is a key resourcefor an understanding of the historical development of theseproducts, their known mechanisms of action and their degree ofefficacy as presently demonstrated in the literature. The fundamental material provided on the gut microbiota itself,and more broad aspects of microbe-live feed interactions, provideessential reading for researchers, academics and students in theareas of aquaculture nutrition, fish veterinary science,microbiology, aquaculture, fish biology and fisheries. Thoseinvolved in the development and formulation of aquaculture feedsand those with broader roles within the aquaculture industry willfind a huge wealth of commercially-important information within thebook’s covers. All libraries in universities and researchestablishments where biological sciences, nutrition and aquacultureare studied and taught, should have copies of this excellent bookon their shelves.

Nutrient Requirements of Laboratory Animals,

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309051266
Total Pages : 188 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Nutrient Requirements of Laboratory Animals, by : National Research Council

Download or read book Nutrient Requirements of Laboratory Animals, written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Microbial Evolution and Co-Adaptation

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309131219
Total Pages : 330 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microbial Evolution and Co-Adaptation by : Institute of Medicine

Download or read book Microbial Evolution and Co-Adaptation written by Institute of Medicine and published by National Academies Press. This book was released on 2009-05-10 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.